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What is Septra Ds
SulfamethoxazoleThe Generic name of this drug
Treatment SummarySulfamethoxazole is an antibiotic that helps fight bacterial infections. It works by blocking the bacteria's ability to make folic acid, which is necessary for the bacteria to multiply and grow. Sulfamethoxazole is usually given in combination with trimethoprim, which blocks another step in the bacteria's folic acid production. This combination is used to treat infections of the urinary, respiratory, and gastrointestinal tracts.
Septra DSis the brand name
Septra Ds Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Septra DS
Sulfamethoxazole
1973
278
Approved as Treatment by the FDA
Sulfamethoxazole, otherwise known as Septra DS, is approved by the FDA for 15 uses like Brucellosis and Nocardiosis .Brucellosis
Used to treat Brucellosis in combination with Gentamicin
Nocardiosis
Used to treat Nocardiosis in combination with Trimethoprim
Otitis Media
Used to treat Acute Otitis Media caused by susceptible bacteria in combination with Trimethoprim
Shigellosis
Used to treat Dysentery, Bacillary in combination with Trimethoprim
Diarrhea
Used to treat susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection in combination with Trimethoprim
susceptible Enteritis infectious caused by Shigella flexneri
Used to treat susceptible Enteritis infectious caused by Shigella flexneri in combination with Trimethoprim
Immunocompromised
Used to treat Immunocompromised in combination with Trimethoprim
Pneumocystis Jirovecii Pneumonia
Used to treat Pneumocystis Jirovecii Pneumonia in combination with Trimethoprim
Genus Pneumocystis
Used to treat risk of Pneumocystis jiroveci pneumonia (PCP) in combination with Trimethoprim
Electrolyte replacement
Used to treat Electrolyte replacement in combination with Trimethoprim
Fluid replacement therapy
Used to treat Fluid replacement therapy in combination with Trimethoprim
Cholera
Used to treat susceptible Cholera in combination with Trimethoprim
Bronchitis
Used to treat Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria in combination with Trimethoprim
susceptible Enteritis infectious caused by Shigella sonnei
Used to treat susceptible Enteritis infectious caused by Shigella sonnei in combination with Trimethoprim
Urinary tract infection
Used to treat Urinary Tract Infection caused by susceptible bacteria in combination with Trimethoprim
Effectiveness
How Septra Ds Affects PatientsSulfamethoxazole is an antibiotic used to treat bacterial infections. It works by blocking a crucial step in bacterial growth. It is commonly paired with another drug called trimethoprim, which inhibits a different step in bacterial growth. Together, these drugs are better at slowing down bacterial resistance than either one alone. Sulfamethoxazole can cause allergic reactions, so if you experience a rash while taking this drug, you should stop immediately. It may also contribute to folate deficiency, so people at a higher risk of developing a deficiency should be cautious when taking this drug. People with glucose-6-phosph
How Septra Ds works in the bodySulfamethoxazole works by stopping bacteria from being able to produce folic acid. Most bacteria get the folic acid they need by converting PABA into it, which Sulfamethoxazole prevents. This stops the bacteria from making purines and DNA, keeping it from multiplying and causing an infection.
When to interrupt dosage
The suggested dosage of Septra Ds is contingent upon the diagnosed condition, including Urinary tract infection, Pneumocystis Jirovecii Pneumonia and Fluid replacement therapy. The degree of dosage fluctuates as per the system of delivery featured in the table beneath.Condition
Dosage
Administration
susceptible Enteritis infectious caused by Shigella sonnei
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Genus Pneumocystis
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Shigellosis
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Nocardiosis
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Brucellosis
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Immunocompromised
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Electrolyte replacement
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Fluid replacement therapy
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Pneumocystis Jirovecii Pneumonia
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Urinary tract infection
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Bronchitis
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Cholera
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Diarrhea
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
susceptible Enteritis infectious caused by Shigella flexneri
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Otitis Media
800.0 mg, , 400.0 mg, 200.0 mg/mL, 0.8 mg, 8.0 mg, 500.0 mg, 100.0 mg, 80.0 mg/mL, 200.0 mg, 40.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Solution, Injection, Injection - Intravenous
Warnings
Septra Ds ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sulfamethoxazole may interact with Pulse Frequency
Megaloblastic anemia caused by Folate deficiency
Do Not Combine
hepatic damage
Do Not Combine
history of immune thrombocytopenia caused by trimethoprim and/or sulfonamide therapy
Do Not Combine
Pulse Frequency
Do Not Combine
Disease
Do Not Combine
unable to monitor renal function
Do Not Combine
Common Septra Ds Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Sulfamethoxazole.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Sulfamethoxazole.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Sulfamethoxazole.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Sulfamethoxazole.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Sulfamethoxazole.
