Pentothal

Epilepsy
Treatment
19 Active Studies for Pentothal

What is Pentothal

ThiopentalThe Generic name of this drug
Treatment SummaryThiopental is a type of barbiturate drug used to induce general anesthesia and complete short-term anesthesia for surgery. It is also used for hypnosis and to control seizure activity. In some cases, thiopental can help reduce increased pressure inside the skull. This drug does not cause excitement but has limited ability to reduce pain and relax muscles. However, small doses of thiopental may have the opposite effect and actually increase pain sensitivity.
Thiopental Sodiumis the brand name
Pentothal Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thiopental Sodium
Thiopental
2010
0

Effectiveness

How Pentothal Affects PatientsThiopental is a type of barbiturate that is used to put a patient to sleep before anesthesia. It takes effect quickly, within 30-40 seconds of injection, and can cause drowsiness and memory loss. If multiple doses are taken, it can cause a longer period of sleep. The drug is stored in fatty tissues, so it can be released slowly over time, leading to a longer period of sleep.
How Pentothal works in the bodyThiopental works by binding to the GABA receptor in the thalamus, causing the chloride ion pore to stay open longer. This allows the inhibitory effects of GABA in the thalamus to last longer.

When to interrupt dosage

The proposed dosage of Pentothal is contingent upon the diagnosed condition. The quantity of dosage fluctuates based on the method of delivery (e.g. Powder, for solution or Intravenous) featured in the table beneath.
Condition
Dosage
Administration
Epilepsy
, 1000.0 mg, 5000.0 mg, 500.0 mg, 250.0 mg, 50.0 mg/mL, 25.0 mg/mL
Intravenous, , Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Warnings

Pentothal Contraindications
Condition
Risk Level
Notes
Myotonic Dystrophy
Do Not Combine
Asthma
Do Not Combine
Shock
Do Not Combine
Porphyrias
Do Not Combine
respiratory obstruction
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Thiopental may interact with Pulse Frequency
There are 20 known major drug interactions with Pentothal.
Common Pentothal Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Thiopental.
Azelastine
Major
Thiopental may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Thiopental.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Thiopental is combined with Deutetrabenazine.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Thiopental.
Pentothal Toxicity & Overdose RiskTaking too much of a barbiturate, or taking it too quickly, can lead to a dangerously low blood pressure and even shock. Breathing difficulty, coughing, and laryngospasms may occur. In extreme cases, even a tiny amount of barbiturate in the bloodstream can be deadly if combined with other depressant drugs or alcohol.

Pentothal Novel Uses: Which Conditions Have a Clinical Trial Featuring Pentothal?

Currently, 89 active trials are examining the potential of Pentothal to alleviate Epileptic symptoms.
Condition
Clinical Trials
Trial Phases
Epilepsy
19 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1

Patient Q&A Section about pentothal

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is sodium panthenol used for?

"Sedative- hypnotic drugs are chemical substances that are used to reduce tension, anxiety and induce calmness or sleep. Most of these drugs have a calming effect at low doses and can induce sleep in larger doses."

Answered by AI

Why did they stop using Sodium Pentothal?

"Sodium thiopental was historically used to induce medical comas, but it has now been replaced by drugs such as propofol because propofol's effects wear off more quickly."

Answered by AI

What is pentothal used for?

"Pentothal (thiopental sodium for injection) is a barbiturate that helps patients relax before receiving general anesthesia with an inhaled medication."

Answered by AI

What drug is truth serum?

"Ether, a drug which induces truthfulness, prompted a confession from a police officer who had murdered his wife. But the first drug to be approved as a truth-inducing drug was scopolamine. This drug was discovered by Dr. Robert House, an obstetrician."

Answered by AI

Clinical Trials for Pentothal

Image of University of Texas Southwestern Medical Center in Dallas, United States.

Cobenfy KarXT for Memory Loss

18 - 75
All Sexes
Dallas, TX
The goal of this study is to learn about the effects of Cobenfy KarXT (xanomeline and trospium chloride) on episodic memory processing, including specific effects on areas of the brain involved in memory and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether Cobenfy KarXT changes memory activity based on its agonist effect on muscarinic receptors and acetylcholine, and 2) what the nature of these brain activity changes are. This work builds on previous experiments evaluating cholinergic antagonists. Participants will complete two treatment arms. One of these will be with the drug, and the other will be with a placebo pill, so that the participants are unaware which session the actual drug has been received. Patients will complete a verbal serial recall and/or associative recognition task each of the two days. An anesthesiologist or patient nurse will administer either the drug or the placebo at a critical point which addresses both of the research questions. Researchers will compare the brain activity between the two treatment arms to determine what brain activity changes, and whether there is an additional behavioral effect on memory.
Phase < 1
Waitlist Available
University of Texas Southwestern Medical CenterBradley C Lega, MD
Image of Yale Comprehensive Epilepsy Center in New Haven, United States.

