Onmel

Blastomycosis, Paracoccidioidomycosis, Chromoblastomycosis + 15 more
Treatment
8 FDA approvals
20 Active Studies for Onmel

What is Onmel

ItraconazoleThe Generic name of this drug
Treatment SummaryItraconazole is an antifungal medication that prevents the growth of fungi. It targets a specific enzyme in fungi to disrupt the production of a substance called ergosterol, which is needed for their survival. Itraconazole is used to treat infections caused by fungi such as histoplasmosis, blastomycosis, cryptococcal meningitis and aspergillosis.
Sporanoxis the brand name
image of different drug pills on a surface
Onmel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sporanox
Itraconazole
1992
35

Approved as Treatment by the FDA

Itraconazole, otherwise known as Sporanox, is approved by the FDA for 8 uses which include Fungal skin infection and Sporotrichosis .
Fungal skin infection
Sporotrichosis
Sporotrichosis
Cellulitis
Esophageal Candidiasis
Oropharyngeal Candidiasis
Chromoblastomycosis
Paracoccidioidomycosis

Effectiveness

How Onmel Affects PatientsItraconazole is a medicine used to treat fungal infections. It works by stopping the growth of fungi by blocking a specific enzyme that helps fungi build their cell walls. This medicine has been shown to be effective against certain types of fungi, including Cryptococcus neoformans and Candida spp. Studies in both healthy and immunocompromised animals have shown itraconazole to be effective against fungal infections like Cryptococcus neoformans and Candida albicans.
How Onmel works in the bodyItraconazole works by blocking the production of a certain molecule in fungi cells, called ergosterol. Without this molecule, the cell membrane loses its strength and becomes more permeable, which leads to the leaking of cellular contents. Itraconazole may also prevent the transformation of yeasts to mycelial forms, interfere with respiration, and block the absorption of some nutrients.

When to interrupt dosage

The recommended measure of Onmel is contingent upon the diagnosed state, including Onychomycosis, prophylaxis of Penicilliosis and Coccidioidal meningitis. The quantity of dosage is contingent upon the execution approach detailed in the table underneath.
Condition
Dosage
Administration
Blastomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Paracoccidioidomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Chromoblastomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Onychomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Sporotrichosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Histoplasmosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Cellulitis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Coccidioidomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
disseminated Other specified protozoal diseases
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
prophylaxis of Histoplasmosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
prophylaxis of Penicilliosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Aspergillosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Candidiasis, Vulvovaginal
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
talaromycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Coccidioides
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
HIV
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Oropharyngeal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Esophageal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous

Warnings

Onmel has four contraindications, so it should not be utilized while going through the conditions specified in the following table.Onmel Contraindications
Condition
Risk Level
Notes
Congestive Heart Failure
Do Not Combine
Congestive heart failure
Do Not Combine
Cytochrome P450
Do Not Combine
suspected pregnancy
Do Not Combine
There are 20 known major drug interactions with Onmel.
Common Onmel Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Itraconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Itraconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Itraconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Itraconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Itraconazole.
Onmel Toxicity & Overdose RiskItraconazole has not been found to be fatal when given to mice, rats, and dogs at doses of 320mg/kg, 200mg/kg respectively.
image of a doctor in a lab doing drug, clinical research

Onmel Novel Uses: Which Conditions Have a Clinical Trial Featuring Onmel?

137 active trials are evaluating the potential of Onmel to mitigate Chromomycosis, Dermatomycoses and Sporotrichosis.
Condition
Clinical Trials
Trial Phases
prophylaxis of Histoplasmosis
0 Actively Recruiting
Cellulitis
0 Actively Recruiting
Sporotrichosis
0 Actively Recruiting
Onychomycosis
0 Actively Recruiting
disseminated Other specified protozoal diseases
0 Actively Recruiting
Histoplasmosis
0 Actively Recruiting
Chromoblastomycosis
0 Actively Recruiting
Paracoccidioidomycosis
0 Actively Recruiting
Coccidioidomycosis
0 Actively Recruiting
prophylaxis of Penicilliosis
0 Actively Recruiting
Candidiasis, Vulvovaginal
2 Actively Recruiting
Not Applicable, Phase 3
Coccidioides
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
talaromycosis
0 Actively Recruiting
Oropharyngeal Candidiasis
0 Actively Recruiting
HIV
155 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
Blastomycosis
0 Actively Recruiting

Patient Q&A Section about onmel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Onmel used for?

