Phisohex

surgical scrub therapy, prophylaxis of infection in minor cuts, scrapes, or burns, Antibiotics + 1 more
Treatment
5 FDA approvals
6 Active Studies for Phisohex

What is Phisohex

HexachloropheneThe Generic name of this drug
Treatment SummaryChlorinated bisphenol is an antiseptic found in soaps and creams used to treat skin disorders. It works by stopping the growth of bacteria, particularly those that are gram-positive, but is less effective against gram-negative bacteria.
Phisohexis the brand name
Phisohex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Phisohex
Hexachlorophene
1976
3

Approved as Treatment by the FDA

Hexachlorophene, also called Phisohex, is approved by the FDA for 5 uses including prophylaxis of infection in minor cuts, scrapes, or burns and Bacterial Infections .
prophylaxis of infection in minor cuts, scrapes, or burns
Bacterial Infections
surgical scrub therapy
Urinary Tract Infection (UTI)
Antibiotics

Effectiveness

How Phisohex Affects PatientsHexachlorophene is a cleansing agent used to clean the skin. It helps to kill bacteria and can build up its effectiveness when used multiple times. It is important to use alcohol-based soaps or alcohol to remove the antibacterial residue after use.
How Phisohex works in the bodyHexachlorophene works by blocking the energy-producing processes in bacteria. This stops the bacteria from functioning and can eventually lead to the bacteria dying.

When to interrupt dosage

The advised measure of Phisohex is contingent upon the diagnosed affliction, including Communicable Diseases, prophylaxis of infection in minor cuts, scrapes, or burns and Antibiotics. The amount of dosage hinges on the technique of delivery (e.g. Emulsion - Topical or Emulsion) noted in the table beneath.
Condition
Dosage
Administration
surgical scrub therapy
, 30.0 mg/mL, 2.0 %, 3.0 %, 5.0 mg/mL
, Topical, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Cream - Topical
prophylaxis of infection in minor cuts, scrapes, or burns
, 30.0 mg/mL, 2.0 %, 3.0 %, 5.0 mg/mL
, Topical, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Cream - Topical
Antibiotics
, 30.0 mg/mL, 2.0 %, 3.0 %, 5.0 mg/mL
, Topical, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Cream - Topical
Urinary Tract Infection (UTI)
, 30.0 mg/mL, 2.0 %, 3.0 %, 5.0 mg/mL
, Topical, Emulsion, Emulsion - Topical, Liquid, Liquid - Topical, Cream - Topical

Warnings

Phisohex Contraindications
Condition
Risk Level
Notes
use as a vaginal pack
Do Not Combine
use as tampon
Do Not Combine
use as wetpack
Do Not Combine
Burn injury
Do Not Combine
routine use for prophylactic total body bathing
Do Not Combine
Occlusive Dressings
Do Not Combine
use as lotion
Do Not Combine
use on mucous membranes
Do Not Combine
Photophobia
Do Not Combine
bathing
Do Not Combine
Common Phisohex Drug Interactions
Drug Name
Risk Level
Description
Phisohex Toxicity & Overdose RiskThe toxic dose of this drug in rats is 66mg/kg. Taking too much of this drug can lead to a loss of appetite, vomiting, stomach cramps, severe diarrhea, dehydration, seizures, low blood pressure, and shock. In some cases, it has been fatal.
image of a doctor in a lab doing drug, clinical research

Phisohex Novel Uses: Which Conditions Have a Clinical Trial Featuring Phisohex?

27 active trials are currently being conducted to probe Phisohex's potential in treating Communicable Diseases, as well as its applicability in surgical scrub therapy and Antibiotic regimens.
Condition
Clinical Trials
Trial Phases
prophylaxis of infection in minor cuts, scrapes, or burns
0 Actively Recruiting
surgical scrub therapy
0 Actively Recruiting
Urinary Tract Infection (UTI)
6 Actively Recruiting
Phase 1, Phase 3, Phase 4, Phase 2
Antibiotics
0 Actively Recruiting

Patient Q&A Section about phisohex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What was pHisoHex used for?

"Phisohex is a surgical scrub and a bacteriostatic skin cleanser. It is indicated for use to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful."

Answered by AI

Is pHisoHex good for acne?

"Hisohex is an anti-bacterial wash that helps fight the bacteria responsible for skin problems such as pimples and acne. It is also a skin cleanser, so it removes dirt and oil from blocked pores without upsetting the skin's normal pH balance."

Answered by AI

Can I use pHisoHex on face?

