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What is Xiidra
LifitegrastThe Generic name of this drug
Treatment SummaryLifitegrast is a medication approved by the FDA to treat dry eye syndrome. It works by blocking a certain protein linked to the cause of the condition and helps protect the corneal surface. It was approved in 2016 under the brand name Xiidra and has been shown to provide fast relief of symptoms with a well-tolerated profile.
Xiidrais the brand name
Xiidra Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xiidra
Lifitegrast
2016
2
Effectiveness
How Xiidra Affects PatientsLifitegrast helps to reduce the symptoms and physical damage of dry eye syndrome by blocking a molecule that causes inflammation in the eyes. It works by competing with a certain type of cell (T-cells) and preventing them from recruiting, activating, and releasing chemicals that lead to inflammation.
How Xiidra works in the bodyLifitegrast works by stopping a special type of cell, called leukocytes, from attaching to another type of cell, called intercellular adhesion molecule-1 (ICAM-1). This interaction can cause inflammation and other damaging effects in tissues affected by dry eye disease. Lifitegrast prevents the interaction so that the leukocytes can't cause further damage. In laboratory studies, Lifitegrast was also found to reduce the release of inflammatory molecules from leukocytes.
When to interrupt dosage
The suggested measure of Xiidra is based on the identified issue. The amount of dose is contingent upon the technique of delivery (e.g. Solution - Ophthalmic or Ophthalmic) detailed in the table beneath.Condition
Dosage
Administration
Dry Eye Syndrome
, 50.0 mg/mL, 5.0 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic
Warnings
Xiidra ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Lifitegrast may interact with Pulse Frequency
Common Xiidra Drug Interactions
Drug Name
Risk Level
Description
Xiidra Toxicity & Overdose RiskSome people may experience irritation or burning sensation at the application site, changes in taste, or reduced vision after taking this drug. There is no evidence that this drug can cause cancer, genetic mutations, or fertility problems.
Xiidra Novel Uses: Which Conditions Have a Clinical Trial Featuring Xiidra?
Currently, 14 active studies are being conducted to evaluate the potential of Xiidra to alleviate symptoms of Dry Eye Syndrome.Condition
Clinical Trials
Trial Phases
Dry Eye Syndrome
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Xiidra Reviews: What are patients saying about Xiidra?
3.3Patient Review
4/14/2022 I find that this medication works best if I take it around mealtime and then eat afterwards. It prevents the aftertaste issue. These drops, like many other Drops, burn like crazy and will likely cause some temporary blurred vision. Blink frequently after a few minutes of putting the meds in and you'll decrease how long you are blurry for. At first I blurred for 15+ minutes but now it's about 5. I have Sjogrens and thisdrops worked far better than Restasis did for me.
3Patient Review
7/24/2022 At first, this medication really helped with my dry eyes. But now, a few months later, my eyes are burning and itching almost all the time. I actually preferred Restasis; it never gave me any trouble with burning sensation. The only reason I switched was that insurance wouldn't cover Restasis and wanted me to try something less expensive.
2.7Patient Review
4/30/2022 The container this comes in is not user friendly at all. You basically have to use a needle and syringe to get all of the liquid out, including the drop left in the twist-off top. And then you have to remove the needle and use the syringe to put the drops into each eye. That requires a second person to accomplish effectively.
2.3Patient Review
10/12/2022 The dropper is difficult to use as it is somewhat wide and flat. My eyes immediately burn, become extremely blurry, and it leaves a horrible taste. The blurred vision last about 20 minutes or longer. I continued to use it for over 2 weeks to see if there was any change; however, the side effects remained and I did not notice a change with my dry eyes. Consequently, I will be going back to my previous medication.
2Patient Review
3/26/2022 This didn't help my dry eye condition at all.
1.3Patient Review
5/22/2022 I had a really terrible experience with this medication. It caused my eyelashes to fall out, I got cysts, and my body hurt all over. I went to the doctor and he told me that I was experiencing symptoms of anaphylactic shock and needed to stop using the drops immediately.
1Patient Review
7/3/2022 I tried Xiidra for two weeks and unfortunately experienced every single side effect that they advertise on TV. My eyes couldn't handle the burning sensation. I would not recommend this product to anyone!
1Patient Review
5/23/2022 I tried using this treatment, but it made my dryness and blurred vision so much worse than before. I stopped using it entirely.
Patient Q&A Section about xiidra
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effect of Xiidra?
"Some possible symptoms of Covid-19 include: blurry vision, headache, eye irritation, itchy eyes, dysgeusia (metallic taste in mouth), redness of the eyes, sinusitis (sinus infection), watery eyes."
Answered by AI
How much does a 30 day supply of Xiidra cost?
"The price for a 30-day prescription of Xiidra (lifitegrast 5%) is $522.21. The cash price for medications can vary based on pharmacy, your insurance and deductible, or any discount coupons you may be able to use. Xiidra is an eye drop used for the treatment of the signs and symptoms of dry eye disease."
Answered by AI
Which is better Restasis or Xiidra?
"Both Xiidra and Restasis are effective treatments for chronic dry eye symptoms. However, Xiidra may work more quickly than Restasis. In most cases, Relief with Xiidra can be seen in as little as two weeks while it may take up to three months to see any improvement when using Restasis."
Answered by AI
How long should you use Xiidra eye drops?
"While neither drug is recommended over the other, the AAO guidelines point out that studies of Xiidra for treating this condition only looked at the drug's usage over a period of 3 months. The safety of using Xiidra long term (12 months or longer) is unknown at this time."
Answered by AI
What is the side effect of Xiidra?
"It is possible that Xiidra may cause blurry vision, eye irritation, and other eye discomfort as side effects. If you experience these symptoms, your vision may worsen. If your condition deteriorates while you are using Xiidra, you should tell your doctor."
Answered by AI