Omega-3-Acid Ethyl Esters

Hypertriglyceridemia
Treatment
2 FDA approvals
8 Active Studies for Omega-3-Acid Ethyl Esters

What is Omega-3-Acid Ethyl Esters

Omega-3-acid ethyl estersThe Generic name of this drug
Treatment SummaryOmega-3-acid ethyl esters are a type of prescription medication used to lower triglyceride levels in adults with very high triglyceride levels (above 500 mg/dL). The drug is found under the brand name Lovaza in the US, EU, and other regions. It is taken in combination with dietary changes to reduce triglyceride levels.
Tandem DHAis the brand name
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Omega-3-Acid Ethyl Esters Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tandem DHA
Omega-3-acid ethyl esters
2007
57

Approved as Treatment by the FDA

Omega-3-acid ethyl esters, also called Tandem DHA, is approved by the FDA for 2 uses which include Hypertriglyceridemia and Severe Hypertriglyceridemia (sHTG) .
Hypertriglyceridemia
Helps manage Severe Hypertriglyceridemia (sHTG)
Severe Hypertriglyceridemia (sHTG)
Helps manage Severe Hypertriglyceridemia (sHTG)

Effectiveness

How Omega-3-Acid Ethyl Esters Affects PatientsOmega-3-acid ethyl esters help to lower triglyceride levels, speed up how your body breaks down fatty acids, prevent fatty acids from being released, increase the rate at which triglycerides are cleared from the body, and reduce very low density lipoprotein cholesterol (VLDL-C).
How Omega-3-Acid Ethyl Esters works in the bodyOmega-3-acid ethyl esters lower triglyceride levels in the body by reducing the amount of triglycerides produced in the liver. They also block the release of fatty acids, which helps the body break down triglycerides faster. Finally, they increase the activity of an enzyme called lipoprotein lipase, which helps clear away triglycerides from the body.

When to interrupt dosage

The prescribed dosage of Omega-3-Acid Ethyl Esters is contingent upon the determined condition. The amount of dosage may be found in the table beneath, contingent upon the technique of administration.
Condition
Dosage
Administration
Hypertriglyceridemia
, 1000.0 mg, 300.0 mg, 900.0 mg, 1.0 mg/mg, 500.0 mg, 250.0 mg, 667.0 mg, 1050.0 mg, 430.0 mg, 400.0 mg, 200.0 mg, 310.1 mg, 1220.0 mg
Capsule, liquid filled, Oral, Capsule, liquid filled - Oral, , Capsule, Capsule - Oral, Capsule, Delayed Release, Capsule, Delayed Release - Oral, Kit, Kit - Oral, Tablet - Oral, Tablet

Warnings

Omega-3-Acid Ethyl Esters has one contraindication and should never be taken in the presence of any of the conditions described in the following table.Omega-3-Acid Ethyl Esters Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Omega-3-acid Ethyl Esters may interact with Pulse Frequency
There are 20 known major drug interactions with Omega-3-Acid Ethyl Esters.
Common Omega-3-Acid Ethyl Esters Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
The risk or severity of bleeding can be increased when Omega-3-acid ethyl esters is combined with (R)-warfarin.
(S)-Warfarin
Minor
The risk or severity of bleeding can be increased when Omega-3-acid ethyl esters is combined with (S)-Warfarin.
4-hydroxycoumarin
Minor
The risk or severity of bleeding can be increased when Omega-3-acid ethyl esters is combined with 4-hydroxycoumarin.
Abciximab
Minor
The risk or severity of bleeding can be increased when Omega-3-acid ethyl esters is combined with Abciximab.
Acenocoumarol
Minor
The risk or severity of bleeding can be increased when Omega-3-acid ethyl esters is combined with Acenocoumarol.
Omega-3-Acid Ethyl Esters Toxicity & Overdose RiskStudies in rats have found that omega-3-acid ethyl esters are not dangerous and do not affect fertility. It is unclear if it is safe to use during pregnancy, but it has been linked to an embryocidal effect in rats when taken in high doses. It is also unknown if it is safe for nursing mothers or children, and it has not been tested on those under the age of 60.
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Omega-3-Acid Ethyl Esters Novel Uses: Which Conditions Have a Clinical Trial Featuring Omega-3-Acid Ethyl Esters?

Currently, there are 4 active trials assessing the potential of Omega-3-Acid Ethyl Esters to treat Hypertriglyceridemia.
Condition
Clinical Trials
Trial Phases
Hypertriglyceridemia
8 Actively Recruiting
Phase 3, Phase 2

Omega-3-Acid Ethyl Esters Reviews: What are patients saying about Omega-3-Acid Ethyl Esters?

5Patient Review
2/28/2021
Omega-3-Acid Ethyl Esters for High Amount of Triglyceride in the Blood
I had extremely high triglyceride levels when I started taking this medication, but they normalized within five weeks.
5Patient Review
2/16/2016
Omega-3-Acid Ethyl Esters for High Amount of Triglyceride in the Blood
No noticeable side effects when taking 4 grams per day.
4.7Patient Review
8/6/2015
Omega-3-Acid Ethyl Esters for High Amount of Triglyceride in the Blood
Lovaza has been hugely effective in managing my cholesterol and osteoarthritis. I don't have any swelling or pain in my joints anymore.
4.7Patient Review
8/30/2011
Omega-3-Acid Ethyl Esters for High Amount of Triglyceride in the Blood
4Patient Review
2/23/2008
Omega-3-Acid Ethyl Esters for High Amount of Triglyceride in the Blood
View All Reviews
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Patient Q&A Section about omega-3-acid ethyl esters

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is omega-3-acid ethyl esters used for?

"Omega-3-acid ethyl esters are used to lower triglyceride levels when following a proper diet. This medicine may help prevent medical problems caused by clogged blood vessels such as heart attacks and strokes. This medicine is available with a doctor's prescription."

Answered by AI

Is omega-3-acid ethyl esters safe?

"Omega-3-Acid Ethyl Esters capsules may cause serious side effects, including changes in certain blood tests. Omega-3-Acid Ethyl Esters capsules may cause an increase in the results of blood tests used to check your liver function and your bad cholesterol levels."

Answered by AI

What is the difference between omega-3 and omega-3 ethyl esters?

"The two different forms of omega-3 fatty acids, EPA and DHA, occur naturally in fish in the triglyceride form. The ethyl ester form is synthesized from the triglyceride form."

Answered by AI

Clinical Trials for Omega-3-Acid Ethyl Esters

Have you considered Omega-3-Acid Ethyl Esters clinical trials? We made a collection of clinical trials featuring Omega-3-Acid Ethyl Esters, we think they might fit your search criteria.
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