Procardia Xl

Anal sphincter hypertonia, Proctalgia, Altitude Sickness + 12 more

Treatment

3 FDA approvals

20 Active Studies for Procardia Xl

What is Procardia Xl

Nifedipine

The Generic name of this drug

Treatment Summary

Nifedipine, also known as BAY a 1040, is a medication used to treat high blood pressure. It works by changing the way calcium moves into cells of the heart and blood vessels, which helps relax the blood vessels and reduce the pressure of the blood. It was developed by Bayer in 1972 and approved by the FDA in 1981. It is part of a family of medications called dihydropyridine L-type calcium channel blockers and is one of the first such drugs approved for use. Since then, newer medications with slower onsets and longer durations of action, such as amlodipine, have

Procardia

is the brand name

image of different drug pills on a surface

Procardia Xl Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Procardia

Nifedipine

1981

355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Angina, Stable and Failed conventional therapy .

Angina, Stable

Helps manage Chronic Stable Angina Pectoris

Failed conventional therapy

Helps manage Failed conventional therapy

Vasospastic Angina

Helps manage Vasospastic Angina

Effectiveness

How Procardia Xl Affects Patients

Nifedipine helps to reduce blood pressure and increase oxygen to the heart. It typically needs to be taken three times a day, with the amount taken depending on the individual's needs. People taking this drug should be aware of the risks of low blood pressure, chest pain, and heart attack.

How Procardia Xl works in the body

Nifedipine is a drug that helps reduce blood pressure and ease chest pain. It works by blocking calcium channels in the walls of blood vessels, which prevents calcium from entering the cells. This reduces resistance in the arteries, increasing blood flow and oxygen to the heart.

When to interrupt dosage

The amount of Procardia Xl is contingent upon the established condition, such as Achalasia, Ureteral Calculus and Hypertensive disease. The dosage depends on the approach of delivery (e.g. Tablet, film coated, extended release or Capsule) as delineated in the table below.

Condition

Dosage

Administration

Ureteral Calculi

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Angina, Stable

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Fissure in Ano

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Vasospastic Angina

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Failed conventional therapy

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Proctalgia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Pulmonary Edema

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Altitude Sickness

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Raynaud Disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Hypertensive disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Hypertensive Emergency

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Anal sphincter hypertonia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Obstetric Labor, Premature

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Esophageal Achalasia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Pulmonary Hypertension

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Warnings

Procardia Xl has one identified contraindication, so it should not be employed for the circumstances noted in the following table.

Procardia Xl Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Nifedipine may interact with Pulse Frequency

There are 20 known major drug interactions with Procardia Xl.

Common Procardia Xl Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Nifedipine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Nifedipine.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.

Procardia Xl Toxicity & Overdose Risk

The lowest toxic dose of this drug in rats is 1022mg/kg and 202mg/kg in mice. Overdosing on this drug can lead to low blood pressure, abnormal heart rate, and abnormal communication between the upper and lower parts of the heart. Treatment may involve monitoring vital signs, elevating extremities, and administering medications to raise the blood pressure and increase calcium levels.

image of a doctor in a lab doing drug, clinical research

Procardia Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Procardia Xl?

101 active studies are underway to investigate the potential of Procardia Xl in providing relief for Achalasia, Hypertensive Emergency and Anal Fissure.

Condition

Clinical Trials

Trial Phases

Obstetric Labor, Premature

2 Actively Recruiting

Not Applicable

Pulmonary Edema

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Angina, Stable

0 Actively Recruiting

Esophageal Achalasia

0 Actively Recruiting

Altitude Sickness

0 Actively Recruiting

Raynaud Disease

1 Actively Recruiting

Phase 4

Pulmonary Hypertension

33 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Proctalgia

0 Actively Recruiting

Hypertensive Emergency

1 Actively Recruiting

Phase 4

Fissure in Ano

0 Actively Recruiting

Vasospastic Angina

1 Actively Recruiting

Phase 2, Phase 3

Anal sphincter hypertonia

0 Actively Recruiting

Ureteral Calculi

0 Actively Recruiting

Failed conventional therapy

0 Actively Recruiting

Procardia Xl Reviews: What are patients saying about Procardia Xl?

5

Patient Review

10/6/2016

Procardia Xl for High Blood Pressure

I started this medication when I was pregnant with my first child at 32 years old. I had been diagnosed with preeclampsia and toxemia, which resulted in high blood pressure that needed to be controlled with medication. This drug has worked well for me and I have not experienced any side effects.

5

Patient Review

6/18/2012

Procardia Xl for High Blood Pressure

I appreciate that this medication doesn't make me drowsy.

4.7

Patient Review

1/18/2012

Procardia Xl for Chronic Stable Angina

4

Patient Review

3/26/2014

Procardia Xl for High Blood Pressure

I've been taking Procardia XL for five years to manage hypertension, and it's been effective. However, the side effects have gradually gotten worse and now include joint pain, gas, indigestion, hair loss, decreased libido, and more. The most recent change has been my doctor lowering my dose--here's hoping that helps!

