Thorazine

Lockjaw, Mania, Schizophrenia + 11 more

Treatment

19 FDA approvals

20 Active Studies for Thorazine

What is Thorazine

Chlorpromazine

The Generic name of this drug

Treatment Summary

Chlorpromazine is a type of antipsychotic medicine used to treat mental health conditions. It works by blocking dopamine receptors in the brain, which helps to restore balance and reduce symptoms. This medication can also be used to treat nausea and persistent hiccups.

Chlorpromazine Hydrochloride

is the brand name

image of different drug pills on a surface

Thorazine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Chlorpromazine Hydrochloride

Chlorpromazine

1973

205

Approved as Treatment by the FDA

Chlorpromazine, also called Chlorpromazine Hydrochloride, is approved by the FDA for 19 uses which include Psychomotor Agitation and Attention Deficit and Disruptive Behavior Disorders .

Psychomotor Agitation

Attention Deficit and Disruptive Behavior Disorders

Helps manage Defiant Disorder, Oppositional

Nausea and vomiting

severe behavioural problems

Helps manage severe behavioural problems

Defiant Disorder, Oppositional

Helps manage Defiant Disorder, Oppositional

Manic

Helps manage Mania

Acute Coryza

Operative Surgery

Intractable hiccups

Mania

Helps manage Mania

Behcet Syndrome

Helps manage Bipolar Disorder (BD)

Tetanus

Schizophrenia

Helps manage Schizophrenia

Restlessness

Bipolar Disorder (BD)

Helps manage Bipolar Disorder (BD)

short term Hyperactivity

Nausea

Apprehension

Lockjaw

Effectiveness

How Thorazine Affects Patients

Chlorpromazine is a drug used to treat schizophrenia and can also help reduce anxiety and vomiting. It has a range of effects on the brain and other organs, including blocking some hormones and chemicals. It has strong effects on the nervous system, including calming effects, and can also reduce the activity of some other hormones and chemicals.

How Thorazine works in the body

Chlorpromazine is a blocking agent that works on different types of receptors in the brain. It blocks dopamine receptors to help reduce both productive and unproductive symptoms of psychosis. It also blocks serotonin, histamine, alpha and muscarinic receptors, which can lead to side effects like sedation, weight gain, and blood pressure changes. Chlorpromazine also weakly inhibits dopamine reuptake, which may lead to mild antidepressant or antiparkinsonian effects, as well as an increase in psychomotor agitation.

When to interrupt dosage

The recommended amount of Thorazine is contingent upon the diagnosed affliction, for instance Bipolar Disorder, short term Hyperactivity and Hiccough. The dosage fluctuates, per the approach of delivery detailed in the table below.

Condition

Dosage

Administration

Psychomotor Agitation

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Acute Coryza

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Apprehension

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Local Anaesthesia therapy

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Nausea

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Schizophrenia

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Operative Surgery

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

severe behavioural problems

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

short term Hyperactivity

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Mania

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Behcet Syndrome

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Lockjaw

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

induction of Local Anaesthesia

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Attention Deficit and Disruptive Behavior Disorders

, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Warnings

There are 20 known major drug interactions with Thorazine.

Common Thorazine Drug Interactions

Drug Name

Risk Level

Description

2,5-Dimethoxy-4-ethylamphetamine

Major

The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when used in combination with Chlorpromazine.

2,5-Dimethoxy-4-ethylthioamphetamine

Major

The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when used in combination with Chlorpromazine.

4-Bromo-2,5-dimethoxyamphetamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when used in combination with Chlorpromazine.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Chlorpromazine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Chlorpromazine.

Thorazine Toxicity & Overdose Risk

Overdosing on this drug can cause a person to become agitated, fall into a coma, have seizures, have difficulty breathing or swallowing, have dry mouth, become extremely tired, have a fever, be unable to pass food through their intestines, have an irregular heart rate, or have low blood pressure.

image of a doctor in a lab doing drug, clinical research

Thorazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Thorazine?

265 active clinical trials are currently assessing the possibilities of Thorazine in providing relief from Nausea, Hiccough and Schizophrenia.

