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What is Pizensy
LactitolThe Generic name of this drug
Treatment SummaryLactitol is a sugar alcohol used in food to sweeten it. It is not as sweet as regular sugar, but still has a mild sweetness. It has also been clinically studied as a laxative and is used to help treat liver disease in patients with cirrhosis. Pizensy, an oral lactitol powder, was approved by the FDA in 2020 to treat chronic idiopathic constipation.
Pizensyis the brand name
Pizensy Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pizensy
Lactitol
2020
1
Effectiveness
How Pizensy Affects PatientsLactitol helps make it easier to go to the bathroom by bringing water into the digestive system. When taking lactitol, it is important to take any other medications at least two hours before or after taking lactitol to avoid reducing their effectiveness.
How Pizensy works in the bodyLactitol works as a laxative by increasing the amount of water in the small intestine. This extra water softens stool and helps people pass it more easily.
When to interrupt dosage
The measure of Pizensy is based on the diagnosed situation, like chronic idiopathic constipation (CIC), Constipation and Hepatic Encephalopathy. The dosage depends on the method of delivery as detailed in the table below.Condition
Dosage
Administration
Hepatic Encephalopathy
, 1.0 mg/mg
, Powder, for solution - Oral, Oral, Powder, for solution
Constipation
, 1.0 mg/mg
, Powder, for solution - Oral, Oral, Powder, for solution
Constipation
, 1.0 mg/mg
, Powder, for solution - Oral, Oral, Powder, for solution
chronic idiopathic constipation (CIC)
, 1.0 mg/mg
, Powder, for solution - Oral, Oral, Powder, for solution
Warnings
Pizensy ContraindicationsCondition
Risk Level
Notes
Galactosemias
Do Not Combine
Mechanical Intestinal Obstruction
Do Not Combine
Common Pizensy Drug Interactions
Drug Name
Risk Level
Description
Alloin
Minor
The risk or severity of adverse effects can be increased when Lactitol is combined with Alloin.
Calcium polycarbophil
Minor
The risk or severity of adverse effects can be increased when Lactitol is combined with Calcium polycarbophil.
Deacetylbisacodyl
Minor
The risk or severity of adverse effects can be increased when Lactitol is combined with Deacetylbisacodyl.
Frangula purshiana bark
Minor
The risk or severity of adverse effects can be increased when Lactitol is combined with Frangula purshiana bark.
Konjac mannan
Minor
The risk or severity of adverse effects can be increased when Lactitol is combined with Konjac mannan.
Pizensy Toxicity & Overdose RiskThe lowest toxic dose of lactitol in mice has been found to be 23g/kg, and greater than 30g/kg in rats. There is not much experience with acute overdosage, but it is likely to cause significant stomach discomfort and diarrhea. Treatment for overdosing on lactitol should involve supportive measures to manage the symptoms.
Pizensy Novel Uses: Which Conditions Have a Clinical Trial Featuring Pizensy?
Presently, 26 active studies are investigating the utility of Pizensy in managing chronic idiopathic constipation (CIC), Constipation and Hepatic Encephalopathy.Condition
Clinical Trials
Trial Phases
Hepatic Encephalopathy
0 Actively Recruiting
Constipation
38 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Early Phase 1
chronic idiopathic constipation (CIC)
0 Actively Recruiting
Constipation
0 Actively Recruiting
Pizensy Reviews: What are patients saying about Pizensy?
5Patient Review
6/17/2020 Given to me after being in a prison riot, this medication really helped with the nightmares and replay of events. I would caution anyone taking it not to shower immediately afterwards though - I did and ended up passing out cold!
5Patient Review
6/2/2021 This medication has helped my urination and BPH a lot. I take it twice a day, once at night and once at noon, and it's lowered my blood pressure by 20 points.
5Patient Review
12/16/2017 I had severe, trauma-related nightmares for 20 years. This medication worked for me instantly. I have zero side effects. I will take this medicine forever.
5Patient Review
6/2/2021 I've been taking this medication for years to help with my BPH and it's really effective. I urinate once during the night and it lowers my blood pressure by 20 points.
