Nexium

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 14 more

Treatment

5 FDA approvals

18 Active Studies for Nexium

What is Nexium

Esomeprazole

The Generic name of this drug

Treatment Summary

Esomeprazole (brand name Nexium) is a type of medication called a proton pump inhibitor (PPI). This drug is used to reduce the amount of stomach acid in people with gastroesophageal reflux disease (GERD), peptic ulcers, and other conditions caused by high levels of stomach acid. It is also used in combination with antibiotics to treat H. pylori infections. Esomeprazole works by binding to an enzyme in the stomach which helps to slow down the production of acid. It is usually safe and effective, however long-term use may be associated with some side effects

Nexium

is the brand name

image of different drug pills on a surface

Nexium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nexium

Esomeprazole

2001

347

Approved as Treatment by the FDA

Esomeprazole, otherwise called Nexium, is approved by the FDA for 5 uses including Heartburn and Heartburn .

Heartburn

Heartburn

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Gastro-esophageal Reflux Disease (GERD)

Helps manage Gastro-esophageal Reflux Disease (GERD)

Heartburn

Helps manage Gastro-esophageal Reflux Disease (GERD)

Effectiveness

How Nexium Affects Patients

Esomeprazole reduces the amount of acid that is produced in the stomach. It is used to treat gastroesophageal reflux disease (GERD), heal erosive esophagitis, and remove the bacterial infection H. pylori to prevent duodenal ulcers from forming. It works by blocking an enzyme (H+/K+ ATPase) that produces stomach acid. Esomeprazole is similar to other proton pump inhibitors (PPIs) and has been linked to an increased risk of cardiovascular events, bacterial infections, reduced absorption of micronutrients, and low levels of

How Nexium works in the body

Esomeprazole works to reduce stomach acid production by attaching itself to the proteins that create acid in the stomach. This binding is permanent and prevents the body from creating more acid, providing a long-lasting acid-suppressing effect.

When to interrupt dosage

The endorsed dose of Nexium relies upon the diagnosed condition, for instance Curling Ulcer, Hemorrhage and Critical Illness. The magnitude of dosage is contingent upon the system of delivery (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) as noted in the table below.

Condition

Dosage

Administration

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stomach Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

antibacterial therapy

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Zollinger-Ellison Syndrome

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Curling Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

maintenance of healing Erosive esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Gastric ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Erosive Esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Critical Illness

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Helicobacter Pylori Infection

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

prophylaxis of Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Nexium Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Nexium.

Common Nexium Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.

Atazanavir

Major

Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Esomeprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.

Infigratinib

Major

The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.

Nexium Toxicity & Overdose Risk

Overdosing on ibuprofen can lead to blurry vision, confusion, sleepiness, dry mouth, feeling hot, headaches, nausea, fast heartbeat, and sweating.

image of a doctor in a lab doing drug, clinical research

Nexium Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexium?

At this time, 26 active trials are assessing the potential of Nexium to treat previous gastric or duodenal ulcers, Stomach Ulcers and Peptic Ulcers.

Condition

Clinical Trials

Trial Phases

Hemorrhage

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Gastric ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Stomach Ulcer

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Stress Ulcers

0 Actively Recruiting

maintenance of healing Erosive esophagitis

0 Actively Recruiting

Peptic Ulcer

0 Actively Recruiting

Critical Illness

0 Actively Recruiting

Hemorrhage

0 Actively Recruiting

Heartburn

12 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Peptic Ulcer

0 Actively Recruiting

prophylaxis of Stress Ulcers

0 Actively Recruiting

Nexium Reviews: What are patients saying about Nexium?

5

Patient Review

12/30/2015

Nexium for Condition in which Stomach Acid is Pushed Into the Esophagus

Nexium has been an absolute game-changer for me. I no longer have to deal with the heartburn that was a constant part of my life.

5

Patient Review

8/2/2016

Nexium for Ulcer of Duodenum caused by Bacteria Helicobacter Pylori

I've been taking this since it came out and it's really worked well for me. My doctor recommended I switch to something stronger than Zantac, and this has done the trick. I am a little concerned about the long-term effects of blocking stomach acid, but so far so good.

