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What is Rapaflo
SilodosinThe Generic name of this drug
Treatment SummarySilodosin is a medication used to relax the muscles in the prostate, bladder neck and prostatic urethra to treat the symptoms of benign prostatic hyperplasia (BPH). This condition is more common in men over the age of 40 and can cause urinary issues that affect quality of life. Silodosin works by targeting the α1A receptors with high affinity and relaxing the muscles to reduce bladder outlet obstruction. The drug was approved by the FDA in 2008 and is available under the trade names Rapaflo and Urorec.
Rapaflois the brand name
Rapaflo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rapaflo
Silodosin
2009
34
Approved as Treatment by the FDA
Silodosin, also known as Rapaflo, is approved by the FDA for 1 uses including Enlarged Prostate .Enlarged Prostate
Effectiveness
How Rapaflo Affects PatientsSilodosin is a drug that blocks certain hormones in the body. It is most effective at blocking the Alpha 1A receptor subtype, which is 162 times more effective than Alpha 1B and about 50 times more effective than Alpha 1D. Clinical trials have shown that silodosin can improve the flow of urine, reduce symptoms related to the bladder and prostate, and provide relief within two to six hours. Silodosin weakly affects the cardiovascular system, but it can cause a condition called intraoperative floppy iris syndrome during cataract surgery in those taking alpha 1-AR antagonists.
How Rapaflo works in the bodyThe cause of benign prostatic hyperplasia (BPH) is not fully understood, but it is believed to involve inflammation, apoptosis, and cellular proliferation. Silodosin is a drug used to treat BPH that works by blocking α1A-adrenoceptor receptors in the prostate and bladder. Blocking these receptors decreases muscle contraction in the prostate and urethra, which improves lower urinary tract symptoms like slow urine stream and postvoid dribbling. Silodosin also targets nerves in the bladder, helping to reduce bladder overactivity and storage symptoms.
When to interrupt dosage
The prescribed dose of Rapaflo is contingent upon the diagnosed situation. The measure of dosage fluctuates, in accordance with the method of administration outlined in the table beneath.Condition
Dosage
Administration
Enlarged Prostate
4.0 mg, , 8.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated
Warnings
Rapaflo ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Silodosin may interact with Pulse Frequency
Common Rapaflo Drug Interactions
Drug Name
Risk Level
Description
Alfuzosin
Major
Silodosin may increase the hypotensive activities of Alfuzosin.
Aripiprazole lauroxil
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Asenapine
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Asenapine.
Brexpiprazole
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Brexpiprazole.
Bucindolol
Major
Silodosin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Bucindolol.
Rapaflo Toxicity & Overdose RiskIn rats, the lowest toxic dose of silodosin is 800mg/kg. During clinical trials, low blood pressure was the most common serious side effect. If someone overdoses on silodosin, they should be laid down to restore their blood pressure and heart rate. Additional treatments, like administering intravenous fluids or using vasopressors, may be needed. Since silodosin binds to proteins in the blood, dialysis is not likely to be helpful.
Rapaflo Novel Uses: Which Conditions Have a Clinical Trial Featuring Rapaflo?
21 active investigations are currently being conducted to evaluate the efficacy of Rapaflo in managing Enlarged Prostate conditions.Condition
Clinical Trials
Trial Phases
Enlarged Prostate
21 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3
Rapaflo Reviews: What are patients saying about Rapaflo?
4.3Patient Review
5/4/2016 I took this medication for a year as prescribed by my doctor for IC. However, after stopping the medicine, I started experiencing a lot of side effects, which led me to believe that this drug is not yet approved for public use. If you are considering taking this drug, especially if you are a woman, I would urge you to reconsider.
3.7Patient Review
12/19/2020 I was recommended this medication by my doctor, alongside Avodart, for an enlarged prostate. Unfortunately, I stopped taking the medication after just two days due to the severe side effects I experienced, which included but were not limited to dizziness, congestion, insomnia and a total loss of sex drive. In comparison to those quality of life concerns, having to urinate frequently at night seems like a walk in the park.
3.3Patient Review
5/23/2017 I went to the urologist because I was experiencing painful erections at night (as well as pain in my groin area). He prescribed Rapaflow. Initially, there were fewer nighttime urinations, but after about a month, I'm back to my original 3 per night with the same level of pain. Ejaculations are weird like other commenters have said. I might give it one more month, but then stop. I see no improvement now.
3.3Patient Review
5/6/2015 I was recommended this by my urologist for weak urine flow. I tried it out with some sample doses, and after six weeks I discontinued use due to lack of effectiveness. It also interfered considerably with sexual performance, which is something to keep in mind. Lastly, it's quite overpriced compared to other medications available; buyer beware.
2.7Patient Review
10/22/2014 I have been unable to reach orgasm and ejaculate.
2.7Patient Review
12/14/2015 I was really hoping this drug would help me with my urinary issues, but unfortunately it didn't. Not only that, but it caused some serious sexual side effects that I wasn't expecting.
2.7Patient Review
10/6/2017 I, too, have experienced dry orgasms with this treatment. Additionally, I'm still having issues with urine flow.
2.3Patient Review
7/13/2015 I'm currently taking Rapaflow and Fineresteride, but I'm still waking up 4-6 times each night to urinate. Not only that, but I have retrograde ejaculations during sex. I've been prescribed Cialis (tadalafil) for ED, which has helped somewhat.
2.3Patient Review
4/18/2016 This medication helped me to urinate less frequently; however, I experienced some stomach upset and diarrhea as side effects.
2Patient Review
5/19/2017 This has been a very effective treatment for my prostate, but I'm not happy about the side effects. Sinus congestion, headaches, indigestion, and no discharge during ejaculation are all pretty unpleasant. I wasn't made aware of any potential side effects before starting this medication, so I don't know if the benefits outweigh the risks.
2Patient Review
10/23/2015 I found no change in the frequency of my urination while taking this medication. Additionally, I experienced a stuffy nose and difficulty breathing; however, these effects were minor compared to the diarrhea I also had. Ultimately, I stopped taking the medication per my doctor's recommendation.
1Patient Review
4/10/2018 I tried Rapadflo for a couple of weeks to see if it would help with my urinary issues. Unfortunately, it created too many other problems like shortness of breath, sinus congestion, and ejaculation difficulties. I stopped taking the medication and will now explore other options or just learn to live with the problem. If it gets bad enough, I might look into getting the Urolift procedure done.
1Patient Review
12/22/2018 I'm 75 years old and have BPH. I tried Rapaflo for two days and experienced a runny nose and premature ejaculation. I stopped the medication immediately and fired my urologist.
Patient Q&A Section about rapaflo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Rapaflo used for?
"Rapaflo is used to help improve urination for men who have benign prostatic hyperplasia (an enlarged prostate)."
Answered by AI
Is Rapaflo the same as Flomax?
"Silodosin and tamsulosin are bothalpha blockers that work at the same receptors in our bodies. However, this does not mean that they are identical. Some people may respond better to silodosin while others may respond better to tamsulosin. Additionally, the side effects that each person experiences may differ."
Answered by AI