Sulindac

acute supraspinatus tendinitis, acute Subacromial bursitis, Tendinitis + 6 more
Treatment
10 FDA approvals
20 Active Studies for Sulindac

What is Sulindac

SulindacThe Generic name of this drug
Treatment SummarySulindac is a type of anti-inflammatory medication that is used to reduce inflammation and treat inflammatory conditions. It is sold under the brand name Clinoril and is part of a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Sulindac is a prodrug, meaning it must be converted by the liver into an active form before it can be used by the body. Studies have suggested that sulindac may cause fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be because the active form of
Clinorilis the brand name
image of different drug pills on a surface
Sulindac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clinoril
Sulindac
1978
55

Approved as Treatment by the FDA

Sulindac, also known as Clinoril, is approved by the FDA for 10 uses such as Ankylosing Spondylitis (AS) and Osteoarthritis (OA) .
Ankylosing Spondylitis (AS)
Osteoarthritis (OA)
Tendonitis exacerbated
Osteoarthritis
acute Subacromial bursitis
acute supraspinatus tendinitis
Rheumatoid Arthritis
Tendinitis
Arthritis, Gouty
Ankylosing Spondylitis

Effectiveness

How Sulindac Affects PatientsSulindac is a medication used to reduce inflammation, pain, and fever. It belongs to a type of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).
How Sulindac works in the bodySulindac works to reduce inflammation, but the exact mechanism is unknown. Its effects are likely due to blocking the production of prostaglandins, which are responsible for inflammation. It may also reduce fever by increasing blood flow and causing the body to release more heat.

When to interrupt dosage

The endorsed amount of Sulindac is based upon the diagnosed condition, such as Osteoarthritis (OA), Ankylosing Spondylitis and acute supraspinatus tendinitis. The dosage is contingent upon the mode of delivery (e.g. Oral or Tablet) specified in the table below.
Condition
Dosage
Administration
acute supraspinatus tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Adenomatous Polyposis Coli
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Arthritis, Gouty
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Colorectal Adenomas
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Osteoarthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Ankylosing Spondylitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
acute Subacromial bursitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Rheumatoid Arthritis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Tendinitis
, 150.0 mg, 200.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Sulindac Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Sulindac.
Common Sulindac Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Sulindac.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Sulindac.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Sulindac.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Sulindac is combined with Omacetaxine mepesuccinate.
Sulindac Toxicity & Overdose RiskThe toxic dose of Lasix in rats has been found to be 264mg/kg. Signs of overdose include confusion, loss of consciousness, reduced urine output, and low blood pressure. In rare cases, death may occur.
image of a doctor in a lab doing drug, clinical research

Sulindac Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulindac?

99 active trials are being conducted to assess the efficacy of Sulindac in treating Adenomatous Polyposis Coli, Osteoarthritis (OA) and Gouty Arthritis.
Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
54 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Adenomatous Polyposis Coli
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Osteoarthritis
0 Actively Recruiting
acute Subacromial bursitis
0 Actively Recruiting
Colorectal Adenomas
9 Actively Recruiting
Phase 2, Not Applicable, Phase 1
acute supraspinatus tendinitis
0 Actively Recruiting
Tendinitis
0 Actively Recruiting
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Arthritis, Gouty
0 Actively Recruiting

Sulindac Reviews: What are patients saying about Sulindac?

