Thalomid

Stomatitis, Aphthous, severe Erythema nodosum leprosum, Disease + 9 more
Treatment
6 FDA approvals
20 Active Studies for Thalomid

What is Thalomid

ThalidomideThe Generic name of this drug
Treatment SummaryThalidomide is a drug used to treat certain immunological and inflammatory disorders. It works by suppressing the immune system and blocking the growth of new blood vessels in tumors. It also stops the release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. The drug was originally used as a non-barbiturate hypnotic, but was removed from the market due to its teratogenic effects. It has since been reintroduced with additional safety precautions in place.
Thalomidis the brand name
image of different drug pills on a surface
Thalomid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thalomid
Thalidomide
2003
4

Approved as Treatment by the FDA

Thalidomide, also known as Thalomid, is approved by the FDA for 6 uses including Multiple Myeloma (MM) and treatment naive multiple myeloma .
Multiple Myeloma (MM)
Used to treat Multiple Myeloma (MM) in combination with Dexamethasone
treatment naive multiple myeloma
Used to treat treatment naive multiple myeloma in combination with Melphalan
severe Erythema nodosum leprosum
Multiple Myeloma
Used to treat treatment naive multiple myeloma in combination with Melphalan
moderate Erythema nodosum leprosum
Multiple Myeloma
Used to treat Multiple Myeloma (MM) in combination with Dexamethasone

Effectiveness

How Thalomid Affects PatientsThalidomide is a prescription medication originally developed to act as a sedative. It works by altering the levels of certain substances that cause inflammation, such as tumor necrosis factor-alpha (TNF-a), IL-6, basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). It is made up of two different isomers, a (+)R and a (−)S, which are both necessary for its effects. When taken alone, only one enantiomer is present, which may lead to its teratogenic (causing birth defects) effects in humans
How Thalomid works in the bodyThalidomide works in a few ways to stop the growth and spread of cancer cells. It binds to a protein that helps to break down two transcription factors which are important for cancer cell survival. It also blocks the production of TNF-alpha, a molecule that helps cancer cells grow, by blocking proteins and RNA related to its production. Finally, it stops the NF-kB and MyD88 pathways, which allow cancer cells to communicate with each other and grow, from working properly. This also gives it an anti-angiogenic effect, meaning it can stop new blood vessels from forming.

When to interrupt dosage

The suggested measure of Thalomid is reliant upon the diagnosed ailment, such as Disease, Uremia and Multiple Myeloma. The amount of dosage can be located in the table beneath, contingent upon the method of delivery (e.g. Tablet, coated - Oral or Capsule).
Condition
Dosage
Administration
Multiple Myeloma
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Erythema Nodosum Leprosum
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Disease
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Acquired Immunodeficiency Syndrome
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Uremia
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Multiple Myeloma
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Stomatitis, Aphthous
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
moderate Erythema nodosum leprosum
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Amyloidosis
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Disease
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
Waldenstrom Macroglobulinemia
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral
severe Erythema nodosum leprosum
, 200.0 mg, 100.0 mg, 150.0 mg, 50.0 mg
Capsule - Oral, Capsule, , Oral

Warnings

Thalomid Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Thalidomide may interact with Pulse Frequency
There are 20 known major drug interactions with Thalomid.
Common Thalomid Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with Acteoside.
Aldosterone
Major
The risk or severity of adverse effects can be increased when Thalidomide is combined with Aldosterone.
Thalomid Toxicity & Overdose RiskThe toxic dose of thalidomide in rats is 113 mg/kg and 2 g/kg in mice. Studies have found no cancer-causing effects in mice and rats at doses up to 3,000 mg/kg/day and 300 mg/kg/day respectively. Thalidomide also did not cause any mutations or genetic damage in tests. No effects on mating or fertility were seen in rabbits at doses of 100 mg/kg/day for females and 500 mg/kg/day for males. There is no known antidote for an overdose of thalidomide, so supportive care should be given to maintain vital signs
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Thalomid Novel Uses: Which Conditions Have a Clinical Trial Featuring Thalomid?

