Thorazine

Lockjaw, Mania, Schizophrenia + 11 more
Treatment
19 FDA approvals
20 Active Studies for Thorazine

What is Thorazine

ChlorpromazineThe Generic name of this drug
Treatment SummaryChlorpromazine is a type of antipsychotic medicine used to treat mental health conditions. It works by blocking dopamine receptors in the brain, which helps to restore balance and reduce symptoms. This medication can also be used to treat nausea and persistent hiccups.
Chlorpromazine Hydrochlorideis the brand name
image of different drug pills on a surface
Thorazine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Chlorpromazine Hydrochloride
Chlorpromazine
1973
205

Approved as Treatment by the FDA

Chlorpromazine, also called Chlorpromazine Hydrochloride, is approved by the FDA for 19 uses which include Psychomotor Agitation and Attention Deficit and Disruptive Behavior Disorders .
Psychomotor Agitation
Attention Deficit and Disruptive Behavior Disorders
Helps manage Defiant Disorder, Oppositional
Nausea and vomiting
severe behavioural problems
Helps manage severe behavioural problems
Defiant Disorder, Oppositional
Helps manage Defiant Disorder, Oppositional
Manic
Helps manage Mania
Acute Coryza
Operative Surgery
Intractable hiccups
Mania
Helps manage Mania
Behcet Syndrome
Helps manage Bipolar Disorder (BD)
Tetanus
Schizophrenia
Helps manage Schizophrenia
Restlessness
Bipolar Disorder (BD)
Helps manage Bipolar Disorder (BD)
short term Hyperactivity
Nausea
Apprehension
Lockjaw

Effectiveness

How Thorazine Affects PatientsChlorpromazine is a drug used to treat schizophrenia and can also help reduce anxiety and vomiting. It has a range of effects on the brain and other organs, including blocking some hormones and chemicals. It has strong effects on the nervous system, including calming effects, and can also reduce the activity of some other hormones and chemicals.
How Thorazine works in the bodyChlorpromazine is a blocking agent that works on different types of receptors in the brain. It blocks dopamine receptors to help reduce both productive and unproductive symptoms of psychosis. It also blocks serotonin, histamine, alpha and muscarinic receptors, which can lead to side effects like sedation, weight gain, and blood pressure changes. Chlorpromazine also weakly inhibits dopamine reuptake, which may lead to mild antidepressant or antiparkinsonian effects, as well as an increase in psychomotor agitation.

When to interrupt dosage

The recommended amount of Thorazine is contingent upon the diagnosed affliction, for instance Bipolar Disorder, short term Hyperactivity and Hiccough. The dosage fluctuates, per the approach of delivery detailed in the table below.
Condition
Dosage
Administration
Psychomotor Agitation
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Acute Coryza
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Apprehension
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Local Anaesthesia therapy
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Nausea
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Schizophrenia
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Operative Surgery
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
severe behavioural problems
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
short term Hyperactivity
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Mania
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Behcet Syndrome
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Lockjaw
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
induction of Local Anaesthesia
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate
Attention Deficit and Disruptive Behavior Disorders
, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 10.0 mg, 25.0 mg/mL, 27.9 mg, 11.16 mg, 55.8 mg, 111.6 mg, 55.7 mg, 111.4 mg, 223.2 mg, 5.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL, 40.0 mg/mL, 22.2 mg/mL, 27.9 mg/mL, 44.5 mg/mL, 100.0 mg/mL, 30.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Tablet, Tablet - Oral, Injection - Intramuscular, Intramuscular, Injection, Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Suppository, Rectal, Suppository - Rectal, Solution / drops - Oral, Solution / drops, Solution - Intramuscular; Intravenous, Solution, Syrup - Oral, Syrup, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection, solution, Injection, solution - Intramuscular, Concentrate - Oral, Concentrate

Warnings

There are 20 known major drug interactions with Thorazine.
Common Thorazine Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when used in combination with Chlorpromazine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when used in combination with Chlorpromazine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when used in combination with Chlorpromazine.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Chlorpromazine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Chlorpromazine.
Thorazine Toxicity & Overdose RiskOverdosing on this drug can cause a person to become agitated, fall into a coma, have seizures, have difficulty breathing or swallowing, have dry mouth, become extremely tired, have a fever, be unable to pass food through their intestines, have an irregular heart rate, or have low blood pressure.
image of a doctor in a lab doing drug, clinical research

Thorazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Thorazine?

