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What is Nexium
EsomeprazoleThe Generic name of this drug
Treatment SummaryEsomeprazole (brand name Nexium) is a type of medication called a proton pump inhibitor (PPI). This drug is used to reduce the amount of stomach acid in people with gastroesophageal reflux disease (GERD), peptic ulcers, and other conditions caused by high levels of stomach acid. It is also used in combination with antibiotics to treat H. pylori infections. Esomeprazole works by binding to an enzyme in the stomach which helps to slow down the production of acid. It is usually safe and effective, however long-term use may be associated with some side effects
Nexiumis the brand name
Nexium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexium
Esomeprazole
2001
347
Approved as Treatment by the FDA
Esomeprazole, otherwise called Nexium, is approved by the FDA for 3 uses including Heartburn and Heartburn .Heartburn
Heartburn
Helps manage Gastro-esophageal Reflux Disease (GERD)
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Effectiveness
How Nexium Affects PatientsEsomeprazole reduces the amount of acid that is produced in the stomach. It is used to treat gastroesophageal reflux disease (GERD), heal erosive esophagitis, and remove the bacterial infection H. pylori to prevent duodenal ulcers from forming. It works by blocking an enzyme (H+/K+ ATPase) that produces stomach acid. Esomeprazole is similar to other proton pump inhibitors (PPIs) and has been linked to an increased risk of cardiovascular events, bacterial infections, reduced absorption of micronutrients, and low levels of
How Nexium works in the bodyEsomeprazole works to reduce stomach acid production by attaching itself to the proteins that create acid in the stomach. This binding is permanent and prevents the body from creating more acid, providing a long-lasting acid-suppressing effect.
When to interrupt dosage
The endorsed dose of Nexium relies upon the diagnosed condition, for instance Curling Ulcer, Hemorrhage and Critical Illness. The magnitude of dosage is contingent upon the system of delivery (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) as noted in the table below.Condition
Dosage
Administration
develop NSAID-induced gastric ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
maintenance of healing Erosive esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
antibacterial therapy
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Critical Illness
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Helicobacter Pylori Infection
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Peptic Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
previous gastric or duodenal ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Erosive Esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Gastric ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
prophylaxis of Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Zollinger-Ellison Syndrome
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Curling Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Warnings
Nexium ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Nexium Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.
Atazanavir
Major
Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Esomeprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.
Nexium Toxicity & Overdose RiskOverdosing on ibuprofen can lead to blurry vision, confusion, sleepiness, dry mouth, feeling hot, headaches, nausea, fast heartbeat, and sweating.
Nexium Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexium?
At this time, 26 active trials are assessing the potential of Nexium to treat previous gastric or duodenal ulcers, Stomach Ulcers and Peptic Ulcers.Condition
Clinical Trials
Trial Phases
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Helicobacter Pylori Infection
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
previous gastric or duodenal ulcer
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
develop NSAID-induced gastric ulcers
0 Actively Recruiting
Peptic Ulcer
2 Actively Recruiting
Not Applicable, Phase 4
Hemorrhage
1 Actively Recruiting
Phase 4
Gastric ulcer
0 Actively Recruiting
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
maintenance of healing Erosive esophagitis
0 Actively Recruiting
Heartburn
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
Hemorrhage
0 Actively Recruiting
prophylaxis of Stress Ulcers
0 Actively Recruiting
Stress Ulcers
0 Actively Recruiting
Critical Illness
0 Actively Recruiting
Nexium Reviews: What are patients saying about Nexium?
5Patient Review
12/30/2015 Nexium has been an absolute game-changer for me. I no longer have to deal with the heartburn that was a constant part of my life.
5Patient Review
8/2/2016 I've been taking this since it came out and it's really worked well for me. My doctor recommended I switch to something stronger than Zantac, and this has done the trick. I am a little concerned about the long-term effects of blocking stomach acid, but so far so good.
5Patient Review
3/29/2018 I've been using Nexium for over 15 years. I started with the 40mg dosage but when the price went up, I switched to the 20mg OTC version. I take it every morning and have never experienced any side effects. It's been working great for me all this time and I don't see any reason to stop taking it now.