43 active trials are being conducted to investigate the potential of Thalomid in ameliorating Primary Amyloidosis, Disease and Uremia.
Condition
Clinical Trials
Trial Phases
Multiple Myeloma
6 Actively Recruiting
Phase 1, Phase 2
moderate Erythema nodosum leprosum
0 Actively Recruiting
Stomatitis, Aphthous
0 Actively Recruiting
severe Erythema nodosum leprosum
0 Actively Recruiting
Disease
9 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Waldenstrom Macroglobulinemia
7 Actively Recruiting
Phase 2, Phase 1
Erythema Nodosum Leprosum
0 Actively Recruiting
Amyloidosis
0 Actively Recruiting
Disease
0 Actively Recruiting
Uremia
0 Actively Recruiting
Acquired Immunodeficiency Syndrome
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Multiple Myeloma
0 Actively Recruiting

Thalomid Reviews: What are patients saying about Thalomid?

5Patient Review
4/28/2010
Thalomid for Repeatedly Occurring Small Ulcers of the Mouth
This is the only thing that has worked for my bechet's syndrom in the ten years I've been searching.
5Patient Review
11/11/2008
Thalomid for Multiple Myeloma
Thalomid put my multiple myeloma into remission, and I couldn't be happier with the results.
5Patient Review
11/16/2008
Thalomid for Multiple Myeloma
I had to up my dosage, but now I'm feeling really good! I'm able to stay active and do the things I love without any problems.
5Patient Review
5/21/2009
Thalomid for Skin Disease in Patients with Discoid Lupus Erythematosus
My skin lessons have cleared up,where nothing else worked. After being on it now for 5 months,I currently have burning of the feet.
4.3Patient Review
8/31/2011
Thalomid for Multiple Myeloma
This medication is doing its job in keeping me in remission, but I have to say that the side effects are pretty tough to deal with. I constantly feel like I have a hangover and I've been on the med for five years now.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about thalomid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Thalomid prescribed for?

"This medication is used to treat or prevent certain skin conditions such as erythema nodosum leprosum, which is caused by Hansen's disease. Thalidomide is also used to treat a certain type of cancer called multiple myeloma. It works in Hansen's disease by reducing the swelling and redness caused by inflammation."

Answered by AI

Who should not take Thalomid?

"If you are a female and think you may be pregnant, stop taking THALOMID right away and call your doctor right away.

THALOMID may cause severe birth defects or death in unborn babies. If you are pregnant or planning on becoming pregnant, you should not take THALOMID. If you are a female and think you may be pregnant, stop taking THALOMID and call your doctor immediately."

Answered by AI

What was the thalidomide tragedy?

"This paper discusses the evolution of thalidomide as a drug and the potential uses of thalidomide as an anticancer agent.

In the late 1950s and early 1960s, thalidomide was a widely used drug for the treatment of nausea in pregnant women. However, it became apparent in the 1960s that thalidomide treatment resulted in severe birth defects in thousands of children. This paper discusses the evolution of thalidomide as a drug and the potential uses of thalidomide as an anticancer agent."

Answered by AI

What type of drug is Thalomid?

"Thalomid is a medication used to treat the symptoms of bone marrow cancer (Multiple myeloma) and Erythema Nodosum Leprosum (ENL). Thalomid may be used alone or with other medications. Thalomid belongs to a class of drugs called Antineoplastics, Angiogenesis Inhibitor."

Answered by AI

Clinical Trials for Thalomid

Have you considered Thalomid clinical trials? We made a collection of clinical trials featuring Thalomid, we think they might fit your search criteria.
Have you considered Thalomid clinical trials? We made a collection of clinical trials featuring Thalomid, we think they might fit your search criteria.
Have you considered Thalomid clinical trials? We made a collection of clinical trials featuring Thalomid, we think they might fit your search criteria.
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