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What is Thalomid
ThalidomideThe Generic name of this drug
Treatment SummaryThalidomide is a drug used to treat certain immunological and inflammatory disorders. It works by suppressing the immune system and blocking the growth of new blood vessels in tumors. It also stops the release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. The drug was originally used as a non-barbiturate hypnotic, but was removed from the market due to its teratogenic effects. It has since been reintroduced with additional safety precautions in place.
Thalomidis the brand name
Thalomid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thalomid
Thalidomide
2003
4
Approved as Treatment by the FDA
Thalidomide, also known as Thalomid, is approved by the FDA for 4 uses including severe Erythema nodosum leprosum and Multiple Myeloma .severe Erythema nodosum leprosum
Multiple Myeloma
Used to treat Multiple Myeloma (MM) in combination with Dexamethasone
Multiple Myeloma
Used to treat treatment naive multiple myeloma in combination with Melphalan
moderate Erythema nodosum leprosum
Effectiveness
How Thalomid Affects PatientsThalidomide is a prescription medication originally developed to act as a sedative. It works by altering the levels of certain substances that cause inflammation, such as tumor necrosis factor-alpha (TNF-a), IL-6, basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). It is made up of two different isomers, a (+)R and a (−)S, which are both necessary for its effects. When taken alone, only one enantiomer is present, which may lead to its teratogenic (causing birth defects) effects in humans
How Thalomid works in the bodyThalidomide works in a few ways to stop the growth and spread of cancer cells. It binds to a protein that helps to break down two transcription factors which are important for cancer cell survival. It also blocks the production of TNF-alpha, a molecule that helps cancer cells grow, by blocking proteins and RNA related to its production. Finally, it stops the NF-kB and MyD88 pathways, which allow cancer cells to communicate with each other and grow, from working properly. This also gives it an anti-angiogenic effect, meaning it can stop new blood vessels from forming.
When to interrupt dosage
The suggested measure of Thalomid is reliant upon the diagnosed ailment, such as Disease, Uremia and Multiple Myeloma. The amount of dosage can be located in the table beneath, contingent upon the method of delivery (e.g. Tablet, coated - Oral or Capsule).Condition
Dosage
Administration
Disease
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Multiple Myeloma
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Multiple Myeloma
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
moderate Erythema nodosum leprosum
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Stomatitis, Aphthous
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Erythema Nodosum Leprosum
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Disease
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Amyloidosis
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Acquired Immunodeficiency Syndrome
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Uremia
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
severe Erythema nodosum leprosum
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Waldenstrom Macroglobulinemia
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Warnings
Thalomid ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Thalidomide may interact with Pulse Frequency
Common Thalomid Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with Acteoside.
Aldosterone
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with Aldosterone.
Thalomid Toxicity & Overdose RiskThe toxic dose of thalidomide in rats is 113 mg/kg and 2 g/kg in mice. Studies have found no cancer-causing effects in mice and rats at doses up to 3,000 mg/kg/day and 300 mg/kg/day respectively. Thalidomide also did not cause any mutations or genetic damage in tests. No effects on mating or fertility were seen in rabbits at doses of 100 mg/kg/day for females and 500 mg/kg/day for males. There is no known antidote for an overdose of thalidomide, so supportive care should be given to maintain vital signs
Thalomid Novel Uses: Which Conditions Have a Clinical Trial Featuring Thalomid?
43 active trials are being conducted to investigate the potential of Thalomid in ameliorating Primary Amyloidosis, Disease and Uremia.Condition
Clinical Trials
Trial Phases
Stomatitis, Aphthous
0 Actively Recruiting
Amyloidosis
1 Actively Recruiting
Not Applicable
severe Erythema nodosum leprosum
0 Actively Recruiting
Waldenstrom Macroglobulinemia
8 Actively Recruiting
Phase 2, Phase 1
Multiple Myeloma
0 Actively Recruiting
Erythema Nodosum Leprosum
0 Actively Recruiting
moderate Erythema nodosum leprosum
0 Actively Recruiting
Disease
19 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable
Disease
0 Actively Recruiting
Uremia
0 Actively Recruiting
Acquired Immunodeficiency Syndrome
5 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable
Multiple Myeloma
12 Actively Recruiting
Phase 2, Phase 1
Thalomid Reviews: What are patients saying about Thalomid?
5Patient Review
4/28/2010 This is the only thing that has worked for my bechet's syndrom in the ten years I've been searching.
5Patient Review
11/11/2008 Thalomid put my multiple myeloma into remission, and I couldn't be happier with the results.
5Patient Review
11/16/2008 I had to up my dosage, but now I'm feeling really good! I'm able to stay active and do the things I love without any problems.
5Patient Review
5/21/2009 My skin lessons have cleared up,where nothing else worked. After being on it now for 5 months,I currently have burning of the feet.
4.3Patient Review
8/31/2011 This medication is doing its job in keeping me in remission, but I have to say that the side effects are pretty tough to deal with. I constantly feel like I have a hangover and I've been on the med for five years now.
3.7Patient Review
8/18/2009 My feet and ankles began to feel numb and tingly, which then progressed to my fingers. I also started seeing large veins in my feet and legs. Additionally, my legs would occasionally throb. However, I am currently in remission but weak and dizzy.
3.3Patient Review
1/15/2012 I've been experiencing some uncomfortable side effects since starting Thalomid, like tingling and numbness in my extremities as well as all-over body jitteriness. I'm going to have an ultrasound soon to see if there are any clots.
2.3Patient Review
11/23/2008 This medicine initially helped with my itchy skin, but then I began to experience bad cramps as a side effect. Additionally, because I have hep C, this medication damaged my liver more and caused me to develop cirrhosis.
Patient Q&A Section about thalomid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Thalomid prescribed for?
"This medication is used to treat or prevent certain skin conditions such as erythema nodosum leprosum, which is caused by Hansen's disease. Thalidomide is also used to treat a certain type of cancer called multiple myeloma. It works in Hansen's disease by reducing the swelling and redness caused by inflammation."
Answered by AI
Who should not take Thalomid?
"If you are a female and think you may be pregnant, stop taking THALOMID right away and call your doctor right away.
THALOMID may cause severe birth defects or death in unborn babies. If you are pregnant or planning on becoming pregnant, you should not take THALOMID. If you are a female and think you may be pregnant, stop taking THALOMID and call your doctor immediately."
Answered by AI
What was the thalidomide tragedy?
"This paper discusses the evolution of thalidomide as a drug and the potential uses of thalidomide as an anticancer agent.
In the late 1950s and early 1960s, thalidomide was a widely used drug for the treatment of nausea in pregnant women. However, it became apparent in the 1960s that thalidomide treatment resulted in severe birth defects in thousands of children. This paper discusses the evolution of thalidomide as a drug and the potential uses of thalidomide as an anticancer agent."
Answered by AI
What type of drug is Thalomid?
"Thalomid is a medication used to treat the symptoms of bone marrow cancer (Multiple myeloma) and Erythema Nodosum Leprosum (ENL). Thalomid may be used alone or with other medications. Thalomid belongs to a class of drugs called Antineoplastics, Angiogenesis Inhibitor."
Answered by AI