Nipride

Hypertension, Patients Undergoing Surgery, Intraoperative Blood Loss + 2 more
Treatment
5 Active Studies for Nipride

What is Nipride

NitroprussideThe Generic name of this drug
Treatment SummaryNitroprusside is a medication used to widen and relax blood vessels, specifically those leading away from the heart. It is administered intravenously to treat high blood pressure in medical emergencies. Nitroprusside works by releasing nitric oxide, a molecule that relaxes the walls of the blood vessels.
Nitropressis the brand name
Nipride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nitropress
Nitroprusside
2005
30

Effectiveness

How Nipride Affects PatientsNitroprusside is a drug that relaxes the muscles in the walls of blood vessels, leading to an increase in their size. This effect is stronger on veins than on arteries, and will not affect smooth muscle in other parts of the body such as the uterus or duodenum.
How Nipride works in the bodySodium nitroprusside is a drug that helps reduce blood pressure by releasing nitric oxide into the bloodstream. This nitric oxide binds to guanylate cyclase in the cells of the blood vessels, increasing the amount of cGMP. This cGMP then causes calcium ions to move from the cytoplasm to the endoplasmic reticulum, reducing the amount of available calcium ions. This ultimately leads to blood vessel dilation and lower blood pressure. Sodium nitroprusside also breaks down into cyanide and methemoglobin, which binds to the cyanide and helps flush it out of the body

When to interrupt dosage

The prescribed dosage of Nipride is contingent upon the ascertained condition, such as induction of Intraoperative Hypotension, Hypertensive crisis and Intraoperative Blood Loss. The dosage fluctuates as per the method of delivery indicated in the table below.
Condition
Dosage
Administration
Hypertension
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
Patients Undergoing Surgery
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
Intraoperative Blood Loss
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
Heart Failure
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous
induction of Intraoperative Hypotension
, 50.0 mg/mL, 50.0 mg, 25.0 mg/mL, 0.5 mg/mL, 0.2 mg/mL
, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous

Warnings

Nipride has six contraindications and should not be taken if any of the circumstances in the following table are present.Nipride Contraindications
Condition
Risk Level
Notes
compensatory hypertension
Do Not Combine
tobacco ambylopia
Do Not Combine
Operative Surgery
Do Not Combine
Emergency Surgery
Do Not Combine
Optic Atrophy
Do Not Combine
Pulmonary Vascular Resistance
Do Not Combine
There are 20 known major drug interactions with Nipride.
Common Nipride Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Nitroprusside may increase the hypotensive activities of Amifostine.
Technetium Tc-99m oxidronate
Major
Nitroprusside can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Minor
Nitroprusside can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Abacavir
Minor
Nitroprusside may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
Nitroprusside may increase the hypotensive activities of Acebutolol.
Nipride Toxicity & Overdose RiskTaking too much nitroprusside can lead to low blood pressure, cyanide poisoning, or thiocyanate poisoning. The average lethal dose of nitroprusside in rabbits, dogs, mice, and rats is 2.8, 5.0, 8.4, and 11.2 mg/kg respectively.
image of a doctor in a lab doing drug, clinical research

Nipride Novel Uses: Which Conditions Have a Clinical Trial Featuring Nipride?

Currently, there are 7 active trials assessing the potential of Nipride in relieving Hypertensive crisis, Acute Heart Failure (AHF) and providing Intraoperative Hypotension.
Condition
Clinical Trials
Trial Phases
Heart Failure
4 Actively Recruiting
Phase 4, Phase 2, Phase 3
Intraoperative Blood Loss
1 Actively Recruiting
Not Applicable
Patients Undergoing Surgery
0 Actively Recruiting
Hypertension
0 Actively Recruiting
induction of Intraoperative Hypotension
0 Actively Recruiting

Patient Q&A Section about nipride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does Nipride decrease blood pressure?

"1 Once in the body, sodium nitroprusside is quickly broken down into nitric oxide, a powerful vasodilator. This nitric oxide works as a vasodilator, causing the muscles surrounding blood vessels to relax, allowing the blood vessels themselves to expand. As the blood vessels expand, blood pressure drops."

Answered by AI

What is Nipride used for?

"Nipride RTU is a medication used to treat the symptoms of high blood pressure, low blood pressure during surgery, and heart failure. It may be used alone or with other medications. Nipride RTU is a type of drug called a vasodilator."

Answered by AI

What drug class is nitroprusside?

"A class of drugs is a group of medications that work similarly.

The drug Nitropress belongs to a class of medications called vasodilators. Vasodilators are a group of drugs that work in a similar way."

Answered by AI

Is Nipride a vasodilator?

"Sodium nitroprusside is a medication used to manage acute hypertension. It is a potent vasodilator and is administered as an IV infusion with intensive monitoring."

Answered by AI

Clinical Trials for Nipride

Have you considered Nipride clinical trials? We made a collection of clinical trials featuring Nipride, we think they might fit your search criteria.
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