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What is Octreotide Acetate
OctreotideThe Generic name of this drug
Treatment SummaryAcromegaly is a disorder caused by too much growth hormone in the body, changing the size of body tissues and resulting in metabolic issues. It is usually caused by a tumor in the pituitary gland. Symptoms may include abnormally large feet, hands and face, as well as organ enlargement and insulin resistance. Octreotide is a medication that mimics the natural hormone somatostatin, which helps to prevent the secretion of growth hormone. It is used to treat acromegaly and other tumors, such as carcinoid tumors and VIPomas. On June 26, 2020, Mycapssa, the first FDA
Octreotide Acetateis the brand name
Octreotide Acetate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Octreotide Acetate
Octreotide
1988
89
Approved as Treatment by the FDA
Octreotide, otherwise known as Octreotide Acetate, is approved by the FDA for 4 uses such as Acromegaly and Flushing .Acromegaly
Helps manage Acromegaly
Flushing
Gastroenteritis
metastatic Carcinoid Tumors
Effectiveness
How Octreotide Acetate Affects PatientsOctreotide is a hormone-like medication that works similarly to the natural hormone somatostatin. It can help treat abnormal tissue growth and poor insulin regulation in people with acromegaly, and can also reduce flushing and diarrhea in those with gastrointestinal tumors. Taking octreotide may reduce the function of the gallbladder and bile secretion, as well as reduce levels of thyroid-stimulating hormone (TSH) and vitamin B12. People using this medication should have their vitamin B12 levels monitored.
How Octreotide Acetate works in the bodyOctreotide targets the hormones that cause abnormal growth, like growth hormone, luteinizing hormone, and serotonin. It works by blocking the receptors that receive these hormones and causes them to become inactive. Octreotide also reduces blood flow to the digestive organs, which can help relieve gastrointestinal symptoms. This drug can be used to treat acromegaly and carcinoid and/or VIPoma tumors.
When to interrupt dosage
The proposed dosage of Octreotide Acetate is contingent upon the detected malady, including Acromegaly, Vasoactive Intestinal Peptide Tumors and metastatic Carcinoid Tumors. The amount of dosage can be located in the table below, based on the delivery approach (e.g. Injection - Intravenous; Subcutaneous or Capsule, delayed release).Condition
Dosage
Administration
Acromegaly
, 1.0 mg/mL, 0.2 mg/mL, 0.05 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 10.0 mg, 20.0 mg, 30.0 mg, 3.33 mg/mL, 5.0 mg/mL, 1.667 mg/mL, 2.5 mg/mL
Intravenous; Subcutaneous, Injection, solution, , Injection, solution - Intravenous; Subcutaneous, Injection, Injection - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Intramuscular, Kit, Injection - Intravenous, Intravenous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection - Subcutaneous, Subcutaneous, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Kit - Intramuscular
Gastroenteritis
, 1.0 mg/mL, 0.2 mg/mL, 0.05 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 10.0 mg, 20.0 mg, 30.0 mg, 3.33 mg/mL, 5.0 mg/mL, 1.667 mg/mL, 2.5 mg/mL
Intravenous; Subcutaneous, Injection, solution, , Injection, solution - Intravenous; Subcutaneous, Injection, Injection - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Intramuscular, Kit, Injection - Intravenous, Intravenous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection - Subcutaneous, Subcutaneous, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Kit - Intramuscular
Vasoactive Intestinal Peptide Tumors
, 1.0 mg/mL, 0.2 mg/mL, 0.05 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 10.0 mg, 20.0 mg, 30.0 mg, 3.33 mg/mL, 5.0 mg/mL, 1.667 mg/mL, 2.5 mg/mL
Intravenous; Subcutaneous, Injection, solution, , Injection, solution - Intravenous; Subcutaneous, Injection, Injection - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Intramuscular, Kit, Injection - Intravenous, Intravenous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection - Subcutaneous, Subcutaneous, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Kit - Intramuscular
long-term maintenance therapy
, 1.0 mg/mL, 0.2 mg/mL, 0.05 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 10.0 mg, 20.0 mg, 30.0 mg, 3.33 mg/mL, 5.0 mg/mL, 1.667 mg/mL, 2.5 mg/mL
Intravenous; Subcutaneous, Injection, solution, , Injection, solution - Intravenous; Subcutaneous, Injection, Injection - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Intramuscular, Kit, Injection - Intravenous, Intravenous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection - Subcutaneous, Subcutaneous, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Kit - Intramuscular
octreotide
, 1.0 mg/mL, 0.2 mg/mL, 0.05 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 10.0 mg, 20.0 mg, 30.0 mg, 3.33 mg/mL, 5.0 mg/mL, 1.667 mg/mL, 2.5 mg/mL
Intravenous; Subcutaneous, Injection, solution, , Injection, solution - Intravenous; Subcutaneous, Injection, Injection - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Intramuscular, Kit, Injection - Intravenous, Intravenous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection - Subcutaneous, Subcutaneous, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Kit - Intramuscular
metastatic Carcinoid Tumors
, 1.0 mg/mL, 0.2 mg/mL, 0.05 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 10.0 mg, 20.0 mg, 30.0 mg, 3.33 mg/mL, 5.0 mg/mL, 1.667 mg/mL, 2.5 mg/mL
Intravenous; Subcutaneous, Injection, solution, , Injection, solution - Intravenous; Subcutaneous, Injection, Injection - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Intramuscular, Kit, Injection - Intravenous, Intravenous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection - Subcutaneous, Subcutaneous, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Kit - Intramuscular
Flushing
, 1.0 mg/mL, 0.2 mg/mL, 0.05 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 10.0 mg, 20.0 mg, 30.0 mg, 3.33 mg/mL, 5.0 mg/mL, 1.667 mg/mL, 2.5 mg/mL
Intravenous; Subcutaneous, Injection, solution, , Injection, solution - Intravenous; Subcutaneous, Injection, Injection - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Intramuscular, Kit, Injection - Intravenous, Intravenous, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Injection - Subcutaneous, Subcutaneous, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Injection, powder, for suspension, extended release; Kit, Injection, powder, for suspension, extended release; Kit - Intramuscular, Kit - Intramuscular
Warnings
Octreotide Acetate ContraindicationsCondition
Risk Level
Notes
known hypersensitivity to the drug or any of the ingredients
Do Not Combine
Common Octreotide Acetate Drug Interactions
Drug Name
Risk Level
Description
Dotatate gallium Ga-68
Major
Octreotide may decrease effectiveness of Dotatate gallium Ga-68 as a diagnostic agent.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Octreotide.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Octreotide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Octreotide is combined with Hydroxyzine.
