Contingency Management for Methamphetamine Addiction

(RCT (05) Trial)

Overseen By William W Stoops, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: William Stoops

Must be taking: Buprenorphine, Methadone

Disqualifiers: Unstable angina, Cardiac arrhythmia, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 weeks

300 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a treatment called contingency management to help reduce methamphetamine use. The goal is to understand how reducing meth use can benefit health and social lives, potentially improving future treatment development. Participants will be divided into two groups: one group earns rewards for providing drug-free urine samples, while the other provides samples without rewards. This trial suits individuals who have recently used meth, meet specific criteria for methamphetamine use disorder, and seek treatment. As an unphased trial, it offers participants the chance to contribute to innovative research that could shape future treatment options.

What prior data suggests that Contingency Management is safe for methamphetamine addiction treatment?

Research has shown that contingency management is a safe and well-accepted method to help people reduce methamphetamine use. Studies indicate it is among the most effective methods for this purpose. As individuals continue with this treatment, they typically attend more sessions and further decrease their drug use. A 2020 review of 27 studies found that this approach offers long-term benefits for managing methamphetamine use disorder. Reports of harmful effects are not significant, making it a promising option for those seeking to reduce methamphetamine use. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about Contingency Management for methamphetamine addiction because it offers a unique approach compared to traditional treatments like cognitive-behavioral therapy and pharmacotherapy. Unlike these standard methods, Contingency Management provides tangible rewards, like payments, for producing drug-free urine samples, directly motivating individuals to abstain from drug use. This method taps into the brain's reward system, making it a potentially powerful tool in encouraging long-term behavioral change. By harnessing positive reinforcement, this approach could lead to higher success rates in maintaining sobriety, which is a major challenge with current treatments.

What evidence suggests that contingency management is effective for methamphetamine addiction?

Research has shown that contingency management (CM), which participants in this trial may receive, effectively helps people reduce methamphetamine use. Studies have found that CM works by rewarding individuals who provide drug-free urine samples. Evidence from various clinics and groups, including men who have sex with men (MSM), supports this method. Reviews also highlight CM as one of the best-proven treatments for methamphetamine addiction. Overall, CM offers a promising approach for treating methamphetamine use disorder. ^{1 3 6 7 8}

Who Is on the Research Team?

William W Stoops, PhD

Principal Investigator

University of Kentucky

Are You a Good Fit for This Trial?

This trial is for adults over 18 with moderate to severe Methamphetamine Use Disorder (MUD), who have used methamphetamine in the week before screening and tested positive for it. They must be willing to commit to a 12-week intervention and follow-up, seeking treatment for meth use. Those on buprenorphine or methadone for Opioid Use Disorder can also join.

Inclusion Criteria

I am 18 years old or older.

I have used methamphetamine in the last week.

My urine test for methamphetamine was positive.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants provide urine samples and receive payments based on methamphetamine-negative results

12 weeks

Weekly visits

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Contingency Management

Trial Overview

The study tests Contingency Management, an approach that rewards individuals when they reduce their drug use, aiming to demonstrate the benefits of reduced methamphetamine use. The goal is to establish new treatment endpoints and speed up therapy development for MUD.

How Is the Trial Designed?

Group I: Contingency Management Group Experimental Treatment 1 Intervention

This group will receive payment for providing methamphetamine negative urine samples throughout the trial.

Group II: Control Group Active Control 1 Intervention

This group will receive payment for providing urine samples throughout the trial.

Who Is Running the Clinical Trial?

William Stoops

Lead Sponsor

Trials

9

Recruited

240+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials

2,658

Recruited

3,409,000+

Citations

1.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/17074952/

Contingency management for the treatment of ... - PubMed

Conclusions: These results suggest that contingency management has promise as a component in treatment strategies for methamphetamine use disorder.

2.

sciencedirect.com

sciencedirect.com/science/article/abs/pii/S0376871620304725

Contingency management for the treatment of ...

Contingency management (CM) effectively reduces methamphetamine use. · CM effectiveness has been observed in community clinics and MSM subgroups.

3.

psychiatryonline.org

psychiatryonline.org/doi/10.1176/ajp.2006.163.11.1993

Contingency Management for the Treatment of ...

Conclusions: These results suggest that contingency management has promise as a component in treatment strategies for methamphetamine use ...

4.

societyforpsychotherapy.org

societyforpsychotherapy.org/contingency-management-for-stimulant-addiction-the-most-effective-evidence-based-treatment-youve-never-used/

Contingency Management for Stimulant Addiction

Two recent reviews provide strong evidence supporting the efficacy of contingency management for cocaine and methamphetamine addiction (Brown & ...

5.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/33007699/

Contingency management for the treatment of ...

Contingency management is among the most effective interventions for reducing methamphetamine use. It has been more than ten years since the ...

6.

sciencedirect.com

sciencedirect.com/science/article/abs/pii/S0306460313000907

Duration effects in contingency management treatment of ...

Attendance over time increased as Contingency Management (CM) duration increased. · Methamphetamine abstinence also increase over time as CM duration increased.

7.

chess.health

chess.health/blog/contingency-management-myths-vs-facts/

Contingency Management Myths vs. Facts

Similarly, a 2020 systematic review of 27 studies on methamphetamine use disorder ... The long-term outcomes meta-analysis found that benefits of ...

8.

library.samhsa.gov

library.samhsa.gov/sites/default/files/contingency-management-advisory-pep24-06-001.pdf

contingency-management-advisory-pep24-06-001.pdf

disorder involving cocaine, methamphetamine, or prescription stimulants [SAMHSA, 2024]). ... Contingency management for alcohol use disorder reduces cannabis use ...