5

Patient Review

3/29/2018

Nexium for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been using Nexium for over 15 years. I started with the 40mg dosage but when the price went up, I switched to the 20mg OTC version. I take it every morning and have never experienced any side effects. It's been working great for me all this time and I don't see any reason to stop taking it now.

5

Patient Review

5/20/2016

Nexium for Heartburn

I had been struggling with chronic heartburn for months before I found this medication. It worked within days, and I'm now able to sleep through the night without pain.

5

Patient Review

4/30/2022

Nexium for eosinophilic inflammation of the esophagus

I was really struggling before I found this treatment, constantly having to eat Tums and drink water to try and combat the burning in my throat. Now, I can finally sleep without any pain!

5

Patient Review

11/19/2018

Nexium for Condition in which Stomach Acid is Pushed Into the Esophagus

Though it's on the expensive side, this treatment is worth every penny when you're experiencing severe acid reflux.

5

Patient Review

9/20/2019

Nexium for Heartburn

I had chronic heartburn before starting this medication, and now I don't at all. I take it every other day, as directed, and have experienced zero negative side effects.

4.7

Patient Review

4/18/2019

Nexium for Inflammation of the Stomach Lining caused by H. Pylori

I am epileptic and I take phenytoin primidone and zonisamide. Recently, my chest started hurting from inflammation of my stomach. I went to the ER to make sure it wasnâ??t my heart, but everything came back fine. The doctor prescribed me nexium 40mg for about a week; however, I have been having anxiety, headaches, dizziness, and blurred vision about an hour after taking the medication. I just called the doctor and am waiting to hear back on what I should do next.

4.3

Patient Review

5/26/2016

Nexium for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking this for years now and it's helped me a lot. It's not perfect, but nothing is; as long as you're aware of its limitations, I think you'll be pleased with the results.

4

Patient Review

3/23/2019

Nexium for Excessive Production of Stomach Acid

I took this medication for a month in an effort to reduce the amount of stomach acid I was producing. Unfortunately, after only two weeks I started experiencing intense pain in my intestines and by the third week my breasts had grown painfully large. Not sure if these side effects are common, but they're definitely not worth it in my opinion.

3

Patient Review

4/15/2019

Nexium for Condition in which Stomach Acid is Pushed Into the Esophagus

I started taking Nexium for GERD 4 months ago. It did control my GERD, but I experienced some pretty significant side effects, like hair loss, elevated blood pressure and sinus congestion. When I stopped taking it for a week, the GERD came back full force. Now I'm trying to taper off of it, but wish I had never started in the first place.

3

Patient Review

5/11/2020

Nexium for Heartburn

Unfortunately, this drug didn't agree with me. After taking it for a week as directed, I experienced heart palpitations and diarrhea every time. The last dose also resulted in vomiting and severe itching all over my body.

1

Patient Review

7/8/2016

Nexium for Condition in which Stomach Acid is Pushed Into the Esophagus

I developed osteoporosis after using this treatment for just three years. It inhibits the production of stomach acid, which is essential for calcium absorption and strong bones. I stopped taking it and instead drink a glass of water at bedtime whenever I get heartburn or acid reflux.

1

Patient Review

5/13/2022

Nexium for Increased Stomach Acid from Systemic Mastocytosis

I had an incredibly severe allergic reaction the first time I took this medicine. Please, avoid this medication if you can. I didn't have any allergies to medications prior and only seasonal allergies. Consult a doctor before taking any over the counter medicines. I have three young kids at home and nearly put my life at risk.

1

Patient Review

9/27/2016

Nexium for Excessive Production of Stomach Acid

Do not take this drug. I developed osteoporosis after years of taking it. Acid is important for calcium production, so instead I take a glass of water before bedtime and that has worked just fine.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nexium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Nexium drug used for?

"Esomeprazole is a medication that helps with heartburn, difficulty swallowing, and persistent cough. It also helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus."

