Tambocor

Atrial Fibrillation, severe Atrioventricular nodal reentrant tachycardia, Tachycardia, Ventricular + 11 more
Treatment
13 FDA approvals
20 Active Studies for Tambocor

What is Tambocor

FlecainideThe Generic name of this drug
Treatment SummaryFlecainide is a medication used to treat abnormal heart rhythms such as atrial fibrillation and flutter. It was first developed in 1966 and synthesized in 1972, and was officially approved by the FDA in 1985. Flecainide belongs to a class of medications called Class I anti-arrhythmic agents, which also includes drugs like encainide and propafenone.
Tambocoris the brand name
Tambocor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tambocor
Flecainide
1985
82

Approved as Treatment by the FDA

Flecainide, commonly known as Tambocor, is approved by the FDA for 13 uses like Tachycardia, Ventricular and Paroxysmal supraventricular tachycardia .
Tachycardia, Ventricular
Paroxysmal supraventricular tachycardia
Supraventricular tachycardia
prophylaxis of severe ventricular arrhythmias
prophylaxis of severe Paroxysmal atrial fibrillation
severe ventricular arrhythmias
Tachycardia, Ventricular
severe Atrioventricular nodal reentrant tachycardia
Tachycardia, Atrioventricular Nodal Reentry
Paroxysmal supraventricular tachycardia
Ventricular Tachycardia
severe Supraventricular Tachycardias
severe Paroxysmal atrial fibrillation

Effectiveness

How Tambocor Affects PatientsFlecainide is a medication used to treat heart arrhythmias by blocking sodium and potassium ion channels in the heart and increasing the amount of energy needed for the heart to beat. It needs to be taken once a day, but it is important to be careful with this medication as it can easily become dangerous if the dose is too high. People with existing structural heart disease or poor heart function should not take flecainide.
How Tambocor works in the bodyFlecainide works by blocking sodium channels in the heart and preventing potassium channels from opening. This helps to prolong the refractory period of the heart and lengthen the action potentials in the Purkinjie fibers and muscle fibers. It also blocks the release of calcium from the sarcoplasmic reticulum, reducing the depolarization of cells.

When to interrupt dosage

The amount of Tambocor is contingent upon the diagnosed disorder, including Paroxysmal supraventricular tachycardia, severe Atrioventricular nodal reentrant tachycardia and Tachycardia, Ventricular. The dosage fluctuates, in accordance with the mode of administration (e.g. Tablet - Oral or Oral) detailed in the next table.
Condition
Dosage
Administration
Paroxysmal supraventricular tachycardia
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
severe ventricular arrhythmias
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Supraventricular tachycardia
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Ventricular Tachycardia
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Paroxysmal supraventricular tachycardia
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Tachycardia, Ventricular
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Tachycardia, Atrioventricular Nodal Reentry
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Tachycardia, Ventricular
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Atrial Fibrillation
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
severe Paroxysmal atrial fibrillation
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
prophylaxis of severe Paroxysmal atrial fibrillation
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
prophylaxis of severe ventricular arrhythmias
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
severe Supraventricular Tachycardias
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
severe Atrioventricular nodal reentrant tachycardia
100.0 mg, , 50.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Tambocor has five counter-indications, meaning it should not be taken when experiencing the conditions in the following table.Tambocor Contraindications
Condition
Risk Level
Notes
bundle branch block (right)
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Atrioventricular Block
Do Not Combine
persistent second-degree atrioventricular block
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Flecainide may interact with Pulse Frequency
There are 20 known major drug interactions with Tambocor.
Common Tambocor Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Flecainide.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Flecainide.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Flecainide is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Flecainide is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Flecainide is combined with Artemether.
Tambocor Toxicity & Overdose RiskThe lethal dose of flecainide in rats is 1346mg/kg and in mice is 170mg/kg. For those who overdose, symptoms may include changes in their heart's electrical activity such as a slower heartbeat, a longer time between heartbeats, a longer QRS duration, a longer QT interval, increased T wave size, lower heart rate, and weaker heart contractions. Low blood pressure or death may also occur. Treatment should involve providing supportive care and administering drugs to help the heart function. Hemodialysis is not expected to help remove flecainide from the bloodstream.

Tambocor Novel Uses: Which Conditions Have a Clinical Trial Featuring Tambocor?

176 active studies are examining the potential of Tambocor to reduce severe ventricular arrhythmias, provide prophylaxis against severe ventricular arrhythmias, and treat Ventricular Tachycardia.
Condition
Clinical Trials
Trial Phases
Tachycardia, Ventricular
0 Actively Recruiting
severe Paroxysmal atrial fibrillation
0 Actively Recruiting
prophylaxis of severe Paroxysmal atrial fibrillation
0 Actively Recruiting
Paroxysmal supraventricular tachycardia
0 Actively Recruiting
Paroxysmal supraventricular tachycardia
0 Actively Recruiting
Supraventricular tachycardia
0 Actively Recruiting
prophylaxis of severe ventricular arrhythmias
0 Actively Recruiting
Atrial Fibrillation
148 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Tachycardia, Ventricular
0 Actively Recruiting
Ventricular Tachycardia
15 Actively Recruiting
Phase 3, Phase 4, Early Phase 1, Not Applicable, Phase 2
severe Atrioventricular nodal reentrant tachycardia
0 Actively Recruiting
severe ventricular arrhythmias
0 Actively Recruiting
severe Supraventricular Tachycardias
0 Actively Recruiting
Tachycardia, Atrioventricular Nodal Reentry
0 Actively Recruiting

Tambocor Reviews: What are patients saying about Tambocor?

