Vibramycin

Rocky Mountain Spotted Fever, Acinetobacter Infections, Ureaplasma Infections + 61 more

Treatment

93 FDA approvals

20 Active Studies for Vibramycin

Treatment for

Rocky Mountain Spotted Fever

What is Vibramycin

Doxycycline

The Generic name of this drug

Treatment Summary

Doxycycline is a synthetic antibiotic used to treat a variety of bacterial infections. It is a second-generation tetracycline, meaning it is less toxic than other related antibiotics. Doxycycline can be used to treat various bacterial infections depending on the results of antibiotic susceptibility testing.

Vibramycin Hyclate

is the brand name

image of different drug pills on a surface

Vibramycin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Vibramycin Hyclate

Doxycycline

1967

728

Approved as Treatment by the FDA

Doxycycline, otherwise known as Vibramycin Hyclate, is approved by the FDA for 93 uses such as Severe Acne and Streptococcus Pneumoniae Infections .

Severe Acne

Streptococcus Pneumoniae Infections

Intestinal Amebiasis

Chlamydia Infections

Primary Syphilis

Anal chlamydia infection

Upper Respiratory Tract Infection

Clostridium difficile Infection

Genus Chlamydia

Communicable Diseases

Actinomycosis

Secondary Syphilis

Rickettsialpox

Klebsiella Infections

Cholera (Disorder)

Campylobacter Infections

Mycoplasma Pneumoniae

Inclusion conjunctivitis

Necrotizing ulcerative gingivostomatitis

Chlamydia Infections

Urethritis

Ureaplasma urethritis

Chlamydial Urethritis

Listeria infection

Urinary Tract Infections

Bacteriological Techniques

Staphylococcus (S.) Aureus Infection

Relapsing fever caused by Borrelia recurrentis

Campylobacter Infection

Tick-borne fever

Plasmodium Infections

Skin Infections

Chlamydia trachomatis

Typhus, Endemic Flea-Borne

Communicable Diseases

Chlamydial cervicitis

Haemophilus Influenzae Infections

Calymmatobacterium granulomatis

Lymphogranuloma Venereum

Dysentery, Bacillary

Fever

Gonorrhea

Bartonella Infections

Acne Vulgaris

Q Fever

Acinetobacter Infections

Ureaplasma Infections

Communicable Diseases

Uterine Cervicitis

Tularemia

Typhus infections

Epididymo-orchitis gonococcal

Trachoma

Neisseria Gonorrhoeae Infection

Rocky Mountain Spotted Fever

Bartonella bacilliformis infections

Malaria

Bacterial Infection caused by Enterobacter aerogenes

Relapsing Fever

Yaws

Chancroid

Amebic colitis

Brucellosis

Used to treat Brucellosis in combination with Streptomycin

Recurrent Upper and Lower Respiratory Tract Infections (RTIs)

Plague

Chlamydia trachomatis

Cat-Scratch Disease

Shigella Infection

inhaled anthrax caused by Bacillus anthracis

Pneumococcal Infections

Clostridium Infections

Common Cold

Brucellosis

Used to treat Brucellosis in combination with Streptomycin

Trachoma

Plague

Urethritis

Acinetobacter Infections

Yersinia pestis

Psittacosis

Chlamydia psitacci infection

Ureaplasma Infections

Infection Due to Escherichia Coli

Trachoma inclusion conjunctivitis

Listeriosis

Yaws

Relapsing Fever

Vibrio Cholerae Infection

Disease

Haemophilus ducreyi infection

Tularemia

prophylaxis of Malaria

Respiratory Tract Infections

Granuloma Inguinale

Effectiveness

How Vibramycin Affects Patients

Doxycycline is a type of medication called a tetracycline, which is designed to stop the growth of bacteria. It works by blocking the protein production of the bacteria, preventing it from continuing to spread. Doxycycline is also lipophilic and can penetrate the cell walls of bacteria. This makes it effective in treating a wide range of bacterial infections. Additionally, it has been shown to have anti-parasitic and anti-inflammatory effects, and has been used to treat certain skin conditions such as bullous dermatoses and rosacea.

How Vibramycin works in the body

Doxycycline stops bacteria from being able to make proteins they need to survive. It works by preventing an amino acid-carrying molecule from binding to the ribosome, a component of bacterial cells. This blocks the production of essential proteins and eventually kills the bacteria. Doxycycline also reduces inflammation by blocking the movement of white blood cells and stopping an enzyme that produces a chemical messenger that causes inflammation.

When to interrupt dosage

The suggested dosage of Vibramycin is reliant upon the determined condition, including Urethritis, Chlamydia trachomatis and Respiratory Tract Infections. The measure of dosage varies, as per the technique of delivery (e.g. Capsule or Syrup - Oral) listed in the table beneath.

