Timolol

Migraine, Open-angle glaucoma, prophylaxis of migraine headaches + 6 more
Treatment
20 Active Studies for Timolol

What is Timolol

TimololThe Generic name of this drug
Treatment SummaryTimolol is a medicine used to lower pressure in the eyes and reduce hypertension. It is available as an eye drop solution and a tablet. Timolol was first approved by the FDA in 1978 and is now made by several companies. It is used to treat open-angle glaucoma and high blood pressure.
Timopticis the brand name
image of different drug pills on a surface
Timolol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Timoptic
Timolol
1978
167

Effectiveness

How Timolol Affects PatientsTimolol, when taken as eye drops, quickly lowers the pressure in the eyes. When taken as a tablet, it lowers blood pressure, heart rate, and the amount of blood pumped by the heart, as well as reducing the activity of the sympathetic nervous system. The effects of this drug can be felt in as little as 20 minutes after taking the eye drop form, with effects lasting up to 24 hours if taken at the 0.5% or 0.25% doses.
How Timolol works in the bodyTimolol blocks certain receptors in the heart, blood vessels, and bronchial muscles to reduce the effects of catecholamines. This reduces heart rate, blood pressure, and reflex orthostatic hypotension. The exact way timolol reduces pressure in the eye is unknown, but one study suggests it is due to a decrease in blood supply that affects the active transport system or prostaglandin biosynthesis.

When to interrupt dosage

The suggested dosage of Timolol is contingent upon the recognized condition, such as Open Angle Glaucoma, needing ancillary or substitution therapy and Ocular Hypertension. The quantity of dosage is dictated by the approach of delivery (e.g. Ophthalmic or Solution, gel forming / drops) recorded in the table beneath.
Condition
Dosage
Administration
insufficient response to beta-blockers
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Migraine
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open-angle glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Ocular Hypertension
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
inadequate response to other therapeutic measures
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
prophylaxis of migraine headaches
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open Angle Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
requiring adjunctive or replacement therapy
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Increased Intra Ocular Pressure (IOP)
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic

Warnings

Timolol Contraindications
Condition
Risk Level
Notes
Lung Diseases, Obstructive
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
second or third degree AV block
Do Not Combine
Asthma
Do Not Combine
overt cardiac failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Timolol may interact with Pulse Frequency
There are 20 known major drug interactions with Timolol.
Common Timolol Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Timolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Timolol.
Abediterol
Major
Timolol may decrease the bronchodilatory activities of Abediterol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Timolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Timolol.
Timolol Toxicity & Overdose RiskThe lowest toxic dose of timolol maleate for a rat is 1028mg/kg, and 1137mg/kg for a mouse. Overdosing on timolol can cause symptoms such as dizziness, headache, shallow breathing, slow heart rate, and narrowing of the airways. In extreme cases, an overdose may lead to cardiac arrest, which can be reversed with dialysis. Those with kidney problems may not respond as well to dialysis treatment.
image of a doctor in a lab doing drug, clinical research

Timolol Novel Uses: Which Conditions Have a Clinical Trial Featuring Timolol?

172 ongoing clinical trials are assessing the utility of Timolol in providing an adequate response to beta-blockers, as an adjunct or replacement therapy in cases of inadequate response to other treatments.
Condition
Clinical Trials
Trial Phases
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
Open-angle glaucoma
84 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1
prophylaxis of migraine headaches
0 Actively Recruiting
requiring adjunctive or replacement therapy
0 Actively Recruiting
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
inadequate response to other therapeutic measures
0 Actively Recruiting
insufficient response to beta-blockers
0 Actively Recruiting
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Open Angle Glaucoma
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2

Timolol Reviews: What are patients saying about Timolol?

