Trandate

Hypertension, Subarachnoid Hemorrhage, Hypertensive disease + 3 more
Treatment
1 FDA approval
20 Active Studies for Trandate

What is Trandate

LabetalolThe Generic name of this drug
Treatment SummaryLabetalol is a medication used to treat high blood pressure. It is a combination of two different substances that are available as an injection or tablets. Labetalol was approved by the FDA in 1984.
Trandateis the brand name
image of different drug pills on a surface
Trandate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trandate
Labetalol
1984
261

Approved as Treatment by the FDA

Labetalol, commonly known as Trandate, is approved by the FDA for 1 uses including Hypertensive disease .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Trandate Affects PatientsLabetalol works by blocking certain hormones that control blood pressure. It is usually taken twice a day and the dose can range from 200-400mg. People with asthma should not take labetalol unless other blood pressure medications have not worked for them.
How Trandate works in the bodyLabetalol works by blocking certain hormones which control the body's response to stress. This has the effect of widening blood vessels, which in turn lowers blood pressure. It also slows the heart rate slightly. The effects of labetalol last for a long time and don't decrease the heart's ability to pump blood or reduce the amount of blood pumped.

When to interrupt dosage

The recommended portion of Trandate is contingent upon the diagnosed condition, such as Subarachnoid Hemorrhage, Hypertensive Emergency and Chronic Stable Angina Pectoris. The amount of dosage is contingent upon the approach of delivery (e.g. Oral or Tablet, film coated - Oral) outlined in the table below.
Condition
Dosage
Administration
Angina, Stable
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertension
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Subarachnoid Hemorrhage
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Pheochromocytoma
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive Emergency
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral

Warnings

Trandate has nine contraindications, so it should not be consumed when confronted with any of the conditions in the accompanying table.Trandate Contraindications
Condition
Risk Level
Notes
Asthma
Do Not Combine
severe bradycardia
Do Not Combine
Hypotension
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Heart Failure
Do Not Combine
Hypotension
Do Not Combine
Heart Block
Do Not Combine
Lung Diseases, Obstructive
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Labetalol may interact with Pulse Frequency
There are 20 known major drug interactions with Trandate.
Common Trandate Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Labetalol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Labetalol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Labetalol.
Acepromazine
Major
Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Labetalol.
Trandate Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice is 600mg/kg and more than 2g/kg in rats. Those who overdose may experience low blood pressure and slow heart rate. To reverse the effects, they should be laid on their back with their legs raised to keep the brain supplied with blood. Treatment options include gastric lavage or inducing vomiting, using atropine or epinephrine to restore heart rate, using digitalis and a diuretic for heart failure, using vasopressors to treat hypotension, using epinephrine or a beta2 agonist to treat bronchospasms, and using diazep
image of a doctor in a lab doing drug, clinical research

Trandate Novel Uses: Which Conditions Have a Clinical Trial Featuring Trandate?

81 active trials are being conducted to assess the efficacy of Trandate in treating Hypertensive disease, Hypertensive crisis and Chronic Stable Angina Pectoris.
Condition
Clinical Trials
Trial Phases
Hypertension
0 Actively Recruiting
Pheochromocytoma
0 Actively Recruiting
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Subarachnoid Hemorrhage
8 Actively Recruiting
Not Applicable, Phase 1
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Trandate Reviews: What are patients saying about Trandate?

5Patient Review
5/18/2010
Trandate for High Blood Pressure
This medication was prescribed to me by a cardiologist after my blood pressure spiked to an extremely dangerous level. Almost immediately, this treatment began effectively regulating my blood pressure.
3.7Patient Review
12/11/2012
Trandate for High Blood Pressure
I feel like my patient is being given too high of a dose for blood pressure medication. They have an RX for 300 mg twice a day, but I want to double check and see if that's what other people think is appropriate.
3.7Patient Review
6/6/2013
Trandate for High Blood Pressure
I began this treatment to help me get pregnant. I started with 200mg twice a day, and now I'm up to 300mg 3 times a day. It took some getting used to the side effects like tingly head, headaches, and numbness in legs; but now they seem manageable. Also have to be careful about my diet and not overindulging in alcohol while on this medication because it raises my blood pressure if I do.
3.7Patient Review
8/11/2014
Trandate for High Blood Pressure
While Trandate has been successful in lowering my blood pressure, I have unfortunately experienced a significant decline in kidney function since beginning the medication.
3Patient Review
8/9/2008
Trandate for High Blood Pressure
While this medication has helped lower my blood pressure, I still have issues with swelling and weight loss.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about trandate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is Trandate?

"Trandate is a prescription medicine that is used to treat the symptoms of high blood pressure (hypertension). It may be used alone or with other medications. Trandate belongs to a class of drugs called beta-blockers, alpha activity."

Answered by AI

What is Trandate used for?

"Labetalol is used to lower blood pressure, either with or without other medications. High blood pressure can lead to strokes, heart attacks, and kidney problems, so lowering it can help prevent these issues. Labetalol works as both an alpha blocker and beta blocker."

Answered by AI

Is Trandate the same as labetalol?

"A healthcare provider will give you the IV form if you have very high blood pressure that needs to be lowered immediately.

The oral tablet form of labetalol is available as both a brand-name drug and a generic drug. The brand name for this form of labetalol is Trandate. Labetalol also comes in an intravenous (IV) injection form. A healthcare provider will give you the IV form if you have very high blood pressure that needs to be lowered immediately."

Answered by AI

What are the side effects of Trandate?

"You may feel dizzy, have a spinning sensation, feel tired, nauseous, have an upset stomach, a stuffy nose, or a tired feeling, or have difficulty having an orgasm."

Answered by AI

Clinical Trials for Trandate

Have you considered Trandate clinical trials? We made a collection of clinical trials featuring Trandate, we think they might fit your search criteria.
Have you considered Trandate clinical trials? We made a collection of clinical trials featuring Trandate, we think they might fit your search criteria.
Have you considered Trandate clinical trials? We made a collection of clinical trials featuring Trandate, we think they might fit your search criteria.
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