Xcopri

Seizures

Treatment

4 Active Studies for Xcopri

What is Xcopri

Cenobamate

The Generic name of this drug

Treatment Summary

Cenobamate (also known as YKP-3089) is a medication used to treat partial onset seizures. It works by increasing the activity of the neurotransmitter GABA and inhibiting voltage-gated sodium channels. The drug was approved by the FDA in 2019 and is manufactured by SK Pharmaceuticals.

Xcopri

is the brand name

image of different drug pills on a surface

Xcopri Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Xcopri

Cenobamate

2020

11

Effectiveness

How Xcopri Affects Patients

The exact way cenobamate works is not known, but it affects a neurotransmitter (GABA<sub>A</sub>) and inhibits a type of protein in the body (voltage gated sodium channels). Taking one dose of cenobamate per day can provide long-lasting effects and it is considered to be a safe drug even at high doses. However, patients should be aware that there are risks associated with taking cenobamate, including developing a rare skin reaction (DRESS syndrome), changes in the electrical activity of the heart, suicidal behavior, and neurological side effects.

How Xcopri works in the body

Cenobamate works by reducing the number of electrical signals sent out by your nerves. It does this by blocking sodium channels, which control how much electricity passes through a nerve cell. By blocking these channels, Cenobamate makes it harder for nerves to send signals. It also works to increase the activity of GABA, which is a chemical messenger that helps to reduce nerve activity.

When to interrupt dosage

The quantity of Xcopri is reliant upon the identified condition. The dosage is contingent upon the procedure of delivery featured in the table below.

Condition

Dosage

Administration

Seizures

200.0 mg, 50.0 mg, 150.0 mg, , 100.0 mg, 25.0 mg, 12.5 mg

Tablet, film coated - Oral, Kit, Oral, , Tablet, film coated, Kit - Oral

Warnings

Xcopri Contraindications

Condition

Risk Level

Notes

familial short QT syndrome

Do Not Combine

There are 20 known major drug interactions with Xcopri.

Common Xcopri Drug Interactions

Drug Name

Risk Level

Description

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Cenobamate.

Eliglustat

Major

The metabolism of Eliglustat can be decreased when combined with Cenobamate.

Entrectinib

Major

The metabolism of Entrectinib can be increased when combined with Cenobamate.

Fentanyl

Major

The metabolism of Fentanyl can be decreased when combined with Cenobamate.

Fluorouracil

Major

The metabolism of Fluorouracil can be increased when combined with Cenobamate.

Xcopri Toxicity & Overdose Risk

An overdose of cenobamate can cause unknown side effects, and the best treatment is to provide supportive care. There is also limited evidence on whether dialysis can be used to effectively remove cenobamate from the bloodstream.

image of a doctor in a lab doing drug, clinical research

Xcopri Novel Uses: Which Conditions Have a Clinical Trial Featuring Xcopri?

Two active studies are assessing the potential of Xcopri to ameliorate Seizure symptoms.

Condition

Clinical Trials

Trial Phases

Seizures

5 Actively Recruiting

Phase 3, Phase 2, Phase 1

Xcopri Reviews: What are patients saying about Xcopri?

5

Patient Review

8/3/2021

Xcopri for Simple Seizure

I find that this medication makes me drowsy, so I take it before bed. I was glad that this one was available as I have become resistant to other medications.

4.7

Patient Review

9/25/2021

Xcopri for Simple Seizure

I switched to taking this medication at night because it made me sleepy, but I haven't had a seizure in almost four months! It's not time-released, so if I take it late I don't have to countdown when I'm going to seize. I feel like I can start living again!

4.3

Patient Review

2/8/2022

Xcopri for Simple Seizure

This medication has been excellent for my seizures, but unfortunately makes me very drowsy. I take it at night in order to sleep through the worst of the fatigue, but even still I wake up feeling groggy and out-of-it. I'm considering cutting back on the dose to see if that helps; otherwise, this is by far the best seizure medication I've found in over 20 years. Thank you!

2

Patient Review

8/3/2021

Xcopri for Simple Seizure

I have had extremely negative effects while taking this medicine, to the point where I need to stop taking it as soon as possible.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about xcopri

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Xcopri a narcotic?

"The DEA has officially announced that Xcopri will be classified as a schedule V drug, meaning it has a low potential for abuse. This announcement comes after the FDA approved Xcopri for the treatment of partial-onset seizures in adults back in November 2019."

Answered by AI

What is Xcopri used for?

"This medication is used to treat a certain type of seizure disorder (partial onset). It is not known exactly how it works, but it may affect the action of some nerves that cause seizures."

Answered by AI

How fast does Xcopri work?

"effects.Sep It typically takes several weeks to months for Xcopri to start working. Your doctor will usually start you on a low dosage and then gradually increase your dosage over 12 weeks. Because of this gradual increase, it can take some time for Xcopri to build up in your system and reach its full effects."

Answered by AI

What is the new drug for epilepsy?

"The U.S. Food and Drug Administration today approved XCOPRI to treat partial-onset seizures in adults."

Answered by AI

Clinical Trials for Xcopri