5Patient Review
10/20/2015
Sulindac for Inflammation of the Sac Surrounding the Joint - Bursitis
This prescription has been great for my bursitis-related hip pain as well as the aches in my hands. I started out taking 200mg once a day, and then increased to twice a day after three months. The tinnitus has gotten worse since starting this medication, but the benefits outweigh that side effect.
5Patient Review
11/26/2016
Sulindac for Joint Damage causing Pain and Loss of Function
After years of knee pain, this treatment has finally given me some relief. I'm amazed at how well it works!
5Patient Review
4/25/2013
Sulindac for Gout
I got nauseous about two hours after taking this medication, followed by diarrhea and stomach pain.
5Patient Review
4/7/2014
Sulindac for Joint Damage causing Pain and Loss of Function
Though I had to lower the dosage, this medicine still helped me a lot.
5Patient Review
8/2/2013
Sulindac for Inflammation of the Tendon
This medication has been an absolute lifesaver for my chronic leg and hip pain. I can hardly walk if I'm not taking it, and I've had no negative side effects in the two years that I've been on it.
4.3Patient Review
1/13/2012
Sulindac for Rheumatoid Arthritis
4Patient Review
1/30/2021
Sulindac for Rheumatic Disease causing Pain & Stiffness in Backbone
This treatment takes a bit of time to work, but it really does help with constant pain in my back, knees, and hips. I can move around much better now!
4Patient Review
2/22/2012
Sulindac for Joint Damage causing Pain and Loss of Function
For the first time in a while, I was able to wake up and grab the coffee pot with one hand. My knees didn't shake when going down stairs, and I generally felt less pain overall. I was amazed and very happy.
4Patient Review
7/23/2022
Sulindac for Inflammation of the Covering of the Tendon
It significantly lessened the pain and inflammation I was experiencing. So far, so good!
2.3Patient Review
12/18/2012
Sulindac for Inflammation of a Shoulder Joint
This medication caused my urine to smell like pistachio nuts.
2Patient Review
3/4/2015
Sulindac for Joint Damage causing Pain and Loss of Function
Sulindac was prescribed to me by a doctor for severe lower back pain. Unfortunately, within 24 hours I developed hives all over my body--which were intensely itchy and uncomfortable. With no other choice, I had to take cold baths every hour just to be able to function or get any rest. Thankfully, I was eventually able to get a prescription that helped shrink the hives and ease the itching.
1.7Patient Review
3/27/2013
Sulindac for Inflammation of the Tendon
I had to stop taking this medication after only a few days because it made my ankles swell up.
1.3Patient Review
9/10/2015
Sulindac for Joint Damage causing Pain and Loss of Function
The prescribed dosage of 200mg x2 per day felt unbearable to me. It was like being stabbed with an ice pick.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sulindac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is sulindac the same as ibuprofen?

"This study found that sulindac is effective in treating musculo-skeletal diseases and does not have any side-effects at the recommended dosage."

Answered by AI

What is the drug sulindac used for?

"Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis (e.g., osteoarthritis and rheumatoid arthritis) or acute gout, such as inflammation, swelling, stiffness, and joint pain. The drug can also be used to help reduce the risk of colorectal cancer.Jun 1, 2022"

Answered by AI

Is sulindac a pain killer?

"Sulindac is a medication used to treat pain, swelling, and stiffness from arthritis. It is also used to treat arthritis of the spine, gouty arthritis, and shoulder bursitis/tendonitis. This medication is classified as a nonsteroidal anti-inflammatory drug (NSAID)."

Answered by AI

What are the side effects of taking sulindac?

"You may experience a headache, dizziness, nervousness, diarrhea, constipation, gas, or ringing in the ears."

Answered by AI

Clinical Trials for Sulindac

Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
Image of Humana Healthcare Research, Inc. in Louisville, United States.

Academic Detailing for Rheumatoid Arthritis

Any Age
All Sexes
Louisville, KY
The goal of this trial is to learn if an interactive evidence-based educational outreach visits to clinicians who prescribe biologics change prescribing of biosimilar medications. The main questions it aims to answer are: 1. Do educational outreach visits lead to a higher number of prescriptions for biosimilar versions of adalimumab? 2. Do in-person or virtual visits work better? Researchers will compare clinicians offered the educational outreach visit to those who are not offered the visit to see if there is a difference in prescribing of biosimilar versions of adalimumab instead of the original brand-name version. Participants will be offered the chance to meet with a trained clinician who will provide educational information tailored to their knowledge and attitudes on the topic. They will also be provided an educational brochure and patient educational materials.
Waitlist Available
Has No Placebo
Humana Healthcare Research, Inc. (+1 Sites)
Image of Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016) in New York, United States.

