What is Safyral
EthinylestradiolThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the female hormone estrogen. It was developed in the 1930s and is more easily absorbed than other forms of estrogen. It is most commonly found in birth control pills and has been approved by the FDA since 1943.
LOESTRIN Fe 1.5/30is the brand name
Safyral Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
674
Approved as Treatment by the FDA
Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .Birth Control
Used to treat Contraception in combination with Levonorgestrel
Effectiveness
How Safyral Affects PatientsEthinylestradiol is a synthetic estrogen used to stop ovulation and prevent the growth of the uterine lining. It is taken once daily and is generally considered to be a safe drug, although it can increase the risk of blood clots. Patients should speak to their doctor about the potential risks.
How Safyral works in the bodyEthinylestradiol is a synthetic form of estrogen. Taking ethinylestradiol can reduce bone density and suppress ovulation. It works by stopping the hormones that help control ovulation, blocking sperm from traveling to the egg, and preventing the endometrium from changing to allow a fertilized egg to implant. It also reduces luteinizing hormone, making the endometrium less vascular, and increases the amount of sex hormone binding globulin.
When to interrupt dosage
The magnitude of Safyral is contingent upon the determined disorder, including Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The measure of dosage is delineated in the following table, in accordance with the mode of administration.Condition
Dosage
Administration
Premenstrual Dysphoric Disorder
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Mild to Moderate Acne
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Birth Control
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Acne Vulgaris
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Patient desires oral contraception for birth control
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Menopausal Osteoporosis
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Hormonal Contraception
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Folate supplementation therapy
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Menopause
, 0.02 mg, 0.035 mg, 0.03 mg, 0.025 mg, 0.01 mg, 0.05 mg, 0.04 mg, 0.35 mg, 0.005 mg, 2.7 mg, 0.0025 mg, 0.6 mg, 2.6 mg, 0.5 mg, 0.0015 mg/hour, 0.0035 mg/hour, 0.75 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 1.0 mg, 0.1 mg, 17.4 mg, 0.085 mg, 2.3 mg
Oral, , Kit; Tablet, coated - Oral, Tablet, Kit; Tablet, chewable - Oral, Kit, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Patch, extended release, Tablet - Oral, Kit; Tablet, film coated, Tablet, film coated, Vaginal, Kit; Tablet, film coated - Oral, Kit; Tablet, coated, Kit; Tablet; Tablet, chewable - Oral, Ring - Vaginal, Tablet, film coated - Oral, Kit; Tablet, chewable, Kit; Tablet; Tablet, chewable, Capsule, liquid filled; Kit, Patch - Transdermal, Transdermal, Capsule, liquid filled; Kit - Oral, Patch, extended release - Transdermal, Capsule - Oral, Ring, Patch, Insert, extended release - Vaginal, Tablet, chewable - Oral, Insert, extended release, Tablet, chewable, Capsule
Warnings
Safyral ContraindicationsCondition
Risk Level
Notes
Coronary Artery Disease
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Toxoplasma Infections
Do Not Combine
Breast
Do Not Combine
Adrenal Insufficiency
Do Not Combine
Breast Cancer
Do Not Combine
Toxoplasma Infections
Do Not Combine
Thrombophlebitis
Do Not Combine
Breast
Do Not Combine
Toxoplasma Infections
Do Not Combine
Severe Hypertension
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
Impaired Renal Function
Do Not Combine
Metrorrhagia
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Heavy Smoking
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Hypersensitivity
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Toxoplasma Infections
Common Safyral Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Safyral Toxicity & Overdose RiskWomen who overdose on birth control pills may experience bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment should include monitoring of potassium and sodium levels in the body, as well as signs of metabolic acidosis.
Safyral Novel Uses: Which Conditions Have a Clinical Trial Featuring Safyral?
38 active investigations are examining the potential of Safyral in providing Folate supplementation therapy, Premenstrual Dysphoric Disorder and Menopausal relief.Condition
Clinical Trials
Trial Phases
Menopause
0 Actively Recruiting
Premenstrual Dysphoric Disorder
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Birth Control
36 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Phase 2, Early Phase 1
Hormonal Contraception
0 Actively Recruiting
Patient desires oral contraception for birth control
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Safyral Reviews: What are patients saying about Safyral?