5Patient Review
5/20/2016 I had been struggling with chronic heartburn for months before I found this medication. It worked within days, and I'm now able to sleep through the night without pain.
5Patient Review
4/30/2022 I was really struggling before I found this treatment, constantly having to eat Tums and drink water to try and combat the burning in my throat. Now, I can finally sleep without any pain!
5Patient Review
11/19/2018 Though it's on the expensive side, this treatment is worth every penny when you're experiencing severe acid reflux.
5Patient Review
9/20/2019 I had chronic heartburn before starting this medication, and now I don't at all. I take it every other day, as directed, and have experienced zero negative side effects.
4.7Patient Review
4/18/2019 I am epileptic and I take phenytoin primidone and zonisamide. Recently, my chest started hurting from inflammation of my stomach. I went to the ER to make sure it wasnâ??t my heart, but everything came back fine. The doctor prescribed me nexium 40mg for about a week; however, I have been having anxiety, headaches, dizziness, and blurred vision about an hour after taking the medication. I just called the doctor and am waiting to hear back on what I should do next.
4.3Patient Review
5/26/2016 I've been taking this for years now and it's helped me a lot. It's not perfect, but nothing is; as long as you're aware of its limitations, I think you'll be pleased with the results.
4Patient Review
3/23/2019 I took this medication for a month in an effort to reduce the amount of stomach acid I was producing. Unfortunately, after only two weeks I started experiencing intense pain in my intestines and by the third week my breasts had grown painfully large. Not sure if these side effects are common, but they're definitely not worth it in my opinion.
3Patient Review
4/15/2019 I started taking Nexium for GERD 4 months ago. It did control my GERD, but I experienced some pretty significant side effects, like hair loss, elevated blood pressure and sinus congestion. When I stopped taking it for a week, the GERD came back full force. Now I'm trying to taper off of it, but wish I had never started in the first place.
3Patient Review
5/11/2020 Unfortunately, this drug didn't agree with me. After taking it for a week as directed, I experienced heart palpitations and diarrhea every time. The last dose also resulted in vomiting and severe itching all over my body.
1Patient Review
7/8/2016 I developed osteoporosis after using this treatment for just three years. It inhibits the production of stomach acid, which is essential for calcium absorption and strong bones. I stopped taking it and instead drink a glass of water at bedtime whenever I get heartburn or acid reflux.
1Patient Review
5/13/2022 I had an incredibly severe allergic reaction the first time I took this medicine. Please, avoid this medication if you can. I didn't have any allergies to medications prior and only seasonal allergies. Consult a doctor before taking any over the counter medicines. I have three young kids at home and nearly put my life at risk.
1Patient Review
9/27/2016 Do not take this drug. I developed osteoporosis after years of taking it. Acid is important for calcium production, so instead I take a glass of water before bedtime and that has worked just fine.
Patient Q&A Section about nexium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Nexium drug used for?
"Esomeprazole is a medication that helps with heartburn, difficulty swallowing, and persistent cough. It also helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus."
Answered by AI
How long does Nexium 40 mg take to work?
"If you start taking esomeprazole, you should start feeling better within a few days. It may take up to a month for the medicine to start working properly, but you may still have symptoms during this time."
Answered by AI
How long should you take Nexium 40 mg?
"Adults should take 20-40 mg of the medication once a day for 4-8 weeks. The dose may be adjusted as needed. To prevent the return of esophagitis, the doctor may recommend taking 20 mg once a day for up to 6 months."
Answered by AI
Is Nexium good for gastritis?
"These medications work by either blocking the production of stomach acid or reducing the amount of stomach acid that is released into your digestive tract. This promotes the healing of inflammation. Some common medications include Prilosec, Nexium, and Zantac."
Answered by AI
When should you take Nexium morning or night?
"To take esomeprazole, swallow the capsule whole with water. You can take it with or without food. If you take esomeprazole twice a day, take the first dose in the morning and the second dose in the evening."
Answered by AI