Nisoldipine

Hypertensive disease
Treatment
1 FDA approval
20 Active Studies for Nisoldipine

What is Nisoldipine

NisoldipineThe Generic name of this drug
Treatment SummaryNisoldipine is a medication used to treat high blood pressure. It works by blocking the calcium channels in the walls of the blood vessels, preventing them from tightening and reducing the flow of blood. Nisoldipine can be taken alone or in combination with other blood pressure medications.
Sularis the brand name
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Nisoldipine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sular
Nisoldipine
1995
23

Approved as Treatment by the FDA

Nisoldipine, also called Sular, is approved by the FDA for 1 uses which include Hypertensive disease .
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Nisoldipine Affects PatientsNisoldipine is a drug used to treat high blood pressure, chest pain (angina), and a type of chest pain called Prinzmetal angina. It works by blocking calcium from entering certain cells in the body, which relaxes the muscles in the walls of the blood vessels and increases the flow of oxygen-rich blood to the heart. This helps to lower the total peripheral resistance and blood pressure, which reduces the strain on the heart.
How Nisoldipine works in the bodyNisoldipine works by changing how calcium moves in and out of cells in the heart and vascular muscles. This reduces the contractions of those cells, which widens the coronary and systemic arteries. This increases oxygen delivery to the heart, lowers total peripheral resistance, lowers blood pressure, and reduces the amount of work the heart has to do.

When to interrupt dosage

The proposed dosage of Nisoldipine is contingent upon the diagnosed condition. The measure additionally depends upon the technique of application as found in the table beneath.
Condition
Dosage
Administration
Hypertensive disease
8.5 mg, , 25.5 mg, 34.0 mg, 17.0 mg, 40.0 mg, 20.0 mg, 30.0 mg, 10.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release

Warnings

Nisoldipine Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Nisoldipine may interact with Pulse Frequency
There are 20 known major drug interactions with Nisoldipine.
Common Nisoldipine Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Nisoldipine may increase the hypotensive activities of Amifostine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Nisoldipine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Nisoldipine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Nisoldipine.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Nisoldipine.
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Nisoldipine Novel Uses: Which Conditions Have a Clinical Trial Featuring Nisoldipine?

18 active trials are underway to explore the potential of Nisoldipine in attenuating Hypertensive disease.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Nisoldipine Reviews: What are patients saying about Nisoldipine?

5Patient Review
3/22/2008
Nisoldipine for High Blood Pressure
I was having serious problems with my legs swelling and aching after being on my feet for just a couple of hours.
4.3Patient Review
10/23/2008
Nisoldipine for High Blood Pressure
I'm generally pleased with this medication. It's effective and easy to use; however, since taking it I've developed unexplained pain in my knees. Hoping this isn't a long-term side effect...
3.7Patient Review
3/6/2011
Nisoldipine for High Blood Pressure
My blood pressure has lowered since starting this medication, but I have noticed some uncomfortable side effects. My legs and knees feel swollen by the end of the day, even though they don't look visibly swollen. Additionally, my eyes seem sensitive to light and puffy.
3.7Patient Review
4/6/2011
Nisoldipine for High Blood Pressure
I've been taking Sular for four years now. I have experienced some side effects, such as swelling of the legs, pounding heart, and facial rash.
3.7Patient Review
8/2/2008
Nisoldipine for High Blood Pressure
I experienced some swelling in my feet and ankles as a side effect of this treatment.
View All Reviews
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Patient Q&A Section about nisoldipine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of nisoldipine?

"The side effects of the medication are: headaches, an upset stomach, dizziness or lightheadedness, flushing, a fast heartbeat, excessive tiredness, nasal congestion, and a sore throat."

Answered by AI

What is the generic for nisoldipine?

"Nisoldipine is used to treat hypertension, but it is not approved for the treatment of chest pain like other popular calcium channel blockers."

Answered by AI

What kind of drug is nisoldipine?

"Nisoldipine is a calcium channel blocker that relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload."

Answered by AI

Is nisoldipine better than nifedipine?

"Nisoldipine is a new derivative of dihydropyridine that is chemically similar to nifedipine. Laboratory tests have shown that it is 10 to 100 times more effective than nifedipine, with a longer duration of action and a more targeted effect on blood vessels."

Answered by AI

Clinical Trials for Nisoldipine

Have you considered Nisoldipine clinical trials? We made a collection of clinical trials featuring Nisoldipine, we think they might fit your search criteria.
Have you considered Nisoldipine clinical trials? We made a collection of clinical trials featuring Nisoldipine, we think they might fit your search criteria.
Have you considered Nisoldipine clinical trials? We made a collection of clinical trials featuring Nisoldipine, we think they might fit your search criteria.
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