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What is Testosterone Cypionate
Testosterone cypionateThe Generic name of this drug
Treatment SummaryTestosterone cypionate is a synthetic form of testosterone that is injected into the body. It is made of oil-soluble 17 (beta)-cyclopentylpropionate ester and is released and active in the body for a longer period of time than other testosterone derivatives. Testosterone cypionate was developed by the company Pharmacia and Upjohn and approved by the FDA in 1979.
Depo-Testosteroneis the brand name
Testosterone Cypionate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Depo-Testosterone
Testosterone cypionate
1979
51
Approved as Treatment by the FDA
Testosterone cypionate, also known as Depo-Testosterone, is approved by the FDA for 10 uses including Pituitary gonadotropin hypofunction and Hypothalamic Diseases .Pituitary gonadotropin hypofunction
Hypothalamic Diseases
Orchiectomy
Hypogonadotropic hypogonadism
Orchitis
Testicular hypogonadism
Testicular hypogonadism
Gonadotrophin releasing hormone deficiency
Hypergonadotropic Hypogonadism
Testicular hypogonadism
Effectiveness
How Testosterone Cypionate Affects PatientsTestosterone cypionate is an ester derivative of testosterone that, when taken, can raise testosterone levels in the body up to 400% within 24 hours. These increased levels stay elevated for 3-5 days. Taking testosterone cypionate can cause mood swings and changes in libido, as well as minor inflammation in the area where it is injected.
How Testosterone Cypionate works in the bodyTestosterone works by activating receptors in the body. It can bind directly to androgen receptors, or it can be converted to a more potent form called Dihydrotestosterone (DHT) which binds even more strongly to these receptors. The receptors then move into the cell nucleus and bind to specific sections of DNA, affecting how certain genes are expressed and creating the androgen effects.
When to interrupt dosage
The suggested dosage of Testosterone Cypionate is contingent upon the diagnosed circumstance, including Hypergonadotropic Hypogonadism, Testicular hypogonadism and Gonadotrophin releasing hormone deficiency. The measure of dosage is based on the technique of administration (e.g. Injection, solution or Injection, solution - Intramuscular) outlined in the table below.Condition
Dosage
Administration
Testicular hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Testicular hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Hypergonadotropic Hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Hypothalamic Diseases
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Hypogonadotropic hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Gonadotrophin releasing hormone deficiency
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Pituitary gonadotropin hypofunction
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Orchitis
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Testicular hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Orchiectomy
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Warnings
There are 20 known major drug interactions with Testosterone Cypionate.Common Testosterone Cypionate Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Testosterone cypionate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Testosterone cypionate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Testosterone cypionate.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Testosterone cypionate.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Testosterone cypionate.
Testosterone Cypionate Toxicity & Overdose RiskIn animal studies, using testosterone implants has been linked to cervical and uterine tumors that spread in some cases. Some reports suggest that using testosterone cypionate in female patients can increase the risk of liver cancer and the number of tumors. Clinical studies have also reported cases of liver cancer in patients who received high doses of testosterone for a long period of time.
Testosterone Cypionate Novel Uses: Which Conditions Have a Clinical Trial Featuring Testosterone Cypionate?
Currently, two clinical trials are assessing the potential of Testosterone Cypionate to alleviate Hypothalamic Diseases, Hypogonadotropic Hypogonadism and Orchitis.Condition
Clinical Trials
Trial Phases
Gonadotrophin releasing hormone deficiency
1 Actively Recruiting
Phase 1
Orchiectomy
0 Actively Recruiting
Hypogonadotropic hypogonadism
0 Actively Recruiting
Hypothalamic Diseases
0 Actively Recruiting
Hypergonadotropic Hypogonadism
0 Actively Recruiting
Testicular hypogonadism
0 Actively Recruiting
Pituitary gonadotropin hypofunction
0 Actively Recruiting
Testicular hypogonadism
0 Actively Recruiting
Testicular hypogonadism
0 Actively Recruiting
Orchitis
0 Actively Recruiting
Testosterone Cypionate Reviews: What are patients saying about Testosterone Cypionate?
5Patient Review
10/20/2018 I've been taking 200mg every week for over a year and have been feeling great. Worked with my doc on getting the dosing right, but have not had any issues. Drive is up, and not as tired as I was.
5Patient Review
9/9/2021 This was a really great treatment.
5Patient Review
9/5/2021 I thought this treatment was very effective and well worth the money.
5Patient Review
10/18/20164.3Patient Review
7/4/2022 I was struggling in a lot of areas before I started this treatment. My libido and ability to get erections were shot, my hair was falling out, and I just didn't feel good about myself. After six months of testosterone shots, though, I'm feeling like a new person.
4Patient Review
11/12/2016 This drug has made a great difference. I started with the Gel, but my insurance quit covering the cost, so I switched to injection which seems to work much better. I have more energy and I have lost 30 lbs and have maintained the weight loss. My body is much leaner with occasional exercise and yard work
4Patient Review
7/16/2020 It can take a while to see results from this treatment- so don't give up after only a few weeks!
4Patient Review
9/5/2021 This was a great treatment.
3.3Patient Review
12/5/2021 I stopped seeing hair growth on my body, plus my testicles shrunk and my nipples started to hurt. Now I have bigger breasts.
3Patient Review
1/17/2019 I was put on testosterone cypionate injection 200 mg once a month on june 21st 2018 for hypogonadism and every was great for me from then on through january 3rd 2019 when i was put on 400 mg a month every 2 weeks. Since the new dosage, I have had nonstop severe anxiety and diarrhea.
3Patient Review
4/18/2017 I've been using this medication for five years. It usually works, but I still have low testosterone levels unless I get a weekly injection, which are quite painful and leave my leg sore for several days. The benefits (e.g., helping with depression, muscle fatigue, weight gain) outweigh the negatives for me, but it's not ideal to have to do injections forever.
1Patient Review
11/5/2017 These shots did nothing but make my testosterone levels go down, which in turn impacted my liver function. I've also lost all energy and sex drive, can't focus on hobbies like I used to, and have had terrible memory for a long time now.
Patient Q&A Section about testosterone cypionate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How much does testosterone cypionate raise testosterone?
"Testosterone cypionate, an ester derivative of testosterone, causes a dramatic increase in serum testosterone levels, reaching 400% of the baseline within 24 hours of administration. These androgen levels remain elevated for 3-5 days."
Answered by AI
What does cypionate testosterone do for you?
"Testosterone cypionate is used to treat symptoms of hypogonadism, a condition where males don't produce enough of the sex hormone testosterone. Low testosterone levels in males can lead to mood changes, poor concentration, erectile dysfunction, and low sex drive."
Answered by AI
How long does a testosterone cypionate injection last?
"The time it takes for testosterone cypionate levels to decrease by half when injected into muscle is about eight days."
Answered by AI
How long does it take for cypionate testosterone to kick in?
"It may take up to three weeks for someone to notice changes in their sexual interest after taking this medication, with the changes plateauing at six weeks. There are no further increments expected after six weeks. It may take up to six months for someone to notice changes in their erections and ejaculations. Changes in quality of life may manifest within three to four weeks, but the person may not experience the maximum benefits for some time."
Answered by AI