Condition

Dosage

Administration

Urinary Tract Infections

10.0 mg/mL, , 75.0 mg, 100.0 mg, 150.0 mg, 50.0 mg, 200.0 mg, 20.0 mg, 1.0 mg/mg, 40.0 mg, 5.0 mg/mg, 7.5 mg/mg, 25.0 mg/mL, 50.0 mg/mL, 120.0 mg, 60.0 mg, 0.1 mg/mg, 5.0 mg/mL, 8.8 %, 20.0 mg/mL, 0.75 mg/mg, 0.5 mg/mg, 80.0 mg

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, extended release - Oral, Capsule, extended release, Powder - Intravenous, Powder, Powder, for suspension, Syrup, Syrup - Oral, Powder, for suspension - Oral, Kit - Oral, For suspension, For suspension - Oral, Capsule, Delayed Release - Oral, Capsule, Delayed Release, Kit, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Oral; Topical, Capsule - Oral; Topical, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Gel - Oral, Suspension - Oral

Primary Syphilis

inhaled anthrax caused by Bacillus anthracis

Psittacosis

Brucellosis

Bacteriological Techniques

Relapsing Fever

Actinomycosis

prophylaxis of Malaria

Mycoplasma Pneumoniae

Chlamydia Infections

Ureaplasma Infections

Q Fever

Epididymo-orchitis gonococcal

Rosacea

Listeriosis

Necrotizing ulcerative gingivostomatitis

Dysentery, Bacillary

Pneumococcal Infections

Klebsiella Infections

Warnings

Vibramycin Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Doxycycline may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Doxycycline may interact with Pulse Frequency

There are 20 known major drug interactions with Vibramycin.

Common Vibramycin Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Doxycycline.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Doxycycline.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Doxycycline.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Doxycycline.

Amdinocillin

Major

The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Doxycycline.

Vibramycin Toxicity & Overdose Risk

The dose of doxycycline that is toxic to rats, mice, and dogs is 2000 mg/kg, 1870 mg/kg, and 500 mg/kg respectively. If someone overdoses on doxycycline, they should stop taking it and receive supportive care. Dialysis will not reduce the amount of doxycycline in the bloodstream.

image of a doctor in a lab doing drug, clinical research

Vibramycin Novel Uses: Which Conditions Have a Clinical Trial Featuring Vibramycin?

34 active clinical trials are currently underway to determine the effectiveness of Vibramycin in treating Haemophilus Influenzae Infections, Respiratory Tract Infections and Amebic Colitis.

Condition

Clinical Trials

Trial Phases

Plague

0 Actively Recruiting

Plague

0 Actively Recruiting

Epididymo-orchitis gonococcal

0 Actively Recruiting

Lymphogranuloma Venereum

0 Actively Recruiting

Gonorrhea

0 Actively Recruiting

Urinary Tract Infections

9 Actively Recruiting

Not Applicable, Phase 4, Early Phase 1

Chlamydia trachomatis

0 Actively Recruiting

Pneumococcal Infections

0 Actively Recruiting

Urethritis

0 Actively Recruiting

Typhus, Endemic Flea-Borne

0 Actively Recruiting

Clostridium difficile Infection

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Chlamydia Infections

0 Actively Recruiting

inhaled anthrax caused by Bacillus anthracis

0 Actively Recruiting

Calymmatobacterium granulomatis

0 Actively Recruiting

Haemophilus Influenzae Infections

0 Actively Recruiting

Chancroid

0 Actively Recruiting

Klebsiella Infections

0 Actively Recruiting

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Rocky Mountain Spotted Fever

0 Actively Recruiting

Vibramycin Reviews: What are patients saying about Vibramycin?

Patient Review

5/5/2019

Vibramycin for Acne

I've been using this for two years to great success. It's the only thing that has worked on my acne cysts. Just remember to take it with food, or you'll be incredibly nauseous.

Patient Review

5/5/2019

Vibramycin for Acne

I've been using this medication for two years to help with my acne. It's been effective in keeping the painful cysts away, as long as I don't miss a dose. The pill can make you nauseous if you don't take it with food. Otherwise, no problems here!

3.7

Patient Review

2/9/2021

Vibramycin for A Sexually Transmitted Disease due to Chlamydia

Worked well, but I experienced some pretty severe psychological side effects. On day two of the treatment, I had a panic attack in the car and begged my wife to crash and kill me. We knew it was the doxycycline that caused it, so I stayed home with her. Suicide ideation can be random while taking this medication, so self-talk and staying busy help a lot. I will never go back on anything in the tetracycline family again; this is the worst experience I've ever had with a medication.

