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Zide
Treatment
0 Active Studies for Zide
What is Zide
TrichlormethiazideThe Generic name of this drug
Treatment SummaryLevodopa is a medication used to treat Parkinson's disease. When taken alone, levodopa can cause side effects like nausea and vomiting, so it is often combined with a drug called benserazide. This combination helps prevent the formation of dopamine from levodopa in tissues outside the brain, reducing the occurrence of side effects. Levodopa/benserazide products are approved for use in Canada and Europe, while the FDA has approved levodopa/carbidopa for use in the United States. Additionally, benserazide has been given an orphan designation by the European Medicines Agency for its potential to treat
Zide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trichlormethiazide
0
Effectiveness
How Zide Affects PatientsLevadopa is a medication used to treat Parkinson's disease. It works by converting into dopamine in the body, but this can cause unpleasant side effects like nausea, vomiting, and even heart problems. To reduce these side effects, levadopa is often taken with a drug called benserazide. Benserazide can't pass through the brain's barrier, so it stops levadopa from turning into dopamine in other parts of the body and helps minimize side effects.
How Zide works in the bodyLevodopa and benserazide are used to treat Parkinson's disease. Levodopa is converted to dopamine, which is a chemical that helps with movement control and is depleted in people with Parkinson's. Benserazide helps levodopa get to the brain more easily, reducing side effects like nausea, vomiting, and arrhythmias. It also helps with symptoms of Parkinson's, but it won't work if levodopa alone is already helping. Benserazide has also been studied as a potential treatment for beta thalassaemia, a type of blood disorder. It may help keep fetal hemoglobin active
Warnings
There are 20 known major drug interactions with Zide.Common Zide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Trichlormethiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Trichlormethiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Trichlormethiazide is combined with Dofetilide.
Lithium carbonate
Major
Trichlormethiazide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium citrate
Major
Trichlormethiazide may decrease the excretion rate of Lithium citrate which could result in a higher serum level.
Zide Toxicity & Overdose RiskTaking too much of this drug can lead to heart rhythm problems, confusion and restlessness, nausea and vomiting, and awkward movements. Toxic doses of this drug have been found to be 5300mg/kg in rats.
Zide Reviews: What are patients saying about Zide?
5Patient Review
9/24/2022 This, in concert with Losartan, has been very successful in keeping my blood pressure regulated for over a year now. I'm a 66-year-old male and have experienced no negative side effects.
5Patient Review
10/19/2022 This drug, in addition to potassium and maintaining hydration, has been incredibly effective for managing my blood pressure and fluid levels. I'm now in my 70s and have never had any issues with this medication, which was originally prescribed to me many years ago.
5Patient Review
6/23/2022 Hydrochlorothiazide has been a life-saver for me. I spent two years trying different pills that made me miserable, but this one keeps my blood pressure at an even 120 over 80 with no side effects.
5Patient Review
10/19/2022 I've been taking this for years, and it's always managed my blood pressure and fluid build-up effectively. I'm grateful that it doesn't interact negatively with any of the other drugs I take.
5Patient Review
6/23/2022 Hydrochlorothiazide has been a life-saver for me. It doesn't have any side effects that I've experienced, and it keeps my blood pressure at a healthy level. I spent two years trying out different pills before finding this one, and I'm so glad that I did.
Patient Q&A Section about zide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is hydrochlorothiazide 25 mg?
"This helps your body get rid of extra water and salt.
This medication lowers blood pressure by causing the body to get rid of extra water and salt through increased urination."
Answered by AI
Should I take high blood pressure medication?
"If you have high blood pressure, your doctor may advise you to take medicine. This is because high blood pressure can lead to organ damage or other health problems, such as heart failure, coronary artery disease, diabetes, or kidney disease. Additionally, if you have one or more risk factors for heart attack or stroke, your doctor may advise you to take medicine to help prevent these conditions."
Answered by AI
What happens if you take high blood pressure medicine and don t need it?
"If you don't take your medicine at the right doses or times, or you stop taking your medicine for high blood pressure suddenly, it can be really dangerous to your health. If your blood pressure stays too high, you're more likely to develop other serious problems like heart attacks, strokes, or kidney disease."
Answered by AI
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