200 Participants Needed

Saliva Testing for Strep Throat

Recruiting at 2 trial locations
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: The Hospital for Sick Children
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

This study is being done to evaluate whether saliva can be used to diagnose GAS infection and also to compare different testing methods in the microbiology lab. The saliva sample testing will be compared to the throat swab testing to see if saliva testing works as well. The lab will also try different testing methods to see if a faster type of testing (e.g. molecular testing) works as well as the regular method, which takes 48 hours to get results.This is important because throat swabs can be challenging to collect in some children, and saliva is often much easier and more acceptable by children to collect. This could improve our ability to accurately diagnose and treat GAS infections.

Eligibility Criteria

This study is for individuals, particularly children, who may have a streptococcal infection or strep throat. It's designed to see if saliva can be used instead of throat swabs for diagnosis. The specific eligibility criteria are not provided but would typically include having symptoms of a GAS infection.

Inclusion Criteria

I have given a sample for a throat infection test as advised by my doctor.
I am under 19 years old.
I can provide a saliva sample.

Exclusion Criteria

Unable to provide a saliva sample
I or my guardian cannot give consent.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Sample Collection

Participants self-collect saliva samples for testing and comparison with throat swab testing

1 day
1 visit (in-person)

Laboratory Testing

Saliva and throat swab samples are tested using different methods, including molecular testing and bacterial culture

48 hours

Follow-up

Participants are monitored for safety and effectiveness of the saliva testing method

1-2 weeks

Treatment Details

Interventions

  • Saliva Collection
Trial Overview The trial is testing the effectiveness of using saliva samples to diagnose Group A Streptococcus (GAS) infections. It compares saliva sample results with traditional throat swab tests and evaluates different lab testing methods, including faster molecular techniques.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Saliva collectionExperimental Treatment1 Intervention
Self-collected saliva sample

Find a Clinic Near You

Who Is Running the Clinical Trial?

The Hospital for Sick Children

Lead Sponsor

Trials
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Recruited
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