Regitine
Hypertension, phentolamine blocking test, Anesthesia procedures + 5 more
Treatment
11 FDA approvals
0 Active Studies for Regitine
Treatment for
Hypertension
What is Regitine
Phentolamine
The Generic name of this drug
Treatment Summary
Phentolamine is a type of medication used to help lower high blood pressure, reduce symptoms related to pheochromocytoma, Raynaud's disease, clonidine withdrawal, and other conditions. It works by blocking signals from certain hormones in the body that cause blood vessels to constrict. It is sometimes used to treat impotence and peripheral vascular disease.
Regitine
is the brand name
Regitine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Regitine
Phentolamine
1952
7
Approved as Treatment by the FDA
Phentolamine, also known as Regitine, is approved by the FDA for 11 uses which include Hypertensive crisis and Necrosis caused by Administration site extravasation, Norepinephrine .
Hypertensive crisis
Necrosis caused by Administration site extravasation, Norepinephrine
Pheochromocytomas
Anesthesia, Reversal
Hypertension
Pheochromocytoma
Necrosis
prophylaxis of Hypertensive crisis
phentolamine blocking test
prophylaxis of Necrosis caused by Administration site extravasation, Norepinephrine
Anesthesia procedures
Effectiveness
How Regitine Affects Patients
Phentolamine is used to treat episodes of high blood pressure and sweating due to a condition called pheochromocytoma. It may be necessary to also take a beta-blocker if your heart rate gets too high. Phentolamine is a long-acting medication that relaxes the walls of blood vessels, resulting in lower blood pressure. It does this by blocking alpha receptors in certain parts of the body, which cause the muscle around the walls of the blood vessels to relax and widen. This allows more blood to flow, which lowers the pressure. It does not affect the parasympathetic system.
How Regitine works in the body
Phentolamine works by blocking the receptors that normally cause muscles to tense and blood vessels to narrow. This makes the muscles relax and the blood vessels widen, which lowers blood pressure. Although phentolamine can block responses to adrenaline and similar hormones, it does not work as well on nerve endings. It also stimulates the beta adrenergic receptors in the heart, making it beat faster and increasing cardiac output.
When to interrupt dosage
The amount of Regitine relies upon the recognized issue, including prophylaxis of Hypertensive crisis, Necrosis brought about by Administration site extravasation, Norepinephrine and Anesthesia, Reversal. The dosage can be found in the table beneath, contingent upon the method of delivery (e.g. Solution or Injection, solution).
Condition
Dosage
Administration
prophylaxis of Necrosis caused by Administration site extravasation, Norepinephrine
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
prophylaxis of Hypertensive crisis
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
Anesthesia, Reversal
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
Hypertension
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
phentolamine blocking test
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
Necrosis
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
Anesthesia procedures
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
Pheochromocytoma
5.0 mg/mL, , 0.235 mg/mL, 5.0 mg, 0.4 mg/mL, 10.0 mg/mL
, Injection, powder, for solution, Intramuscular; Intravenous, Injection, powder, for solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Submucosal, Submucosal, Solution, Solution - Intramuscular; Intravenous, Solution - Submucosal, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, powder, lyophilized, for suspension, Injection, powder, lyophilized, for suspension - Intramuscular; Intravenous, Injection - Intramuscular; Intravenous; Parenteral, Intramuscular; Intravenous; Parenteral
Warnings
Regitine has four contraindications, thus it should not be taken when dealing with the following conditions in the table.
Regitine Contraindications
Condition
Risk Level
Notes
Angina Pectoris
Do Not Combine
Heart Attack
Do Not Combine
Coronary Artery Disease
Do Not Combine
Coronary Artery Disease
Do Not Combine
There are 20 known major drug interactions with Regitine.
Common Regitine Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Phentolamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alfuzosin
Major
Phentolamine may increase the hypotensive activities of Alfuzosin.
Amifostine
Major
Phentolamine may increase the hypotensive activities of Amifostine.
Aripiprazole
Major
Phentolamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Aripiprazole lauroxil
Major
Phentolamine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Regitine Novel Uses: Which Conditions Have a Clinical Trial Featuring Regitine?
Currently, there are no active studies investigating the potential of Regitine to prevent Hypertensive crisis, conduct a phentolamine blocking test and protect against Necrosis caused by Norepinephrine extravasation at the administration site.
Condition
Clinical Trials
Trial Phases
Anesthesia, Reversal
0 Actively Recruiting
prophylaxis of Necrosis caused by Administration site extravasation, Norepinephrine
0 Actively Recruiting
Necrosis
0 Actively Recruiting
Hypertension
0 Actively Recruiting
prophylaxis of Hypertensive crisis
0 Actively Recruiting
phentolamine blocking test
0 Actively Recruiting
Anesthesia procedures
0 Actively Recruiting
Pheochromocytoma
0 Actively Recruiting
Regitine Reviews: What are patients saying about Regitine?
5
Patient Review
11/13/2010
Regitine for Inability to have an Erection
Patient Q&A Section about regitine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How do you give phentolamine for extravasation?
"Depending on the size of the extravasation, the nurse will need to bring 5 to 10 mg of phentolamine to the bedside. This will need to be reconstituted, and further diluted to 0.5 mg/mL in normal saline. Treatment of the extravasation will involve the nurse administering the phentolamine intradermally around the site of the extravasation."
Answered by AI
What is Regitine used for?
"Regitine can help prevent or treat skin death and shedding that can occur after injecting norepinephrine intravenously, or when it leaks out of blood vessels. Regitine can also be used in a test to diagnose pheochromocytoma, a type of tumor."
Answered by AI
Is Regitine still available?
"In 2000, Novartis stopped selling Regitine under its brand name in the United States."
Answered by AI
What is phentolamine used to treat?
"Phentolamine is a non-selective alpha blocker. It is used to treat high blood pressure due to noradrenaline."
Answered by AI