Procardia Xl

Anal sphincter hypertonia, Proctalgia, Other and unspecified effects of high altitude + 12 more

Treatment

3 FDA approvals

20 Active Studies for Procardia Xl

Treatment for

Anal sphincter hypertonia

What is Procardia Xl

NifedipineThe Generic name of this drug

Treatment SummaryNifedipine, also known as BAY a 1040, is a medication used to treat high blood pressure. It works by changing the way calcium moves into cells of the heart and blood vessels, which helps relax the blood vessels and reduce the pressure of the blood. It was developed by Bayer in 1972 and approved by the FDA in 1981. It is part of a family of medications called dihydropyridine L-type calcium channel blockers and is one of the first such drugs approved for use. Since then, newer medications with slower onsets and longer durations of action, such as amlodipine, have

Procardiais the brand name

image of different drug pills on a surface

Procardia Xl Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Procardia

Nifedipine

1981

355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Vasospastic Angina and Chronic Stable Angina Pectoris .

Vasospastic Angina

Helps manage Vasospastic Angina

Chronic Stable Angina Pectoris

Helps manage Chronic Stable Angina Pectoris

Failed conventional therapy

Helps manage Failed conventional therapy

Effectiveness

How Procardia Xl Affects PatientsNifedipine helps to reduce blood pressure and increase oxygen to the heart. It typically needs to be taken three times a day, with the amount taken depending on the individual's needs. People taking this drug should be aware of the risks of low blood pressure, chest pain, and heart attack.

How Procardia Xl works in the bodyNifedipine is a drug that helps reduce blood pressure and ease chest pain. It works by blocking calcium channels in the walls of blood vessels, which prevents calcium from entering the cells. This reduces resistance in the arteries, increasing blood flow and oxygen to the heart.

When to interrupt dosage

The amount of Procardia Xl is contingent upon the established condition, such as Achalasia, Ureteral Calculus and Hypertensive disease. The dosage depends on the approach of delivery (e.g. Tablet, film coated, extended release or Capsule) as delineated in the table below.

Condition

Dosage

Administration

Anal sphincter hypertonia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Achalasia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Hypertensive disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Other and unspecified effects of high altitude

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Vasospastic Angina

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Pulmonary Edemas

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Premature Labour

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Fissure;Anal

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Hypertensive Emergency

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Ureteral Calculus

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Pulmonary Hypertension

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Raynaud's Phenomenon

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Chronic Stable Angina Pectoris

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Failed conventional therapy

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Proctalgia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Warnings

Procardia Xl has one identified contraindication, so it should not be employed for the circumstances noted in the following table.Procardia Xl Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Nifedipine may interact with Pulse Frequency

There are 20 known major drug interactions with Procardia Xl.

Common Procardia Xl Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Nifedipine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Nifedipine.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.

Procardia Xl Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 1022mg/kg and 202mg/kg in mice. Overdosing on this drug can lead to low blood pressure, abnormal heart rate, and abnormal communication between the upper and lower parts of the heart. Treatment may involve monitoring vital signs, elevating extremities, and administering medications to raise the blood pressure and increase calcium levels.

image of a doctor in a lab doing drug, clinical research

Procardia Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Procardia Xl?

101 active studies are underway to investigate the potential of Procardia Xl in providing relief for Achalasia, Hypertensive Emergency and Anal Fissure.

Condition

Clinical Trials

Trial Phases

Fissure;Anal

0 Actively Recruiting

Pulmonary Hypertension

26 Actively Recruiting

Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1

Anal sphincter hypertonia

0 Actively Recruiting

Vasospastic Angina

0 Actively Recruiting

Failed conventional therapy

0 Actively Recruiting

Raynaud's Phenomenon

1 Actively Recruiting

Phase 4

Chronic Stable Angina Pectoris

1 Actively Recruiting

Not Applicable

Hypertensive Emergency

1 Actively Recruiting

Phase 4

Proctalgia

0 Actively Recruiting

Pulmonary Edemas

0 Actively Recruiting

Ureteral Calculus

0 Actively Recruiting

Achalasia

7 Actively Recruiting

Phase 2, Not Applicable, Phase 4

Other and unspecified effects of high altitude

0 Actively Recruiting

Premature Labour

4 Actively Recruiting

Not Applicable, Phase 2

Hypertensive disease

19 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Procardia Xl Reviews: What are patients saying about Procardia Xl?