Electromagnetic Resonance Therapy for Autoimmune Diseases

Any Age
All Sexes
New York, NY
The ImmuneNet study is a Phase I/II clinical trial sponsored by Truway Health, Inc. It will test whether gentle, low-frequency electromagnetic resonance (LF-EMR) can influence how immune cells communicate and synchronize with each other. The goal is to see if this "quantum-synaptic" signaling effect can help stabilize immune activity and reduce the number of autoimmune flare-ups in people living with conditions such as lupus, rheumatoid arthritis, or multiple sclerosis. Participants will receive either an active or a sham (placebo) LF-EMR session three times per week for twelve weeks. Each session is completely non-invasive. Blood samples will be collected to study cytokines (immune-system messenger molecules), gene-expression patterns, and electrical field coherence among immune cells. A machine-learning system will analyze these data to predict inflammation patterns and guide individualized treatment settings. All participant data will be securely recorded and time-stamped to ensure transparency and privacy. The expected outcome of the study is a measurable reduction in autoimmune flare frequency and symptom severity, along with improved understanding of how electromagnetic signaling might safely regulate immune function.
Phase 1 & 2
Waitlist Available
Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016)Gavin Solomon, President & CEOTruway Health, Inc.
Image of University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases in Minneapolis, United States.

Ultrasound Therapy for Rheumatoid Arthritis

18+
All Sexes
Minneapolis, MN
The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs). The non-invasive study device delivers ultrasound stimulation to the spleen to reduce inflammation. The study will enroll at least 60 participants at up to 8 sites. There will be three arms consisting of two active stimulation groups (treatment) and one non-active stimulation group (sham-control). After completing the double-blinded primary endpoint assessment period at Week 12, there will be a one-way crossover of control participants to active stimulation and an additional 12 week follow-up with all participants to evaluate long-term outcomes.
Recruiting
Drug
University of Minnesota Medical School, Division of Rheumatic and Autoimmune DiseasesHubert LimSecondWave Systems Inc.
Have you considered Sulindac clinical trials? We made a collection of clinical trials featuring Sulindac, we think they might fit your search criteria.Go to Trials
Image of St. Lawrence Health in Potsdam, United States.

Primary Care for Rheumatoid Arthritis

18+
All Sexes
Potsdam, NY
Rheumatoid arthritis (RA) is a complex autoimmune disease where the immune system attacks healthy joint tissue; causing pain, swelling, and stiffness of the joints. This disease effects lots of people in the US and can lead to major joint damage if not properly treated. In rural areas like northern NY, these are underserved areas for RA patients, thus many patients struggle to get the appropriate care. This model is testing whether primary care providers (PCP) can safely and effectively provide stable RA patients with the proper treatment rather than send them to a specialist. PCPs were trained through classes, case reviews, and a final exam. Patients will be randomly assigned to either see a trained PCP or their normal rheumatologist at the rheumatology clinic. This study will examine how patients are doing over a year using medical exams and patient feedback. If this model proves to be successful, it will make RA treatment easier and more affordable for patients.
Recruiting
Has No Placebo
St. Lawrence HealthEyal Kedar, MD
Have you considered Sulindac clinical trials? We made a collection of clinical trials featuring Sulindac, we think they might fit your search criteria.Go to Trials
Image of Clinical Research Of West Florida - Phase I Unit /ID# 272428 in Clearwater, United States.

Targeted Therapies for Rheumatoid Arthritis

18+
All Sexes
Clearwater, FL
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Clinical Research Of West Florida - Phase I Unit /ID# 272428 (+30 Sites)ABBVIE INC.AbbVie
Have you considered Sulindac clinical trials? We made a collection of clinical trials featuring Sulindac, we think they might fit your search criteria.Go to Trials
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