3.7

Patient Review

2/9/2021

Vibramycin for A Sexually Transmitted Disease due to Chlamydia

Worked well, though I did experience some pretty severe psychological side effects. On day two, I had a panic attack so bad that I was screaming for my wife to crash the car and kill me. We knew it was from the doxycycline, so luckily I stayed home with her that day. If you're considering this medication, just be aware that thoughts of suicide can be a random side effect while taking it. Talk to your doctor about whether or not this is the right choice for you.

Patient Review

6/27/2022

Vibramycin for infection caused by bacteria

While this did lower my infection symptoms, I unfortunately experienced very intense anxiety and depression as a result. These thoughts only cleared up about ten days after I stopped taking the medication. If possible, avoid tetracycline medications altogether.

Patient Review

4/11/2018

Vibramycin for Pneumonia caused by Bacteria

I constantly felt dizzy and had headaches. Additionally, I was always cold.

Patient Review

4/11/2018

Vibramycin for Pneumonia caused by Bacteria

I constantly felt dizzy and got headaches. I also experienced chills regularly.

Patient Review

6/27/2022

Vibramycin for infection caused by bacteria

While this drug was effective in reducing infection symptoms, I experienced very intense anxiety and depression. These thoughts only cleared up about 10 days after taking the medication. I would urge others to avoid this drug if possible.

2.7

Patient Review

5/26/2022

Vibramycin for Acne

Nausea, anxiety, and heart palpitations drove me away from this treatment.

2.7

Patient Review

8/14/2022

Vibramycin for infection caused by bacteria

I've been taking this medication for a possible prostate infection. The stomach pain has been manageable, however I have had terrible insomnia as a result. I'm sweating and hot at night, and somewhat congested during the day. It's Day 6, and I haven't slept more than 5 hours total since starting this treatment.

2.7

Patient Review

5/26/2022

Vibramycin for Acne

My skin cleared up for the first two weeks, but I experienced dryness and peeling as well. Around the second or third week, I started having heart palpitations and feeling nauseous and anxious. Overall, not a great experience.

2.7

Patient Review

8/14/2022

Vibramycin for infection caused by bacteria

I was taking this medication for a possible prostate bacterial infection. Though the stomach pain has been tolerable, I have had severe insomnia. I seem to be hot and sweating at night and somewhat congested. I am on day 6 and I have not slept more than 5 hours on any day. Cannot get to sleep at all!

2.3

Patient Review

4/14/2022

Vibramycin for Bacterial Urinary Tract Infection

I've been feeling terrible since taking this pill. They say to take it with no dairy and on an empty stomach, which is already inconvenient. I've been dizzy and sick for three days now, and it's all thanks to this medication that was supposed to help treat a bacterial infection in my bladder.

2.3

Patient Review

10/27/2022

Vibramycin for Acne

Unfortunately, this medication had some pretty severe and dangerous side effects for my teenager. We saw a significant increase in aggressive behaviors, which then led to suicidal thoughts and dreams. However, we stopped the medication and those symptoms subsided relatively quickly.

2.3

Patient Review

10/27/2022

Vibramycin for Acne

I unfortunately found that this medication caused my teen to become aggressive, to the point of suicidal ideation. Thankfully, once we stopped the medication, these behaviors and thoughts subsided.

2.3

Patient Review

4/14/2022

Vibramycin for Bacterial Urinary Tract Infection

I've been feeling really awful since starting this medication. I get vertigo and nauseous every time I take it, even though I follow the instructions to the letter. It's been three days now and I'm no better off.

Patient Review

4/25/2018

Vibramycin for Acne

I would stay away from this medication, as it caused me a lot of anxiety and depression. A simple Google search will show you that I'm far from the only one who experienced these negative effects.

Patient Review

1/27/2022

Vibramycin for infection caused by bacteria

I had some pretty severe side effects from this medication, including chills, headaches, fatigue, and muscle pain. I stopped taking it after just two days because I felt worse than before I started.

Patient Review

11/1/2022

Vibramycin for Acne Rosacea

I only took this for eight days because the side effects were so bad. I felt nauseous, had headaches and fatigue, but also couldn't sleep. On top of all that, my hair started falling out in clumps. I would not recommend this medication to anyone.

Patient Review

11/1/2022

Vibramycin for Acne Rosacea

I only made it through eight days of taking this medication because the side effects were so severe. I felt nauseous, had headaches and fatigue, but also insomnia and then on day seven my hair started shedding quite severely. Additionally, I felt unlike myself: sad and depressed.

Patient Review

4/25/2018

Vibramycin for Acne

I would stay away from this medication, as it caused me severe anxiety and depression. If you're considering taking it, please look up "doxycycline depression" to get an idea of the potential side effects.