265 active clinical trials are currently assessing the possibilities of Thorazine in providing relief from Nausea, Hiccough and Schizophrenia.
Condition
Clinical Trials
Trial Phases
Operative Surgery
75 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1
Lockjaw
0 Actively Recruiting
severe behavioural problems
0 Actively Recruiting
Mania
1 Actively Recruiting
Phase 3
Behcet Syndrome
1 Actively Recruiting
Not Applicable
Apprehension
0 Actively Recruiting
Local Anaesthesia therapy
0 Actively Recruiting
Attention Deficit and Disruptive Behavior Disorders
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
induction of Local Anaesthesia
0 Actively Recruiting
short term Hyperactivity
0 Actively Recruiting
Psychomotor Agitation
0 Actively Recruiting
Nausea
0 Actively Recruiting
Schizophrenia
97 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2
Acute Coryza
0 Actively Recruiting

Thorazine Reviews: What are patients saying about Thorazine?

5Patient Review
6/3/2013
Thorazine for Mania associated with Bipolar Disorder
When I was first given this drug for IBS, about 35 years ago, it made me feel really high. I often wondered why a GI doctor would ever give this to a patient?
5Patient Review
10/19/2013
Thorazine for Mania associated with Bipolar Disorder
I've had success with this treatment in the past, and it's my go-to when other medications haven't worked.
5Patient Review
7/8/2013
Thorazine for Mental Disorder with Loss of Normal Personality & Reality
For the first time, I feel hopeful. This medication has truly helped me by stopping my racing thoughts and OCD behaviors, as well as suicidal ideation.
5Patient Review
7/31/2013
Thorazine for Schizophrenia
Thorazine has been really effective for me in terms of being able to sleep and managing my bipolar disorder.
5Patient Review
9/1/2013
Thorazine for Mania associated with Bipolar Disorder
This medication has helped me a lot with my manic symptoms. I'm able to sleep through the night without any issue now.
5Patient Review
1/23/2018
Thorazine for Nausea and Vomiting
I was really struggling with nausea before I found this medicine. It was a total lifesaver.
4.7Patient Review
1/13/2014
Thorazine for Schizophrenia
I've found that this medication heightens my emotions, which can be difficult to manage at times. When I miss someone, it feels very intense. Additionally, I've become more aggressive and territorial since starting this treatment; it's almost like being manic all the time
4.3Patient Review
2/19/2014
Thorazine for Apprehension
I was given this medication as a child to relieve stress from witnessing a man get decapitated in a car accident. I took it for approximately one year, starting in 1958.
4Patient Review
5/6/2014
Thorazine for Hiccups that are Hard to Cure
This treatment was extremely effective at stopping my hiccups after lumbar laminectomy surgery.
3.7Patient Review
9/9/2012
Thorazine for Schizophrenia
3.3Patient Review
8/1/2014
Thorazine for Mania associated with Bipolar Disorder
Thorazine makes me really tired and I tend to sleep a lot more than usual. I also feel like I'm overmedicated and have gotten a hint of the "Thorazine shuffle." If I get up too quickly, I feel faint.
3Patient Review
10/9/2012
Thorazine for Mental Disorder with Loss of Normal Personality & Reality
My daughter took thorzine and it kept her calm, but then our doctor said something about the dosage going from 500 to 720. He said we needed to stop giving her thorzine or she would die.
3Patient Review
10/7/2012
Thorazine for Mania associated with Bipolar Disorder
2.7Patient Review
9/30/2012
Thorazine for Mania associated with Bipolar Disorder
2.3Patient Review
11/16/2012
Thorazine for Schizophrenia
I tried taking this medication at different dosages, but found that it only made me more agitated and unable to sleep. I even had an incident where I passed out while driving (fortunately, I was going slow at the time). Needless to say, I stopped taking Thorazine after that.
2.3Patient Review
1/2/2014
Thorazine for Apprehension
I've just started using this medication, and so far I'm not seeing the results that I was hoping for.
1.3Patient Review
9/8/2021
Thorazine for Feel Like Throwing Up
I have gastritis and sometimes experience nausea as a result. I tried this medication again, and unfortunately it did nothing to help.
1Patient Review
3/3/2013
Thorazine for Schizophrenia
While this treatment did help with my anxiety somewhat, I found that it left me feeling very tired. Additionally, I still experienced paranoia even while taking the medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about thorazine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Thorazine a sedating?