"Onmel requires a prescription and is used to treat fungal infections of the toenails."

Answered by AI

Is itraconazole an antibiotic?

"Itraconazole is an antifungal medication used to treat infections caused by fungi in adults. This includes infections in any part of the body, such as the lungs, mouth or throat, toenails, or fingernails."

Answered by AI

How much does Sporanox cost?

"With a free SingleCare Sporanox coupon, you can purchase Sporanox for a lower cost than the retail price of $247.79 per 0.60, 150ML of 10MG/ML Solution."

Answered by AI

What is itraconazole used for?

"The following is a list of possible side effects that may occur from the use of itraconazole capsule.

Itraconazole capsule is used to treat aspergillosis, blastomycosis, histoplasmosis and onychomycosis. Some of the possible side effects of using this medication include skin rash, headache, diarrhea, and itching."

Answered by AI

Clinical Trials for Onmel

Image of University of Alabama at Birmingham in Birmingham, United States.

Olfactory Training for HIV

18+
All Sexes
Birmingham, AL
The goal of this study is to examine two types of olfactory interventions (olfactory training vs overnight odor diffuser) in adults with HIV. The two research questions are: 1. Determine if participants find the intervention acceptable and assess feasibility of the study. 2. Determine if the intervention improves olfactory function and cognitive function. Participants will come to our office and be administered the baseline battery of questions including olfactory and cognitive performance tests. Then they will be randomized and sent home with one of the two interventions (below) in which they will engage in it for 8 weeks, after which they come back to our office for the posttest battery of questions including olfactory and cognitive performance test. 1. Olfactory Training at Home -- 4 scents in which they will smell twice a day for 8 weeks. 2. Overnight Diffuser Group -- a single scent diffuser that participants will turn on while they sleep and use for 8 weeks.
Phase < 1
Waitlist Available
University of Alabama at Birmingham
Image of Los Angeles General Medical Center in Los Angeles, United States.

Decision Support Tool for HIV Treatment

18+
All Sexes
Los Angeles, CA
This study is testing software designed to help healthcare providers choose the best HIV treatment combinations for their patients. HIV medicines, known as antiretroviral therapy (ART), can be complex to manage because the right regimen depends on many factors-such as drug resistance, other health conditions, and medication schedules. Many people with HIV are cared for by general clinicians who may not have access to HIV specialists, which can make treatment decisions more challenging. In this study, healthcare providers will use patient cases to compare standard HIV treatment resources with a new clinical decision support tool that gives evidence-based ART recommendations at the point of care. The investigators hypothesize that using the tool will help providers select treatment plans that better match clinical guidelines, make decisions faster, reduce mental effort, and increase overall satisfaction with the prescribing process.
Waitlist Available
Has No Placebo
Los Angeles General Medical CenterHayoun Lee, PhD
Image of University of North Carolina in Chapel Hill, United States.

