Prilosec

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 15 more

Treatment

15 FDA approvals

20 Active Studies for Prilosec

What is Prilosec

Omeprazole

The Generic name of this drug

Treatment Summary

Omeprazole is a medication used to reduce the production of stomach acid in patients with gastrointestinal disorders. The drug was the first of its kind to be introduced in 1989 and is commonly used to treat gastroesophageal reflux disease (GERD) and peptic ulcer disease. It has been proven to be effective and well-tolerated by both children and adults and is one of the most commonly prescribed drugs for gastric acid related disorders.

Prilosec

is the brand name

image of different drug pills on a surface

Prilosec Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Prilosec

Omeprazole

1990

669

Approved as Treatment by the FDA

Omeprazole, otherwise called Prilosec, is approved by the FDA for 15 uses which include multiple endocrine adenomas and Gastro-esophageal Reflux Disease (GERD) .

multiple endocrine adenomas

Gastro-esophageal Reflux Disease (GERD)

Gastric Ulcer

Gastroesophageal Reflux

Healing

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

Heartburn

Helps manage Heartburn

Stomach Ulcer

Duodenal Ulcer

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Heartburn

Helps manage Heartburn

Heartburn

Erosive Esophagitis

Adenoma

Curling Ulcer

Effectiveness

How Prilosec Affects Patients

This drug reduces the amount of acid produced in the stomach. It usually starts to work within an hour, and its effect increases with repeat daily dosing, reaching its peak after four days. Taking this drug can also increase the levels of gastrin, a hormone which can affect certain medical tests. Long-term use has not been linked to any changes in the central nervous system, cardiovascular system, or respiratory system. It also does not appear to have an effect on thyroid function, blood sugar levels, or other hormones.

How Prilosec works in the body

Hydrochloric acid (HCl) is naturally produced by stomach cells and helps create an acidic environment in the stomach. Omeprazole is a drug used to reduce the amount of HCl produced in the stomach, which helps reduce symptoms of stomach distress. It works by blocking the enzyme responsible for producing HCl, so that less acid is produced. This effect can last up to 36 hours. Omeprazole is also used to treat infections caused by the bacteria Helicobacter pylori (H. pylori). H. pylori grows best in an acidic environment, so by raising the stomach

When to interrupt dosage

The recommended dosage of Prilosec is contingent upon the diagnosed condition, such as Stomach Ulcer, Heartburn and Zollinger-Ellison Syndrome. The magnitude of dosage also relies upon the delivery technique delineated in the table below.

Condition

Dosage

Administration

Rheumatoid Arthritis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet - Oral, Tablet, Delayed Release, Tablet, Kit - Oral, For suspension - Oral, For suspension

Prophylaxis of NSAID gastric ulceration

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Heartburn

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Ankylosing Spondylitis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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hypersecretory conditions

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Gastroesophageal Reflux

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Heartburn

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet - Oral, Tablet, Delayed Release, Tablet, Kit - Oral, For suspension - Oral, For suspension

Mastocytosis, Systemic

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Stomach Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Helicobacter Pylori Infection

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Osteoarthritis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Zollinger-Ellison Syndrome

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Curling Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Adenoma

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Erosive Esophagitis

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet - Oral, Tablet, Delayed Release, Tablet, Kit - Oral, For suspension - Oral, For suspension

Stomach Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet - Oral, Tablet, Delayed Release, Tablet, Kit - Oral, For suspension - Oral, For suspension

Healing

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

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Peptic Ulcer

40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg

Oral, Capsule, delayed release pellets - Oral, , Capsule, delayed release pellets, Capsule, delayed release - Oral, Capsule, delayed release, Tablet, delayed release - Oral, Tablet, delayed release, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet - Oral, Tablet, Delayed Release, Tablet, Kit - Oral, For suspension - Oral, For suspension

Warnings

Prilosec Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Omeprazole may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Omeprazole may interact with Pulse Frequency

There are 20 known major drug interactions with Prilosec.

Common Prilosec Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Omeprazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Omeprazole.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Omeprazole.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Omeprazole.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Omeprazole.

