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What is Primsol
TrimethoprimThe Generic name of this drug
Treatment SummaryTrimethoprim is a type of antibacterial medication used to prevent the growth of bacteria. It works by blocking the production of an enzyme called dihydrofolate reductase (DHFR), which stops bacteria from making an important building block for DNA. Trimethoprim is often used in combination with sulfamethoxazole, but can be used alone to treat or prevent urinary tract infections. It is related to another antifolate drug called pyrimethamine, which is used to treat infections caused by parasites.
Septra DSis the brand name
Primsol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Septra DS
Trimethoprim
1973
343
Approved as Treatment by the FDA
Trimethoprim, also called Septra DS, is approved by the FDA for 15 uses including Fluid replacement therapy and Cholera .Fluid replacement therapy
Used to treat Fluid replacement therapy in combination with Sulfamethoxazole
Cholera
Used to treat susceptible Cholera in combination with Sulfamethoxazole
Shigellosis
Used to treat Dysentery, Bacillary in combination with Sulfamethoxazole
Urinary tract infection
Used to treat Urinary Tract Infection caused by susceptible bacteria in combination with Sulfamethoxazole
Otitis Media
Used to treat Acute Otitis Media caused by susceptible bacteria in combination with Sulfamethoxazole
Pneumocystis Jirovecii Pneumonia
Used to treat Pneumocystis Jirovecii Pneumonia in combination with Sulfamethoxazole
Bronchitis
Used to treat Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria in combination with Sulfamethoxazole
susceptible Enteritis infectious caused by Shigella sonnei
Used to treat susceptible Enteritis infectious caused by Shigella sonnei in combination with Sulfamethoxazole
Immunocompromised
Used to treat Immunocompromised in combination with Sulfamethoxazole
Electrolyte replacement
Used to treat Electrolyte replacement in combination with Sulfamethoxazole
Diarrhea
Used to treat susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection in combination with Sulfamethoxazole
Genus Pneumocystis
Used to treat risk of Pneumocystis jiroveci pneumonia (PCP) in combination with Sulfamethoxazole
susceptible Enteritis infectious caused by Shigella flexneri
Used to treat susceptible Enteritis infectious caused by Shigella flexneri in combination with Sulfamethoxazole
Nocardiosis
Used to treat Nocardiosis in combination with Sulfamethoxazole
Brucellosis
Used to treat Brucellosis in combination with Rifampicin
Effectiveness
How Primsol Affects PatientsTrimethoprim prevents certain bacteria from making the proteins and acids they need to survive. It works mainly against gram-negative bacteria and some species of Staphylococcus. Bacteria can become resistant to trimethoprim, which means it may not work as well. Rarely, this drug can cause blood disorders like low platelets, low white blood cells, or sore throat with fever, pallor, or purpura. It's important to check the local antibiotic resistance patterns before using this drug.
How Primsol works in the bodyTrimethoprim works to kill bacteria by blocking an enzyme that helps bacteria create proteins and nucleic acids. It has a stronger binding affinity to the bacterial enzyme than its mammalian counterpart, allowing it to selectively target bacteria. When taken alone, it can stop bacteria from reproducing, but when taken in combination with sulfamethoxazole, it stops two consecutive steps in the bacteria's protein and nucleic acid creation, resulting in the bacteria's death.
When to interrupt dosage
The measure of Primsol is contingent upon the manifested affliction, including Urinary tract infection, Immunocompromised and Pneumocystis Jirovecii Pneumonia. The quantity of dosage varies, as per the administration strategy (e.g. Tablet - Oral or Tablet) detailed in the accompanying table.Condition
Dosage
Administration
Pneumocystis Jirovecii Pneumonia
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Urinary tract infection
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
susceptible Enteritis infectious caused by Shigella sonnei
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Urinary tract infection
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Bacterial conjunctivitis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Diarrhea
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Blepharoconjunctivitis caused by susceptible bacteria
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Electrolyte replacement
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Bronchitis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Otitis Media
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Nocardiosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Immunocompromised
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Brucellosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Shigellosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Fluid replacement therapy
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Genus Pneumocystis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
susceptible Enteritis infectious caused by Shigella flexneri
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
bacterial blepharitis caused by susceptible bacteria
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Cholera
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Warnings
Primsol has eight contraindications, so it should be avoided in cases of the afflictions listed in the ensuing table.Primsol ContraindicationsCondition
Risk Level
Notes
history of immune thrombocytopenia caused by trimethoprim and/or sulfonamide therapy
Do Not Combine
hepatic damage
Do Not Combine
Megaloblastic anemia caused by Folate deficiency
Do Not Combine
unable to monitor renal function
Do Not Combine
Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Trimethoprim may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Trimethoprim may interact with Pulse Frequency
Common Primsol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Trimethoprim.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Trimethoprim.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Trimethoprim.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Trimethoprim.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Trimethoprim.
Primsol Toxicity & Overdose RiskThe most toxic dose of trimethoprim in mice and rats is 2764 mg/kg and over 5300 mg/kg, respectively. Taking more than 1 gram of trimethoprim can cause symptoms such as nausea, vomiting, dizziness, headaches, depression, confusion, and a decrease in red blood cells. Treatment should include supportive care and rinsing the stomach if necessary. Acidic urine can help to remove trimethoprim from the body more quickly, but dialysis is only moderately effective.
Primsol Novel Uses: Which Conditions Have a Clinical Trial Featuring Primsol?
Eight active studies are currently investigating the potential of Primsol in treating Shigella flexneri-induced Enteritis, Bacterial-induced Blepharoconjunctivitis, and Diarrhea.Condition
Clinical Trials
Trial Phases
Fluid replacement therapy
0 Actively Recruiting
Otitis Media
0 Actively Recruiting
Genus Pneumocystis
0 Actively Recruiting
bacterial blepharitis caused by susceptible bacteria
0 Actively Recruiting
Brucellosis
0 Actively Recruiting
Bronchitis
0 Actively Recruiting
Pneumocystis Jirovecii Pneumonia
1 Actively Recruiting
Phase 3
susceptible Enteritis infectious caused by Shigella sonnei
0 Actively Recruiting
Bacterial conjunctivitis
0 Actively Recruiting
Blepharoconjunctivitis caused by susceptible bacteria
0 Actively Recruiting
Nocardiosis
0 Actively Recruiting
Shigellosis
3 Actively Recruiting
Phase 2, Phase 1
Diarrhea
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
susceptible Enteritis infectious caused by Shigella flexneri
0 Actively Recruiting
Immunocompromised
4 Actively Recruiting
Phase 3, Not Applicable, Phase 1
Cholera
0 Actively Recruiting
Electrolyte replacement
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Patient Q&A Section about primsol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is trimethoprim used to treat?
"Trimethoprim is an antibiotic medication prescribed to treat and prevent urinary tract infections, as well as other infections such as chest infections and acne."
Answered by AI
What is Ciprodenk used for?
"This medication is a broad-spectrum antibiotic used to treat bacterial infections of the urinary tract, nose, throat, skin, and soft tissues. It is also effective against pneumonia."
Answered by AI
What are the side effects of taking trimethoprim?
"You may have internal bleeding if you experience any of the following: dark, sticky stool, blood in your urine or stool, fingers or lips that look blue, changes to the color of your facial skin, difficulty breathing or feeling short of breath, a fever with or without chills, feeling generally unwell or sick, or stiffness in your neck."
Answered by AI
What is Primsol used for?
"Primsol is an antibiotic used to treat bladder or kidney infections, or ear infections caused by certain bacteria."
Answered by AI