Tambocor

Atrial Fibrillation, Tachycardia, Atrioventricular Nodal Reentry, Tachycardia, Ventricular + 11 more

Treatment

22 FDA approvals

20 Active Studies for Tambocor

Treatment for

Atrial Fibrillation

What is Tambocor

FlecainideThe Generic name of this drug

Treatment SummaryFlecainide is a medication used to treat abnormal heart rhythms such as atrial fibrillation and flutter. It was first developed in 1966 and synthesized in 1972, and was officially approved by the FDA in 1985. Flecainide belongs to a class of medications called Class I anti-arrhythmic agents, which also includes drugs like encainide and propafenone.

Tambocoris the brand name

Tambocor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tambocor

Flecainide

1985

Approved as Treatment by the FDA

Flecainide, commonly known as Tambocor, is approved by the FDA for 22 uses like severe Paroxysmal atrial fibrillation and severe Atrioventricular nodal reentrant tachycardia .

severe Paroxysmal atrial fibrillation

severe Atrioventricular nodal reentrant tachycardia

Tachycardia, Supraventricular

Supraventricular tachycardia

Atrial Fibrillation

severe ventricular arrhythmias

severe Paroxysmal supraventricular tachycardia

prophylaxis of severe Paroxysmal supraventricular tachycardia

prophylaxis of severe Supraventricular Tachycardias

prophylaxis of severe Sustained ventricular tachycardia

prophylaxis of severe ventricular arrhythmias

severe Sustained ventricular tachycardia

Ventricular Tachycardia

severe Supraventricular Tachycardias

prophylaxis of severe Atrioventricular nodal reentrant tachycardia

Paroxysmal supraventricular tachycardia

Tachycardia, Ventricular

prophylaxis of severe Paroxysmal atrial fibrillation

Tachycardia, Ventricular

Tachycardia, Atrioventricular Nodal Reentry

Effectiveness

How Tambocor Affects PatientsFlecainide is a medication used to treat heart arrhythmias by blocking sodium and potassium ion channels in the heart and increasing the amount of energy needed for the heart to beat. It needs to be taken once a day, but it is important to be careful with this medication as it can easily become dangerous if the dose is too high. People with existing structural heart disease or poor heart function should not take flecainide.

How Tambocor works in the bodyFlecainide works by blocking sodium channels in the heart and preventing potassium channels from opening. This helps to prolong the refractory period of the heart and lengthen the action potentials in the Purkinjie fibers and muscle fibers. It also blocks the release of calcium from the sarcoplasmic reticulum, reducing the depolarization of cells.

When to interrupt dosage

The amount of Tambocor is contingent upon the diagnosed disorder, including Paroxysmal supraventricular tachycardia, severe Atrioventricular nodal reentrant tachycardia and Tachycardia, Ventricular. The dosage fluctuates, in accordance with the mode of administration (e.g. Tablet - Oral or Oral) detailed in the next table.

Condition

Dosage

Administration

Paroxysmal supraventricular tachycardia

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Tachycardia, Atrioventricular Nodal Reentry

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Tachycardia, Ventricular

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Tachycardia, Supraventricular

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

prophylaxis of severe Paroxysmal atrial fibrillation

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Tachycardia, Ventricular

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

prophylaxis of severe ventricular arrhythmias

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Supraventricular tachycardia

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Ventricular Tachycardia

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Tachycardia, Atrioventricular Nodal Reentry

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Paroxysmal supraventricular tachycardia

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Atrial Fibrillation

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

severe ventricular arrhythmias

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Atrial Fibrillation

100.0 mg, , 50.0 mg, 150.0 mg

, Oral, Tablet, Tablet - Oral

Warnings

Tambocor has five counter-indications, meaning it should not be taken when experiencing the conditions in the following table.Tambocor Contraindications

Condition

Risk Level

Notes

Bundle-Branch Block

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Atrioventricular Block

Do Not Combine

persistent second-degree atrioventricular block

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Flecainide may interact with Pulse Frequency

There are 20 known major drug interactions with Tambocor.

Common Tambocor Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The excretion of Abemaciclib can be decreased when combined with Flecainide.

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Flecainide.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Flecainide is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Flecainide is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Flecainide is combined with Artemether.