BHV-7000 for Epilepsy

18 - 75
All Sexes
New Haven, CT
This is an open label study to assess the biological effect of BHV-7000 on abnormal activity recorded by the RNS System in patients with focal epilepsy implanted with the RNS System. BHV-7000 is a potassium channel activator being evaluated for use in epilepsy. Participants are offered the drug for 4 weeks. Activity during that treatment period is compared to a 90-day retrospective baseline period in which other medications and device settings were stable, and also to a 4-week withdrawal period after treatment is discontinued. The study is open to patients with RNS regardless of whether they report clinical seizures, as long as the device recordings continue to show epileptiform activity.
Phase 1
Recruiting
Yale Comprehensive Epilepsy CenterImran Quraishi, MD, PhDBiohaven Pharmaceuticals, Inc.
Image of Hamilton Health Sciences - General Hospital in Hamilton, Canada.

Tranexamic Acid Timing for Postoperative Bleeding

18 - 100
All Sexes
Hamilton, Canada
The goal of this clinical trial is to establish the feasibility of conducting a large trial to determine the optimal timing of intravenous tranexamic acid administration in cardiac surgery. The main questions it aims to answer are: * Is it feasible to conduct a larger definitive trial? * Can we measure the systemic tranexamic acid concentration and fibrinolytic potential in the blood samples? Researchers will compare intravenous tranexamic acid administered before cardiopulmonary bypass versus after cardiopulmonary bypass to see if the systemic tranexamic acid concentration and fibrinolytic potential are similar or better. Participants will: * Provide written informed consent * Receive tranexamic acid during surgery * Provide blood samples at 5 time points: before surgery, on arrival in intensive care unit, 3 hours after arrival, 6 hours after arrival, and on the next morning.
Phase 3
Waitlist Available
Hamilton Health Sciences - General HospitalAndre Lamy, MD
Have you considered Pentothal clinical trials? We made a collection of clinical trials featuring Pentothal, we think they might fit your search criteria.Go to Trials
Have you considered Pentothal clinical trials? We made a collection of clinical trials featuring Pentothal, we think they might fit your search criteria.Go to Trials
Image of Duke University Health Sustem in Durham, United States.

Factors Affecting Oxygen Toxicity

18 - 45
All Sexes
Durham, NC
The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: * How does the training of respiratory muscles affect oxygen toxicity? * How do environmental factors, such as sleep deprivation, the ingestion of commonly utilized medications, and chronic exposure to carbon dioxide, impact the risk of oxygen toxicity? * How does immersion in water affect the development of oxygen toxicity? Participants will be asked to do the following: * Undergo a basic screening exam composed of health history, vital signs, and some respiratory function tests * Train their respiratory muscles at regular intervals * Exercise on a cycle ergometer both in dry conditions and underwater/under pressure in the context of medication, sleep deprivation, or carbon dioxide exposure Researchers will compare the performance of each subject before and after the possible interventions described above to see if there are changes in exercise performance, respiratory function, cerebral blood flow, and levels of gene expression.
Recruiting
Has No Placebo
Duke University Health SustemDerek B Covington, MD
Image of University of Texas Southwestern Medical Center in Dallas, United States.

Scopolamine for Memory Loss

18 - 55
All Sexes
Dallas, TX
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether scopolamine changes memory activity solely at encoding (the time when the person perceives and determines to remember an item or event) as has previously been found, or if it also can selectively impact retrieval (when the item or event which has been processed is recalled or remembered), and 2) what the nature of the brain activity changes is. Participants will complete two treatment arms. One of these will be with the drug, and the other will be with a saline solution, so that the participants are unaware which session the actual drug has been received. Patients will complete a verbal and/or spatial task each of the two days. An anesthesiologist will administer either the drug or the saline at a critical point which addresses both of the research questions. Researchers will compare the brain activity between the two treatment arms to determine what brain activity changes, and at what time point during memory formation.
Phase < 1
Recruiting
University of Texas Southwestern Medical CenterBradley C Lega, MD
Have you considered Pentothal clinical trials? We made a collection of clinical trials featuring Pentothal, we think they might fit your search criteria.Go to Trials
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