Posaconazole

Mucormycosis, Coccidioidomycosis, Neutropenia + 11 more
Treatment
1 FDA approval
20 Active Studies for Posaconazole

What is Posaconazole

PosaconazoleThe Generic name of this drug
Treatment SummaryPosaconazole is a medication used to treat fungal infections in people whose immune systems are weakened. It is used to treat infections caused by Candida and Aspergillus species.
Noxafilis the brand name
Posaconazole Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Noxafil
Posaconazole
2006
25

Approved as Treatment by the FDA

Posaconazole, also known as Noxafil, is approved by the FDA for 1 uses including Bronchopulmonary Aspergillosis .
Bronchopulmonary Aspergillosis

Effectiveness

How Posaconazole Affects PatientsPosaconazole is a powerful antifungal medication. It is similar to itraconazole, but has a few changes to the structure that makes it stronger and more effective. Posaconazole can either kill fungi or stop it from growing.
How Posaconazole works in the bodyPosaconazole is a triazole antifungal drug that works by blocking the cytochrome P-450 enzyme in fungi, which is essential for producing ergosterol. Without ergosterol, the fungal cell membrane can't be made, leading to the death of the fungus.

When to interrupt dosage

The measure of Posaconazole is contingent upon the determined condition, including prophylaxis of Aspergillus infection, HIV and Coccidioidomycosis. The magnitude of dosage is subject to the technique of administration (e.g. Intravenous or Solution - Intravenous) noted in the subsequent table.
Condition
Dosage
Administration
prophylaxis of Candida Infections
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
prophylaxis of Aspergillus infection
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Oropharyngeal Candidiasis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Esophageal Candidiasis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
HIV
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Mucormycosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Coccidioidomycosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Yeast Infection
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Chronic Graft Versus Host Disease
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Neutropenia
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Cryptococcosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Invasive Aspergillosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Bronchopulmonary Aspergillosis
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Immunocompromised
, 100.0 mg, 40.0 mg/mL, 300.0 mg, 18.0 mg/mL, 30.0 mg/mL, 200.0 mg/mL
, Suspension, Oral, Suspension - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Tablet, coated, Tablet, coated - Oral, Powder, for suspension, Powder, for suspension - Oral

Warnings

Posaconazole has three identified contraindications, so it should not be utilized while confronting any of the conditions in the following table.Posaconazole Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Posaconazole.
Common Posaconazole Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Posaconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Posaconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Posaconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Posaconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Posaconazole.
Posaconazole Toxicity & Overdose RiskIn clinical trials, patients were given up to 1600mg/day of posaconazole with no adverse effects. One patient did accidentally take 1200mg twice a day for 3 days, but there were no noticeable side effects from the overdose.

Posaconazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Posaconazole?

187 active studies are underway to evaluate the potential of Posaconazole to provide prophylaxis against Aspergillus infection, Candida Infections and HIV.
Condition
Clinical Trials
Trial Phases
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Bronchopulmonary Aspergillosis
0 Actively Recruiting
Invasive Aspergillosis
1 Actively Recruiting
Phase 3
Cryptococcosis
0 Actively Recruiting
Mucormycosis
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
Immunocompromised
4 Actively Recruiting
Phase 3, Not Applicable, Phase 1
prophylaxis of Aspergillus infection
0 Actively Recruiting
Oropharyngeal Candidiasis
0 Actively Recruiting
Neutropenia
14 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
Coccidioidomycosis
1 Actively Recruiting
Phase 2
Yeast Infection
6 Actively Recruiting
Phase 1, Phase 2, Phase 3, Early Phase 1, Not Applicable
Chronic Graft Versus Host Disease
29 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
prophylaxis of Candida Infections
0 Actively Recruiting

Posaconazole Reviews: What are patients saying about Posaconazole?

5Patient Review
1/2/2008
Posaconazole for Prevention of Invasive Pulmonary Aspergillosis
I'm a heart transplant patient who developed aspergillosis pneumonia, as well as mucormyosis. The typical treatment was destroying my kidneys, but doctors tried this new medication when it was just released from the ADA. That was a year ago and my "spot" in my lungs has all but disappeared. The infectious disease doctors at the University of Michigan are all amazed.
4.3Patient Review
4/26/2011
Posaconazole for Prevention of Invasive Pulmonary Aspergillosis
This medication had few side effects and I was able to tolerate it well.
3Patient Review
3/16/2010
Posaconazole for Osteoporosis
This treatment is great. I love how it helps me feel better.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about posaconazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is posaconazole used for?

"The tablets, suspension, and delayed-release suspension of posaconazole are used to prevent certain fungal infections, such as Aspergillus or Candida, in patients with a weakened immune system."

Answered by AI

Is posaconazole an antibiotic?

"This medication is used to prevent certain fungal infections in people who have a weakened immune system. It belongs to a group of drugs called azole antifungals. It works by stopping the growth of fungi."

Answered by AI

How long should posaconazole be taken?

"For adults and children 13 years of age and older, the recommended dosage is 300 milligrams (mg) (three 100 mg delayed-release tablets) 2 times a day on the first day, followed by 300 mg once a day for 6 to 12 weeks."

Answered by AI

Is posaconazole a steroid?

"Posaconazole is an antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients."

Answered by AI

Clinical Trials for Posaconazole

Have you considered Posaconazole clinical trials? We made a collection of clinical trials featuring Posaconazole, we think they might fit your search criteria.
Have you considered Posaconazole clinical trials? We made a collection of clinical trials featuring Posaconazole, we think they might fit your search criteria.
Have you considered Posaconazole clinical trials? We made a collection of clinical trials featuring Posaconazole, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top