Prilosec Toxicity & Overdose Risk

The toxic dose of oral omeprazole in mice is 4000mg/kg and 2210mg/kg in rats. Overdosing on this drug may cause confusion, drowsiness, blurred vision, fast heartbeat, nausea, sweating, flushing, headache, and a dry mouth. In studies, rats given high doses of omeprazole developed gastric carcinoid tumors and abnormal cells in their stomachs. The drug was also found to have a positive effect on chromosomal aberrations in a few tests. It is unknown if omeprazole is present in breast milk or what its effects would be, so benefits

image of a doctor in a lab doing drug, clinical research

Prilosec Novel Uses: Which Conditions Have a Clinical Trial Featuring Prilosec?

96 active trials are currently being conducted to assess the potential of Prilosec in treating Rheumatoid Arthritis, Acid-mediated Gastroesophageal Reflux Disease and Curling Ulcer.

Condition

Clinical Trials

Trial Phases

Rheumatoid Arthritis

58 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 1, Phase 4

Heartburn

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 1

Gastroesophageal Reflux

0 Actively Recruiting

Prophylaxis of NSAID gastric ulceration

0 Actively Recruiting

Mastocytosis, Systemic

0 Actively Recruiting

hypersecretory conditions

0 Actively Recruiting

Stomach Ulcer

2 Actively Recruiting

Phase 4, Not Applicable

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Ankylosing Spondylitis

2 Actively Recruiting

Phase 3, Not Applicable

Stomach Ulcer

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Zollinger-Ellison Syndrome

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

Peptic Ulcer

0 Actively Recruiting

Adenoma

0 Actively Recruiting

Healing

0 Actively Recruiting

Prilosec Reviews: What are patients saying about Prilosec?

5

Patient Review

8/26/2020

Prilosec for Condition in which Stomach Acid is Pushed Into the Esophagus

This drug provided me instant relief from a very bad case of GERD. I've been taking it for two weeks now and have only experienced mild side effects. If these don't get worse, I would say this is a miracle drug.

5

Patient Review

3/14/2021

Prilosec for Condition in which Stomach Acid is Pushed Into the Esophagus

This treatment is effective and does what it's supposed to do.

5

Patient Review

4/11/2021

Prilosec for Condition in which Stomach Acid is Pushed Into the Esophagus

I have been taking this medication for about a year to treat my GERD, and it has worked wonderfully. I am now able to drink coffee without any issues, whereas before I would have to rush to the bathroom within 10-15 minutes of drinking it.

5

Patient Review

8/26/2020

Prilosec for Condition in which Stomach Acid is Pushed Into the Esophagus

I had a very severe case of GERD and this drug provided immediate relief. I've been taking it for two weeks now with only mild side effects. If the side effects don't get worse, I would say that this is a miracle drug.

5

Patient Review

4/11/2021

Prilosec for Condition in which Stomach Acid is Pushed Into the Esophagus

I've had great success in treating my esophageal acid reflux with this medication. I'm now able to drink coffee without any issues, where before it would come right back up.

5

Patient Review

11/12/2020

Prilosec for Heartburn

I did experience some dizziness and it took about 4 days to start lessening the nausea. However, I am very pleased with this treatment overall.

5

Patient Review

11/12/2020

Prilosec for Heartburn

I did experience some dizziness and it took about four days for the nausea to start subsiding.

5

Patient Review

3/14/2021

Prilosec for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication is effective.

2.3

Patient Review

10/3/2022

Prilosec for Excessive Production of Stomach Acid

I noticed an initial improvement after starting this medication, but after five days I started feeling silly and unfocused. Additionally, I developed chest and back pain. Thankfully, these symptoms all subsided within two days of no longer taking the medication.

2.3

Patient Review

10/3/2022

Prilosec for Excessive Production of Stomach Acid

At first it was effective but after five days I started feeling silly and experiencing chest and back pain. After two days of not taking the medication, I definitely noticed an improvement.