Lutetium Lu 177 dotatate
Major
The therapeutic efficacy of Lutetium Lu 177 dotatate can be decreased when used in combination with Octreotide.
Octreotide Acetate Toxicity & Overdose RiskOctreotide overdose can lead to a variety of side effects, including low blood pressure, reduced oxygen to the brain, irregular heartbeat, heart attack, excess lactic acid in the body, inflammation of the pancreas, enlargement of the liver, diarrhea, reddening of the skin, tiredness, and weakness.
Octreotide Acetate Novel Uses: Which Conditions Have a Clinical Trial Featuring Octreotide Acetate?
41 active clinical trials are being conducted to assess the potential of Octreotide Acetate in providing therapeutic benefit for metastatic Carcinoid Tumors, Flushing and long-term maintenance therapy.Condition
Clinical Trials
Trial Phases
Gastroenteritis
26 Actively Recruiting
Phase 1, Phase 2, Phase 4, Phase 3, Not Applicable
Vasoactive Intestinal Peptide Tumors
0 Actively Recruiting
octreotide
0 Actively Recruiting
Acromegaly
6 Actively Recruiting
Phase 3, Phase 2, Not Applicable
long-term maintenance therapy
0 Actively Recruiting
Flushing
2 Actively Recruiting
Not Applicable
metastatic Carcinoid Tumors
2 Actively Recruiting
Phase 2, Early Phase 1
Octreotide Acetate Reviews: What are patients saying about Octreotide Acetate?
5Patient Review
3/12/2012 I take one large shot at the hospital every 21 days and 1-3 shots daily at home. Before, I couldn't sleep due to side effects like sweating, flushing, stomach upset, and needing to be near a restroom for 4-6 hours after eating. Now I'm back to working full time, maintaining my weight, and enjoying life outside the house. Thank god for health insurance--I don't know how people manage without it if they have to rely on government assistance.
4.7Patient Review
12/28/2010 Octreotide was a lifesaver for me. I had severe nausea and diarrhea after surgery, to the point where I lost 20 pounds. This medication completely cured those symptoms and allowed me to regain my strength and weight.
4.3Patient Review
3/22/2011 I've been using this treatment for 17 years, and it's helped me a lot. Recently I've started having some difficulty getting the same results, but overall it's still a great medication.
4.3Patient Review
7/31/2011 I've just started this medication and I'm not sure of the effects yet.
4Patient Review
1/15/2011 I receive monthly injections for carcinoid cancer of the small intestine which has metastisized to the liver. My diahrea, flushing, pain has decreases somewhat. I still have diahrea afer each meal but it is not as watery. Certain foods trigger my attacks, so I have to be real careful while eating. I am weak and sometimes confused, could be the drug.
1Patient Review
4/28/2012 I started with 100 micrograms twice a day, self injected in my abdomen. I had severe diarrhea right from the start. The dosage was reduced to 100micrograms once a day, with same result. the dosage was reduced to 50 micrograms once a day and the diarrhea continued.
Patient Q&A Section about octreotide acetate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is octreotide used in GI bleed?
"Octreotide can also be given as a continuous infusion.
Octreotide inhibits the secretion of acid and pepsin, preventing the dissolution of freshly formed clots. It can also be given as a continuous infusion."
Answered by AI
Is octreotide a chemo drug?
"(2018). Chemocare.com. Retrieved from https://chemocare.com/chemotherapy/drug-info/octreotide.aspx
Octreotide is used to treat certain types of cancer. It is a man-made protein that is similar to a hormone found in the body. Octreotide works by slowing the growth of certain tumors and by decreasing the amount of certain hormones in the body. Octreotide is used to treat the following types of cancer: acromegaly, carcinoid tumors, neuroendocrine tumors, and VIPomas."
Answered by AI
What is octreotide acetate used for?
"Octreotide is used to stop severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors. These tumors are usually found in the intestines and pancreas."
Answered by AI
What is the action of octreotide?
"The drug octreotide mimics the effects of the hormone somatostatin. Somatostatin regulates growth hormone and insulin, so octreotide is effective in treating disorders like acromegaly that involve abnormal tissue growth and insulin regulation."
Answered by AI