Septra Ds Toxicity & Overdose RiskSulfamethoxazole has a toxic dose of 2300 mg/kg in mice and 6200 mg/kg in rats. Symptoms of an overdose may include loss of appetite, stomach pain, nausea, vomiting, dizziness, headache, drowsiness, and passing out. In more severe cases, people may also experience fever, blood in urine, or kidney stones. Treatment for overdose includes treating the symptoms, inducing vomiting or using a stomach pump, and monitoring the patient’s blood work for signs of blood disorders or electrolyte imbalances.
Septra Ds Novel Uses: Which Conditions Have a Clinical Trial Featuring Septra Ds?
8 active clinical trials are currently being conducted to evaluate the potential of Septra DS in aiding Immunocompromised Patients, Fluid Replacement Therapy and treating susceptible Enteritis Infections caused by Shigella sonnei.Condition
Clinical Trials
Trial Phases
Urinary tract infection
0 Actively Recruiting
Shigellosis
3 Actively Recruiting
Phase 2, Phase 1
Genus Pneumocystis
0 Actively Recruiting
susceptible Enteritis infectious caused by Shigella flexneri
0 Actively Recruiting
Cholera
0 Actively Recruiting
Otitis Media
0 Actively Recruiting
Electrolyte replacement
0 Actively Recruiting
Bronchitis
0 Actively Recruiting
Fluid replacement therapy
0 Actively Recruiting
Diarrhea
0 Actively Recruiting
Brucellosis
0 Actively Recruiting
Nocardiosis
0 Actively Recruiting
susceptible Enteritis infectious caused by Shigella sonnei
0 Actively Recruiting
Immunocompromised
4 Actively Recruiting
Phase 3, Not Applicable, Phase 1
Pneumocystis Jirovecii Pneumonia
1 Actively Recruiting
Phase 3
Septra Ds Reviews: What are patients saying about Septra Ds?
5Patient Review
9/10/2018 So far, this medication has been working well for me. I experienced some leg cramps on the first night, but I think that was because I wasn't staying hydrated enough. But since then, no issues whatsoever and my UTI symptoms have vanished.
5Patient Review
1/24/2016 I've had to take this medication a few times now, and it's always worked well in clearing up my skin infections. I haven't experienced any negative side effects, which is great.
4.7Patient Review
11/11/2014 I've taken this medication multiple times to treat cystic acne, and it works great. I haven't had any significant side effects from it.
3Patient Review
12/9/2013 I got an infection from a cyst on my leg, and this medication made me feel nauseous for three days. I was also itchy, tired, and overall felt worse than before I saw the doctor.
2.7Patient Review
9/8/2014 I was prescribed this medication for a week-long UTI, and within an hour of taking the pill I started feeling intense pain in my lips. They swelled up until they burst, and I was left with oozing inflammation for two weeks.
2.3Patient Review
7/13/2013 Avoid this treatment at all costs.
1.7Patient Review
9/30/2019 I was unfortunately one of the people who had a really negative reaction to this drug. I felt nauseous and sweaty, had a headache and pain in my back, and generally felt awful. My heart also started acting up, which was really scary. I would never recommend this to anyone.
1Patient Review
3/25/2015 Unfortunately, I had a really negative reaction to this drug. I felt nauseous and threw up, and also had a headache.
1Patient Review
7/25/2014 I had a really negative reaction to this medication, including chills and difficulty breathing. The effects were so bad that I didn't even finish the course of pills.
1Patient Review
7/16/2013 I had a terrible reaction to this drug. I started experiencing diarrhea within two hours of taking the first pill. The next day, my fever was so high that I had to go to the emergency room and get a breathing treatment. After discontinuing the drug, I developed mouth sores around my lips.
Patient Q&A Section about septra ds
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Are Septra and Bactrim the same?
"Sulfamethoxazole and trimethoprim are medications that are used to treat bacterial infections. These two medications are usually given together in a combination antibiotic treatment. The combination of these antibiotics is used to treat a variety of infections, including urinary tract infections (UTIs)."
Answered by AI
What is Septra DS used for?
"The drug is effective in treating a variety of bacterial infections, including those in the middle ear, urine, respiratory system, and intestines. It can also be used to prevent and treat pneumonia caused by the pneumocystis virus."
Answered by AI
How long does it take for Septra DS to work?
"For more common problems such as urinary tract infections and ear infections, most people will start to feel relief after a few days. However, for more complicated problems such as pneumonia, it might take 2 to 3 weeks to feel improvement."
Answered by AI
What does DS stand for in septra DS?
"40, hypromellose, magnesium stearate, and polyethylene glycol.
Each SEPTRA DS tablet contains 160 mg trimethoprim, 800 mg sulfamethoxazole, 0.8 mg docusate sodium, FD&C Red No. 40, hypromellose, magnesium stearate, and polyethylene glycol."
Answered by AI