Answered by AI

How long does Nexium 40 mg take to work?

"If you start taking esomeprazole, you should start feeling better within a few days. It may take up to a month for the medicine to start working properly, but you may still have symptoms during this time."

Answered by AI

How long should you take Nexium 40 mg?

"Adults should take 20-40 mg of the medication once a day for 4-8 weeks. The dose may be adjusted as needed. To prevent the return of esophagitis, the doctor may recommend taking 20 mg once a day for up to 6 months."

Answered by AI

Is Nexium good for gastritis?

"These medications work by either blocking the production of stomach acid or reducing the amount of stomach acid that is released into your digestive tract. This promotes the healing of inflammation. Some common medications include Prilosec, Nexium, and Zantac."

Answered by AI

When should you take Nexium morning or night?

"To take esomeprazole, swallow the capsule whole with water. You can take it with or without food. If you take esomeprazole twice a day, take the first dose in the morning and the second dose in the evening."

Answered by AI

Clinical Trials for Nexium

Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA

Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.

Waitlist Available
Has No Placebo

University of California, Irvine - UCI Medical Center

Jason Samarasena, MD, MBA

Image of Del Sol Research Management, LLC in Tucson, United States.

Linaprazan Glurate vs Lansoprazole for Acid Reflux

18 - 80
All Sexes
Tucson, AZ

The goal of this clinical trial is to find out how well linaprazan glurate can heal erosive esophagitis (EE) caused by gastroesophageal reflux disease (GERD), compared to lansoprazole, a commonly used medication. Researchers will also evaluate whether linaprazan glurate: * Reduces heartburn symptoms more effectively than lansoprazole * Is safe and well tolerated, based on physical exams, blood tests, and vital signs (heart rate, blood pressure, temperature, and breathing rate) * Causes any side effects during treatment * Has different effects depending on how much of the drug is in the blood * Works differently depending on participants' genes Participants must be between 18 to 80 years old and have EE due to GERD confirmed by an endoscopy. Participants cannot join if they have an active Helicobacter pylori (HP) infection or were treated for HP in the past 6 weeks or have taken antibiotics or bismuth-containing drugs in the past 6 weeks. The study is a randomized, double-blind, active comparator-controlled trial lasting up to 4 months. Randomized means that participants are assigned by chance (like flipping a coin) to one of the treatment groups and double-blind means neither the participants nor the study team will know which treatment is given. Participants will be placed into one of three groups (about 167 people in each group): * Linaprazan glurate 50 mg twice a day * Linaprazan glurate 50 mg once a day * Lansoprazole 30 mg once a day Everyone will take 2 tablets and 1 capsule by mouth daily for 8 weeks. Some tablets or capsules will be placebos (look like medicine but contain no active drug). Participants will: * Undergo an endoscopy in the beginning and after 4 weeks of treatment * If healing is not observed, another endoscopy may be done at 8 weeks * During the procedure, doctors will use a thin, flexible tube with a camera to look at the esophagus and take small tissue samples (biopsies) * Have blood and urine tests at clinic visits to check overall health * Receive electrocardiograms (ECGs) to monitor heart function * Complete daily questionnaires on an electronic device about symptoms and experiences

Phase 3
Waitlist Available

Del Sol Research Management, LLC (+24 Sites)

Cinclus Pharma Holding AB

Have you considered Nexium clinical trials?

We made a collection of clinical trials featuring Nexium, we think they might fit your search criteria.
Go to Trials
Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting
Has No Placebo

Brigham and Women's Hospital

Christopher C Thompson, MD

Erbe Elektromedizin GmbH

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Mesh vs Pledgets for Hernia Repair

18+
All Sexes
Cleveland, OH

The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: * Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. * Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms

Recruiting
Has No Placebo

Cleveland Clinic Center for Abdominal Core Health

David M Krpata, MD

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Have you considered Nexium clinical trials?

We made a collection of clinical trials featuring Nexium, we think they might fit your search criteria.
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