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What is Protonix
PantoprazoleThe Generic name of this drug
Treatment SummaryPantoprazole is a medication used to reduce the production of stomach acid. It is a proton pump inhibitor (PPI) and is used to treat gastroesophageal reflux disease (GERD), ulcers caused by long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), and other diseases that cause too much stomach acid. Pantoprazole is typically used alongside other antibiotics to treat infection from Helicobacter pylori (H. pylori). Pantoprazole works by binding to the enzyme in the stomach that produces acid, and it has a long-lasting effect,
Protonix Delayed-releaseis the brand name
Protonix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Protonix Delayed-release
Pantoprazole
2000
353
Approved as Treatment by the FDA
Pantoprazole, also called Protonix Delayed-release, is approved by the FDA for 11 uses like Pathological Conditions, Anatomical and GERD With Erosive Esophagitis .Pathological Conditions, Anatomical
GERD With Erosive Esophagitis
conditions where a reduction of gastric acid secretion is required
Curling Ulcer
Reflux Esophagitis (RE)
Heartburn
Gastroesophageal reflux disease
Erosive Esophagitis
Gastric Ulcer
Healing
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
Effectiveness
How Protonix Affects PatientsPantoprazole is a medication used to reduce the amount of stomach acid. It has been shown to be more effective than other antacids in reducing symptoms related to acid reflux. It usually has few side effects and minimal drug interactions. However, long-term use of pantoprazole can increase the risk of bacterial infections, reduced absorption of certain vitamins, and lower levels of magnesium and calcium which may lead to osteoporosis and bone fractures. Additionally, pantoprazole may have an effect on cardiovascular health. Before taking any tests for neuroendocrine tumors, pantoprazole should be stopped for 14 days.
How Protonix works in the bodyHydrochloric acid (HCl) is normally produced in the stomach by the proton pump - an enzyme which helps move hydrogen and potassium in and out of cells. Pantoprazole is a drug that blocks the action of this enzyme, stopping the production of HCl. It works by attaching itself to the proton pump and preventing it from working correctly. This reduces the amount of HCl that is produced, and results in longer lasting inhibition than with other drugs.
When to interrupt dosage
The recommended measure of Protonix is contingent upon the ascertained condition, including Gastric Ulcer, Healing and Heartburn. The measure of dosage is contingent upon the technique of delivery listed in the table below.Condition
Dosage
Administration
Stress Ulcers
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Erosive Esophagitis
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
conditions where a reduction of gastric acid secretion is required
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Gastroesophageal reflux disease
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
GERD With Erosive Esophagitis
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Helicobacter Pylori Infection
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Heartburn
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Gastric Ulcer
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Curling Ulcer
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Reflux Esophagitis (RE)
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
patients who are unable to continue taking pantoprazole delayed-release tablets
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pathological Conditions, Anatomical
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Zollinger-Ellison Syndrome
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Critical Illness
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Healing
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
prophylaxis of Stress Ulcers
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Heartburn
, 4.0 mg/mL, 40.0 mg, 20.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Granule, delayed release, Granule, delayed release - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Warnings
Protonix ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
HIV Positive
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pantoprazole may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Pantoprazole may interact with Pulse Frequency
Common Protonix Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Pantoprazole.
Atazanavir
Major
The therapeutic efficacy of Atazanavir can be decreased when used in combination with Pantoprazole.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Pantoprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Pantoprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Pantoprazole.
Protonix Toxicity & Overdose RiskIn lab tests, pantoprazole was found to be toxic to rats when given in doses of 747mg/kg. While no long-term studies have been done on humans, it has been found to potentially cause rare types of gastrointestinal tumors in rodents. It is not known if the same holds true for humans. Pregnancy category B means that studies in pregnant animals did not show any risk to the fetus, but no studies have been done with pregnant women. It has also been found to be present in breast milk, but it is not known if it can harm nursing infants.
Protonix Novel Uses: Which Conditions Have a Clinical Trial Featuring Protonix?
23 active clinical trials are presently examining the effect of Protonix for treating Gastric Ulcers, Critical Illness and Stress Ulcerations.Condition
Clinical Trials
Trial Phases
Curling Ulcer
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Helicobacter Pylori Infection
0 Actively Recruiting
Reflux Esophagitis (RE)
0 Actively Recruiting
Pathological Conditions, Anatomical
0 Actively Recruiting
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
Gastroesophageal reflux disease
0 Actively Recruiting
GERD With Erosive Esophagitis
0 Actively Recruiting
Healing
0 Actively Recruiting
patients who are unable to continue taking pantoprazole delayed-release tablets
0 Actively Recruiting
Stress Ulcers
0 Actively Recruiting
Critical Illness
0 Actively Recruiting
Heartburn
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
conditions where a reduction of gastric acid secretion is required
0 Actively Recruiting
Gastric Ulcer
1 Actively Recruiting
Phase 4
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
prophylaxis of Stress Ulcers
0 Actively Recruiting
Protonix Reviews: What are patients saying about Protonix?
