Procardia Xl

Anal sphincter hypertonia, Proctalgia, Altitude Sickness + 12 more
Treatment
3 FDA approvals
20 Active Studies for Procardia Xl

What is Procardia Xl

NifedipineThe Generic name of this drug
Treatment SummaryNifedipine, also known as BAY a 1040, is a medication used to treat high blood pressure. It works by changing the way calcium moves into cells of the heart and blood vessels, which helps relax the blood vessels and reduce the pressure of the blood. It was developed by Bayer in 1972 and approved by the FDA in 1981. It is part of a family of medications called dihydropyridine L-type calcium channel blockers and is one of the first such drugs approved for use. Since then, newer medications with slower onsets and longer durations of action, such as amlodipine, have
Procardiais the brand name
image of different drug pills on a surface
Procardia Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Procardia
Nifedipine
1981
355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Angina, Stable and Failed conventional therapy .
Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Failed conventional therapy
Helps manage Failed conventional therapy
Vasospastic Angina
Helps manage Vasospastic Angina

Effectiveness

How Procardia Xl Affects PatientsNifedipine helps to reduce blood pressure and increase oxygen to the heart. It typically needs to be taken three times a day, with the amount taken depending on the individual's needs. People taking this drug should be aware of the risks of low blood pressure, chest pain, and heart attack.
How Procardia Xl works in the bodyNifedipine is a drug that helps reduce blood pressure and ease chest pain. It works by blocking calcium channels in the walls of blood vessels, which prevents calcium from entering the cells. This reduces resistance in the arteries, increasing blood flow and oxygen to the heart.

When to interrupt dosage

The amount of Procardia Xl is contingent upon the established condition, such as Achalasia, Ureteral Calculus and Hypertensive disease. The dosage depends on the approach of delivery (e.g. Tablet, film coated, extended release or Capsule) as delineated in the table below.
Condition
Dosage
Administration
Vasospastic Angina
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Ureteral Calculi
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Angina, Stable
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Fissure in Ano
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Failed conventional therapy
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Proctalgia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Pulmonary Edema
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Altitude Sickness
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Raynaud Disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Hypertensive disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Hypertensive Emergency
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Anal sphincter hypertonia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Obstetric Labor, Premature
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Esophageal Achalasia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release
Pulmonary Hypertension
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Warnings

Procardia Xl has one identified contraindication, so it should not be employed for the circumstances noted in the following table.Procardia Xl Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Nifedipine may interact with Pulse Frequency
There are 20 known major drug interactions with Procardia Xl.
Common Procardia Xl Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Nifedipine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Nifedipine.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.
Procardia Xl Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 1022mg/kg and 202mg/kg in mice. Overdosing on this drug can lead to low blood pressure, abnormal heart rate, and abnormal communication between the upper and lower parts of the heart. Treatment may involve monitoring vital signs, elevating extremities, and administering medications to raise the blood pressure and increase calcium levels.
image of a doctor in a lab doing drug, clinical research

Procardia Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Procardia Xl?

101 active studies are underway to investigate the potential of Procardia Xl in providing relief for Achalasia, Hypertensive Emergency and Anal Fissure.
Condition
Clinical Trials
Trial Phases
Obstetric Labor, Premature
2 Actively Recruiting
Not Applicable
Pulmonary Edema
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Angina, Stable
0 Actively Recruiting
Esophageal Achalasia
0 Actively Recruiting
Altitude Sickness
0 Actively Recruiting
Raynaud Disease
1 Actively Recruiting
Phase 4
Pulmonary Hypertension
30 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Proctalgia
0 Actively Recruiting
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Fissure in Ano
0 Actively Recruiting
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Anal sphincter hypertonia
0 Actively Recruiting
Ureteral Calculi
0 Actively Recruiting
Failed conventional therapy
0 Actively Recruiting

Procardia Xl Reviews: What are patients saying about Procardia Xl?

