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What is Pifeltro
DoravirineThe Generic name of this drug
Treatment SummaryDoravirine is a medication used to treat HIV-1 infections in adults who have not taken any antiretroviral medication before. It is available as a single drug or as a combination of doravirine, lamivudine, and tenofovir disoproxil fumarate. Doravirine is intended to be used with other antiretroviral medicines to provide more treatment options for HIV-1 infection.
Delstrigois the brand name
Pifeltro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Delstrigo
Doravirine
2018
4
Approved as Treatment by the FDA
Doravirine, also called Delstrigo, is approved by the FDA for 2 uses including HIV and Pharmacotherapy .HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with null
Pharmacotherapy
Used to treat responsive to previous drug therapy in combination with null
Effectiveness
How Pifeltro Affects PatientsA clinical trial testing different doses of doravirine (combined with emtricitabine/tenofovir) in HIV-1 infected people without prior antiretroviral treatment did not find a link between the dose taken and its effectiveness. Additionally, taking a dose of 1200 mg (which is 4 times more than the recommended dose) did not cause any significant changes to the QT interval.
How Pifeltro works in the bodyDoravirine works to stop HIV from replicating. It does this by targeting the HIV enzyme reverse transcriptase. Doravirine blocks the enzyme, preventing HIV from turning its RNA into DNA. This stops HIV from reproducing and spreading. Doravirine does not interfere with the body's normal DNA polymerases.
When to interrupt dosage
The dosage of Pifeltro is contingent upon the specified condition, including Antiretroviral Therapy, Human Immunodeficiency Virus Type 1 (HIV-1) and HIV (Human Immunodeficiency Virus). The measure varies, as per the administration approach (e.g. Tablet, film coated or Oral) provided in the table beneath.Condition
Dosage
Administration
Pharmacotherapy
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
no doravirine resistance-associated mutations
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Human Immunodeficiency Virus Type 1 (HIV-1)
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
treatment failure
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Antiretroviral Therapy
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
HIV
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Antiretroviral Treatment-Naïve
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
virologically-suppressed
100.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Pifeltro has two contraindications, and so its use should be avoided in cases of the conditions outlined in the following table.Pifeltro ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Doravirine may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
Common Pifeltro Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Doravirine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Doravirine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Doravirine.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Doravirine.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Doravirine.
Pifeltro Toxicity & Overdose RiskDoravirine affects people differently based on age, sex, race/ethnicity, kidney function, and liver function. It is not known if doravirine is safe for pregnant women or if it is present in breastmilk, so mothers should not breastfeed when taking doravirine. Doravirine has not been tested for safety in children under 18 years old or in elderly people. People with mild or moderate kidney or liver damage do not need to adjust their dosage, but people with severe kidney or liver damage have not been studied. In animal studies, Doravirine did not cause cancer,
Pifeltro Novel Uses: Which Conditions Have a Clinical Trial Featuring Pifeltro?
51 active studies are examining the viability of Pifeltro in providing Pharmacotherapy, HIV (Human Immunodeficiency Virus) and treatment failure remedies.Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Human Immunodeficiency Virus Type 1 (HIV-1)
6 Actively Recruiting
Phase 3, Phase 2, Phase 1, Early Phase 1
virologically-suppressed
0 Actively Recruiting
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
no doravirine resistance-associated mutations
0 Actively Recruiting
Pharmacotherapy
0 Actively Recruiting
Antiretroviral Treatment-Naïve
0 Actively Recruiting
Pifeltro Reviews: What are patients saying about Pifeltro?
3.7Patient Review
9/8/2021 Since taking Pifeltro, I've developed a yeast rash and my skin has become extremely dry--neither of which were issues before. Additionally, I'm losing hair at an alarming rate. Doctors have noticed this as well. I can't take a break from the medication, so I'm wondering if anyone else has had similar problems?
2.7Patient Review
10/4/2021 I was experiencing extensive hair loss, skin problems, and general malaise while taking Pifeltro. Once I stopped the medication, everything returned to normal. Thank goodness!
Patient Q&A Section about pifeltro
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of PIFELTRO?
"The most frequently reported side effects of PIFELTRO are: nausea, dizziness, headache, tiredness, diarrhea, stomach (abdominal) pain, and abnormal dreams."
Answered by AI
How much does PIFELTRO cost?
"A single dose of Pifeltro is around $56
The cost of Pifeltro oral tablet 100 mg is $1,691 for a supply of 30 tablets. Prices may vary depending on the pharmacy you visit. A single dose of Pifeltro is $56. Note that prices listed here are for cash paying customers only and may not be valid with some insurance plans."
Answered by AI
What class is Doravirine?
"Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that reduces the amount of HIV in the blood."
Answered by AI
What is PIFELTRO used for?
"This drug is used with other HIV medications to control the HIV infection by lowering the amount of HIV in the body. This, in turn, allows the immune system to work better, decreasing the likelihood of HIV complications, and improving the quality of life."
Answered by AI