5Patient Review

10/6/2016

Procardia Xl for High Blood Pressure

I started this medication when I was pregnant with my first child at 32 years old. I had been diagnosed with preeclampsia and toxemia, which resulted in high blood pressure that needed to be controlled with medication. This drug has worked well for me and I have not experienced any side effects.

5Patient Review

6/18/2012

Procardia Xl for High Blood Pressure

I appreciate that this medication doesn't make me drowsy.

4.7Patient Review

1/18/2012

Procardia Xl for Chronic Stable Angina

4Patient Review

3/26/2014

Procardia Xl for High Blood Pressure

I've been taking Procardia XL for five years to manage hypertension, and it's been effective. However, the side effects have gradually gotten worse and now include joint pain, gas, indigestion, hair loss, decreased libido, and more. The most recent change has been my doctor lowering my dose--here's hoping that helps!

4Patient Review

11/23/2013

Procardia Xl for Chronic Stable Angina

I've been on Procardia for nine months now. I generally feel tired, and my legs often ache. Additionally, I experience swelling in my hands and feet when standing for long periods of time. headaches are also common. However, I haven't had to use nitroglycerin once since starting this medication regimen.

3.7Patient Review

3/18/2013

Procardia Xl for High Blood Pressure

I experienced some pretty bad joint pain after starting this medication. It began about two weeks in and I also felt dizzy and had low blood pressure.

3.7Patient Review

2/12/2012

Procardia Xl for High Blood Pressure

I've been on this medication for a little over a week now. So far, I'm experiencing mood swings, slow heart rate, and shortness of breath.

3.7Patient Review

11/18/2015

Procardia Xl for High Blood Pressure

I started noticing my gums were growing over my teeth, so I went to the dentist. Turns out, one of the side effects of the Procardia I'd been taking was gum growth. I've also experienced frequent urination as a result of this medication.

3.7Patient Review

1/29/2012

Procardia Xl for Occasional Numbness, Prickling, or Tingling of Fingers and Toes

3.7Patient Review

5/2/2013

Procardia Xl for High Blood Pressure

I've been taking this for a little over three months now and I started to notice that about 10-12 hours after taking it, I would feel dizzy. My doctor diagnosed me with vertigo but I'm not convinced it's entirely unrelated to the Procardia XL. Has anyone else experienced this side effect?

3Patient Review

9/22/2016

Procardia Xl for High Blood Pressure

I saw some improvement when I increased my dosage, but the swelling in my ankles has become really bad. I'm going to try discontinuing the medication and see if that helps.

2.7Patient Review

6/8/2015

Procardia Xl for High Blood Pressure

Since starting this medication, I have been very tired in the mornings. In addition, I've experienced increased muscle and joint pain, as well as constipation. The side effects of this drug are terrible; 60mgs once a day has been my dosage. I'm going to lower the mgs and see if that helps. If not, we'll try another medication.

2.7Patient Review

2/25/2020

Procardia Xl for High Blood Pressure

I took this medication at night because I had heard it would make me sleepy. Unfortunately, I found that it made me exhausted during the day and also gave me headaches that no amount of painkillers could touch.

2.7Patient Review

11/12/2011

Procardia Xl for High Blood Pressure

2.3Patient Review

7/14/2021

Procardia Xl for High Blood Pressure

Procardia was given to me to help with preeclampsia a few weeks after giving birth. It did lower my blood pressure, but the migraines and flush feelings were really unpleasant. I stopped taking it after a few months and switched to diet and exercise, which worked out better for me in the long run.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about procardia xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is nifedipine no longer used?

"Initially, nifedipine was one of the most popular medications to treat hypertension. However, concerns about its safety and tolerability, as well as the introduction of new types of antihypertensive medications, led to its decline in use. Additionally, data showing that other types of medications are more effective in reducing mortality rates has also contributed to nifedipine's decline in popularity."

Answered by AI

Does Procardia XL cause weight gain?

"This medicine may cause fluid retention in some patients, which can lead to symptoms such as bloating or swelling of the face, arms, hands, lower legs, or feet; tingling of the hands or feet; or unusual weight gain or loss. If you experience any of these symptoms, be sure to tell your doctor right away."

