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What is Xcopri
CenobamateThe Generic name of this drug
Treatment SummaryCenobamate (also known as YKP-3089) is a medication used to treat partial onset seizures. It works by increasing the activity of the neurotransmitter GABA and inhibiting voltage-gated sodium channels. The drug was approved by the FDA in 2019 and is manufactured by SK Pharmaceuticals.
Xcopriis the brand name
Xcopri Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xcopri
Cenobamate
2020
11
Effectiveness
How Xcopri Affects PatientsThe exact way cenobamate works is not known, but it affects a neurotransmitter (GABA<sub>A</sub>) and inhibits a type of protein in the body (voltage gated sodium channels). Taking one dose of cenobamate per day can provide long-lasting effects and it is considered to be a safe drug even at high doses. However, patients should be aware that there are risks associated with taking cenobamate, including developing a rare skin reaction (DRESS syndrome), changes in the electrical activity of the heart, suicidal behavior, and neurological side effects.
How Xcopri works in the bodyCenobamate works by reducing the number of electrical signals sent out by your nerves. It does this by blocking sodium channels, which control how much electricity passes through a nerve cell. By blocking these channels, Cenobamate makes it harder for nerves to send signals. It also works to increase the activity of GABA, which is a chemical messenger that helps to reduce nerve activity.
When to interrupt dosage
The quantity of Xcopri is reliant upon the identified condition. The dosage is contingent upon the procedure of delivery featured in the table below.Condition
Dosage
Administration
Seizures
200.0 mg, 50.0 mg, 150.0 mg, , 100.0 mg, 25.0 mg, 12.5 mg
Tablet, film coated - Oral, Kit, Oral, , Tablet, film coated, Kit - Oral
Warnings
Xcopri ContraindicationsCondition
Risk Level
Notes
familial short QT syndrome
Do Not Combine
Common Xcopri Drug Interactions
Drug Name
Risk Level
Description
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Cenobamate.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Cenobamate.
Entrectinib
Major
The metabolism of Entrectinib can be increased when combined with Cenobamate.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Cenobamate.
Fluorouracil
Major
The metabolism of Fluorouracil can be increased when combined with Cenobamate.
Xcopri Toxicity & Overdose RiskAn overdose of cenobamate can cause unknown side effects, and the best treatment is to provide supportive care. There is also limited evidence on whether dialysis can be used to effectively remove cenobamate from the bloodstream.
Xcopri Novel Uses: Which Conditions Have a Clinical Trial Featuring Xcopri?
Two active studies are assessing the potential of Xcopri to ameliorate Seizure symptoms.Condition
Clinical Trials
Trial Phases
Seizures
2 Actively Recruiting
Phase 3
Xcopri Reviews: What are patients saying about Xcopri?
5Patient Review
8/3/2021 I find that this medication makes me drowsy, so I take it before bed. I was glad that this one was available as I have become resistant to other medications.
4.7Patient Review
9/25/2021 I switched to taking this medication at night because it made me sleepy, but I haven't had a seizure in almost four months! It's not time-released, so if I take it late I don't have to countdown when I'm going to seize. I feel like I can start living again!
4.3Patient Review
2/8/2022 This medication has been excellent for my seizures, but unfortunately makes me very drowsy. I take it at night in order to sleep through the worst of the fatigue, but even still I wake up feeling groggy and out-of-it. I'm considering cutting back on the dose to see if that helps; otherwise, this is by far the best seizure medication I've found in over 20 years. Thank you!
2Patient Review
8/3/2021 I have had extremely negative effects while taking this medicine, to the point where I need to stop taking it as soon as possible.
Patient Q&A Section about xcopri
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Xcopri a narcotic?
"The DEA has officially announced that Xcopri will be classified as a schedule V drug, meaning it has a low potential for abuse. This announcement comes after the FDA approved Xcopri for the treatment of partial-onset seizures in adults back in November 2019."
Answered by AI
What is Xcopri used for?
"This medication is used to treat a certain type of seizure disorder (partial onset). It is not known exactly how it works, but it may affect the action of some nerves that cause seizures."
Answered by AI
How fast does Xcopri work?
"effects.Sep It typically takes several weeks to months for Xcopri to start working. Your doctor will usually start you on a low dosage and then gradually increase your dosage over 12 weeks. Because of this gradual increase, it can take some time for Xcopri to build up in your system and reach its full effects."
Answered by AI
What is the new drug for epilepsy?
"The U.S. Food and Drug Administration today approved XCOPRI to treat partial-onset seizures in adults."
Answered by AI