Patient Review

1/27/2022

Vibramycin for infection caused by bacteria

I unfortunately didn't have a great experience with this medication. It gave me chills, headaches, and made my muscles feel worse. I stopped taking it after only two days.

Patient Review

6/19/2022

Vibramycin for Non-Contagious Disease due to Actinomyces Bacteria

Unfortunately, I had a severe allergic reaction to this treatment.

Patient Review

6/19/2022

Vibramycin for Non-Contagious Disease due to Actinomyces Bacteria

Unfortunately, I had a severe allergic reaction to this treatment.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about vibramycin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What bacteria does vibramycin treat?

"The text describes various infections caused by different bacteria. Vibrio cholerae causes an infection that can lead to severe diarrhea. Campylobacter fetus causes an infection that can lead to inflammation of the reproductive organs. Plague is a serious infectious disease that is caused by the bacteria Yersinia pestis. A deer fly, flea or tick bite can cause a bacterial infection that can lead to skin infection or pneumonia. Anthrax is a bacteria that can cause stomach or intestine infections."

Answered by AI

Is vibramycin a penicillin?

"Doxycycline (Vibramycin) is a good bacteria fighting alternative for people who are allergic to penicillin. It comes in a generic form and as a liquid for those who have trouble swallowing pills. Doxycycline is safe for most people, but should be used with caution in people age 65 or older and those with kidney problems."

Answered by AI

Is vibramycin a strong antibiotic?

"Vibramycin is one of the most widely prescribed antibiotics in the world, and its safety and efficacy have been well-documented.

Vibramycin is a brand name antibiotic that contains the active ingredient doxycycline. Doxycycline is a powerful antibiotic that is used to treat cholera, typhus, plague, pneumonia, urinary tract infections, eye infections, gut infections, and a host of others. Vibramycin is one of the most widely prescribed antibiotics in the world and its safety and efficacy have been well-documented."

Answered by AI

What is vibramycin used for?

"This medication can be used to treat a wide variety of bacterial infections, including those that cause acne. It is also effective in preventing malaria. As a tetracycline antibiotic, it works by inhibiting the growth of bacteria."

Answered by AI

Clinical Trials for Vibramycin

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17

All Sexes

Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4

Waitlist Available

New This Month

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc

Have you considered Vibramycin clinical trials?

We made a collection of clinical trials featuring Vibramycin, we think they might fit your search criteria.

Image of Baylor College of Medicine in Houston, United States.

Educational Tool for Urinary Tract Infections

18+

All Sexes

Houston, TX

Urine culture is the most common microbiological test in the outpatient setting in the United States. Unfortunately, contamination during collection is prevalent and undermines test accuracy, leading to incorrect diagnosis, unnecessary treatment, wasted laboratory resources, and inflated costs. Unnecessary antibiotic treatment increases the risk of developing antimicrobial resistance, one of the most serious threats to patients and public health. The goal of this clinical trial is to test whether a bilingual (English and Spanish) educational intervention, an animated video and pictorial flyer, can reduce urine culture contamination and associated inappropriate antibiotic use in adult patients visiting safety-net primary care clinics. The main questions it aims to answer are: 1. Does providing patients with a bilingual educational intervention reduce urine culture contamination rates? 2. Does the intervention lead to fewer unnecessary urinary antibiotic prescriptions? 3. Does providing patients with a bilingual educational intervention reduce contaminated urinalyses? Researchers will compare patients randomized to receive the educational intervention (video and flyer) to those receiving usual care to see if the intervention improves urine collection accuracy and reduces inappropriate antibiotic use. Participants will watch a short, animated video with step-by-step instructions for proper midstream clean-catch urine (MSCC) collection, receive a pictorial flyer (with stills from the video) reinforcing the instructions, and provide a urine sample for culture. Hypothesis: patients who receive the educational intervention will have: lower urine culture contamination rates (primary outcome), fewer urinary antibiotic prescriptions (secondary outcome), and fewer contaminated urinalyses (secondary outcome). The objectives are to (1) develop educational tools: Create an animated video and pictorial flyer with step-by-step urine collection instructions for women and men, developed through an iterative, stakeholder-engaged process, (2) assess acceptability: Use mixed methods (quantitative surveys and qualitative interviews) to evaluate and refine the tools for usability and cultural/linguistic appropriateness, and (3) test effectiveness: Conduct a randomized controlled trial to assess the intervention's impact on urine contamination rates, antibiotic prescribing, and patient satisfaction.

Waitlist Available

Has No Placebo

Baylor College of Medicine

Larissa Grigoryan, MD, PhD