5Patient Review
10/6/2016
Procardia Xl for High Blood Pressure
I started this medication when I was pregnant with my first child at 32 years old. I had been diagnosed with preeclampsia and toxemia, which resulted in high blood pressure that needed to be controlled with medication. This drug has worked well for me and I have not experienced any side effects.
5Patient Review
6/18/2012
Procardia Xl for High Blood Pressure
I appreciate that this medication doesn't make me drowsy.
4.7Patient Review
1/18/2012
Procardia Xl for Chronic Stable Angina
4Patient Review
3/26/2014
Procardia Xl for High Blood Pressure
I've been taking Procardia XL for five years to manage hypertension, and it's been effective. However, the side effects have gradually gotten worse and now include joint pain, gas, indigestion, hair loss, decreased libido, and more. The most recent change has been my doctor lowering my dose--here's hoping that helps!
4Patient Review
11/23/2013
Procardia Xl for Chronic Stable Angina
I've been on Procardia for nine months now. I generally feel tired, and my legs often ache. Additionally, I experience swelling in my hands and feet when standing for long periods of time. headaches are also common. However, I haven't had to use nitroglycerin once since starting this medication regimen.
3.7Patient Review
3/18/2013
Procardia Xl for High Blood Pressure
I experienced some pretty bad joint pain after starting this medication. It began about two weeks in and I also felt dizzy and had low blood pressure.
3.7Patient Review
2/12/2012
Procardia Xl for High Blood Pressure
I've been on this medication for a little over a week now. So far, I'm experiencing mood swings, slow heart rate, and shortness of breath.
3.7Patient Review
11/18/2015
Procardia Xl for High Blood Pressure
I started noticing my gums were growing over my teeth, so I went to the dentist. Turns out, one of the side effects of the Procardia I'd been taking was gum growth. I've also experienced frequent urination as a result of this medication.
3.7Patient Review
1/29/2012
Procardia Xl for Occasional Numbness, Prickling, or Tingling of Fingers and Toes
3.7Patient Review
5/2/2013
Procardia Xl for High Blood Pressure
I've been taking this for a little over three months now and I started to notice that about 10-12 hours after taking it, I would feel dizzy. My doctor diagnosed me with vertigo but I'm not convinced it's entirely unrelated to the Procardia XL. Has anyone else experienced this side effect?
3Patient Review
9/22/2016
Procardia Xl for High Blood Pressure
I saw some improvement when I increased my dosage, but the swelling in my ankles has become really bad. I'm going to try discontinuing the medication and see if that helps.
2.7Patient Review
6/8/2015
Procardia Xl for High Blood Pressure
Since starting this medication, I have been very tired in the mornings. In addition, I've experienced increased muscle and joint pain, as well as constipation. The side effects of this drug are terrible; 60mgs once a day has been my dosage. I'm going to lower the mgs and see if that helps. If not, we'll try another medication.
2.7Patient Review
2/25/2020
Procardia Xl for High Blood Pressure
I took this medication at night because I had heard it would make me sleepy. Unfortunately, I found that it made me exhausted during the day and also gave me headaches that no amount of painkillers could touch.
2.7Patient Review
11/12/2011
Procardia Xl for High Blood Pressure
2.3Patient Review
7/14/2021
Procardia Xl for High Blood Pressure
Procardia was given to me to help with preeclampsia a few weeks after giving birth. It did lower my blood pressure, but the migraines and flush feelings were really unpleasant. I stopped taking it after a few months and switched to diet and exercise, which worked out better for me in the long run.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about procardia xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is nifedipine no longer used?

"Initially, nifedipine was one of the most popular medications to treat hypertension. However, concerns about its safety and tolerability, as well as the introduction of new types of antihypertensive medications, led to its decline in use. Additionally, data showing that other types of medications are more effective in reducing mortality rates has also contributed to nifedipine's decline in popularity."

Answered by AI

Does Procardia XL cause weight gain?

"This medicine may cause fluid retention in some patients, which can lead to symptoms such as bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or loss. If you experience any of these symptoms, be sure to tell your doctor right away."

