Testosterone Cypionate

Gonadotrophin releasing hormone deficiency, Hypogonadism, Hypogonadism + 7 more
Treatment
12 FDA approvals
5 Active Studies for Testosterone Cypionate

What is Testosterone Cypionate

Testosterone cypionateThe Generic name of this drug
Treatment SummaryTestosterone cypionate is a synthetic form of testosterone that is injected into the body. It is made of oil-soluble 17 (beta)-cyclopentylpropionate ester and is released and active in the body for a longer period of time than other testosterone derivatives. Testosterone cypionate was developed by the company Pharmacia and Upjohn and approved by the FDA in 1979.
Depo-Testosteroneis the brand name
image of different drug pills on a surface
Testosterone Cypionate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Depo-Testosterone
Testosterone cypionate
1979
51

Approved as Treatment by the FDA

Testosterone cypionate, also known as Depo-Testosterone, is approved by the FDA for 12 uses including Hypergonadotropic Hypogonadism and Pituitary gonadotropin hypofunction .
Hypergonadotropic Hypogonadism
Pituitary gonadotropin hypofunction
Hypothalamic Diseases
Hypogonadism
Orchitis
Orchiectomy
Gonadotrophin releasing hormone deficiency
Hypogonadism
Hypogonadotropic hypogonadism
Testicular hypogonadism
Testicular hypogonadism
Testicular hypogonadism

Effectiveness

How Testosterone Cypionate Affects PatientsTestosterone cypionate is an ester derivative of testosterone that, when taken, can raise testosterone levels in the body up to 400% within 24 hours. These increased levels stay elevated for 3-5 days. Taking testosterone cypionate can cause mood swings and changes in libido, as well as minor inflammation in the area where it is injected.
How Testosterone Cypionate works in the bodyTestosterone works by activating receptors in the body. It can bind directly to androgen receptors, or it can be converted to a more potent form called Dihydrotestosterone (DHT) which binds even more strongly to these receptors. The receptors then move into the cell nucleus and bind to specific sections of DNA, affecting how certain genes are expressed and creating the androgen effects.

When to interrupt dosage

The suggested dosage of Testosterone Cypionate is contingent upon the diagnosed circumstance, including Hypergonadotropic Hypogonadism, Testicular hypogonadism and Gonadotrophin releasing hormone deficiency. The measure of dosage is based on the technique of administration (e.g. Injection, solution or Injection, solution - Intramuscular) outlined in the table below.
Condition
Dosage
Administration
Gonadotrophin releasing hormone deficiency
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Hypogonadotropic hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Testicular hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Hypothalamic Diseases
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Orchitis
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Testicular hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Orchiectomy
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous
Testicular hypogonadism
200.0 mg/mL, , 100.0 mg/mL, 20.0 mg/mL
, Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular, Solution, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Intramuscular; Topical, Injection - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous

Warnings

There are 20 known major drug interactions with Testosterone Cypionate.
Common Testosterone Cypionate Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Testosterone cypionate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Testosterone cypionate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Testosterone cypionate.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Testosterone cypionate.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Testosterone cypionate.
Testosterone Cypionate Toxicity & Overdose RiskIn animal studies, using testosterone implants has been linked to cervical and uterine tumors that spread in some cases. Some reports suggest that using testosterone cypionate in female patients can increase the risk of liver cancer and the number of tumors. Clinical studies have also reported cases of liver cancer in patients who received high doses of testosterone for a long period of time.
image of a doctor in a lab doing drug, clinical research

Testosterone Cypionate Novel Uses: Which Conditions Have a Clinical Trial Featuring Testosterone Cypionate?

Currently, two clinical trials are assessing the potential of Testosterone Cypionate to alleviate Hypothalamic Diseases, Hypogonadotropic Hypogonadism and Orchitis.
Condition
Clinical Trials
Trial Phases
Testicular hypogonadism
5 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Testicular hypogonadism
0 Actively Recruiting
Orchitis
0 Actively Recruiting
Hypogonadotropic hypogonadism
0 Actively Recruiting
Hypogonadism
0 Actively Recruiting
Gonadotrophin releasing hormone deficiency
0 Actively Recruiting
Testicular hypogonadism
0 Actively Recruiting
Hypogonadism
0 Actively Recruiting
Hypothalamic Diseases
0 Actively Recruiting
Orchiectomy
0 Actively Recruiting

Testosterone Cypionate Reviews: What are patients saying about Testosterone Cypionate?

5Patient Review
10/20/2018
Testosterone Cypionate for Deficient Activity of the Testis
I've been taking 200mg every week for over a year and have been feeling great. Worked with my doc on getting the dosing right, but have not had any issues. Drive is up, and not as tired as I was.
5Patient Review
9/9/2021
Testosterone Cypionate for Hormone Receptor Positive Breast Cancer
This was a really great treatment.
5Patient Review
9/5/2021
Testosterone Cypionate for Myotonia Congenita
I thought this treatment was very effective and well worth the money.
5Patient Review
10/18/2016
Testosterone Cypionate for Deficient Activity of the Testis
4.3Patient Review
7/4/2022
Testosterone Cypionate for Hormone Receptor Positive Breast Cancer
I was struggling in a lot of areas before I started this treatment. My libido and ability to get erections were shot, my hair was falling out, and I just didn't feel good about myself. After six months of testosterone shots, though, I'm feeling like a new person.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about testosterone cypionate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How much does testosterone cypionate raise testosterone?

"Testosterone cypionate, an ester derivative of testosterone, causes a dramatic increase in serum testosterone levels, reaching 400% of the baseline within 24 hours of administration. These androgen levels remain elevated for 3-5 days."

Answered by AI

What does cypionate testosterone do for you?

"Testosterone cypionate is used to treat symptoms of hypogonadism, a condition where males don't produce enough of the sex hormone testosterone. Low testosterone levels in males can lead to mood changes, poor concentration, erectile dysfunction, and low sex drive."

Answered by AI

How long does a testosterone cypionate injection last?

"The time it takes for testosterone cypionate levels to decrease by half when injected into muscle is about eight days."

Answered by AI

How long does it take for cypionate testosterone to kick in?

"It may take up to three weeks for someone to notice changes in their sexual interest after taking this medication, with the changes plateauing at six weeks. There are no further increments expected after six weeks. It may take up to six months for someone to notice changes in their erections and ejaculations. Changes in quality of life may manifest within three to four weeks, but the person may not experience the maximum benefits for some time."

Answered by AI

Clinical Trials for Testosterone Cypionate

Have you considered Testosterone Cypionate clinical trials? We made a collection of clinical trials featuring Testosterone Cypionate, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top