5Patient Review
4/4/2022 I've been using this drug for seven months to great success. I haven't experienced any significant side effects, and it's really helped reduce my PTSD-related night terrors and anxiety.
5Patient Review
6/17/2020 After being in a prison riot and seeing some pretty traumatizing things, I started having bad nightmares. My doctor prescribed me this medication, and it's been really effective. I don't remember what I dream now, but that's probably for the best. Just be careful not to take it before you shower; I did that once and ended up passing out!
5Patient Review
12/16/2017 I had suffered from severe nightmares for two decades before finally trying this medication. It worked immediately and I haven't experienced any negative side effects.
5Patient Review
12/16/2017 I had suffered from severe nightmares for two decades before trying this medication. It worked immediately and I haven't experienced any negative side effects. This is a lifelong treatment for me.
5Patient Review
6/17/2020 This treatment was a lifesaver for me. I was in a prison riot and saw some pretty traumatizing things. Ever since then, I've been plagued by nightmares and night terrors. But this medication helped me sleep soundly through the night without any issues. I don't remember anything from my dreams, but that's okay. Just be careful not to take it right before you shower; I did that once and ended up passing out!
5Patient Review
6/2/2021 This medication not only makes it easier for me to urinate, but also significantly lowers my blood pressure. I've been taking it for years with no side effects whatsoever.
5Patient Review
4/4/2022 This drug has been hugely effective in reducing my PTSD-related night terrors and anxiety, and I haven't experienced any major side effects after taking it for seven months.
5Patient Review
4/4/2022 This drug has been hugely effective for me in reducing PTSD-related night terrors and anxiety, and I've taken it now for seven months with no significant side effects.
3.7Patient Review
1/2/2018 I am being treated for combat related PTSD. The medication has helped me to stop having nightmares, but the dreams I have now are strange and often bizarre. My wife once woke me up because I was howling in my sleep; it's better than nightmares, but still not ideal.
3.7Patient Review
4/26/2018 My blood pressure has lowered since taking this medication, however I have also been experiencing some very unpleasant gastrointestinal side effects.
3.7Patient Review
1/2/2018 I am being treated for combat related ptsd. I stopped having nightmares but the dreams I have are crazy. Sometimes they are way off the wall. My wife has woke me because I was howling one night when we were staying in a hotel. Itâ??s a real change but better than nightmares.
3.7Patient Review
4/26/2018 I saw a significant decrease in my blood pressure, but unfortunately experienced very uncomfortable gastrointestinal side effects.
3.7Patient Review
1/2/2018 I am being treated for combat related ptsd. I stopped having nightmares but the dreams I have are crazy. Sometimes they are way off the wall. My wife has woke me because I was howling one night when we were staying in a hotel. Itâ??s a real change but better than nightmares.
3.7Patient Review
4/26/2018 My blood pressure has lowered significantly since taking this medication, but I have also been experiencing some very unpleasant side effects like diarrhea, stomach cramps, fever, chills, and nausea.
3.3Patient Review
8/10/2021 Prazosin was highly effective in curbing my nightmares and PTSD symptoms. However, I could not find a dosage that didn't make me feel faint all the time due to low blood pressure. My blood pressure is on the lower end of optimal and I found that it would drop quite easily. So this might not be for everyone.
3.3Patient Review
8/10/2021 Prazosin was great for treating my nightmares and PTSD symptoms. However, I could never find a dosage that didn't make me feel faint all the time because of low blood pressure. If you have similar issues, this might not be the drug for you.
3.3Patient Review
8/10/2021 Prazosin was great for stopping my nightmares and alleviating some of my PTSD symptoms. However, I could never find a dosage that worked well for me without making me feel faint all the time due to low blood pressure.
3Patient Review
11/29/2021 Unfortunately, the prazosin hcl given to me by the VA hasn't helped with my nightmare problem.
3Patient Review
11/29/2021 Prazosin HCL has been ineffective for me in treating my nightmares. I've tried taking it at different doses (5mg, 15mg) but it never really helped.
3Patient Review
11/29/2021 Unfortunately, this medication didn't help me with my nightmares. I'm currently taking 15mg per night, but it's just not effective.