5Patient Review
1/2/2010
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I used this for about 20 years and it was great. I had to stop because it caused my heart to skip beats (which I didn't know about until I had an ECG). I was surprised because I didn't have any ill feelings. Wish I could still use it because it was the only drop that didn't make my eyes burn, sting, and get red.
5Patient Review
12/21/2016
Timolol for Increased Pressure in the Eye
This has been a big help to me in managing the pressure in my eye after a corneal transplant. I do get some minor itching, but it's tolerable and definitely worth it considering the alternative of living with constant pain.
5Patient Review
2/22/2008
Timolol for Wide-Angle Glaucoma
5Patient Review
3/23/2009
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
4.3Patient Review
3/29/2009
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
This treatment is great for alleviating the pressure in my eyes, which has in turn saved me from a lot of headaches.
4.3Patient Review
11/8/2007
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
4Patient Review
9/27/2009
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I've used this product for over two decades with great success. Recently, however, the pressure has started to creep up again. I'm currently using another eyedrop alongside the timoptic, but it seems to be helping lower the pressure once more.
3.7Patient Review
4/28/2021
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
The timolol did a great job reducing the pressure in my eyes, but the dosage was unfortunately too high. This caused my blood pressure (which I already take medication for) to drop too low, and I felt incredibly fatigued as a result. If there were only a lower dose available, it would have solved both problems--the ocular pressure and the BP. Instead, I had to switch to another eye drop which gives me headaches and pain in my eye muscles, as well as taking an oral beta blocker & other medication for my high blood pressure.
3.3Patient Review
5/23/2014
Timolol for Increased Eye Pressure caused by Another Disease
The eye drops caused me to feel extremely drowsy, which is very out of character for me. I had to take a few naps and was even unable to drive because I felt asleep at the wheel.
3.3Patient Review
3/8/2010
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
Timolol, when used in conjunction with Travatan Z, helped lower my eye pressure to a healthy range. I did experience some itchiness and dryness of the eyes, as well as headaches; however, these side effects were manageable and worth the benefits I received from using this medication.
3Patient Review
3/3/2011
Timolol for Increased Pressure in the Eye
This drug unfortunately had the side effect of giving me blurry vision and making it difficult to wear contacts. Additionally, I experienced redness and swelling in my eyes and under them.
3Patient Review
3/15/2010
Timolol for Osteoporosis
This treatment really helped me. I'm grateful for modern medicine.
2.7Patient Review
9/28/2010
Timolol for Wide-Angle Glaucoma
This drug caused my heart rate to drop precipitously. I was also taking Xalatan at the time. After two years of use, my doctor advised me to stop taking Timolol. This was only caught because my regular doctor checked my blood pressure--something that eye doctors should do more regularly.
2.3Patient Review
5/26/2014
Timolol for Closed Angle Glaucoma
I feel like there's still something in my eye even after using this treatment.
1.7Patient Review
6/29/2010
Timolol for High Eye Pressure or Glaucoma that May Worsen without Treatment
My doctor put me on this medication, and almost immediately I started having heart problems. My blood pressure meds had to be changed every time I went to the ER (which was often). It cost me a lot of money in co-pays. I wish I had known that an eye drop could cause such serious cardiac problems. Now I use marijuana instead, with a prescription, and it keeps my IOPs at 18 and 20 with no side effects.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about timolol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is timolol used for?

"Timolol eye drops are used to treat increased pressure in the eye that is caused by open-angle glaucoma or a condition called ocular (eye) hypertension. This medicine is a beta-blocker."

Answered by AI

What are the side effects of timolol?

"You may experience some temporary side effects such as blurred vision, burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, or headache. If you notice any of these effects lasting or getting worse, be sure to contact your doctor or pharmacist."

Answered by AI

How long should timolol eye drops be used?

"Ophthalmic timolol is a liquid that is instilled in the eye. It is usually instilled once or twice a day, at evenly spaced intervals, until pressure in the eye is controlled (about 4 weeks)."

Answered by AI

Who should not use timolol?

"Do not use this medicine if you have asthma or severe COPD, or a serious heart condition. Side effects may occur if this medicine is absorbed into your bloodstream."

Answered by AI

Clinical Trials for Timolol

Have you considered Timolol clinical trials? We made a collection of clinical trials featuring Timolol, we think they might fit your search criteria.
Have you considered Timolol clinical trials? We made a collection of clinical trials featuring Timolol, we think they might fit your search criteria.
Have you considered Timolol clinical trials? We made a collection of clinical trials featuring Timolol, we think they might fit your search criteria.
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