4.7Patient Review
1/6/2015 I've been taking this treatment for three years and have loved it. I never experienced any of the adverse side effects that others have talked about. However, I am now switching because I have developed nausea, an upset stomach, and heavy periods that start on Thursdays and last until Sunday (previously they started on Tuesdays and were much lighter). I think my body just needs a change. My doctor has put me on cryselle, so we'll see how that goes for me.
4.7Patient Review
7/13/2014 Safryal has been working well for me. My periods are shorter and I don't feel any different than normal. The only downside is that I've gained a few pounds, but it's nothing too drastic.
4.3Patient Review
3/23/2015 I was very happy with this pill while my insurance covered it. My periods became extremely light and only lasted 3 days, which was great. I did experience more headaches and migraines, as well as a lower sex drive. My skin was a bit oilier than usual but no terrible breakouts. I'm really going to miss this one!
4.3Patient Review
7/28/2015 I took this pill for two years and it was overall all right, though it did give me some pretty severe mood swings. My Obgyn doctor switched me to a lower estrogen pill called lo loestrin fe so hopefully my mood swings will end soon.
4Patient Review
3/15/2015 Within a month of using this pill, my skin cleared up perfectly. However, after five months of use, I started to experience low libido, increased potassium levels, and higher cholesterol in my blood work. As a result, I stopped taking the pill and will be seeing a dermatologist instead.
2.7Patient Review
5/16/2012 I have experienced a lot of bloating and stomach pain with this medication. I've experienced nausea and diarrhea, as well as sore breasts. It is also a very costly medication despite the fact that there is nothing particularly special about it other than having folic acid. I switched to a new medication a month after starting Safyral
2.7Patient Review
3/13/2013 I'm not sure if I want to continue using Safyral. I am on day 14 of my period and per my doctor, this is normal. However, I personally don't feel that it is and this whole experience has been quite overwhelming.
2.3Patient Review
3/30/2012 Unfortunately, since starting this birth control, I have gained weight, felt bloated, and constantly desired sweets. In addition, my sex drive has decreased significantly. Although my periods are now lighter, the other negative effects of this medication are not worth it to me.
2.3Patient Review
10/6/2013 I did not enjoy taking this BC pill. I switched from a low estrogen pill and found that it made me gain weight, be more irritable, and my sex drive was lower .
2Patient Review
10/15/2013 I started Safyral in an attempt to level out my hormone-driven emotions. Unfortunately, this led to me having a period for the entire first pack of pills. In addition, I gained a lot of weight and my sex drive plummeted. Intercourse became uncomfortable and eventually avoided altogether. After three months of use, I stopped taking Safyral because my PMDD had gotten worse.
1.7Patient Review
4/5/2012 I have been getting headaches for 6 days in a row. I am have mood swings and i bleed for 18 days with it. This medicine sucks and its raising my blood pressure up. im done taking it
1Patient Review
3/30/2015 This medication has made me incredibly angry and my mood swings are out of control. Additionally, it's killed my sex drive. I'm really unhappy with how this is going and will be speaking to my doctor tomorrow.
Patient Q&A Section about safyral
Is safyral a good birth control?
"Safyral for birth control has an average rating of 6.2 from 59 reviewers." - Anonymous Online Contributor
Unverified Answer
What is Yaz called now?
"There are two birth control pills on the market today: Yaz and Loryna. Loryna is a generic version of Yaz. Yaz is a brand-name drug." - Anonymous Online Contributor
Unverified Answer
What is safyral generic for?
"The active ingredients in this medication are drospirenone, ethinyl estradiol, and levomefolate calcium. This medication comes in the form of tablets, and each tablet contains 3mg of drospirenone, 30micrograms of ethinyl estradiol, and 0.451mg of levomefolate calcium. There are 21 tablets in a package, or 7 tablets for a seven-day supply." - Anonymous Online Contributor
Unverified Answer
What is ethinylestradiol used for?
"Drospirenone; ethinyl estradiol is an oral contraceptive that prevents ovulation and pregnancy. It may also be used to treat acne and premenstrual dysphoric disorder (PMDD). It is a combination of the hormones estrogen and progestin." - Anonymous Online Contributor
Unverified Answer