2Patient Review
12/6/2017 My husband, a 23-year military veteran with PTSD and TBI, was prescribed this for his PTSD nightmares. Unfortunately, it had the opposite effect; he experienced worse dreams (though not nightmares), nausea, headaches, dizziness, and lightheadedness. He also looked like a zombie from lack of sleep. We won't be taking this again.
2Patient Review
12/6/2017 My husband, who is a medically retired 23-year military veteran with PTSD and TBI, was prescribed this for his PTSD nightmares. Unfortunately, it not only failed to help him, but made him worse by causing vivid dreams (not nightmares or terrors) that kept him restless all night long (sleep talking and very active body movements), as well as nausea, headache, severe dizziness and lightheadedness. After a few days of taking this medication, he feels even worse and looks like a zombie from lack of sleep. We won't be taking this again.
2Patient Review
12/6/2017 My husband, a 23-year military veteran who medical retirement due to PTSD and TBI, was prescribed this medication for his PTSD nightmares. Unfortunately, it not only failed to help him, but made him worse. He experienced vivid dreams (not nightmares or terrors), restless sleep (including talking and active body movements all night), nausea, headache, severe dizziness and lightheadedness. After a few days on the medication, he looked like a zombie from lack of sleep. We won't be taking this again.
1.7Patient Review
4/23/2021 This dangerous drug can cause permanent short-term memory loss. Please be informed before taking it. It's effective against PTSD because it makes you forget about the traumatic event. However, this is not necessarily a good thing. If your job requires you to think and remember things, this drug could potentially ruin your career.
1.7Patient Review
4/23/2021 This drug is dangerous and caused me to lose my short-term memory permanently. Be warned: it's effective against PTSD because it makes you forget what happened. NOT GOOD. If your job requires critical thinking, this will destroy your career.
1.7Patient Review
2/20/2019 This medication is unfortunately causing me to wake up more at night to use the restroom.
1.7Patient Review
2/20/2019 I've been having to wake up more at night to use the restroom since starting this treatment.
1.7Patient Review
4/23/2021 This drug has some serious risks associated with it. Namely, it can cause permanent short-term memory loss. I urge you to think long and hard before taking this medication.
1.7Patient Review
2/20/2019 This medication seems to be causing more nocturnal trips to the bathroom.
1Patient Review
12/17/2021 One word of caution: I was instructed to take this before bed, and ended up passing out on my bathroom floor in the middle of the night. Be careful if you decide to try this medication.
1Patient Review
12/17/2021 I was warned by my doctor that this medication could cause people with chronic nightmares and PTSD to pass out. Unfortunately, I experienced this first-hand after taking the recommended dose before bed. I woke up in the middle of the night to use the restroom and ended up passing out on the bathroom floor. Needless to say, I didn't risk taking it again. Please be careful if you do decide to try it.
1Patient Review
12/17/2021 Please be careful with this medication. I was told by my doctor that it has had positive effects for people with chronic nightmares and PTSD, so I took it before bed as directed. However, I woke up in the middle of the night to use the restroom and ended up passing out on the bathroom floor. Fortunately, I only have experience with one dose; however, if you hit your head while taking this medication, it could be very dangerous.
Patient Q&A Section about pizensy
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Who makes Pizensy?
"If the patient experiences loose stools, the dose of Pizensy™ can be lowered to 10 grams mixed with 4 to 8 ounces of fluid."
Answered by AI
What is Pizensy?
"Lactitol (Pizensy) is a medication used to treat adults with long-term constipation of unknown cause or chronic idiopathic constipation (CIC). The medication comes as a powder that needs to be mixed with a liquid before taking. It is only available as a brand medication and might be expensive."
Answered by AI
Is Lactitol FDA approved?
"The new drug is a type of laxative that can be used to treat chronic constipation that doesn't have a specific cause. The U.S. Food and Drug Administration has approved it for use in adults."
Answered by AI
What is the use of lactulose?
"Lactulose is a synthetic sugar used as a laxative to treat constipation. It is broken down in the colon by bacteria into lactic acid and other short-chain fatty acids, which have a osmotic effect and draw water out from the body into the colon, softening stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease."
Answered by AI