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What is Revatio
SildenafilThe Generic name of this drug
Treatment SummarySildenafil is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It works by blocking the enzyme that breaks down cyclic guanosine monophosphate (cGMP). This allows the cGMP present in the penis and lungs to cause smooth muscle relaxation and widen blood vessels, allowing increased flow of blood to the penis and relief of symptoms in pulmonary arterial hypertension. Sildenafil was originally developed as a treatment for chest pain (angina) but was found to be effective for erectile dysfunction. It is available with a prescription and some countries sell it over-the-counter
Viagrais the brand name
Revatio Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viagra
Sildenafil
1998
292
Approved as Treatment by the FDA
Sildenafil, also known as Viagra, is approved by the FDA for 2 uses like Pulmonary Arterial Hypertension and Impotence .Pulmonary Arterial Hypertension
Helps manage NYHA Functional Class II-III Pulmonary arterial hypertension
Impotence
Helps manage Erectile Dysfunction
Effectiveness
How Revatio Affects PatientsSildenafil is a drug that specifically targets the enzyme phosphodiesterase-5 (PDE5). In clinical studies, sildenafil has been found to help improve erectile dysfunction when taken 60 minutes before sexual activity. It is also known to lower systemic blood pressure, but usually only slightly, and usually does not cause any clinical effects. When taken in single doses up to 100 mg, sildenafil has been found to have no effect on the electrocardiogram, and may cause mild, temporary changes in color discrimination. In patients with early age-related macular degeneration,
How Revatio works in the bodySildenafil helps with erectile dysfunction by increasing blood flow to the penis. It does this by blocking the action of an enzyme that breaks down a compound that increases blood flow in the penis. When sexual stimulation is present, this process is activated, allowing sildenafil to increase blood flow. In addition, it also increases blood flow in the lungs of patients with pulmonary arterial hypertension.
When to interrupt dosage
The advised dosage of Revatio is dictated by the established condition, such as Premature Ejaculation, Pulmonary Arterial Hypertension and NYHA Functional Class II-III Pulmonary arterial hypertension. The dose relies on the method of delivery (e.g. Tablet or Oral) specified in the table underneath.Condition
Dosage
Administration
Pulmonary Arterial Hypertension
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral
Pulmonary Arterial Hypertension
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral
Premature Ejaculation
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral
Impotence
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral
Warnings
Revatio has eight contraindications and should not be taken in combination with any of the conditions outlined in the table below.Revatio ContraindicationsCondition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
men for whom sexual activity is inadvisable
Do Not Combine
Pulse Frequency
Do Not Combine
Hypotension
Do Not Combine
Optic Neuropathy, Ischemic
Do Not Combine
Recent Stroke
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Revatio Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Sildenafil.
Alprostadil
Major
The risk or severity of hypotension and priapism can be increased when Sildenafil is combined with Alprostadil.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Sildenafil.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Sildenafil.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Sildenafil.
Revatio Toxicity & Overdose RiskTaking a high dose of sildenafil (up to 800 mg) can lead to increased risks of side effects such as headaches, flushing, dizziness, indigestion, congestion, and vision changes. Sildenafil is not recommended for women who are pregnant or may become pregnant unless they are also taking contraceptive measures. There is not enough data to recommend the use of sildenafil for pregnant women during labor and delivery, and it is not known if sildenafil can be passed through breast milk. Sildenafil has not been studied in children under 1 year old. Elder
Revatio Novel Uses: Which Conditions Have a Clinical Trial Featuring Revatio?
74 active clinical trials are investigating the potential of Revatio for use in treating Pulmonary Arterial Hypertension, Premature Ejaculation and NYHA Functional Class II-III Pulmonary Arterial Hypertension.Condition
Clinical Trials
Trial Phases
Impotence
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3, Phase 2
Pulmonary Arterial Hypertension
5 Actively Recruiting
Phase 1, Not Applicable, Phase 2
Pulmonary Arterial Hypertension
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting
Revatio Reviews: What are patients saying about Revatio?
5Patient Review
8/12/2009 I began seeing improvement in my ability to exercise very soon after starting this treatment back in 2007. Now, I'm able to work out for 60 to 90 minutes six days a week with no issues whatsoever. Additionally, there have been zero negative side effects that I've experienced and my blood pressure is completely normal.
5Patient Review
2/8/20095Patient Review
3/28/20095Patient Review
3/7/2012 This treatment is great! It really helped me out.
5Patient Review
2/12/2013 I have been taking this medication for two months with no change in my shortness of breath. I still can't exercise due to my rapid heartbeat, which has actually gotten worse since starting this treatment.
4.7Patient Review
10/22/2010 I've been using this treatment for three years, and before that I was taking Viagra. I'm 59 years old with congestive heart failure. I couldn't even walk outside to feed my birds before taking this medication, but it has improved my life dramatically. I take nine pills a day; however, the price they charge must go down. Luckily, medical pays for mine or else I wouldn't be able to afford these drugs; they pay $3,100 for me per month.
4.7Patient Review
11/3/2010 Even though it's expensive, this medication has been working well for our daughter. She's been on it for two years now and we've seen a significant reduction in her blood pressure levels.
4.7Patient Review
4/26/2012 Once I started this medication, my lung function increased from 10% to 95%. It's truly a lifesaver.
4Patient Review
8/12/2009 The price my elderly mother has to pay for this drug is outrageous, especially considering it's a life-saving medication.
4Patient Review
8/27/2012 I thought this drug wasn't working, so I asked my doctor to take me off of it. However, after a day without it I realized that it had been keeping my blood pressure down the whole time. I was surprised and pleased that it was so effective.
3.3Patient Review
3/27/20093.3Patient Review
7/13/2010 I'm keeping this brief because I'm frustrated. This hasn't worked for me at all!
3Patient Review
11/2/2011 After being on the medication for two weeks, I was able to go up a flight of stairs without struggling, which was previously an issue.
2.7Patient Review
12/23/20082.3Patient Review
4/19/2009 I saw no change while taking this medication.
2.3Patient Review
10/8/2012 I experienced some facial flushing, but it was no big deal. Otherwise, I was fine.
2Patient Review
9/29/2014 These medications have been essential for me. I'm on them round the clock and they've really made a difference.
1.3Patient Review
9/17/2009 The drug works as it should, but the price is outrageous. I shudder to think what people without insurance have to go through. In the two years since I've been on this medication, my quality of life has improved tremendously.
1Patient Review
10/25/2012 Three weeks in and I haven't noticed any difference. If anything, it's harder to breathe now.
Patient Q&A Section about revatio
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can sildenafil 20 mg be used for erectile dysfunction?
"Sildenafil is a drug used to treat pulmonary arterial hypertension and erectile dysfunction. It comes in a 20 mg dose."
Answered by AI
How do you take Revatio for erectile dysfunction?
"Use REVATIO 5 mg or 20 mg 3 times a day, 4 to 6 hours apart. Higher doses will not work better and are not recommended."
Answered by AI
What is Revatio used to treat?
"In some people, this can cause heart failure.
REVATIO is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH), a condition in which the blood pressure in the lungs is too high. This can put strain on the heart and, in some cases, can lead to heart failure."
Answered by AI
Is Revatio the same as Viagra?
"Both Viagra and Revatio contain sildenafil, but Viagra is for erectile dysfunction and Revatio is for pulmonary arterial hypertension (PAH). They have different strengths and dosages."
Answered by AI