Testosterone Cypionate

Gonadotrophin releasing hormone deficiency, Hypogonadism, Hypogonadism + 7 more

Treatment

12 FDA approvals

8 Active Studies for Testosterone Cypionate

What is Testosterone Cypionate

Testosterone cypionate

The Generic name of this drug

Treatment Summary

Testosterone cypionate is a synthetic form of testosterone that is injected into the body. It is made of oil-soluble 17 (beta)-cyclopentylpropionate ester and is released and active in the body for a longer period of time than other testosterone derivatives. Testosterone cypionate was developed by the company Pharmacia and Upjohn and approved by the FDA in 1979.

Depo-Testosterone

is the brand name

image of different drug pills on a surface

Testosterone Cypionate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Depo-Testosterone

Testosterone cypionate

1979

51

Approved as Treatment by the FDA

Testosterone cypionate, also known as Depo-Testosterone, is approved by the FDA for 12 uses including Hypergonadotropic Hypogonadism and Pituitary gonadotropin hypofunction .

Hypergonadotropic Hypogonadism

Pituitary gonadotropin hypofunction

Hypothalamic Diseases

Hypogonadism

Orchitis

Orchiectomy

Gonadotrophin releasing hormone deficiency

Hypogonadism

Hypogonadotropic hypogonadism

Testicular hypogonadism

Testicular hypogonadism

Testicular hypogonadism

Effectiveness

How Testosterone Cypionate Affects Patients

Testosterone cypionate is an ester derivative of testosterone that, when taken, can raise testosterone levels in the body up to 400% within 24 hours. These increased levels stay elevated for 3-5 days. Taking testosterone cypionate can cause mood swings and changes in libido, as well as minor inflammation in the area where it is injected.

How Testosterone Cypionate works in the body

Testosterone works by activating receptors in the body. It can bind directly to androgen receptors, or it can be converted to a more potent form called Dihydrotestosterone (DHT) which binds even more strongly to these receptors. The receptors then move into the cell nucleus and bind to specific sections of DNA, affecting how certain genes are expressed and creating the androgen effects.

When to interrupt dosage

The suggested dosage of Testosterone Cypionate is contingent upon the diagnosed circumstance, including Hypergonadotropic Hypogonadism, Testicular hypogonadism and Gonadotrophin releasing hormone deficiency. The measure of dosage is based on the technique of administration (e.g. Injection, solution or Injection, solution - Intramuscular) outlined in the table below.

Condition

Dosage

Administration

Gonadotrophin releasing hormone deficiency

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Hypogonadism

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Hypogonadism

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Hypogonadotropic hypogonadism

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Testicular hypogonadism

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Hypothalamic Diseases

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Orchitis

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Testicular hypogonadism

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Orchiectomy

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Testicular hypogonadism

200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL

, Injection, solution, Injection, solution - Intramuscular, Intramuscular, Injection, Injection - Intramuscular, Solution - Intramuscular, Solution, Liquid - Intramuscular, Liquid, Intramuscular; Topical, Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous

Warnings

There are 20 known major drug interactions with Testosterone Cypionate.

Common Testosterone Cypionate Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Testosterone cypionate.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Testosterone cypionate.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Testosterone cypionate.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Testosterone cypionate.

Capmatinib

Major

The serum concentration of Capmatinib can be decreased when it is combined with Testosterone cypionate.

Testosterone Cypionate Toxicity & Overdose Risk

In animal studies, using testosterone implants has been linked to cervical and uterine tumors that spread in some cases. Some reports suggest that using testosterone cypionate in female patients can increase the risk of liver cancer and the number of tumors. Clinical studies have also reported cases of liver cancer in patients who received high doses of testosterone for a long period of time.

image of a doctor in a lab doing drug, clinical research

Testosterone Cypionate Novel Uses: Which Conditions Have a Clinical Trial Featuring Testosterone Cypionate?

Currently, two clinical trials are assessing the potential of Testosterone Cypionate to alleviate Hypothalamic Diseases, Hypogonadotropic Hypogonadism and Orchitis.

Condition

Clinical Trials

Trial Phases

Testicular hypogonadism

0 Actively Recruiting

Testicular hypogonadism

5 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Orchitis

0 Actively Recruiting

Hypogonadotropic hypogonadism

0 Actively Recruiting

Hypogonadism

0 Actively Recruiting

Gonadotrophin releasing hormone deficiency

0 Actively Recruiting

Testicular hypogonadism

0 Actively Recruiting

Hypogonadism

0 Actively Recruiting

Hypothalamic Diseases

0 Actively Recruiting

Orchiectomy

0 Actively Recruiting

Testosterone Cypionate Reviews: What are patients saying about Testosterone Cypionate?

5

Patient Review

10/20/2018

Testosterone Cypionate for Deficient Activity of the Testis

I've been taking 200mg every week for over a year and have been feeling great. Worked with my doc on getting the dosing right, but have not had any issues. Drive is up, and not as tired as I was.

5

Patient Review

9/9/2021

Testosterone Cypionate for Hormone Receptor Positive Breast Cancer

This was a really great treatment.

