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What is Trandate
LabetalolThe Generic name of this drug
Treatment SummaryLabetalol is a medication used to treat high blood pressure. It is a combination of two different substances that are available as an injection or tablets. Labetalol was approved by the FDA in 1984.
Trandateis the brand name
Trandate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trandate
Labetalol
1984
261
Approved as Treatment by the FDA
Labetalol, commonly known as Trandate, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Trandate Affects PatientsLabetalol works by blocking certain hormones that control blood pressure. It is usually taken twice a day and the dose can range from 200-400mg. People with asthma should not take labetalol unless other blood pressure medications have not worked for them.
How Trandate works in the bodyLabetalol works by blocking certain hormones which control the body's response to stress. This has the effect of widening blood vessels, which in turn lowers blood pressure. It also slows the heart rate slightly. The effects of labetalol last for a long time and don't decrease the heart's ability to pump blood or reduce the amount of blood pumped.
When to interrupt dosage
The recommended portion of Trandate is contingent upon the diagnosed condition, such as Subarachnoid Hemorrhage, Hypertensive Emergency and Chronic Stable Angina Pectoris. The amount of dosage is contingent upon the approach of delivery (e.g. Oral or Tablet, film coated - Oral) outlined in the table below.Condition
Dosage
Administration
Hypertensive crisis
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Subarachnoid Hemorrhage
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Pheochromocytomas
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Chronic Stable Angina Pectoris
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Hypertensive Emergency
, 100.0 mg, 200.0 mg, 300.0 mg, 5.0 mg/mL, 400.0 mg, 50.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Tablet, coated, Tablet, coated - Oral
Warnings
Trandate has nine contraindications, so it should not be consumed when confronted with any of the conditions in the accompanying table.Trandate ContraindicationsCondition
Risk Level
Notes
Bronchial Asthma
Do Not Combine
severe bradycardia
Do Not Combine
Hypotension
Do Not Combine
Shock, Cardiogenic
Do Not Combine
overt cardiac failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Labetalol may interact with Pulse Frequency
Hypotension
Do Not Combine
Heart Block
Do Not Combine
Lung Diseases, Obstructive
Do Not Combine
Common Trandate Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Labetalol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Labetalol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Labetalol.
Acepromazine
Major
Labetalol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Labetalol.
Trandate Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice is 600mg/kg and more than 2g/kg in rats. Those who overdose may experience low blood pressure and slow heart rate. To reverse the effects, they should be laid on their back with their legs raised to keep the brain supplied with blood. Treatment options include gastric lavage or inducing vomiting, using atropine or epinephrine to restore heart rate, using digitalis and a diuretic for heart failure, using vasopressors to treat hypotension, using epinephrine or a beta2 agonist to treat bronchospasms, and using diazep
Trandate Novel Uses: Which Conditions Have a Clinical Trial Featuring Trandate?
81 active trials are being conducted to assess the efficacy of Trandate in treating Hypertensive disease, Hypertensive crisis and Chronic Stable Angina Pectoris.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Pheochromocytomas
0 Actively Recruiting
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Hypertensive crisis
0 Actively Recruiting
Subarachnoid Hemorrhage
20 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Early Phase 1, Phase 3
Trandate Reviews: What are patients saying about Trandate?
5Patient Review
5/18/2010 This medication was prescribed to me by a cardiologist after my blood pressure spiked to an extremely dangerous level. Almost immediately, this treatment began effectively regulating my blood pressure.
3.7Patient Review
12/11/2012 I feel like my patient is being given too high of a dose for blood pressure medication. They have an RX for 300 mg twice a day, but I want to double check and see if that's what other people think is appropriate.
3.7Patient Review
6/6/2013 I began this treatment to help me get pregnant. I started with 200mg twice a day, and now I'm up to 300mg 3 times a day. It took some getting used to the side effects like tingly head, headaches, and numbness in legs; but now they seem manageable. Also have to be careful about my diet and not overindulging in alcohol while on this medication because it raises my blood pressure if I do.
3.7Patient Review
8/11/2014 While Trandate has been successful in lowering my blood pressure, I have unfortunately experienced a significant decline in kidney function since beginning the medication.
3Patient Review
8/9/2008 While this medication has helped lower my blood pressure, I still have issues with swelling and weight loss.
Patient Q&A Section about trandate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of drug is Trandate?
"Trandate is a prescription medicine that is used to treat the symptoms of high blood pressure (hypertension). It may be used alone or with other medications. Trandate belongs to a class of drugs called beta-blockers, alpha activity."
Answered by AI
What is Trandate used for?
"Labetalol is used to lower blood pressure, either with or without other medications. High blood pressure can lead to strokes, heart attacks, and kidney problems, so lowering it can help prevent these issues. Labetalol works as both an alpha blocker and beta blocker."
Answered by AI
Is Trandate the same as labetalol?
"A healthcare provider will give you the IV form if you have very high blood pressure that needs to be lowered immediately.
The oral tablet form of labetalol is available as both a brand-name drug and a generic drug. The brand name for this form of labetalol is Trandate. Labetalol also comes in an intravenous (IV) injection form. A healthcare provider will give you the IV form if you have very high blood pressure that needs to be lowered immediately."
Answered by AI
What are the side effects of Trandate?
"You may feel dizzy, have a spinning sensation, feel tired, nauseous, have an upset stomach, a stuffy nose, or a tired feeling, or have difficulty having an orgasm."
Answered by AI