Tambocor Toxicity & Overdose RiskThe lethal dose of flecainide in rats is 1346mg/kg and in mice is 170mg/kg. For those who overdose, symptoms may include changes in their heart's electrical activity such as a slower heartbeat, a longer time between heartbeats, a longer QRS duration, a longer QT interval, increased T wave size, lower heart rate, and weaker heart contractions. Low blood pressure or death may also occur. Treatment should involve providing supportive care and administering drugs to help the heart function. Hemodialysis is not expected to help remove flecainide from the bloodstream.

Tambocor Novel Uses: Which Conditions Have a Clinical Trial Featuring Tambocor?

176 active studies are examining the potential of Tambocor to reduce severe ventricular arrhythmias, provide prophylaxis against severe ventricular arrhythmias, and treat Ventricular Tachycardia.

Condition

Clinical Trials

Trial Phases

prophylaxis of severe Paroxysmal atrial fibrillation

0 Actively Recruiting

Atrial Fibrillation

96 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Paroxysmal supraventricular tachycardia

0 Actively Recruiting

severe ventricular arrhythmias

0 Actively Recruiting

Ventricular Tachycardia

18 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Early Phase 1

Tachycardia, Atrioventricular Nodal Reentry

0 Actively Recruiting

Tachycardia, Ventricular

0 Actively Recruiting

Tachycardia, Ventricular

0 Actively Recruiting

Tachycardia, Atrioventricular Nodal Reentry

0 Actively Recruiting

prophylaxis of severe ventricular arrhythmias

0 Actively Recruiting

Atrial Fibrillation

0 Actively Recruiting

Tachycardia, Supraventricular

0 Actively Recruiting

Paroxysmal supraventricular tachycardia

0 Actively Recruiting

Supraventricular tachycardia

0 Actively Recruiting

Tambocor Reviews: What are patients saying about Tambocor?

5Patient Review

3/9/2013

Tambocor for A Type of Fast Heartbeat - Paroxysmal Atrial Tachycardia

After taking this medication for an extended period of time with no positive results, I was taken off of it. Ablation was attempted but unsuccessful. I experienced several VTach episodes where my heart rate would spike for 15 minutes straight. I was hospitalized and put back on Tambocor at a higher dose. After increasing the dosage and taking it for a full month, I have only had 3 decent days with minimal PVCs.

5Patient Review

4/10/2014

Tambocor for Atrial Fibrillation

Initially, I was only prescribed one 50mg tablet to be taken twice a day. This did not work for me, so my dosage was increased to two 50mg tablets per day. This change has been very effective; it's been over two weeks since my last episode.

5Patient Review

3/5/2012

Tambocor for A Type of Fast Heartbeat - Paroxysmal Atrial Tachycardia

4.7Patient Review

12/21/2011

Tambocor for Atrial Fibrillation

4Patient Review

4/17/2013

Tambocor for Paroxysmal Atrial Fibrillation

Since taking this medication, I have felt very anxious and shaky.

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tambocor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are 3 side effects of flecainide?

"The person may experience shortness of breath, wheezing, difficult or labored breathing, fast or irregular heartbeat, dizziness, lightheadedness, or fainting."

Answered by AI

What is the medicine Tambocor used for?

"This medication is used to treat certain types of serious (possibly fatal) irregular heartbeat. These include conditions such as persistent ventricular tachycardia and paroxysmal supraventricular tachycardia. The medication is used to restore normal heart rhythm and maintain a regular, steady heartbeat."

Answered by AI

What are the most common side effects of flecainide?

"Stomach problems. Symptoms may include: constipation, bloating, gas, diarrhea, and abdominal pain. Vision problems. Symptoms may include: blurred vision, double vision, and decreased vision. Low blood pressure. Symptoms may include: dizziness, lightheadedness, fainting, and fatigue. Uncontrollable shaking of parts of your body, such as your hands, arms, head, or legs. Headache."

Answered by AI

Does Tambocor lower heart rate?

"You may experience nausea, vomiting, slow heart rate, fainting, or seizure (convulsions) if you overdose on Flecainide (Tambocor)."

Answered by AI

Clinical Trials for Tambocor

Have you considered Tambocor clinical trials? We made a collection of clinical trials featuring Tambocor, we think they might fit your search criteria.

Have you considered Tambocor clinical trials? We made a collection of clinical trials featuring Tambocor, we think they might fit your search criteria.