Sevoflurane
General Anesthesia, Induction and Maintenance of General Anesthesia
Treatment
2 FDA approvals
1 Active Study for Sevoflurane
Treatment for
General Anesthesia
What is Sevoflurane
Sevoflurane
The Generic name of this drug
Treatment Summary
Sevoflurane, also known as fluoromethyl, is a safe and easy to administer anesthetic used to put people to sleep during surgery. It is a non-flammable, non-irritant liquid that evaporates quickly and does not dissolve easily in the blood. It is commonly used for the induction and maintenance of general anesthesia.
Ultane
is the brand name
Sevoflurane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ultane
Sevoflurane
1995
11
Approved as Treatment by the FDA
Sevoflurane, also known as Ultane, is approved by the FDA for 2 uses including Induction and Maintenance of General Anesthesia and General Anesthesia .
Induction and Maintenance of General Anesthesia
General Anesthesia
Effectiveness
How Sevoflurane Affects Patients
Sevoflurane helps relax the muscles and reduce pain sensitivity by changing how cells respond to stimulation. It works more quickly than halothane and isoflurane, and does not need to dissolve in the blood for it to take effect. However, sevoflurane can cause several side effects, such as renal injury, respiratory depression, and QT prolongation. It can also lead to malignant hyperthermia, perioperative hyperkalemia, and pediatric neurotoxicity. Additionally, using sevoflurane can make people less alert, so they should not drive or operate machinery after receiving
How Sevoflurane works in the body
Sevoflurane is an anesthetic that works by blocking nerve signals in the brain. It binds to several receptors, including ones that respond to GABA, glycine, acetylcholine, serotonin, and glutamate. It also affects how ions like calcium and potassium flow through the body, which helps regulate the heart.
When to interrupt dosage
The proposed dosage of Sevoflurane is contingent upon the diagnosed condition. The volume of dosage shifts as stipulated by the technique of delivery (e.g. Liquid or Respiratory (inhalation)) featured in the table beneath.
Condition
Dosage
Administration
General Anesthesia
, 1.0 mL/mL, 99.97 %, 2.5 mL/mL
Respiratory (inhalation), Liquid, , Liquid - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Induction and Maintenance of General Anesthesia
, 1.0 mL/mL, 99.97 %, 2.5 mL/mL
Respiratory (inhalation), Liquid, , Liquid - Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation)
Warnings
Sevoflurane has three counter-indications and should not be utilised if you have any of the circumstances highlighted in the table below.
Sevoflurane Contraindications
Condition
Risk Level
Notes
susceptibility to malignant hyperthermia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Sevoflurane may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Sevoflurane may interact with Pulse Frequency
There are 20 known major drug interactions with Sevoflurane.
Common Sevoflurane Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Sevoflurane.
Azelastine
Major
Sevoflurane may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Sevoflurane.
Dosulepin
Major
The metabolism of Dosulepin can be decreased when combined with Sevoflurane.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Sevoflurane.
Sevoflurane Toxicity & Overdose Risk
If someone has taken too much sevoflurane, stop administering it and make sure they can breathe. Assist or control their breathing with oxygen and keep their heart function stable. Overdosing on sevoflurane can lead to serious effects such as damage to the kidneys, lungs, and heart, as well as slowed heart rate and cardiac arrest. Animal studies have shown that long periods of exposure to sevoflurane can cause changes to the brain's synapses and cell growth. The lowest toxic dose of sevoflurane in rats is 10.8 g/kg and 18.2 g
Sevoflurane Novel Uses: Which Conditions Have a Clinical Trial Featuring Sevoflurane?
At present, 4 trials are assessing the capacity of Sevoflurane to Induce and Maintain General Anesthesia.
Condition
Clinical Trials
Trial Phases
General Anesthesia
1 Actively Recruiting
Phase 4
Induction and Maintenance of General Anesthesia
0 Actively Recruiting
Sevoflurane Reviews: What are patients saying about Sevoflurane?
2.7
Patient Review
6/5/2013
Sevoflurane for General Anesthesia
Patient Q&A Section about sevoflurane
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the use of sevoflurane?
"Sevoflurane is sometimes inhaled to anesthesia someone before and during surgery. It is a type of medicine called a general anesthetic."
Answered by AI
What does sevoflurane smell like?
"Sevoflurane is a fluorinated isopropyl ether that smells sweet and only faintly unpleasant, making it a good choice for inhalation inductions."
Answered by AI
What is the mechanism of action of sevoflurane?
"The way sevoflurane works has not been completely explained. Like other drugs used for anesthesia, sevoflurane affects the nervous system by binding to certain channels that control the flow of ions. This action blocks communication between nerve cells."
Answered by AI
What are the possible side effects of sevoflurane?
"Some symptoms of a heart attack are blurred vision, chest pain, tightness or discomfort, choking, fast or irregular heartbeat, lightheadedness, dizziness, or fainting. Other symptoms include a slow or irregular heartbeat, being unable to speak, or unusual tiredness or weakness."
Answered by AI