MGD020 + MGD014 for HIV

18 - 65
All Sexes
Chapel Hill, NC
This research study aims to find out how safe and well tolerated the experimental study drugs are when given to persons with HIV (PWH) taking antiretroviral therapy (ART). The study treatments are MGD014 and MGD020, which are two antibodies developed specifically for HIV, and Vorinostat, an oral medication to help expose HIV in cells to the antibodies. The study will measure the impact of study treatment on non-active HIV in cells, and how long MGD014 and MGD020 stay in the body after they are given. In this study, participants will be randomly assigned to one of three groups. All participants receive MGD014 and MGD020, given sequentially as infusions through an IV for 4 doses. Participants in one group (group A) receive only MGD014 and MGD020. Participants in another group (group B) will stop taking their ART therapy for up to 8 weeks (a temporary treatment interruption (TTI)) while receiving MGD014 and MGD020. Participants in the third group (group C) receive Vorinostat in addition to MGD014 and MGD020. Total time of participation is about 8 months and involves 13 or 18 visits, depending on group assignment.
Phase 1
Recruiting
University of North CarolinaCynthia L. Gay, MD
Have you considered Onmel clinical trials? We made a collection of clinical trials featuring Onmel, we think they might fit your search criteria.Go to Trials
Have you considered Onmel clinical trials? We made a collection of clinical trials featuring Onmel, we think they might fit your search criteria.Go to Trials
Image of UCSF in San Francisco, United States.

N-803 for HIV

18 - 70
All Sexes
San Francisco, CA
Even though HIV medicine stops the virus from making more copies of itself, the virus remains in the body by hiding inside of immune cells. This hidden virus is referred to as the "latent reservoir." Researchers on this team are studying whether stimulating the immune system can change the nature of the latent reservoir and if this could help people control HIV without the need to take regular HIV medicine. This study is testing a drug called N-803. N-803 is also known as Interleukin-15 or "IL-15", a powerful and long lasting protein that can affect the immune system by stimulating immune cells such as CD8+ T cells and natural killer (NK) cells. CD8+ T cells and NK cells are both crucial for eliminating infected cells. The drug is FDA-approved for the treatment of bladder cancer, but in this study the drug is being used experimentally for HIV.
Phase 2
Waitlist Available
UCSF
Image of Alabama CRS (Site ID: 31788) in Birmingham, United States.

Dasatinib + Quercetin for HIV

18+
All Sexes
Birmingham, AL
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail. The study will involve 80 participants, all aged 50 or older, who have been living with HIV for at least 10 years determined to meet criteria for diagnosis of frail or prefrail and are currently on a stable antiretroviral therapy with viral suppression. Participants will be randomly assigned to one of two groups: one group will receive the D+Q treatment, and the other will receive a placebo. The treatment will be given in six cycles over 12 weeks, with participants taking the medication for two days followed by 12 days without treatment. After the 12-week treatment period, participants will be monitored for another 12 weeks to assess the long-term effects. The study aims to determine if D+Q can improve physical function and other health outcomes in this population. Randomization will be stratified by sex and age to ensure balanced groups.
Phase 2
Waitlist Available
Alabama CRS (Site ID: 31788) (+26 Sites)
Image of Yale University in New Haven, United States.

DynamiCare + Patient Navigation for Stimulant Use Disorder

18+
All Sexes
New Haven, CT
Justice-involved individuals face disproportionately high rates of stimulant use disorder and HIV, along with disrupted access to HIV treatment and prevention services like ART and PrEP. Contingency management (CM) is the most effective intervention for stimulant use, but its use in justice-involved populations has been limited by logistical and structural barriers. DynamiCare is an FDA-approved mobile app that delivers behavioral CM and has shown promise in reducing stimulant use, but its impact on HIV-related outcomes remains unknown. The RESTORE study (Recovery and Engagement for Stimulant Users on Re-entry) will evaluate whether combining DynamiCare with patient navigation (DynamiCare-plus) improves PrEP/ART initiation and reduces stimulant use among individuals recently released from justice settings. The R61 phase will assess feasibility, acceptability, and preliminary effectiveness among 40 participants. If milestones are met, the R33 phase will scale to a randomized controlled trial with 252 participants to assess effectiveness, implementation, and cost. This scalable, mobile approach has the potential to address a critical gap in care for a highly vulnerable population.
Waitlist Available
Has No Placebo
Yale University (+1 Sites)Ank Nijhawan, MD
Have you considered Onmel clinical trials? We made a collection of clinical trials featuring Onmel, we think they might fit your search criteria.Go to Trials
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