5Patient Review
5/19/2022 This medication nips my GERD symptoms in the bud. I take it before meals, or if I know I'm going to drink alcohol. My doctor said it's totally fine to take 40mg every day, so that's what I do most days.
5Patient Review
10/7/2021 This medication is by far the best I've tried for my GERD.
4.3Patient Review
1/23/2017 I've found that protonix works best for me when I take it in the morning.
3.3Patient Review
6/18/2022 I found that Pantoprazole/Protonix was effective, but I stopped taking it after putting on 25lbs. The weight gain is becoming a serious problem; I started taking PPIs over five years ago and noticed the weight gain within the first month. Hopefully Pepcid will be just as effective without the same side effect.
3Patient Review
4/18/2017 I took this medication for about a year and saw great results for several months. Recently though, I've been having a lot of problems with acid reflux and heartburn. This medication doesn't seem to be doing anything to help me, even though I'm very careful about my diet.
2.7Patient Review
9/24/2018 I was recently diagnosed with scurvy. I found that a lot of references suggest that PPi's can reduce your levels of Vitamin C. Should there be a warning and suggestion to get these levels checked periodically?
2.3Patient Review
4/11/2021 I don't think this is the right medication for me. I've seemed to put on weight in my mid-section, and I haven't changed my diet at all.
2Patient Review
1/25/2020 I'm a bit worried about potential side effects.
1.7Patient Review
5/31/2017 I started this medication a couple weeks ago and have been having severe leg cramps, nausea, and vomiting. Really not happy with how this is going.
1.7Patient Review
11/4/20161.3Patient Review
2/4/2018 I had an awful reaction to this within 24 hours. My legs and feet itched terribly, to the point where I had to take scalding showers and sleep sitting up. The itching was unrelenting for weeks, even after stopping the medication.
1.3Patient Review
11/3/2017 This medication really dries out my mouth. I also wake up with pain in my stomach every morning.
1Patient Review
3/26/2018 I had an incredibly negative reaction to this medication. It bloated my stomach, made my face and hands swell, and caused me difficulty breathing. I also experienced chest and throat pain. After only three days, I stopped taking the drug due to how awful I felt. Do not take this medication; it is dangerous!
1Patient Review
4/23/2019 I only took this for a couple weeks, but I started feeling really bad. The pain in my shoulder was unbearable, so I stopped taking it entirely. Thankfully, I'm already feeling better.
1Patient Review
10/2/2019 Do not take this medication if you are also taking marijuana, as it will trigger anxiety attacks. I experienced delusions and felt awful for two days after taking this drug.
Patient Q&A Section about protonix
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Prilosec and Protonix the same thing?
"Both medications work by reducing the amount of acid produced by the stomach.
Are Protonix and Prilosec theSame Thing? Protonix (pantoprazole sodium) and Prilosec (omeprazole) are proton pump inhibitors (PPIs) used to treat gastroesophageal reflux disease (GERD) and a history of erosive esophagitis. Prilosec is also used to treat ulcers and frequent heartburn. Both medications work by reducing the amount of acid produced by the stomach."
Answered by AI
What is the medication Protonix used for?
"This medication is used to treat heartburn, difficulty swallowing, and persistent cough. It can also help heal damage to the stomach and esophagus caused by acid, help prevent ulcers, and may help prevent cancer of the esophagus."
Answered by AI
Why should you not take Protonix?
"Pantoprazole may increase your risk of hip, wrist, and spine fractures, especially if you're 50 or older, receive high doses, or use it for more than a year. Contact your doctor immediately if you experience severe bone pain or have difficulty walking or sitting."
Answered by AI
What is the medicine Protonix used for?
"This medication is used to treat symptoms such as heartburn, difficulty swallowing, and persistent cough that are caused by acid damage to the stomach and esophagus. Pantoprazole belongs to a class of drugs known as proton pump inhibitors (PPIs) that work by reducing the amount of acid that is produced by the stomach."
Answered by AI
Which is better omeprazole or Protonix?
"Are pantoprazole and omeprazole equally effective?
Studies comparing pantoprazole and omeprazole have found that they are both effective in treating GERD and stomach ulcers."
Answered by AI