Condition

Clinical Trials

Trial Phases

Operative Surgery

75 Actively Recruiting

Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1

Lockjaw

0 Actively Recruiting

severe behavioural problems

0 Actively Recruiting

Mania

1 Actively Recruiting

Phase 3

Behcet Syndrome

1 Actively Recruiting

Not Applicable

Apprehension

0 Actively Recruiting

Local Anaesthesia therapy

0 Actively Recruiting

Attention Deficit and Disruptive Behavior Disorders

6 Actively Recruiting

Not Applicable, Phase 1, Phase 2

induction of Local Anaesthesia

0 Actively Recruiting

short term Hyperactivity

0 Actively Recruiting

Psychomotor Agitation

0 Actively Recruiting

Nausea

0 Actively Recruiting

Schizophrenia

97 Actively Recruiting

Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2

Acute Coryza

0 Actively Recruiting

Thorazine Reviews: What are patients saying about Thorazine?

5

Patient Review

6/3/2013

Thorazine for Mania associated with Bipolar Disorder

When I was first given this drug for IBS, about 35 years ago, it made me feel really high. I often wondered why a GI doctor would ever give this to a patient?

5

Patient Review

10/19/2013

Thorazine for Mania associated with Bipolar Disorder

I've had success with this treatment in the past, and it's my go-to when other medications haven't worked.

5

Patient Review

7/8/2013

Thorazine for Mental Disorder with Loss of Normal Personality & Reality

For the first time, I feel hopeful. This medication has truly helped me by stopping my racing thoughts and OCD behaviors, as well as suicidal ideation.

5

Patient Review

7/31/2013

Thorazine for Schizophrenia

Thorazine has been really effective for me in terms of being able to sleep and managing my bipolar disorder.

5

Patient Review

9/1/2013

Thorazine for Mania associated with Bipolar Disorder

This medication has helped me a lot with my manic symptoms. I'm able to sleep through the night without any issue now.

5

Patient Review

1/23/2018

Thorazine for Nausea and Vomiting

I was really struggling with nausea before I found this medicine. It was a total lifesaver.

4.7

Patient Review

1/13/2014

Thorazine for Schizophrenia

I've found that this medication heightens my emotions, which can be difficult to manage at times. When I miss someone, it feels very intense. Additionally, I've become more aggressive and territorial since starting this treatment; it's almost like being manic all the time

4.3

Patient Review

2/19/2014

Thorazine for Apprehension

I was given this medication as a child to relieve stress from witnessing a man get decapitated in a car accident. I took it for approximately one year, starting in 1958.

4

Patient Review

5/6/2014

Thorazine for Hiccups that are Hard to Cure

This treatment was extremely effective at stopping my hiccups after lumbar laminectomy surgery.

3.7

Patient Review

9/9/2012

Thorazine for Schizophrenia

3.3

Patient Review

8/1/2014

Thorazine for Mania associated with Bipolar Disorder

Thorazine makes me really tired and I tend to sleep a lot more than usual. I also feel like I'm overmedicated and have gotten a hint of the "Thorazine shuffle." If I get up too quickly, I feel faint.

3

Patient Review

10/9/2012

Thorazine for Mental Disorder with Loss of Normal Personality & Reality

My daughter took thorzine and it kept her calm, but then our doctor said something about the dosage going from 500 to 720. He said we needed to stop giving her thorzine or she would die.

3

Patient Review

10/7/2012

Thorazine for Mania associated with Bipolar Disorder

2.7

Patient Review

9/30/2012

Thorazine for Mania associated with Bipolar Disorder

2.3

Patient Review

11/16/2012

Thorazine for Schizophrenia

I tried taking this medication at different dosages, but found that it only made me more agitated and unable to sleep. I even had an incident where I passed out while driving (fortunately, I was going slow at the time). Needless to say, I stopped taking Thorazine after that.

2.3

Patient Review

1/2/2014

Thorazine for Apprehension

I've just started using this medication, and so far I'm not seeing the results that I was hoping for.

1.3

Patient Review

9/8/2021

Thorazine for Feel Like Throwing Up

I have gastritis and sometimes experience nausea as a result. I tried this medication again, and unfortunately it did nothing to help.

