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What is Propafenone Hydrochloride
PropafenoneThe Generic name of this drug
Treatment SummaryAmiodarone is a medication used to treat irregular heartbeats (arrhythmias) that originate from the ventricles. It also has a mild effect of reducing the speed of the heart rate. Generally, it is well tolerated and has few side effects.
Propafenone HClis the brand name
Propafenone Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Propafenone HCl
Propafenone
2000
140
Approved as Treatment by the FDA
Propafenone, otherwise called Propafenone HCl, is approved by the FDA for 2 uses including Atrial Fibrillation and Atrial Fibrillation .Atrial Fibrillation
Helps manage Atrial Fibrillation
Atrial Fibrillation
Helps manage Atrial Fibrillation
Effectiveness
How Propafenone Hydrochloride Affects PatientsPropafenone is a medication used to treat abnormal heart rhythms. It works by blocking certain pathways in the heart, stopping sodium from entering the heart cells which in turn reduces how much they can get excited. Propafenone has anesthetic effects similar to procaine, a local anesthetic.
How Propafenone Hydrochloride works in the bodyPropafenone helps to prevent arrhythmias by decreasing the speed of electrical signals in the heart. It increases the amount of time that it takes for the heart to reset between electrical signals, reducing the chance of an irregular heart beat. It also reduces the spontaneous and triggered activity of the heart. At very high concentrations, it can also reduce the amount of calcium in the heart, but this does not appear to have an effect on its effectiveness.
When to interrupt dosage
The endorsed dose of Propafenone Hydrochloride is based upon the diagnosed condition, including Paroxysmal Supraventricular Tachycardia (PSVT), Atrial Fibrillation and Atrial Fibrillation. The amount likewise relies upon the technique of delivery (e.g. Tablet, coated or Oral) detailed in the accompanying table.Condition
Dosage
Administration
Paroxysmal Atrial Fibrillation
, 225.0 mg, 325.0 mg, 425.0 mg, 150.0 mg, 300.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral
Atrial Fibrillation
, 225.0 mg, 325.0 mg, 425.0 mg, 150.0 mg, 300.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral
Ventricular Arrhythmia
, 225.0 mg, 325.0 mg, 425.0 mg, 150.0 mg, 300.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral
Tachycardia, Supraventricular
, 225.0 mg, 325.0 mg, 425.0 mg, 150.0 mg, 300.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral
Warnings
Propafenone Hydrochloride has fourteen contraindications. If you have any of the conditions specified in the table below, Propafenone Hydrochloride should not be taken.Propafenone Hydrochloride ContraindicationsCondition
Risk Level
Notes
Cerebral Ventricle Neoplasms
Do Not Combine
Slow Heart Rate
Do Not Combine
Congestive Heart Failure
Do Not Combine
Cerebral Ventricle Neoplasms
Do Not Combine
Lung Diseases, Obstructive
Do Not Combine
Sinus Arrhythmia
Do Not Combine
Sinus Arrhythmia
Do Not Combine
Atrioventricular Block
Do Not Combine
Marked electrolyte imbalance
Do Not Combine
Brugada Syndrome
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Atrioventricular Block
Do Not Combine
Hypotension
Do Not Combine
Bronchospasm
Do Not Combine
Common Propafenone Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Propafenone.
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Propafenone.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Propafenone.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Propafenone.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Propafenone.
Propafenone Hydrochloride Toxicity & Overdose RiskSymptoms of propafenone overdose can include seizures (rarely), abnormal heart rate, low blood pressure, and drowsiness. These symptoms are usually most severe within the first 3 hours.
Propafenone Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Propafenone Hydrochloride?
175 clinical trials are in progress to assess the potential of Propafenone Hydrochloride in providing relief from Ventricular Arrhythmia, Atrial Fibrillation and other Atrial Fibrillation-related ailments.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Ventricular Arrhythmia
5 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Tachycardia, Supraventricular
2 Actively Recruiting
Phase 3, Phase 2
Paroxysmal Atrial Fibrillation
10 Actively Recruiting
Not Applicable, Phase 4
Propafenone Hydrochloride Reviews: What are patients saying about Propafenone Hydrochloride?
5Patient Review
4/28/2012 It's only been four days, so I can't speak to the long-term effects yet. But several people have complained about the cost and I want to say that I got a 90 day supply from Walgreens for around three dollars.
5Patient Review
2/27/2013 The number of times I've experienced a-fib have gone down since I started this treatment. My heart used to stop occasionally, so in March I got a pacemaker installed in combination with this drug. Even though it haven't stopped the a-fib completely, I have more good days than bad now. The only downside is that the medication makes me tired and drowsy.
5Patient Review
4/29/2014 I've been taking this drug for 15 years now at a 600mg/day dose. I've found it to be effective, though not perfect. I still have about 8 episodes per year despite also taking bisoprolol. Ablation has not worked for me.
5Patient Review
5/9/2014 I've been taking this medication for nine years with great success. I did have a reaction to it six years ago while I was undergoing chemotherapy, but that was the only time.
5Patient Review
9/10/2014 I've been dealing with AF for over three years now, and this medication has really helped to reduce the number of episodes I experience. I started off taking Rythmol twice per day, but after a year switched to the generic version with no difference in effectiveness. The only downside is that I have experienced some weight gain and fatigue; however, those are small prices to pay compared to the alternative of living with constant pain.
Patient Q&A Section about propafenone hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What medications should not be taken with propafenone?
"These are drugs that should not be combined with erythromycin."
Answered by AI
Does propafenone lower your blood pressure?
"You can take propafenone with or without food, but you should be aware that you may have very low blood pressure while taking the medication. If you experience vomiting or diarrhea, extreme thirst, or loss of appetite, call your doctor. You may also need frequent blood tests."
Answered by AI
What are the most common side effects of propafenone?
"You may experience dizziness, headaches, a metallic/salty taste in your mouth, nausea or vomiting, constipation, anxiety, or fatigue. If you experience any of these effects for an extended period of time, speak to your doctor or pharmacist."
Answered by AI
What is the drug propafenone used for?
"Propafenone is used to prevent irregular heartbeats such as atrial fibrillation (AF) from occurring again in patients who do not have structural heart disease. Propafenone belongs to the group of medicines known as antiarrhythmics. These medicines work by slowing the nerve impulses in the heart."
Answered by AI
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