5Patient Review
3/9/2013
Tambocor for A Type of Fast Heartbeat - Paroxysmal Atrial Tachycardia
After taking this medication for an extended period of time with no positive results, I was taken off of it. Ablation was attempted but unsuccessful. I experienced several VTach episodes where my heart rate would spike for 15 minutes straight. I was hospitalized and put back on Tambocor at a higher dose. After increasing the dosage and taking it for a full month, I have only had 3 decent days with minimal PVCs.
5Patient Review
4/10/2014
Tambocor for Atrial Fibrillation
Initially, I was only prescribed one 50mg tablet to be taken twice a day. This did not work for me, so my dosage was increased to two 50mg tablets per day. This change has been very effective; it's been over two weeks since my last episode.
5Patient Review
3/5/2012
Tambocor for A Type of Fast Heartbeat - Paroxysmal Atrial Tachycardia
4.7Patient Review
12/21/2011
Tambocor for Atrial Fibrillation
4Patient Review
4/17/2013
Tambocor for Paroxysmal Atrial Fibrillation
Since taking this medication, I have felt very anxious and shaky.
4Patient Review
8/2/2012
Tambocor for Atrial Fibrillation
4Patient Review
9/6/2012
Tambocor for Atrial Fibrillation
3.7Patient Review
9/3/2019
Tambocor for Paroxysmal Atrial Fibrillation
I have been dealing with AFib for a while now, and this medication has really helped to lessen the frequency and severity of my episodes. I still experience some chest pain and palpitations, but it is much better than it was before.
3.3Patient Review
11/11/2021
Tambocor for Atrial Fibrillation
I've only been on this for three weeks, and the only side effect I've noticed is shortness of breath. I contacted my doctor, but they haven't gotten back to me yet; as a result, I ended up cutting the dose myself. This has made a big difference--I no longer have shortness of breath. Instead of taking 50 mg twice a day, I am now taking one 50 mg at night and only a half in the day hours. Recently, I had the Cardioversion which put me back to a normal rhythm.
3Patient Review
7/24/2013
Tambocor for Heart Ventricle Rhythm Problem
The treatment is working which I'm happy about, though the side effects are quite troublesome. Anxiety, hair loss, and shortness of breath have all been issues.
3Patient Review
3/30/2012
Tambocor for Life-Threatening Rapid Ventricular Heartbeat
1.3Patient Review
10/5/2013
Tambocor for Atrial Fibrillation Electrically Shocked to Normal Rhythm
I had a really bad reaction to this drug. It was like poison to my system. I'm going to London to get the Tambacore brand instead.
1Patient Review
5/29/2013
Tambocor for Atrial Fibrillation
Although this is technically effective, I am now having hand tremors and anxiety. These are probable side effects that should be considered before taking the medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tambocor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are 3 side effects of flecainide?

"The person may experience shortness of breath, wheezing, difficult or labored breathing, fast or irregular heartbeat, dizziness, lightheadedness, or fainting."

Answered by AI

What is the medicine Tambocor used for?

"This medication is used to treat certain types of serious (possibly fatal) irregular heartbeat. These include conditions such as persistent ventricular tachycardia and paroxysmal supraventricular tachycardia. The medication is used to restore normal heart rhythm and maintain a regular, steady heartbeat."

Answered by AI

What are the most common side effects of flecainide?

"Stomach problems. Symptoms may include: constipation, bloating, gas, diarrhea, and abdominal pain. Vision problems. Symptoms may include: blurred vision, double vision, and decreased vision. Low blood pressure. Symptoms may include: dizziness, lightheadedness, fainting, and fatigue. Uncontrollable shaking of parts of your body, such as your hands, arms, head, or legs. Headache."

Answered by AI

Does Tambocor lower heart rate?

"You may experience nausea, vomiting, slow heart rate, fainting, or seizure (convulsions) if you overdose on Flecainide (Tambocor)."

Answered by AI

Clinical Trials for Tambocor

Have you considered Tambocor clinical trials? We made a collection of clinical trials featuring Tambocor, we think they might fit your search criteria.
Have you considered Tambocor clinical trials? We made a collection of clinical trials featuring Tambocor, we think they might fit your search criteria.
Have you considered Tambocor clinical trials? We made a collection of clinical trials featuring Tambocor, we think they might fit your search criteria.
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