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What is Prezista
DarunavirThe Generic name of this drug
Treatment SummaryDarunavir is a medication used to treat HIV-1 infections, in combination with other HIV protease inhibitors and ritonavir. It was designed to be more effective at fighting drug-resistant HIV strains, and was approved by the FDA in 2006. It is also being studied as a possible treatment for the coronavirus (COVID-19), with clinical trials expected to finish in August 2020.
Prezistais the brand name
Prezista Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prezista
Darunavir
2006
25
Approved as Treatment by the FDA
Darunavir, otherwise known as Prezista, is approved by the FDA for 1 uses which include HIV .HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with Ritonavir
Effectiveness
How Prezista Affects PatientsDarunavir is used to treat HIV by blocking the virus from replicating. When taken with ritonavir as part of a combination antiretroviral therapy, darunavir can reduce the amount of virus in the body and increase the number of immune cells, making it easier for the body to fight off the virus and reducing the risk of serious health problems.
How Prezista works in the bodyDarunavir is a drug used to treat HIV infection. It works by attaching itself to the HIV-1 protease enzyme, which is necessary for the virus to spread. By attaching itself to this enzyme, darunavir stops the virus from forming mature particles and spreading the infection. Darunavir can attach itself to different parts of the enzyme, and it is also able to adapt to changes in the shape of the enzyme. This makes it an effective treatment for patients with resistant strains of HIV.
When to interrupt dosage
The advised dosage of Prezista depends upon the established condition. The quantity of dosage is contingent upon the method of delivery (e.g. Tablet or Oral) featured in the table underneath.Condition
Dosage
Administration
HIV
, 400.0 mg, 600.0 mg, 75.0 mg, 150.0 mg, 800.0 mg, 300.0 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Suspension, Suspension - Oral
Warnings
Prezista ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Prezista Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Darunavir.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Darunavir.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Darunavir.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Darunavir.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Darunavir.
Prezista Toxicity & Overdose RiskThe toxic dose of darunavir is not known, but doses of up to 3,200 mg in liquid form and 1,600 mg in tablet form with ritonavir have been given without major issues. If someone takes too much of this drug, there is no specific remedy. Treatment involves monitoring vital signs and providing supportive care. Darunavir is unlikely to be removed by dialysis because it binds strongly to proteins.
Prezista Novel Uses: Which Conditions Have a Clinical Trial Featuring Prezista?
43 active clinical trials are currently being conducted to appraise Prezista's effectiveness in treating HIV (Human Immunodeficiency Virus).Condition
Clinical Trials
Trial Phases
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Prezista Reviews: What are patients saying about Prezista?
5Patient Review
4/14/2015 This medication, in combination with others, has helped me a lot. It's made such a difference and I'm so grateful.
5Patient Review
8/4/20105Patient Review
1/9/20115Patient Review
8/19/20124.7Patient Review
8/11/20124.3Patient Review
2/14/2009Patient Q&A Section about prezista
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is PREZISTA generic?
"Prezista is the brand name for the drug darunavir. The generic form of this drug will now be supplied which also contains darunavir."
Answered by AI
What is PREZISTA 800 mg used for?
"Tablets that contain 400 or 800 milligrams (mg) of PREZISTA may be used to create dose regimens that are appropriate for the treatment of HIV-1 infection in adult and pediatric patients who are at least 3 years old and weigh at least 40 kilograms (kg), and who have not previously received antiretroviral therapy (ART) (see section 4.2 for more information)."
Answered by AI