5

Patient Review

9/5/2021

Testosterone Cypionate for Myotonia Congenita

I thought this treatment was very effective and well worth the money.

5

Patient Review

10/18/2016

Testosterone Cypionate for Deficient Activity of the Testis

4.3

Patient Review

7/4/2022

Testosterone Cypionate for Hormone Receptor Positive Breast Cancer

I was struggling in a lot of areas before I started this treatment. My libido and ability to get erections were shot, my hair was falling out, and I just didn't feel good about myself. After six months of testosterone shots, though, I'm feeling like a new person.

4

Patient Review

11/12/2016

Testosterone Cypionate for Deficient Activity of the Testis

This drug has made a great difference. I started with the Gel, but my insurance quit covering the cost, so I switched to injection which seems to work much better. I have more energy and I have lost 30 lbs and have maintained the weight loss. My body is much leaner with occasional exercise and yard work

4

Patient Review

7/16/2020

Testosterone Cypionate for Deficient Activity of the Testis

It can take a while to see results from this treatment- so don't give up after only a few weeks!

4

Patient Review

9/5/2021

Testosterone Cypionate for Significant Weight Loss from HIV

This was a great treatment.

3.3

Patient Review

12/5/2021

Testosterone Cypionate for Rare X Chromosome Abnormality - Klinefelter Syndrome

I stopped seeing hair growth on my body, plus my testicles shrunk and my nipples started to hurt. Now I have bigger breasts.

3

Patient Review

1/17/2019

Testosterone Cypionate for Pituitary Hormone Deficiency

I was put on testosterone cypionate injection 200 mg once a month on june 21st 2018 for hypogonadism and every was great for me from then on through january 3rd 2019 when i was put on 400 mg a month every 2 weeks. Since the new dosage, I have had nonstop severe anxiety and diarrhea.

3

Patient Review

4/18/2017

Testosterone Cypionate for Deficient Activity of Testes or Ovaries due to Chemotherapy

I've been using this medication for five years. It usually works, but I still have low testosterone levels unless I get a weekly injection, which are quite painful and leave my leg sore for several days. The benefits (e.g., helping with depression, muscle fatigue, weight gain) outweigh the negatives for me, but it's not ideal to have to do injections forever.

1

Patient Review

11/5/2017

Testosterone Cypionate for Undescended Testicle

These shots did nothing but make my testosterone levels go down, which in turn impacted my liver function. I've also lost all energy and sex drive, can't focus on hobbies like I used to, and have had terrible memory for a long time now.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about testosterone cypionate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How much does testosterone cypionate raise testosterone?

"Testosterone cypionate, an ester derivative of testosterone, causes a dramatic increase in serum testosterone levels, reaching 400% of the baseline within 24 hours of administration. These androgen levels remain elevated for 3-5 days."

Answered by AI

What does cypionate testosterone do for you?

"Testosterone cypionate is used to treat symptoms of hypogonadism, a condition where males don't produce enough of the sex hormone testosterone. Low testosterone levels in males can lead to mood changes, poor concentration, erectile dysfunction, and low sex drive."

Answered by AI

How long does a testosterone cypionate injection last?

"The time it takes for testosterone cypionate levels to decrease by half when injected into muscle is about eight days."

Answered by AI

How long does it take for cypionate testosterone to kick in?

"It may take up to three weeks for someone to notice changes in their sexual interest after taking this medication, with the changes plateauing at six weeks. There are no further increments expected after six weeks. It may take up to six months for someone to notice changes in their erections and ejaculations. Changes in quality of life may manifest within three to four weeks, but the person may not experience the maximum benefits for some time."

Answered by AI

Clinical Trials for Testosterone Cypionate

Image of University of California, Los Angeles in Los Angeles, United States.

Testosterone Replacement for Kidney Failure

18+
Male
Los Angeles, CA

This prospective study aims to evaluate the safety and efficacy of testosterone replacement therapy (TRT) as an adjunct to an enhanced recover after surgery (ERAS) protocol in men with end-stage renal disease (ESRD) undergoing kidney transplantation. Participants will be highly-listed hypogonadal men, defined as total testosterone level \<300 on two occasions with clinical symptoms of hypogonadism, with ESRD who are expected to receive a kidney transplant within 6 months. Participants will be started on TRT, ideally for at least 3 months prior transplantation. The investigators will perform a subset analysis to evaluate if there is a significant difference in our endpoints by comparing these two subgroups (Three months or more receiving TRT vs. Less than three months receiving TRT). There will be no cut-off time for pre-transplant TRT. Following the intervention period, a historical control cohort of age-matched and health-matched patients will be identified, who have followed a standard transplant protocol that does not incorporate TRT. The primary outcome will evaluate safety, including 30- and 90-day adverse events, 3, 6, and 12-month allograft survival, and overall patient survival. Secondary outcomes will focus on (1) qualitative assessments of symptoms using validated questionnaires, (2) quantitative improvements in the hormonal profile before and after initiation of TRT and surgery, and (3) allograft function and incidence of delayed graft function. The results of this study could provide novel insights into the benefits of TRT in improving surgical outcomes in men with ESRD undergoing kidney transplantation.

Phase 1 & 2
Waitlist Available

University of California, Los Angeles

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