Answered by AI

What are side effects of Procardia XL?

"The following text lists some potential side effects of a medication. If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Procardia Xl

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Image of UPMC Presybeterian in Pittsburgh, United States.

Telaglenastat for Pulmonary Hypertension

18 - 75
All Sexes
Pittsburgh, PA
The research study is being conducted to evaluate the effectiveness of a drug called Telaglenastat in adults diagnosed with Pulmonary Hypertension (PH). PH is a progressive condition that affects the arteries in the lungs, specifically the pulmonary arteries, which carry blood from the right side of the heart to the lungs. Telaglenastat is not currently approved by the Food and Drug Administration for the treatment of PH. However, the study investigators believe that Telaglenastat may help lower blood pressure in the lungs and improve both heart and lung function. It is important to note that the drug will not be available to participants once the study concludes.
Phase 1 & 2
Waitlist Available
UPMC PresybeterianMichael Risbano, MD
Have you considered Procardia Xl clinical trials? We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.Go to Trials
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Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
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Oral Treprostinil for Raynaud's Disease

18+
All Sexes
Boston, MA
Raynaud's phenomenon is a condition where the blood vessels in participants fingers and toes get too narrow when cold or stressed. This makes participants fingers and toes change colors - they might turn white, then blue, and finally red as blood flow returns. It can be painful and cause numbness or tingling. When participants have Raynaud's, blood vessels react too strongly to cold or stress. Fingers and toes may turn white (blood moves away from the area), blue (lack of oxygen), or red and feel painful or tingly when warming up. These episodes usually last from a few minutes to several hours. There are two types of Raynaud's. Primary Raynaud's (also called Raynaud's disease) itself and isn't connected to other health problems. It's the most common type and affects mostly women under 30. Secondary Raynaud's (also called Raynaud's phenomenon) is caused by other diseases like lupus, scleroderma, or rheumatoid arthritis. This type tends to be more serious and may cause painful sores on fingertips called digital ulcers. For mild cases, staying warm might be enough. But if symptoms are severe, participants doctor might prescribe various medications including calcium channel blockers - blood pressure medicines that help open blood vessels, or other vasodilators - medicines that widen blood vessels. About 40% of people with scleroderma develop painful sores on their fingertips called digital ulcers. These happen when there isn't enough blood flow to heal small injuries. For severe cases with digital ulcers, doctors might use prostacyclin therapy - medicines that mimic a natural substance that opens blood vessels. Oral treprostinil is a newer pill form of prostacyclin therapy that helps improve blood flow. The investigators are conducting a research study testing whether oral treprostinil - a pill that mimics prostacyclin (a natural blood vessel opener) - can help people with severe Raynaud's that doesn't respond to usual treatments. This represents hope for better treatment options for people with the most challenging cases of this condition.
Phase 4
Waitlist Available
Brigham and Women's HospitalAaron B Waxman, MD, PhD
Have you considered Procardia Xl clinical trials? We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.Go to Trials
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Neuromodulation for Pulmonary Arterial Hypertension

18 - 90
All Sexes
Oklahoma City, OK
Patients with Group 1 pulmonary hypertension will be enrolled in this study. Investigators will test the hypothesis of low-level tragal stimulation in patients with pulmonary hypertension. The study will be conducted over 4 weeks and patients will undergo low-level tragus stimulation for 1 hour every day for 4 weeks. At baseline the following tests will be conducted-6-minute walk distance, vascular function testing using noninvasive device and blood samples will be collected. Patient will also undergo a limited echocardiography to assess right ventricular function. After 4 weeks of stimulation patients will come back to undergo these tests again. Investigators hypothesized that low-level tragus stimulation (neuromodulation) will lead to improvement in vascular function, 6-minute walk distance and blood based biomarkers in patients with pulmonary hypertension.
Phase 1 & 2
Waitlist Available
University of Oklahoma health sciences CenterTarun Dasari, MD
Have you considered Procardia Xl clinical trials? We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.Go to Trials
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