4

Patient Review

11/23/2013

Procardia Xl for Chronic Stable Angina

I've been on Procardia for nine months now. I generally feel tired, and my legs often ache. Additionally, I experience swelling in my hands and feet when standing for long periods of time. headaches are also common. However, I haven't had to use nitroglycerin once since starting this medication regimen.

3.7

Patient Review

3/18/2013

Procardia Xl for High Blood Pressure

I experienced some pretty bad joint pain after starting this medication. It began about two weeks in and I also felt dizzy and had low blood pressure.

3.7

Patient Review

2/12/2012

Procardia Xl for High Blood Pressure

I've been on this medication for a little over a week now. So far, I'm experiencing mood swings, slow heart rate, and shortness of breath.

3.7

Patient Review

11/18/2015

Procardia Xl for High Blood Pressure

I started noticing my gums were growing over my teeth, so I went to the dentist. Turns out, one of the side effects of the Procardia I'd been taking was gum growth. I've also experienced frequent urination as a result of this medication.

3.7

Patient Review

1/29/2012

Procardia Xl for Occasional Numbness, Prickling, or Tingling of Fingers and Toes

3.7

Patient Review

5/2/2013

Procardia Xl for High Blood Pressure

I've been taking this for a little over three months now and I started to notice that about 10-12 hours after taking it, I would feel dizzy. My doctor diagnosed me with vertigo but I'm not convinced it's entirely unrelated to the Procardia XL. Has anyone else experienced this side effect?

3

Patient Review

9/22/2016

Procardia Xl for High Blood Pressure

I saw some improvement when I increased my dosage, but the swelling in my ankles has become really bad. I'm going to try discontinuing the medication and see if that helps.

2.7

Patient Review

6/8/2015

Procardia Xl for High Blood Pressure

Since starting this medication, I have been very tired in the mornings. In addition, I've experienced increased muscle and joint pain, as well as constipation. The side effects of this drug are terrible; 60mgs once a day has been my dosage. I'm going to lower the mgs and see if that helps. If not, we'll try another medication.

2.7

Patient Review

2/25/2020

Procardia Xl for High Blood Pressure

I took this medication at night because I had heard it would make me sleepy. Unfortunately, I found that it made me exhausted during the day and also gave me headaches that no amount of painkillers could touch.

2.7

Patient Review

11/12/2011

Procardia Xl for High Blood Pressure

2.3

Patient Review

7/14/2021

Procardia Xl for High Blood Pressure

Procardia was given to me to help with preeclampsia a few weeks after giving birth. It did lower my blood pressure, but the migraines and flush feelings were really unpleasant. I stopped taking it after a few months and switched to diet and exercise, which worked out better for me in the long run.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about procardia xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is nifedipine no longer used?

"Initially, nifedipine was one of the most popular medications to treat hypertension. However, concerns about its safety and tolerability, as well as the introduction of new types of antihypertensive medications, led to its decline in use. Additionally, data showing that other types of medications are more effective in reducing mortality rates has also contributed to nifedipine's decline in popularity."

Answered by AI

Does Procardia XL cause weight gain?

"This medicine may cause fluid retention in some patients, which can lead to symptoms such as bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or loss. If you experience any of these symptoms, be sure to tell your doctor right away."

Answered by AI

What are side effects of Procardia XL?

"The following text lists some potential side effects of a medication. If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Procardia Xl

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Image of UPMC Presybeterian in Pittsburgh, United States.

Telaglenastat for Pulmonary Hypertension

18 - 75
All Sexes
Pittsburgh, PA

The research study is being conducted to evaluate the effectiveness of a drug called Telaglenastat in adults diagnosed with Pulmonary Hypertension (PH). PH is a progressive condition that affects the arteries in the lungs, specifically the pulmonary arteries, which carry blood from the right side of the heart to the lungs. Telaglenastat is not currently approved by the Food and Drug Administration for the treatment of PH. However, the study investigators believe that Telaglenastat may help lower blood pressure in the lungs and improve both heart and lung function. It is important to note that the drug will not be available to participants once the study concludes.

Phase 1 & 2
Waitlist Available

UPMC Presybeterian

Michael Risbano, MD

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We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.
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Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL

Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.

Waitlist Available
Has No Placebo

University of Alabama at Birmingham

Pankaj Arora, MD, FAHA

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We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.
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PF-07868489 for Pulmonary Hypertension

18+
All Sexes
San Francisco, CA

The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is high blood pressure in the arteries that carry blood from the heart to the lungs. This high pressure makes it harder for the heart to pump blood through those lungs, potentially damaging the right side of the heart. This is an open-label study. Which means that both the healthcare providers and the study participants are aware of the medicine being given. This study is also an extension study with study medicine (PF-07868489). An extension study allows patients from an earlier clinical study (also called as qualifying study) to continue participating to assess long-term benefits and safety of the medicine.

Phase 2
Recruiting

UCSF Health St. Mary's Hospital (+6 Sites)

Pfizer CT.gov Call Center

Pfizer

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We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.
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