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Sedentary Behavior Interruptions for Sedentary Lifestyle (SWITCH Trial)

N/A
Recruiting
Led By Lee Stoner, PhD
Research Sponsored by University of North Carolina, Chapel Hill
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Sedentary: self-reported sitting >8 hours per day
Self-reported ability to walk 4 blocks and climb 2 flights of stairs
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measurements will be taken immediately before and after each 4-hour sb condition
Awards & highlights

SWITCH Trial Summary

This trial will identify ways to reduce sedentary behavior, which has been linked to cardiovascular disease. The findings will inform a larger clinical trial testing whether sedentary behavior reduction can decrease cardiovascular disease risk.

Who is the study for?
This trial is for adults aged 36-55 who sit for over 8 hours a day, exercise less than 90 minutes per week, can walk and climb stairs without assistance, and own a cell phone. It's not for those on glucose-controlling meds, with conditions limiting movement, heavy drinkers, very high or low blood pressure patients, recent or expecting mothers, those extremely overweight or underweight, on anti-hypertensive drugs or with recent severe cardiovascular issues.Check my eligibility
What is being tested?
The study tests how interrupting sitting time affects heart health. Participants will try different strategies: uninterrupted sitting; walking for 5 minutes each hour; standing for 15 minutes each hour; combining both walking and standing breaks every hour. The goal is to see which method works best to improve cardiovascular health.See study design
What are the potential side effects?
Since the interventions involve basic physical activities like walking and standing there are no direct side effects associated with them. However participants may experience general discomfort from changing their usual sedentary routine.

SWITCH Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I sit for more than 8 hours a day.
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I can walk 4 blocks and climb 2 flights of stairs without help.
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I am between 36 and 55 years old.

SWITCH Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measurements will be taken immediately before and after each 4-hour sb condition
This trial's timeline: 3 weeks for screening, Varies for treatment, and measurements will be taken immediately before and after each 4-hour sb condition for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean Change in Carotid-femoral Pulse Wave Velocity (cfPWV)
Secondary outcome measures
Change in Heart-middle Cerebral Artery Pulse Wave Velocity (Brain PWV)
Mean Change in Femoral-ankle PWV

SWITCH Trial Design

4Treatment groups
Active Control
Group I: One 15-Minute Standing Bout Each HourActive Control1 Intervention
A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. The interruption strategy includes breaking up the 4-hour sitting bout with one 15-minute standing bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.
Group II: One 5-Minute Walking Bout and One 15-Minute Standing Bout Each HourActive Control1 Intervention
A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. The interruption strategy includes breaking up the 4-hour sitting bout with one 5-minute light intensity walking bout and one 15-minute standing bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.
Group III: Uninterrupted SittingActive Control1 Intervention
A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. This uninterrupted sedentary bout will serve as a control. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.
Group IV: One 5-Minute Walking Bout Each HourActive Control1 Intervention
A 4-hour sedentary behavior bout, during which the participant remains seated while watching a non-stimulatory documentary. The interruption strategy includes breaking up the 4-hour sitting bout with one 5-minute light intensity walking bout each hour. Each participant will be re-randomized to any of the non-completed arms after completion of the initial 4-hour sitting bout and interruption strategy until all arms have been completed.

Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillLead Sponsor
1,508 Previous Clinical Trials
4,190,560 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,836 Previous Clinical Trials
47,850,992 Total Patients Enrolled
5 Trials studying Sedentary Lifestyle
2,473 Patients Enrolled for Sedentary Lifestyle
Lee Stoner, PhDPrincipal InvestigatorUniversity of North Carolina, Chapel Hill

Media Library

One 15-Minute Standing Bout Each Hour Clinical Trial Eligibility Overview. Trial Name: NCT05316571 — N/A
Sedentary Lifestyle Research Study Groups: One 15-Minute Standing Bout Each Hour, One 5-Minute Walking Bout and One 15-Minute Standing Bout Each Hour, Uninterrupted Sitting, One 5-Minute Walking Bout Each Hour
Sedentary Lifestyle Clinical Trial 2023: One 15-Minute Standing Bout Each Hour Highlights & Side Effects. Trial Name: NCT05316571 — N/A
One 15-Minute Standing Bout Each Hour 2023 Treatment Timeline for Medical Study. Trial Name: NCT05316571 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any criteria for potential participants in this research project?

"This medical trial requires that potential participants possess a sedentary lifestyle and are between the ages of 36 to 55. The study is looking for 56 volunteers in total."

Answered by AI

Are there any remaining spots available for volunteers in this clinical trial?

"According to clinicaltrials.gov, this study is actively seeking participants as it was recently updated on August 15th of 2022. The initial post for the trial was also made on that same day."

Answered by AI

How many participants have been accepted into this research project?

"Affirmative. According to the records on clinicaltrials.gov, this medical research is actively searching for participants and has been since August 15th 2022. This project requires 56 patients from 1 site to complete its enrollment goals."

Answered by AI

Who else is applying?

What site did they apply to?
University of North Carolina at Chapel Hill
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Sitting Interruption and Whole-body Cardiovascular Health
2022. "Sitting Interruption and Whole-body Cardiovascular Health". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05316571.
~29 spots leftby Feb 2026
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