Tobrex
Bacteria, Cystic Fibrosis, Septicemia + 19 more
Treatment
1 Active Study for Tobrex
Treatment for
Bacteria
What is Tobrex
Tobramycin
The Generic name of this drug
Treatment Summary
Tobramycin is an antibiotic that is used to treat infections caused by bacteria, including Pseudomonas aeruginosa. It can be given as an inhalant, intravenous injection, or as eye drops. While it is generally effective, it can cause side effects such as nephrotoxicity and ototoxicity. Tobramycin was approved by the FDA in 1975 and is available in a variety of forms.
Tobrex
is the brand name
Tobrex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tobrex
Tobramycin
1981
166
Effectiveness
How Tobrex Affects Patients
Tobramycin is an antibiotic used to treat a wide range of bacterial infections, including some biothreat agents. Taking tobramycin can be risky because it can cause damage to the kidneys, ears, and nerves. It can also affect a baby in the womb, leading to permanent hearing loss. All tobramycin formulations carry a risk of allergic reactions, which can sometimes be fatal.
How Tobrex works in the body
Tobramycin works by binding to the cell membranes of bacteria. It increases the permeability of the cell, allowing it to enter the cell and target the bacterial cells' ribosomes, which are responsible for making proteins. This causes proteins to be made incorrectly, leading to the destruction of the cell. Bacteria can become resistant to tobramycin by modifying the ribosome or the tobramycin molecule itself. Tobramycin is also not effective against anaerobic bacteria since it requires active transport across bacterial membranes.
When to interrupt dosage
The suggested dosage of Tobrex is contingent upon the determined circumstance, including Cystic Fibrosis (CF), steroid-responsive inflammation and Meningitis, Bacterial. The amount of dosage can be found in the table below, in accordance with the method of administration.
Condition
Dosage
Administration
concomitant use of NSAID
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Inflammation
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Cystic Fibrosis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Bacterial Infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Burkholderia Cepacia Infection
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Bacterial Peritonitis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
FEV1 <25% predicted
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Septicemia
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Conjunctivitis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Urinary tract infection
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Eye Infections, Bacterial
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Otitis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
External auditory canal structure
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
FEV1 >80% predicted
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Eye Infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Cystic Fibrosis
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Bacteria
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
ocular bacterial infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Adrenal Cortex Hormones
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Intraabdominal Infections
, 0.003 mg/mg, 40.0 mg/mL, 300.0 mg/mL, 0.8 mg/mL, 10.0 mg/mL, 3.0 mg/mL, 120.0 mg/mL, 0.3 %, 1200.0 mg, 28.0 mg, 80.0 mg, 60.0 mg, 1.2 mg/mL, 60.0 mg/mL, 170.0 mg
, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Solution, Oral, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Solution - Ophthalmic, Suspension / drops - Ophthalmic, Suspension / drops, Solution - Respiratory (inhalation), Respiratory (inhalation), Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intravenous, Capsule, Capsule - Respiratory (inhalation), Liquid - Intramuscular; Intravenous, Liquid, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection - Intravenous, Solution / drops - Ophthalmic, Solution / drops, Suspension, Suspension - Ophthalmic, Capsule - Oral; Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Liquid - Intravenous, Solution - Oral; Respiratory (inhalation), Liquid - Ophthalmic, Oral; Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Warnings
Tobrex exhibits one contraindication, so it should not be administered in combination with the conditions outlined in the following table.
Tobrex Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Tobrex.
Common Tobrex Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Tobramycin is combined with Neomycin.
Tenofovir
Major
Tobramycin may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Tobramycin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Tobramycin may increase the nephrotoxic activities of Tenofovir disoproxil.
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Tobramycin.
Tobrex Toxicity & Overdose Risk
Tobramycin can be toxic in large doses and may cause serious side effects such as kidney damage, hearing loss, muscle weakness, and difficulty breathing. Treatment may involve supportive care and dialysis to remove the drug from the body. It is difficult to overdose on tobramycin, as it is not well absorbed in the digestive system. Animal studies have shown that orally administered LD50 values are greater than 7500 mg/kg.
Tobrex Novel Uses: Which Conditions Have a Clinical Trial Featuring Tobrex?
8 active clinical trials are currently being conducted to assess the applicability of Tobrex in the management of Cystic Fibrosis, Ocular Bacterial Infections and Bacterial Infections.
Condition
Clinical Trials
Trial Phases
Bacterial Infections
0 Actively Recruiting
Meningitis, Bacterial
0 Actively Recruiting
Bacteria
0 Actively Recruiting
Inflammation
0 Actively Recruiting
Eye Infections
0 Actively Recruiting
concomitant use of NSAID
0 Actively Recruiting
Cystic Fibrosis
0 Actively Recruiting
Osteomyelitis
0 Actively Recruiting
Burkholderia Cepacia Infection
0 Actively Recruiting
Adrenal Cortex Hormones
0 Actively Recruiting
Bacterial Peritonitis
0 Actively Recruiting
FEV1 <25% predicted
0 Actively Recruiting
ocular bacterial infections
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Eye Infections, Bacterial
0 Actively Recruiting
Cystic Fibrosis
0 Actively Recruiting
Intraabdominal Infections
1 Actively Recruiting
Not Applicable
Septicemia
0 Actively Recruiting
External auditory canal structure
0 Actively Recruiting
Otitis
0 Actively Recruiting
Tobrex Reviews: What are patients saying about Tobrex?
5
Patient Review
3/7/2009
Tobrex for Combined Inflammation of Cornea and Conjunctiva of the Eye
4.3
Patient Review
6/17/2010
Tobrex for Inflammation of Eyelid Edges and the Lining of the Eye
4
Patient Review
10/17/2012
Tobrex for Inflammation of Eyelid Edges and the Lining of the Eye
4
Patient Review
9/19/2010
Tobrex for Bacterial Infection of the Eyelid
2.3
Patient Review
6/17/2014
Tobrex for Inflammation of Cornea due to Improper Closing of the Eye
2
Patient Review
12/15/2008
Tobrex for Pink Eye from Bacterial Infection
1.7
Patient Review
6/24/2021
Tobrex for Inflammation of Eyelid Edges and the Lining of the Eye
1.3
Patient Review
7/25/2017
Tobrex for Inflammation of Eyelid Edges and the Lining of the Eye
1
Patient Review
6/17/2014
Tobrex for Combined Inflammation of Cornea and Conjunctiva of the Eye
Patient Q&A Section about tobrex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What are the side effects of Tobrex?
"If you experience any of the following symptoms, you may have eye allergies: itching or redness in the eyes; mild burning, stinging, or irritation; itchy or puffy eyelids; blurred vision; or increased sensitivity to light."
Answered by AI
How long should you use Tobrex eye drops?
"One drop should be put into the eye(s) every 4 to 6 hours while the patient is awake. For the first 24 to 48 hours, the amount may be increased to one drop every 2 hours while the patient is awake. The medicine should be taken for 14 days, but no more than 24 days."
Answered by AI
What is Tobrex used for?
"Tobrex is a drug used to treat bacterial infections of the external part of the eye. It contains tobramycin, which is an "aminoglycoside" antibiotic. Your doctor will have examined your eye(s) and decided that Tobrex is the right medicine for you before prescribing it."
Answered by AI
Is Tobrex an antibiotics?
"Tobrex is an antibiotic eye ointment used to treat bacterial infections."
Answered by AI