"At high doses, chlorpromazine can make you sleepy and calm. This is especially helpful for people who are in the hospital for mental health reasons."

Answered by AI

What was Thorazine originally used for?

"In 1951, Henri Laborit, a surgeon in the French navy, began experimenting with chlorpromazine, which was originally intended to be used as a surgical anesthetic. He found that it had a calming effect on patients and helped to control their nausea."

Answered by AI

Is the drug Thorazine still used?

"In the U.S., the brand name Thorazine is no longer being used. However, generic forms may still be available."

Answered by AI

Why was Thorazine discontinued?

"The resident physician confirmed to the pharmacist that thioridazine had been prescribed instead of chlorpromazine (brand name Thorazine) to treat persistent hiccups. The medication was discontinued because the patient's mental status possibly changed as a side effect of the medication."

Answered by AI

Clinical Trials for Thorazine

Image of Washington University / Barnes Jewish Hospital in St Louis, United States.

AI-Driven Clinical Decision Support for Surgery

18+
All Sexes
St Louis, MO
20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to evaluate an intelligent clinical decision support system that helps clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don't, potentially improving patient safety while reducing blood waste and healthcare costs.
Recruiting
Has No Placebo
Washington University / Barnes Jewish Hospital
Image of UPMC Shadyside Hospital in Pittsburgh, United States.

Bright Green Light Therapy for Postoperative Pain

18+
All Sexes
Pittsburgh, PA
This is an unblinded, parallel group randomized controlled trial to evaluate bright green light as an adjunct therapy after surgery at UPMC Shadyside. The primary outcome measure will be pain intensity with secondary outcome measures including opioid requirements, sleep quality, mood, and overall post-operative recovery. Specific aims/hypotheses for this study are as follows: Aim 1: To assess bright green light therapy's potential as a complementary post-operative analgesic strategy in patients recovering from surgery Hypothesis 1: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved postoperative pain scores and lower opioid use. Aim 2: To examine the impact of bright green light therapy on patient-centered measures of post-operative recovery that may be related to improved circadian function. Hypothesis 2: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved quality of post-operative recovery, enhanced sleep, and reduced anxiety and depression.
Waitlist Available
Has No Placebo
UPMC Shadyside HospitalRebecca Kotcher, MD
Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Waitlist Available
Has No Placebo
The University of Iowa
Have you considered Thorazine clinical trials? We made a collection of clinical trials featuring Thorazine, we think they might fit your search criteria.Go to Trials
Image of Walter Reed National Military Medical Center in Bethesda, United States.

Corticosteroid Injections for Osteoarthritis

18+
All Sexes
Bethesda, MD
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury. The main questions it aims to answer are: Does adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)? Researchers will compare: Standard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function. (Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.) Participants will: Be randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint Be followed after surgery to measure: Pain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function
Phase 2 & 3
Waitlist Available
Walter Reed National Military Medical CenterJohn P Cody, MD
Image of Woodland International Research Group /ID# 275747 in Little Rock, United States.

Emraclidine for Schizophrenia

18 - 65
All Sexes
Little Rock, AR
Schizophrenia is a common and severe psychiatric illness characterized by extreme disturbances of cognition and thought, affecting language, perception and sense of self. This study will assess adverse events, change in disease activity, and how oral emraclidine moves through the body in adult participants with schizophrenia Emraclidine is an investigational drug being developed for the treatment of schizophrenia. Participants are placed in one of two parts, Part A or Part B, where each group will receive a different treatment. Participants will receive either oral emraclidine or placebo. Approximately 258 participants will be enrolled across roughly 32 sites in the United States. Participants in Part A will be assigned to one of multiple ascending doses of emraclidine or placebo administered orally for 14 days or up to 21 days. Participants in Part B will receive Emraclidine or placebo administered orally for up to 42 days. Participants will be followed for 30 days after the last dose of the study drug. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Woodland International Research Group /ID# 275747 (+4 Sites)ABBVIE INC.AbbVie
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