Answered by AI

What are side effects of Procardia XL?

"The following text lists some potential side effects of a medication. If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Procardia Xl

Image of Davita Durham East in Durham, United States.

Oxygen for Pulmonary Hypertension

This trial aims to see if giving extra oxygen during dialysis can help people with high blood pressure in the lungs and low oxygen levels during dialysis.

Waitlist Available

No Cost For Treatment

Davita Durham East (+10 Sites)Daniel Edmonston, MD, MHS

Image of Cedars-Sinai Medical Center in Los Angeles, United States.

Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome

Los Angeles, CA

"This trial is studying the use of inhaled nitric oxide for patients who develop pulmonary hypertension during Acute Respiratory Distress Syndrome. The goal is to see if giving nitric oxide early in the

Waitlist Available

Cedars-Sinai Medical CenterYuri Matusov, MDMallinckrodt

Image of Mayo Clinic in Rochester in Rochester, United States.

Losartan for Coarctation of the Aorta

This trial investigates if a drug called Losartan can help treat a condition called coarctation of aorta.

Mayo Clinic in RochesterAlexander Egbe, MBBS, MPH

Image of UT Southwestern Medical Center in Dallas, United States.

Polypill for Cardiomyopathy Prevention in Type 2 Diabetes

This trial will test if a polypill with 3 meds can help people with type 2 diabetes and a high risk of heart failure. It will measure if it improves med adherence and physical performance, compared to usual care.

UT Southwestern Medical CenterAmbarish Pandey, MD, MSCS

Have you considered Procardia Xl clinical trials? We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.

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Image of Iowa State University in Ames, United States.

Walking Program for High Blood Pressure

This trial will assess if an 8-week walking program can lower blood pressure in older adults with respiratory impairment, reducing their risk of CVD.

Waitlist Available

Iowa State UniversityDuck-chul Lee, PhD

Image of St. Louis Heart and Vascular in Saint Louis, United States.

TNX-103 +1 More for Pulmonary Hypertension

Saint Louis, MO

This trial is going to compare the effectiveness of a medication called TNX-103 (levosimendan) with a placebo in people who have a condition called PH-HFpEF. They

St. Louis Heart and Vascular (+10 Sites)Tenax Therapeutics, Inc.

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Blood Pressure Medication for Early Pregnancy Hypertension

This trial looks at whether treating high blood pressure in early pregnancy helps outcomes or not.

Marshall Obstetrics and Gynecology

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Tadalafil for COPD with Pulmonary Hypertension

This trial will study whether a drug improves shortness of breath in Veterans with COPD and high blood pressure in the lungs. It will also assess its effect on quality of life, exercise endurance, and more.

Waitlist Available

Rocky Mountain Regional VA Medical Center, Aurora, CO (+4 Sites)Sharon I Rounds, MD

Have you considered Procardia Xl clinical trials? We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.

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Smartwatch Monitoring for Respiratory Diseases

Edmonton, Canada

This trial will study how a smartwatch device can help monitor and detect respiratory disease flare-ups, offering people with the disease more freedom and better care.

University of Alberta Hospital

Image of Brigham and Women's Hospital in Boston, United States.

LAM-001 for Pulmonary Hypertension

This trial will test if a new drug helps treat pulmonary hypertension safely and effectively.

Brigham and Women's Hospital (+1 Sites)OrphAI Therapeutics

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Semaglutide for Obesity

Philadelphia, PA

This trial is studying whether semaglutide, a treatment for diabetes and obesity, is safe and well-tolerated in patients with advanced lung disease. The trial will measure lung function, physical function

University of Pennsylvania Perelman School of MedicineMichaela R Anderson, MD

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Oral L-Citrulline for Bronchopulmonary Dysplasia and Necrotizing Enterocolitis

Toronto, Canada

This trial will study if supplementing preterm infants with an amino acid can help protect from serious diseases, like NEC and BPD.

The Hospital For Sick ChildrenEstelle Gauda, MD

Have you considered Procardia Xl clinical trials? We made a collection of clinical trials featuring Procardia Xl, we think they might fit your search criteria.

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