1

Patient Review

3/3/2013

Thorazine for Schizophrenia

While this treatment did help with my anxiety somewhat, I found that it left me feeling very tired. Additionally, I still experienced paranoia even while taking the medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about thorazine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Thorazine a sedating?

"At high doses, chlorpromazine can make you sleepy and calm. This is especially helpful for people who are in the hospital for mental health reasons."

Answered by AI

What was Thorazine originally used for?

"In 1951, Henri Laborit, a surgeon in the French navy, began experimenting with chlorpromazine, which was originally intended to be used as a surgical anesthetic. He found that it had a calming effect on patients and helped to control their nausea."

Answered by AI

Is the drug Thorazine still used?

"In the U.S., the brand name Thorazine is no longer being used. However, generic forms may still be available."

Answered by AI

Why was Thorazine discontinued?

"The resident physician confirmed to the pharmacist that thioridazine had been prescribed instead of chlorpromazine (brand name Thorazine) to treat persistent hiccups. The medication was discontinued because the patient's mental status possibly changed as a side effect of the medication."

Answered by AI

Clinical Trials for Thorazine

Image of Washington University / Barnes Jewish Hospital in St Louis, United States.

AI-Driven Clinical Decision Support for Surgery

18+
All Sexes
St Louis, MO

20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to evaluate an intelligent clinical decision support system that helps clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don't, potentially improving patient safety while reducing blood waste and healthcare costs.

Recruiting
Has No Placebo

Washington University / Barnes Jewish Hospital

Have you considered Thorazine clinical trials?

We made a collection of clinical trials featuring Thorazine, we think they might fit your search criteria.
Go to Trials
Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA

The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.

Waitlist Available
Has No Placebo

The University of Iowa

Image of Vanderbilt Psychiatric Hospital in Nashville, United States.

Repetitive Transcranial Magnetic Stimulation for Schizophrenia

18 - 65
All Sexes
Nashville, TN

The central hypothesis is this: DMN connectivity can be modulated with inhibitory cTBS when delivered on an accelerated treatment schedule. This study seeks to provide evidence that accelerated, network-targeted inhibitory stimulation of the DMN leads to both altered network activity and a concomitant behavioral change in cognitive performance in individuals with schizophrenia and schizoaffective disorder. This study will also compare the effect of inhibitory cTBS in healthy individuals, as it may also lead to both altered network activity and a behavioral change in cognitive performance in individuals without schizophrenia or schizoaffective disorder. If successful, this study will have identified a safe, effective, and broadly applicable treatment for cognitive impairment in schizophrenia that has potential for translation into many other psychiatric and neurodevelopmental disorders, such as autism.

Waitlist Available
Has No Placebo

Vanderbilt Psychiatric Hospital

Heather Ward, MD

Image of Walter Reed National Military Medical Center in Bethesda, United States.

Corticosteroid Injections for Osteoarthritis

18+
All Sexes
Bethesda, MD

The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury. The main questions it aims to answer are: Does adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)? Researchers will compare: Standard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function. (Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.) Participants will: Be randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint Be followed after surgery to measure: Pain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function

Phase 2 & 3
Waitlist Available

Walter Reed National Military Medical Center

John P Cody, MD

Image of Woodland International Research Group /ID# 275747 in Little Rock, United States.

Emraclidine for Schizophrenia

18 - 65
All Sexes
Little Rock, AR

Schizophrenia is a common and severe psychiatric illness characterized by extreme disturbances of cognition and thought, affecting language, perception and sense of self. This study will assess adverse events, change in disease activity, and how oral emraclidine moves through the body in adult participants with schizophrenia Emraclidine is an investigational drug being developed for the treatment of schizophrenia. Participants are placed in one of two parts, Part A or Part B, where each group will receive a different treatment. Participants will receive either oral emraclidine or placebo. Approximately 258 participants will be enrolled across roughly 32 sites in the United States. Participants in Part A will be assigned to one of multiple ascending doses of emraclidine or placebo administered orally for 14 days or up to 21 days. Participants in Part B will receive Emraclidine or placebo administered orally for up to 42 days. Participants will be followed for 30 days after the last dose of the study drug. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

Phase 2
Recruiting

Woodland International Research Group /ID# 275747 (+6 Sites)

ABBVIE INC.

AbbVie

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