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What is Parnate
TranylcypromineThe Generic name of this drug
Treatment SummaryTranylcypromine is an antidepressant medication used to treat major depression, dysthymic disorder, atypical depression, panic attacks, and phobic disorders. It is a type of monoamine oxidase inhibitor (MAOI) formed from the cyclization of the side chain of amphetamine. Tranylcypromine works by blocking monoamine oxidase, an enzyme that breaks down serotonin, norepinephrine, and dopamine in the brain.
Parnateis the brand name
Parnate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Parnate
Tranylcypromine
1989
17
Approved as Treatment by the FDA
Tranylcypromine, also known as Parnate, is approved by the FDA for 1 uses which include Mental Depression .Mental Depression
Effectiveness
How Parnate Affects PatientsTranylcypromine is a type of antidepressant that works by increasing the levels of certain chemicals (serotonin, norepinephrine, epinephrine, and dopamine) in the brain. It belongs to a group of drugs called monoamine oxidase inhibitors (MAOIs) and is thought to be effective because it increases the amount of these chemicals that are available for the brain to use. It is not clear how it works, but it is believed to be more effective than selective MAO B inhibitors, such as selegiline, which do not have antidepressant effects.
How Parnate works in the bodyTranylcypromine works by blocking the enzyme monoamine oxidase (MAO). This enzyme helps regulate the amount of certain chemicals, such as monoamines, released in the brain. Low levels of these chemicals are associated with depression, so by blocking MAO, Tranylcypromine helps to increase the levels of these chemicals in the brain, easing depression symptoms.
When to interrupt dosage
The recommended amount of Parnate is contingent upon the diagnosed ailment. The dosage fluctuates depending on the technique of delivery (e.g. Tablet, film coated - Oral or Tablet - Oral) as noted in the table below.Condition
Dosage
Administration
Mental Depression
, 10.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Parnate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pheochromocytomas
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
consumption of cheese
Do Not Combine
Pulse Frequency
Do Not Combine
cerebrovascular defects
Do Not Combine
Pulse Frequency
Do Not Combine
Elective Surgeries
Do Not Combine
Pulse Frequency
Do Not Combine
consumption of high tyramine diet
Do Not Combine
Pulse Frequency
Do Not Combine
Cardiovascular Diseases
Do Not Combine
Common Parnate Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
Tranylcypromine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
Tranylcypromine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
Tranylcypromine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Tranylcypromine.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Tranylcypromine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Parnate Toxicity & Overdose RiskAn overdose of this drug can cause sleeplessness, agitation, confusion, dizziness, weakness, and drowsiness. In some cases, blood pressure may either increase or decrease, along with severe headaches. Rarely, increased blood pressure is accompanied by muscle twitching, high body temperature, and ultimately leading to a rigid body and loss of consciousness.
Parnate Novel Uses: Which Conditions Have a Clinical Trial Featuring Parnate?
Five ongoing clinical trials are investigating the potential of Parnate to alleviate Mental Depression.Condition
Clinical Trials
Trial Phases
Mental Depression
3 Actively Recruiting
Not Applicable
Parnate Reviews: What are patients saying about Parnate?
5Patient Review
12/12/2015 Parnate was suggested to me by my doctor after trying a lot of different medications and ECT treatments, and it honestly changed my life. I went from being suicidal and cutting myself regularly to feeling happy and content. There are some diet restrictions that come with this medication, but they're definitely worth it in the long run.
5Patient Review
11/3/2021 Parnate has been a life-saver for me. It's controlled my depression and anxiety better than any of the other 20+ drugs and drug combinations I've tried. And while I do have to be careful with my diet, it's a small price to pay for how well this medication works.
5Patient Review
11/6/2021 Parnate has been an absolute wonder drug for me. I had tried so many different combinations of drugs and nothing seemed to work until I found this one. It's really helped me stabilize my mental health.
5Patient Review
1/17/2014 I've been taking this medicine for over 35 years and it's the only thing that's ever helped me. I've tried many other treatments, but this is the only one that's worked.
5Patient Review
1/15/2014 I've used this treatment for 30 years and it always helps.
4.7Patient Review
1/7/2021 If you haven't tried a classical MAOI for depression, then this drug is definitely worth considering. It's much more effective than anything else on the market, with powerful antidepressant and anxiolytic effects. That said, the side effects can be pretty annoying (especially insomnia and afternoon fatigue).
3.7Patient Review
3/21/2014 Parnate has been great for my depression, however I have gained over 100 pounds since taking it. This is a common side effect that unfortunately makes the drug unusable for me.
2.7Patient Review
6/12/2022 I'm only a month in on this treatment, and I've already got so many questions. I started at 10mg and slowly increased to 20mg over the course of 3 1/2 weeks. It's helped with my depression, but the side effects are really intense. Dizziness, shortness of breath, anxiety, muscle pain, and neck pain have all been issues. If anyone else has experienced even some of these problems, please let me know in the comments!
Patient Q&A Section about parnate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Parnate a stimulant?
"Parnate has stimulating effects at normal doses because it affects the neurotransmitter norepinephrine. At high doses, Parnate can cause a "buzz" similar to the effects of amphetamines or other stimulants."
Answered by AI
What type of antidepressant is Parnate?
"An antidepressant that is also an MAO inhibitor."
Answered by AI
Is Parnate good for anxiety?
"Tranylcypromine, another MAOI, may be effective against panic attacks. Its possible benefits include reducing panic attacks, elevating depressed mood, increasing confidence, and helping OCD, generalized anxiety, PTSD and social anxiety."
Answered by AI
What does the drug Parnate do?
"This text is discussing how tranylcypromine is used to treat depression by restoring the balance of neurotransmitters in the brain. It states that usually this medication is used in persons who have not responded to other drugs."
Answered by AI