Parnate
Mental Depression
Treatment
2 FDA approvals
2 Active Studies for Parnate
Treatment for
Mental Depression
What is Parnate
Tranylcypromine
The Generic name of this drug
Treatment Summary
Tranylcypromine is an antidepressant medication used to treat major depression, dysthymic disorder, atypical depression, panic attacks, and phobic disorders. It is a type of monoamine oxidase inhibitor (MAOI) formed from the cyclization of the side chain of amphetamine. Tranylcypromine works by blocking monoamine oxidase, an enzyme that breaks down serotonin, norepinephrine, and dopamine in the brain.
Parnate
is the brand name
Parnate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Parnate
Tranylcypromine
1989
17
Approved as Treatment by the FDA
Tranylcypromine, also known as Parnate, is approved by the FDA for 2 uses which include Acute Depressive Episode and Mental Depression .
Acute Depressive Episode
Mental Depression
Effectiveness
How Parnate Affects Patients
Tranylcypromine is a type of antidepressant that works by increasing the levels of certain chemicals (serotonin, norepinephrine, epinephrine, and dopamine) in the brain. It belongs to a group of drugs called monoamine oxidase inhibitors (MAOIs) and is thought to be effective because it increases the amount of these chemicals that are available for the brain to use. It is not clear how it works, but it is believed to be more effective than selective MAO B inhibitors, such as selegiline, which do not have antidepressant effects.
How Parnate works in the body
Tranylcypromine works by blocking the enzyme monoamine oxidase (MAO). This enzyme helps regulate the amount of certain chemicals, such as monoamines, released in the brain. Low levels of these chemicals are associated with depression, so by blocking MAO, Tranylcypromine helps to increase the levels of these chemicals in the brain, easing depression symptoms.
When to interrupt dosage
The recommended amount of Parnate is contingent upon the diagnosed ailment. The dosage fluctuates depending on the technique of delivery (e.g. Tablet, film coated - Oral or Tablet - Oral) as noted in the table below.
Condition
Dosage
Administration
Mental Depression
, 10.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Parnate Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pheochromocytoma
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
consumption of cheese
Do Not Combine
Pulse Frequency
Do Not Combine
cerebrovascular defects
Do Not Combine
Pulse Frequency
Do Not Combine
Elective Surgeries
Do Not Combine
Pulse Frequency
Do Not Combine
consumption of high tyramine diet
Do Not Combine
Pulse Frequency
Do Not Combine
Cardiovascular Diseases
Do Not Combine
There are 20 known major drug interactions with Parnate.
Common Parnate Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
Tranylcypromine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
Tranylcypromine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
Tranylcypromine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Tranylcypromine.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Tranylcypromine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Parnate Toxicity & Overdose Risk
An overdose of this drug can cause sleeplessness, agitation, confusion, dizziness, weakness, and drowsiness. In some cases, blood pressure may either increase or decrease, along with severe headaches. Rarely, increased blood pressure is accompanied by muscle twitching, high body temperature, and ultimately leading to a rigid body and loss of consciousness.
Parnate Novel Uses: Which Conditions Have a Clinical Trial Featuring Parnate?
Five ongoing clinical trials are investigating the potential of Parnate to alleviate Mental Depression.
Condition
Clinical Trials
Trial Phases
Mental Depression
2 Actively Recruiting
Phase 2, Not Applicable
Parnate Reviews: What are patients saying about Parnate?
5
Patient Review
12/12/2015
Parnate for Major Depressive Disorder
5
Patient Review
11/3/2021
Parnate for Depression
5
Patient Review
11/6/2021
Parnate for Depression
5
Patient Review
1/17/2014
Parnate for Depression
5
Patient Review
1/15/2014
Parnate for Major Depressive Disorder
4.7
Patient Review
1/7/2021
Parnate for Depression
3.7
Patient Review
3/21/2014
Parnate for Major Depressive Disorder
2.7
Patient Review
6/12/2022
Parnate for Major Depressive Disorder
Patient Q&A Section about parnate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is Parnate a stimulant?
"Parnate has stimulating effects at normal doses because it affects the neurotransmitter norepinephrine. At high doses, Parnate can cause a "buzz" similar to the effects of amphetamines or other stimulants."
Answered by AI
What type of antidepressant is Parnate?
"An antidepressant that is also an MAO inhibitor."
Answered by AI
Is Parnate good for anxiety?
"Tranylcypromine, another MAOI, may be effective against panic attacks. Its possible benefits include reducing panic attacks, elevating depressed mood, increasing confidence, and helping OCD, generalized anxiety, PTSD and social anxiety."
Answered by AI
What does the drug Parnate do?
"This text is discussing how tranylcypromine is used to treat depression by restoring the balance of neurotransmitters in the brain. It states that usually this medication is used in persons who have not responded to other drugs."
Answered by AI