What is Nipride
NitroprussideThe Generic name of this drug
Treatment SummaryNitroprusside is a medication used to widen and relax blood vessels, specifically those leading away from the heart. It is administered intravenously to treat high blood pressure in medical emergencies. Nitroprusside works by releasing nitric oxide, a molecule that relaxes the walls of the blood vessels.
Nitropressis the brand name
Nipride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nitropress
Nitroprusside
2005
30
Effectiveness
How Nipride Affects PatientsNitroprusside is a drug that relaxes the muscles in the walls of blood vessels, leading to an increase in their size. This effect is stronger on veins than on arteries, and will not affect smooth muscle in other parts of the body such as the uterus or duodenum.
How Nipride works in the bodySodium nitroprusside is a drug that helps reduce blood pressure by releasing nitric oxide into the bloodstream. This nitric oxide binds to guanylate cyclase in the cells of the blood vessels, increasing the amount of cGMP. This cGMP then causes calcium ions to move from the cytoplasm to the endoplasmic reticulum, reducing the amount of available calcium ions. This ultimately leads to blood vessel dilation and lower blood pressure. Sodium nitroprusside also breaks down into cyanide and methemoglobin, which binds to the cyanide and helps flush it out of the body
When to interrupt dosage
The prescribed dosage of Nipride is contingent upon the ascertained condition, such as induction of Intraoperative Hypotension, Hypertensive crisis and Intraoperative Blood Loss. The dosage fluctuates as per the method of delivery indicated in the table below.Condition
Dosage
Administration
induction of Intraoperative Hypotension
0.5 mg/mL, , 50.0 mg/mL, 25.0 mg/mL, 50.0 mg, 0.2 mg/mL
, Injection, solution - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, Injection, Injection, solution, concentrate - Intravenous, Injection - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Solution, Solution - Intravenous
Hypertensive crisis
0.5 mg/mL, , 50.0 mg/mL, 25.0 mg/mL, 50.0 mg, 0.2 mg/mL
, Injection, solution - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, Injection, Injection, solution, concentrate - Intravenous, Injection - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Solution, Solution - Intravenous
Intraoperative Blood Loss
0.5 mg/mL, , 50.0 mg/mL, 25.0 mg/mL, 50.0 mg, 0.2 mg/mL
, Injection, solution - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, Injection, Injection, solution, concentrate - Intravenous, Injection - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Solution, Solution - Intravenous
undergoing surgery
0.5 mg/mL, , 50.0 mg/mL, 25.0 mg/mL, 50.0 mg, 0.2 mg/mL
, Injection, solution - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, Injection, Injection, solution, concentrate - Intravenous, Injection - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Solution, Solution - Intravenous
Acute Heart Failure (AHF)
0.5 mg/mL, , 50.0 mg/mL, 25.0 mg/mL, 50.0 mg, 0.2 mg/mL
, Injection, solution - Intravenous, Intravenous, Injection, solution, concentrate, Injection, solution, Injection, Injection, solution, concentrate - Intravenous, Injection - Intravenous, Powder, for solution - Intravenous, Powder, for solution, Solution, Solution - Intravenous
Warnings
Nipride has six contraindications and should not be taken if any of the circumstances in the following table are present.Nipride ContraindicationsCondition
Risk Level
Notes
moribund patients (A.S.A Class 5E)
Do Not Combine
Aortic Coarctation, arteriovenous shunting
Do Not Combine
inadequate cerebral circulation
Do Not Combine
Optic Atrophy
Do Not Combine
Congestive heart failure
Do Not Combine
tobacco ambylopia
Do Not Combine
Common Nipride Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Nitroprusside may increase the hypotensive activities of Amifostine.
Technetium Tc-99m oxidronate
Major
Nitroprusside can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Minor
Nitroprusside can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Abacavir
Minor
Nitroprusside may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abaloparatide
Minor
The risk or severity of adverse effects can be increased when Nitroprusside is combined with Abaloparatide.
Nipride Toxicity & Overdose RiskTaking too much nitroprusside can lead to low blood pressure, cyanide poisoning, or thiocyanate poisoning. The average lethal dose of nitroprusside in rabbits, dogs, mice, and rats is 2.8, 5.0, 8.4, and 11.2 mg/kg respectively.
Nipride Novel Uses: Which Conditions Have a Clinical Trial Featuring Nipride?
Currently, there are 7 active trials assessing the potential of Nipride in relieving Hypertensive crisis, Acute Heart Failure (AHF) and providing Intraoperative Hypotension.Condition
Clinical Trials
Trial Phases
undergoing surgery
0 Actively Recruiting
Acute Heart Failure (AHF)
6 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Hypertensive crisis
0 Actively Recruiting
induction of Intraoperative Hypotension
0 Actively Recruiting
Intraoperative Blood Loss
1 Actively Recruiting
Not Applicable
Patient Q&A Section about nipride
How does Nipride decrease blood pressure?
"1 Once in the body, sodium nitroprusside is quickly broken down into nitric oxide, a powerful vasodilator. This nitric oxide works as a vasodilator, causing the muscles surrounding blood vessels to relax, allowing the blood vessels themselves to expand. As the blood vessels expand, blood pressure drops." - Anonymous Online Contributor
Unverified Answer
What is Nipride used for?
"Nipride RTU is a medication used to treat the symptoms of high blood pressure, low blood pressure during surgery, and heart failure. It may be used alone or with other medications. Nipride RTU is a type of drug called a vasodilator." - Anonymous Online Contributor
Unverified Answer
What drug class is nitroprusside?
"A class of drugs is a group of medications that work similarly.
The drug Nitropress belongs to a class of medications called vasodilators. Vasodilators are a group of drugs that work in a similar way." - Anonymous Online Contributor
Unverified Answer
Is Nipride a vasodilator?
"Sodium nitroprusside is a medication used to manage acute hypertension. It is a potent vasodilator and is administered as an IV infusion with intensive monitoring." - Anonymous Online Contributor
Unverified Answer