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What is Thorazine
ChlorpromazineThe Generic name of this drug
Treatment SummaryChlorpromazine is a type of antipsychotic medicine used to treat mental health conditions. It works by blocking dopamine receptors in the brain, which helps to restore balance and reduce symptoms. This medication can also be used to treat nausea and persistent hiccups.
Chlorpromazine Hydrochlorideis the brand name
Thorazine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Chlorpromazine Hydrochloride
Chlorpromazine
1973
205
Approved as Treatment by the FDA
Chlorpromazine, also called Chlorpromazine Hydrochloride, is approved by the FDA for 19 uses which include severe behavioural problems and Bipolar Disorder (BD) .severe behavioural problems
Helps manage severe behavioural problems
Bipolar Disorder (BD)
Helps manage Bipolar Disorder (BD)
Psychomotor Agitation
Attention Deficit and Disruptive Behavior Disorders
Helps manage Defiant Disorder, Oppositional
Tetanus
Nausea and vomiting
Intractable hiccups
Defiant Disorder, Oppositional
Helps manage Defiant Disorder, Oppositional
Manic
Helps manage Mania
Schizophrenia
Helps manage Schizophrenia
Restlessness
Operative Surgery
Acute Coryza
Mania
Helps manage Mania
Behcet Syndrome
Helps manage Bipolar Disorder (BD)
short term Hyperactivity
Nausea
Apprehension
Lockjaw
Effectiveness
How Thorazine Affects PatientsChlorpromazine is a drug used to treat schizophrenia and can also help reduce anxiety and vomiting. It has a range of effects on the brain and other organs, including blocking some hormones and chemicals. It has strong effects on the nervous system, including calming effects, and can also reduce the activity of some other hormones and chemicals.
How Thorazine works in the bodyChlorpromazine is a blocking agent that works on different types of receptors in the brain. It blocks dopamine receptors to help reduce both productive and unproductive symptoms of psychosis. It also blocks serotonin, histamine, alpha and muscarinic receptors, which can lead to side effects like sedation, weight gain, and blood pressure changes. Chlorpromazine also weakly inhibits dopamine reuptake, which may lead to mild antidepressant or antiparkinsonian effects, as well as an increase in psychomotor agitation.
When to interrupt dosage
The recommended amount of Thorazine is contingent upon the diagnosed affliction, for instance Bipolar Disorder, short term Hyperactivity and Hiccough. The dosage fluctuates, per the approach of delivery detailed in the table below.Condition
Dosage
Administration
Psychomotor Agitation
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Acute Coryza
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Nausea
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Local Anaesthesia therapy
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Apprehension
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Schizophrenia
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Operative Surgery
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
severe behavioural problems
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
short term Hyperactivity
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Mania
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Behcet Syndrome
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Lockjaw
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
induction of Local Anaesthesia
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Attention Deficit and Disruptive Behavior Disorders
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Intramuscular, Injection, Injection - Intramuscular, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution, Solution - Intramuscular; Intravenous, Syrup, Syrup - Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Warnings
There are 20 known major drug interactions with Thorazine.Common Thorazine Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when used in combination with Chlorpromazine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when used in combination with Chlorpromazine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when used in combination with Chlorpromazine.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Chlorpromazine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Chlorpromazine.
Thorazine Toxicity & Overdose RiskOverdosing on this drug can cause a person to become agitated, fall into a coma, have seizures, have difficulty breathing or swallowing, have dry mouth, become extremely tired, have a fever, be unable to pass food through their intestines, have an irregular heart rate, or have low blood pressure.
Thorazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Thorazine?
265 active clinical trials are currently assessing the possibilities of Thorazine in providing relief from Nausea, Hiccough and Schizophrenia.Condition
Clinical Trials
Trial Phases
Operative Surgery
75 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Lockjaw
1 Actively Recruiting
Phase 4
severe behavioural problems
0 Actively Recruiting
Behcet Syndrome
1 Actively Recruiting
Not Applicable
Apprehension
0 Actively Recruiting
Mania
1 Actively Recruiting
Not Applicable
Local Anaesthesia therapy
0 Actively Recruiting
Attention Deficit and Disruptive Behavior Disorders
7 Actively Recruiting
Not Applicable, Phase 1, Phase 2
induction of Local Anaesthesia
0 Actively Recruiting
short term Hyperactivity
0 Actively Recruiting
Psychomotor Agitation
0 Actively Recruiting
Nausea
0 Actively Recruiting
Schizophrenia
109 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 1
Acute Coryza
0 Actively Recruiting
Thorazine Reviews: What are patients saying about Thorazine?
5Patient Review
6/3/2013 When I was first given this drug for IBS, about 35 years ago, it made me feel really high. I often wondered why a GI doctor would ever give this to a patient?
5Patient Review
10/19/2013 I've had success with this treatment in the past, and it's my go-to when other medications haven't worked.
5Patient Review
7/8/2013 For the first time, I feel hopeful. This medication has truly helped me by stopping my racing thoughts and OCD behaviors, as well as suicidal ideation.
5Patient Review
7/31/2013 Thorazine has been really effective for me in terms of being able to sleep and managing my bipolar disorder.
5Patient Review
9/1/2013 This medication has helped me a lot with my manic symptoms. I'm able to sleep through the night without any issue now.
Patient Q&A Section about thorazine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Thorazine a sedating?
"At high doses, chlorpromazine can make you sleepy and calm. This is especially helpful for people who are in the hospital for mental health reasons."
Answered by AI
What was Thorazine originally used for?
"In 1951, Henri Laborit, a surgeon in the French navy, began experimenting with chlorpromazine, which was originally intended to be used as a surgical anesthetic. He found that it had a calming effect on patients and helped to control their nausea."
Answered by AI
Is the drug Thorazine still used?
"In the U.S., the brand name Thorazine is no longer being used. However, generic forms may still be available."
Answered by AI
Why was Thorazine discontinued?
"The resident physician confirmed to the pharmacist that thioridazine had been prescribed instead of chlorpromazine (brand name Thorazine) to treat persistent hiccups. The medication was discontinued because the patient's mental status possibly changed as a side effect of the medication."
Answered by AI
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