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What is Onmel
ItraconazoleThe Generic name of this drug
Treatment SummaryItraconazole is an antifungal medication that prevents the growth of fungi. It targets a specific enzyme in fungi to disrupt the production of a substance called ergosterol, which is needed for their survival. Itraconazole is used to treat infections caused by fungi such as histoplasmosis, blastomycosis, cryptococcal meningitis and aspergillosis.
Sporanoxis the brand name
Onmel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sporanox
Itraconazole
1992
35
Approved as Treatment by the FDA
Itraconazole, otherwise known as Sporanox, is approved by the FDA for 6 uses which include Cellulitis and Esophageal Candidiasis .Cellulitis
Esophageal Candidiasis
Sporotrichosis
Oropharyngeal Candidiasis
Chromoblastomycosis
Paracoccidioidomycosis
Effectiveness
How Onmel Affects PatientsItraconazole is a medicine used to treat fungal infections. It works by stopping the growth of fungi by blocking a specific enzyme that helps fungi build their cell walls. This medicine has been shown to be effective against certain types of fungi, including Cryptococcus neoformans and Candida spp. Studies in both healthy and immunocompromised animals have shown itraconazole to be effective against fungal infections like Cryptococcus neoformans and Candida albicans.
How Onmel works in the bodyItraconazole works by blocking the production of a certain molecule in fungi cells, called ergosterol. Without this molecule, the cell membrane loses its strength and becomes more permeable, which leads to the leaking of cellular contents. Itraconazole may also prevent the transformation of yeasts to mycelial forms, interfere with respiration, and block the absorption of some nutrients.
When to interrupt dosage
The recommended measure of Onmel is contingent upon the diagnosed state, including Onychomycosis, prophylaxis of Penicilliosis and Coccidioidal meningitis. The quantity of dosage is contingent upon the execution approach detailed in the table underneath.Condition
Dosage
Administration
Onychomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Penicillium marneffei infection
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
disseminated Other specified protozoal diseases
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Esophageal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Coccidioidal meningitis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Blastomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Sporotrichosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Coccidioides
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Vulvovaginal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
prophylaxis of Histoplasmosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Chromoblastomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Paracoccidioidomycosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
HIV
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Oropharyngeal Candidiasis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Histoplasmosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Cellulitis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
prophylaxis of Penicilliosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Aspergillosis
, 100.0 mg, 200.0 mg, 10.0 mg/mL, 65.0 mg, 0.01 mg/mg, 0.05 mg/mg
, Capsule - Oral, Capsule, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Capsule, coated pellets - Oral, Capsule, coated pellets, Kit, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Topical, Solution - Topical, Cream - Topical, Cream, Intravenous, Kit - Intravenous
Warnings
Onmel has four contraindications, so it should not be utilized while going through the conditions specified in the following table.Onmel ContraindicationsCondition
Risk Level
Notes
Congestive Heart Failure
Do Not Combine
Congestive heart failure
Do Not Combine
Cytochrome P450
Do Not Combine
suspected pregnancy
Do Not Combine
Common Onmel Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Itraconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Itraconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Itraconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Itraconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Itraconazole.
Onmel Toxicity & Overdose RiskItraconazole has not been found to be fatal when given to mice, rats, and dogs at doses of 320mg/kg, 200mg/kg respectively.
Onmel Novel Uses: Which Conditions Have a Clinical Trial Featuring Onmel?
137 active trials are evaluating the potential of Onmel to mitigate Chromomycosis, Dermatomycoses and Sporotrichosis.Condition
Clinical Trials
Trial Phases
HIV
147 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Paracoccidioidomycosis
0 Actively Recruiting
Vulvovaginal Candidiasis
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
Histoplasmosis
1 Actively Recruiting
Phase 1, Phase 2
Onychomycosis
4 Actively Recruiting
Phase 2, Not Applicable, Phase 1
Oropharyngeal Candidiasis
0 Actively Recruiting
prophylaxis of Histoplasmosis
0 Actively Recruiting
Chromoblastomycosis
0 Actively Recruiting
Coccidioidal meningitis
0 Actively Recruiting
disseminated Other specified protozoal diseases
0 Actively Recruiting
Aspergillosis
2 Actively Recruiting
Phase 3
Penicillium marneffei infection
0 Actively Recruiting
Blastomycosis
0 Actively Recruiting
Coccidioides
0 Actively Recruiting
Sporotrichosis
0 Actively Recruiting
Cellulitis
0 Actively Recruiting
prophylaxis of Penicilliosis
0 Actively Recruiting
Patient Q&A Section about onmel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Onmel used for?
"Onmel requires a prescription and is used to treat fungal infections of the toenails."
Answered by AI
Is itraconazole an antibiotic?
"Itraconazole is an antifungal medication used to treat infections caused by fungi in adults. This includes infections in any part of the body, such as the lungs, mouth or throat, toenails, or fingernails."
Answered by AI
How much does Sporanox cost?
"With a free SingleCare Sporanox coupon, you can purchase Sporanox for a lower cost than the retail price of $247.79 per 0.60, 150ML of 10MG/ML Solution."
Answered by AI
What is itraconazole used for?
"The following is a list of possible side effects that may occur from the use of itraconazole capsule.
Itraconazole capsule is used to treat aspergillosis, blastomycosis, histoplasmosis and onychomycosis. Some of the possible side effects of using this medication include skin rash, headache, diarrhea, and itching."
Answered by AI