Potassium Citrate

Constipation, Uremia, Kidney Stones + 10 more
Treatment
7 FDA approvals
20 Active Studies for Potassium Citrate

What is Potassium Citrate

Potassium citrateThe Generic name of this drug
Treatment SummaryPotassium citrate, or tripotassium citrate, is a white, odorless powder with a salty taste. It contains 38.3% potassium by weight and becomes very moist when exposed to air. Potassium citrate is used to treat kidney stones caused by renal tubular acidosis and hypocitraturic calcium oxalate nephrolithiasis.
Urocit-Kis the brand name
image of different drug pills on a surface
Potassium Citrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Urocit-K
Potassium citrate
1985
60

Approved as Treatment by the FDA

Potassium citrate, otherwise called Urocit-K, is approved by the FDA for 7 uses like NEPHROLITHIASIS, CALCIUM OXALATE and Nephrolithiasis .
NEPHROLITHIASIS, CALCIUM OXALATE
Helps manage Hypocitraturic calcium oxalate nephrolithiasis
Nephrolithiasis
Tubular Acidosis; Renal
Helps manage Tubular Acidosis; Renal
uric acid lithiasis
Helps manage uric acid lithiasis
uric acid
Renal tubular acidosis
Helps manage Tubular Acidosis; Renal
Lithiasis
Helps manage uric acid lithiasis

Effectiveness

How Potassium Citrate Affects PatientsPotassium citrate affects the urine in a way that helps prevent crystals and stones from forming in the kidneys. It increases the citrate levels in the urine to make it harder for salts like calcium oxalate, calcium phosphate, and uric acid to form crystals. It also stops crystals from forming on their own.
How Potassium Citrate works in the bodyAfter taking potassium citrate, it is broken down in the body and produces an alkaline load. Potassium citrate increases the amount of citrate in the urine, as well as its pH level. Potassium citrate also increases the amount of potassium in the urine, but can also cause a temporary decrease in calcium levels.

When to interrupt dosage

The suggested measure of Potassium Citrate is contingent upon the acknowledged disorder, including Metabolic Acidosis, laxative and Renal tubular acidosis. The quantity of dosage is outlined in the table beneath, reliant upon the method of delivery (e.g. Solution - Oral or Liquid).
Condition
Dosage
Administration
Metabolic acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Uremia
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Constipation
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Renal tubular acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Bowel preparation therapy
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Kidney Stones
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Lithiasis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
NEPHROLITHIASIS, CALCIUM OXALATE
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Gout Flares
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Nephrolithiasis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
uric acid
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
laxative
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral

Warnings

Potassium Citrate Contraindications
Condition
Risk Level
Notes
Hyperkalemia
Do Not Combine
Renal Insufficiency
Do Not Combine
Urinary tract infection
Do Not Combine
Gastrointestinal tract structure
Do Not Combine
Peptic Ulcer Disease
Do Not Combine
There are 20 known major drug interactions with Potassium Citrate.
Common Potassium Citrate Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The excretion of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when combined with Potassium citrate.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The excretion of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when combined with Potassium citrate.
4-Bromo-2,5-dimethoxyamphetamine
Major
The excretion of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when combined with Potassium citrate.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Potassium citrate.
Amiloride
Major
The risk or severity of hyperkalemia can be increased when Potassium citrate is combined with Amiloride.
Potassium Citrate Toxicity & Overdose RiskThe toxic dose of this drug in dogs is 176 mg/kg when given intravenously.
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Potassium Citrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Potassium Citrate?

74 ongoing trials are assessing the capacity of Potassium Citrate to provide Bowel preparation therapy, Kidney Stones and Chronic Constipation relief.
Condition
Clinical Trials
Trial Phases
Kidney Stones
42 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4, Phase 2
Constipation
16 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3
Bowel preparation therapy
1 Actively Recruiting
Phase 1, Phase 2
Metabolic acidosis
0 Actively Recruiting
NEPHROLITHIASIS, CALCIUM OXALATE
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
Lithiasis
0 Actively Recruiting
uric acid
1 Actively Recruiting
Phase 4
Acidosis
0 Actively Recruiting
Uremia
0 Actively Recruiting
Renal tubular acidosis
0 Actively Recruiting
laxative
0 Actively Recruiting

Potassium Citrate Reviews: What are patients saying about Potassium Citrate?

5Patient Review
3/28/2013
Potassium Citrate for Calcium Oxalate Kidney Stones
I was having to go through kidney stone surgery multiple times per year, but since I started taking this medication, I haven't had a single operation in 18 months. It has caused irregular heart beat but a heart pill is reducing that.
5Patient Review
9/18/2016
Potassium Citrate for High Amount of Oxalic Acid in the Urine
This medication is great for me, given that I was born with bad kidneys. I have experienced no negative side effects and my kidney count has been stable for 8 years.
5Patient Review
3/23/2022
Potassium Citrate for Prevention of Calcium-Containing Kidney Stones
I had two operations for kidney stones, which caused my kidneys to swell up. Since then, I've passed a kidney stone every year or so. However, since I started taking this medication, I've only passed one stone. And weirdly enough, I also started losing weight without even dieting! I went from a size 18 to a size 14 in just three months. Clearly my body needed some potassium! At first I felt a little strange taking the medication, but after a few weeks I felt perfectly normal again.
5Patient Review
10/8/2013
Potassium Citrate for Calcium Oxalate Kidney Stones
After a few weeks of mild stomach discomfort, this drug really helped to shrink my stones and I haven't had any growth in over two years!
5Patient Review
7/28/2016
Potassium Citrate for Uric Acid Kidney Stones
I had 25 stones and many ER visits and surgical procedures. Since starting this drug over 1 1/2 years ago, no more stones....so happy...
View All Reviews
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Patient Q&A Section about potassium citrate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of taking potassium citrate?

"If you experience any of the following serious side effects while taking this medication, you should tell your doctor right away:

-Muscle cramps or weakness

-Severe dizziness

-Slow or irregular heartbeat

-Mental/mood changes (such as confusion or restlessness)

-Tingling of the hands or feet

-Unusually cold skin"

Answered by AI

Is potassium citrate good for health?

"Potassium citrate is a compound consisting of potassium and citric acid, often used as a food additive. Its health benefits include aiding heart and bone health, as well as helping with conditions like kidney stones."

Answered by AI

What is potassium citrate used for?

"Potassium citrate is used to treat a kidney stone condition called renal tubular acidosis. It is also used to prevent kidney stones from forming in people who have gout. Potassium citrate works by making urine more alkaline, which helps to prevent kidney stones from forming."

Answered by AI

Can I take potassium citrate every day?

"Adults should start by taking 15 to 30 milliequivalents (mEq) of the medication two times a day, or 10 to 20 mEq three times a day. The doctor may increase the dose as needed, but the dose usually should not exceed 100 mEq per day. Children's dosages must be determined by a doctor."

Answered by AI

Clinical Trials for Potassium Citrate

Have you considered Potassium Citrate clinical trials? We made a collection of clinical trials featuring Potassium Citrate, we think they might fit your search criteria.
Have you considered Potassium Citrate clinical trials? We made a collection of clinical trials featuring Potassium Citrate, we think they might fit your search criteria.
Have you considered Potassium Citrate clinical trials? We made a collection of clinical trials featuring Potassium Citrate, we think they might fit your search criteria.
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