"If you have sensitive skin, you should test Phisohex Face Wash on a small area of your face before using it on your whole face. If you develop any irritation, discontinue use. Make sure to close the cap after using. This product is for external use only."

Answered by AI

Do they still make pHisoHex?

"Sanofi-Aventis ceased production of several forms of pHisoHex in August 2009 and entirely discontinued production of pHisoHex in September 2013."

Answered by AI

Clinical Trials for Phisohex

Image of Harbor UCLA Medical Center - Medicine - Infectious Diseases in Torrance, United States.

Optimized Beta-lactam Dosing for Bacterial Infections

18+
All Sexes
Torrance, CA
The purpose of this study is to evaluate the abilities of Cystatin C (CysC) and CysC-based estimated Glomerular Filtration Rate (eGFR) equations to characterize the pharmacokinetics (PK) profiles of meropenem and cefepime relative to Serum Creatinine (SCR), Serum Creatinine based Equation (SCRE)and iohexol at the population and individual levels in critically ill adult patients with suspected or documented AMR Gram-negative infections. We hypothesize that CysC and CysC-based eGFR equations will characterize the PK profiles of meropenem and cefepime at the population and individual levels with greater accuracy and precision than SCR and SCREs. Iohexol will be administered to patients enrolled in the study and serve as the reference indicator of measured Glomerular Filtration Rate (mGFR), which is the gold standard assessment of kidney function. We hypothesize that the predictive performances of CysC and CysC-based eGFR equations in estimating the PK profiles of meropenem and cefepime at the population and individual levels will be comparable to iohexol. The information obtained in this study will be used to develop PK/pharmacodynamics (PD) optimized meropenem and cefepime dosing schemes based on the renal function biomarker population PK (PopPK) model with the best predictive performance for clinical use in the treatment of critically ill adult patients with suspected or documented AMR Gram-negative infections and varying degrees of renal function. The primary objective of this study is to compare the abilities of renal function biomarkers (CysC, CysC-based eGFR equations, SCR, SCREs) relative to iohexol to characterize the PK profiles of meropenem and cefepime in critically ill adult patients with suspected or documented AMR Gram-negative infections.
Phase 4
Recruiting
Harbor UCLA Medical Center - Medicine - Infectious Diseases (+9 Sites)
Image of University of Missouri in Columbia, United States.

Antibiotics for Cat Bite Injuries

18+
All Sexes
Columbia, MO
Cat bites are puncture wounds that have the potential to seed bacteria deep within the joint capsule, periosteum, and bone. The hand is the most common site of bite injuries. Pasteurella multocida is the is the most common organism isolated from the mouths of cats that can cause infections after a bite. Prophylactic antibiotics are often recommended with amoxicillin-clavulanate for 3-5 days to decrease the incidence of developing an infection. However, only one randomized controlled clinical trial consisting of 12 patients has been performed to justify this course of treatment, raising the possibility that the use of antibiotics could be reduced or even eliminated. Investigators will compare different durations of prophylactic antibiotics and a placebo control for cat bites to the hand/forearm presenting to the Emergency Department, Urgent Care, Plastic Surgery Clinic using a randomized, controlled, double-blind clinical trial. Participants presenting to the University of Missouri Hospital Emergency Department, Missouri University (MU) Healthcare Urgent Care, Plastic Surgery Clinic over the next year will be offered the chance to enroll if they meet the inclusion/exclusion criteria. For inclusion, participants will be \>18 years of age, have cat bites to the hand or distal to elbow, and present within 24 hours of the cat bite injury. Participants must not present with active local or systemic infections, have received antibiotics within the past 30 days, or be immunocompromised (primary and secondary immunodeficiencies). Participants will be randomized to one of three treatment arms (placebo; amoxicillin-clavulanate 1 day; amoxicillin-clavulanate 5 days). Outcomes are the development of an infection at the location of the cat bite and/or systemic infection, adverse effects of interventions, disability assessed by Quick Disabilities of Arm, Shoulder and Hand (QuickDASH) scores, and quality of life (QOL) assessed by HAND Questionnaire (HAND-Q) scores. Infection will be assessed at day 0, day 2, day 7+/-2, day 14+/-2, and day 30+/-2 by vital signs, laboratory values, physical examination and with an infrared and digital camera. All measures will be within the standard of care, apart from the infrared camera, QuickDASH, and HAND-Q scores. The anatomic locations of cat bites to the hand/forearm will be assessed for correlations with infections.
Phase 4
Recruiting
University of MissouriKevin M Klifto, DO, PharmD
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