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What is Oxybutynin
OxybutyninThe Generic name of this drug
Treatment SummaryOxybutynin, also known as Ditropan XL, is a medication used to treat overactive bladder. Overactive bladder is a condition that causes frequent urination due to urinary urgency and frequency. This drug was approved by the FDA in 1975 and has been tested for safety and effectiveness. Oxybutynin is often the first medication prescribed to patients with overactive bladder and can help improve their quality of life.
Ditropanis the brand name
Oxybutynin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ditropan
Oxybutynin
1975
256
Effectiveness
How Oxybutynin Affects PatientsOxybutynin helps to reduce the uncomfortable symptoms of overactive bladder, such as frequent or urgent urination. It does this by blocking certain receptors in the bladder. However, there is a risk of angioedema (swelling) and anticholinergic effects (hallucinations, confusion, agitation, and drowsiness). If angioedema is suspected, it is important to stop taking oxybutynin right away and seek medical help. It is also best to avoid operating heavy machinery until you know how your body will respond to oxybutynin. The dose may need to be adjusted depending on your response
How Oxybutynin works in the bodyOxybutynin works to relax the bladder muscles and help increase the amount of urine it can hold. It does this by blocking the effects of a chemical called acetylcholine, which is responsible for muscle contractions. Oxybutynin's active ingredient, N-desethyloxybutynin, competes with acetylcholine at the postganglionic type 1, 2, and 3 muscarinic receptors. This prevents acetylcholine from carrying out its muscle contraction function, resulting in a relaxed bladder and less frequent urges to urinate.
When to interrupt dosage
The recommended dosage of Oxybutynin is contingent upon the diagnosed condition, including Neurological Disorders, Foley Catheterization and Nocturia. The dosage amount depends on the delivery method (e.g. Tablet, extended release or Patch) noted in the table below.Condition
Dosage
Administration
Nocturia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Longterm Indwelling Ureteral Stent
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Overactive Bladder Syndrome
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Spina Bifida
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urgency
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urge Incontinence
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Detrusor Hyperreflexia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Bladder Spasms
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Neurological Disorders
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
increased frequency of urination
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Foley Catheterization
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Warnings
Oxybutynin ContraindicationsCondition
Risk Level
Notes
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Oxybutynin may interact with Pulse Frequency
Gastric Retention
Do Not Combine
Common Oxybutynin Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Oxybutynin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Oxybutynin.
Oxybutynin Toxicity & Overdose RiskThe most toxic dose of oxybutynin for rats is 460 mg/kg. If a person overdoses on oxybutynin, they may experience symptoms such as excessive excitement, fever, irregular heartbeat, difficulty urinating, breathing problems, paralysis, and even a coma. In two reported cases of an overdose involving 100 mg of oxybutynin and alcohol consumption, the patients were treated with supportive care and made a full recovery. Activated charcoal and a cathartic agent should be administered immediately to reduce the effects of the overdose.
Oxybutynin Novel Uses: Which Conditions Have a Clinical Trial Featuring Oxybutynin?
79 active clinical trials are currently being conducted to analyze the potential of Oxybutynin in resolving Overactive Bladder Syndrome, Foley Catheterization and Neurological Disorders.Condition
Clinical Trials
Trial Phases
Nocturia
6 Actively Recruiting
Phase 4, Not Applicable
Spina Bifida
15 Actively Recruiting
Not Applicable
Overactive Bladder Syndrome
32 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
increased frequency of urination
2 Actively Recruiting
Phase 4, Not Applicable
Longterm Indwelling Ureteral Stent
0 Actively Recruiting
Urinary Urge Incontinence
15 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Urinary Urgency
3 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Detrusor Hyperreflexia
0 Actively Recruiting
Foley Catheterization
0 Actively Recruiting
Bladder Spasms
1 Actively Recruiting
Phase 1
Neurological Disorders
6 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Oxybutynin Reviews: What are patients saying about Oxybutynin?
5Patient Review
8/21/2022 I was hesitant to try this medication, but after four months I can say that it works better and is much more affordable than the other options out there.
5Patient Review
2/23/2019 Almost immediately after starting this medication, I developed awful itching on my arms and hands. It was like it started in one spot and then quickly got worse. The worst part is that nothing helped - not evenBenadryl or other creams. So, unfortunately, I'm going to have to stop taking it because of the skin irritation. Hopefully I'll be able to find something else that will help with my bladder issues.
5Patient Review
3/20/20174.3Patient Review
12/4/2019 I had three seizures in quick succession after taking just two doses of this medication. There are much better options out there, so please avoid this one if possible. I was taken to the ER three times and it was an overall terrible experience. The paramedics told my mom that they weren't sure how I survived. I still suffer from PTSD today because of it.
4.3Patient Review
10/8/2019 It's only been three weeks, but I'm already having to urinate more frequently. So far the results haven't been great, but I know it could take a while for the drug to really kick in.
3.3Patient Review
6/18/2018 The medication caused really uncomfortable side effects like dry mouth, dizziness, and fatigue.
3Patient Review
11/1/2021 I had some pretty serious eye trouble after just a few days of taking this medication. I stopped immediately and am seeing a specialist today.
2.3Patient Review
3/24/2018 I only take this medication when my bladder acts up, and every time I take it I immediately feel better. I have never noticed any side effects and I have been taking them for 5 months now.
2Patient Review
3/27/2019 This medication has been a godsend for me. I have diabetic neuropathy, which causes incontinence and an inability to sense when my bladder is full. This often leads to accidents. Since taking this drug, however, I haven't had any accidents or side effects. I'm very pleased with the results so far.
Patient Q&A Section about oxybutynin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Should I take oxybutynin at night?
"Immediate-release oxybutynin is usually taken three or four times per day, unless it is only being used for night-time urinary incontinence, in which case only one dose is taken at night."
Answered by AI
Is oxybutynin a high risk medication?
"The medication oxybutynin, which is commonly used to treat OAB (a combination of urinary tract symptoms including frequent urination and the inability to control urination), may be harmful to brain health and may increase the risk of dementia, according to research."
Answered by AI
What exactly does oxybutynin do?
"What is oxybutynin and how does it work? Oxybutynin is a medicine that relaxes the muscle in the wall of the bladder, increasing the volume of urine the bladder can hold and helping to control the release of urine."
Answered by AI