Pizensy

Constipation, Constipation, Hepatic Encephalopathy + 1 more

Treatment

17 Active Studies for Pizensy

Treatment for

Constipation

What is Pizensy

LactitolThe Generic name of this drug

Treatment SummaryLactitol is a sugar alcohol used in food to sweeten it. It is not as sweet as regular sugar, but still has a mild sweetness. It has also been clinically studied as a laxative and is used to help treat liver disease in patients with cirrhosis. Pizensy, an oral lactitol powder, was approved by the FDA in 2020 to treat chronic idiopathic constipation.

Pizensyis the brand name

Pizensy Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Pizensy

Lactitol

2020

Effectiveness

How Pizensy Affects PatientsLactitol helps make it easier to go to the bathroom by bringing water into the digestive system. When taking lactitol, it is important to take any other medications at least two hours before or after taking lactitol to avoid reducing their effectiveness.

How Pizensy works in the bodyLactitol works as a laxative by increasing the amount of water in the small intestine. This extra water softens stool and helps people pass it more easily.

When to interrupt dosage

The measure of Pizensy is based on the diagnosed situation, like chronic idiopathic constipation (CIC), Constipation and Hepatic Encephalopathy. The dosage depends on the method of delivery as detailed in the table below.

Condition

Dosage

Administration

Constipation

, 1.0 mg/mg

, Powder, for solution - Oral, Oral, Powder, for solution

Constipation

, 1.0 mg/mg

, Powder, for solution - Oral, Oral, Powder, for solution

Hepatic Encephalopathy

, 1.0 mg/mg

, Powder, for solution - Oral, Oral, Powder, for solution

chronic idiopathic constipation (CIC)

, 1.0 mg/mg

, Powder, for solution - Oral, Oral, Powder, for solution

Warnings

Pizensy Contraindications

Condition

Risk Level

Notes

Galactosemias

Do Not Combine

Mechanical Intestinal Obstruction

Do Not Combine

There are 19 known major drug interactions with Pizensy.

Common Pizensy Drug Interactions

Drug Name

Risk Level

Description

Alloin

Minor

The risk or severity of adverse effects can be increased when Lactitol is combined with Alloin.

Calcium polycarbophil

Minor

The risk or severity of adverse effects can be increased when Lactitol is combined with Calcium polycarbophil.

Deacetylbisacodyl

Minor

The risk or severity of adverse effects can be increased when Lactitol is combined with Deacetylbisacodyl.

Frangula purshiana bark

Minor

The risk or severity of adverse effects can be increased when Lactitol is combined with Frangula purshiana bark.

Konjac mannan

Minor

The risk or severity of adverse effects can be increased when Lactitol is combined with Konjac mannan.

Pizensy Toxicity & Overdose RiskThe lowest toxic dose of lactitol in mice has been found to be 23g/kg, and greater than 30g/kg in rats. There is not much experience with acute overdosage, but it is likely to cause significant stomach discomfort and diarrhea. Treatment for overdosing on lactitol should involve supportive measures to manage the symptoms.

image of a doctor in a lab doing drug, clinical research

Pizensy Novel Uses: Which Conditions Have a Clinical Trial Featuring Pizensy?

Presently, 26 active studies are investigating the utility of Pizensy in managing chronic idiopathic constipation (CIC), Constipation and Hepatic Encephalopathy.

Condition

Clinical Trials

Trial Phases

Hepatic Encephalopathy

0 Actively Recruiting

Constipation

0 Actively Recruiting

chronic idiopathic constipation (CIC)

1 Actively Recruiting

Phase 2, Phase 3

Constipation

16 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3

Pizensy Reviews: What are patients saying about Pizensy?

5Patient Review

6/17/2020

Pizensy for Chronic Post Traumatic Stress Disorder with Trauma-related Nightmares

Given to me after being in a prison riot, this medication really helped with the nightmares and replay of events. I would caution anyone taking it not to shower immediately afterwards though - I did and ended up passing out cold!

5Patient Review

6/2/2021

Pizensy for High Blood Pressure

This medication has helped my urination and BPH a lot. I take it twice a day, once at night and once at noon, and it's lowered my blood pressure by 20 points.

5Patient Review

12/16/2017

Pizensy for Chronic Post Traumatic Stress Disorder with Trauma-related Nightmares

I had severe, trauma-related nightmares for 20 years. This medication worked for me instantly. I have zero side effects. I will take this medicine forever.

5Patient Review

6/2/2021

Pizensy for High Blood Pressure

I've been taking this medication for years to help with my BPH and it's really effective. I urinate once during the night and it lowers my blood pressure by 20 points.

5Patient Review

4/4/2022

Pizensy for Posttraumatic Stress Syndrome

I've been using this drug for seven months to great success. I haven't experienced any significant side effects, and it's really helped reduce my PTSD-related night terrors and anxiety.

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about pizensy

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who makes Pizensy?

"If the patient experiences loose stools, the dose of Pizensy™ can be lowered to 10 grams mixed with 4 to 8 ounces of fluid."

Answered by AI

What is Pizensy?

"Lactitol (Pizensy) is a medication used to treat adults with long-term constipation of unknown cause or chronic idiopathic constipation (CIC). The medication comes as a powder that needs to be mixed with a liquid before taking. It is only available as a brand medication and might be expensive."

Answered by AI

Is Lactitol FDA approved?

"The new drug is a type of laxative that can be used to treat chronic constipation that doesn't have a specific cause. The U.S. Food and Drug Administration has approved it for use in adults."

Answered by AI

What is the use of lactulose?

"Lactulose is a synthetic sugar used as a laxative to treat constipation. It is broken down in the colon by bacteria into lactic acid and other short-chain fatty acids, which have a osmotic effect and draw water out from the body into the colon, softening stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease."

Answered by AI