1

Patient Review

6/22/2022

Prilosec for Inflammation of the Esophagus with Erosion

I took this drug for two weeks and it turned me into a different person. I was anxious, depressed, and felt tingling and sadness. I'm off the drug now, but I wonder how long the side effects will last.

1

Patient Review

6/22/2022

Prilosec for Inflammation of the Esophagus with Erosion

This drug turned me into a different person. I felt anxiety, depression, tingling and sadness while taking it for two weeks. I've been off the drug for five days now and I'm wondering how long the side effects will last.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about prilosec

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Prilosec used to treat?

"Prilosec OTC is a medication used to treat heartburn that occurs frequently, defined as heartburn occurring two or more days per week. Heartburn is caused by stomach contents backing up into the esophagus, and is characterized by a burning sensation in the chest."

Answered by AI

Is it OK to take Prilosec every day?

"To use Prilosec OTC, take one pill every day for 14 days. Do not take more than one pill every day or more than every 4 months unless a doctor tells you to."

Answered by AI

What is the difference between omeprazole and Prilosec?

"Omeprazole (Prilosec) is a medication that is cheap and generic that is available both over the counter and with a prescription. It belongs to a class of medications known as proton-pump inhibitors (PPIs) and is one of the most popular medications in the United States. It is used to treat heartburn, reflux disease (GERD), and ulcers."

Answered by AI

Why you should not take Prilosec?

"The dangers of taking Prilosec include an increased risk of kidney disease and long-term kidney damage. In a study of 125,000 PPI users over a five year period, researchers found that kidney problems often developed silently. Half of the people who developed chronic kidney damage had never had any kidney problems before taking PPIs."

Answered by AI

Clinical Trials for Prilosec

Have you considered Prilosec clinical trials?

We made a collection of clinical trials featuring Prilosec, we think they might fit your search criteria.
Go to Trials
Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+
All Sexes
Toronto, Canada

People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What the Investigators Think: The investigators believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What the Investigators are Doing: The investigators will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing the investigators will look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. The investigators will also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: The investigators have already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. The investigators have also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, the investigators need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.

Phase 4
Waitlist Available

Sunnybrook Health Sciences Centre (+4 Sites)

Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY

The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention

Recruiting
Has No Placebo

Weill Cornell Medical College

Iris Y Navarro-Millán, MD

Bristol-Myers Squibb

Image of Humana Healthcare Research, Inc. in Louisville, United States.

Academic Detailing for Rheumatoid Arthritis

Any Age
All Sexes
Louisville, KY

The goal of this trial is to learn if an interactive evidence-based educational outreach visits to clinicians who prescribe biologics change prescribing of biosimilar medications. The main questions it aims to answer are: 1. Do educational outreach visits lead to a higher number of prescriptions for biosimilar versions of adalimumab? 2. Do in-person or virtual visits work better? Researchers will compare clinicians offered the educational outreach visit to those who are not offered the visit to see if there is a difference in prescribing of biosimilar versions of adalimumab instead of the original brand-name version. Participants will be offered the chance to meet with a trained clinician who will provide educational information tailored to their knowledge and attitudes on the topic. They will also be provided an educational brochure and patient educational materials.

Waitlist Available
Has No Placebo

Humana Healthcare Research, Inc. (+1 Sites)

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Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA

Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.

Waitlist Available
Has No Placebo

University of California, Irvine - UCI Medical Center

Jason Samarasena, MD, MBA

Image of University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases in Minneapolis, United States.

Ultrasound Therapy for Rheumatoid Arthritis

18+
All Sexes
Minneapolis, MN

The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs). The non-invasive study device delivers ultrasound stimulation to the spleen to reduce inflammation. The study will enroll at least 60 participants at up to 8 sites. There will be three arms consisting of two active stimulation groups (treatment) and one non-active stimulation group (sham-control). After completing the double-blinded primary endpoint assessment period at Week 12, there will be a one-way crossover of control participants to active stimulation and an additional 12 week follow-up with all participants to evaluate long-term outcomes.

Recruiting
Drug

University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases (+4 Sites)

Daniel Zachs

SecondWave Systems Inc.

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