Neupro

Parkinson's Disease, Restless Legs Syndrome, Restless Legs Syndrome
Treatment
3 FDA approvals
20 Active Studies for Neupro

What is Neupro

RotigotineThe Generic name of this drug
Treatment SummaryRotigotine (Neupro) is a patch that is worn on the skin and slowly releases medication over 24 hours to treat Parkinson’s Disease and Restless Legs Syndrome. It may also have antidepressant effects. Rotigotine was developed by Aderis Pharmaceuticals and licensed to Schwarz Pharma in 1998. It was approved by the EMA in 2006 and the FDA in 2007, but was recalled in 2008 due to delivery problems. Since then, it has been authorized as a treatment for RLS.
Neuprois the brand name
image of different drug pills on a surface
Neupro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Neupro
Rotigotine
2012
7

Approved as Treatment by the FDA

Rotigotine, also called Neupro, is approved by the FDA for 3 uses including Parkinson's Disease and Restless Legs Syndrome .
Parkinson's Disease
Helps manage Parkinson's Disease (PD)
Restless Legs Syndrome
Helps manage Moderate restless legs syndrome (RLS)
Restless Legs Syndrome
Helps manage Severe restless legs syndrome (RLS)

Effectiveness

How Neupro Affects PatientsRotigotine binds to dopamine receptors (D1-D5, with the highest affinity to D3) and has effects on other receptors such as alpha-2-adrenergic and 5HT1A. It also stops dopamine from being taken up and prevents the release of prolactin. Studies have found that even at doses up to 24 mg/24 hours, there is no indication of rotigotine causing a prolonged QT/QTc interval. This was confirmed in a trial with male and female patients with advanced-stage Parkinson's disease where a positive-controlled (moxifloxacin) showed assay
How Neupro works in the bodyRotigotine is a drug that mimics the effects of the chemical dopamine. It is administered through a patch worn on the skin that needs to be replaced every 24 hours. Rotigotine works by activating dopamine receptors in the body, although it is not yet clear exactly how it helps treat Restless Legs Syndrome.

When to interrupt dosage

The recommended dosage of Neupro is contingent upon the determined condition, such as Restless Legs Syndrome, Parkinson's Disease and Restless Legs Syndrome. The measure of dosage is dependent upon the technique of delivery (e.g. Patch - Transdermal or Patch) featured in the table beneath.
Condition
Dosage
Administration
Parkinson's Disease
, 0.2 mg/hour, 0.4 mg/hour, 0.3 mg/hour, 0.6 mg/hour, 0.8 mg/hour, 0.1 mg/hour
, Patch, Transdermal, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal
Restless Legs Syndrome
, 0.2 mg/hour, 0.4 mg/hour, 0.3 mg/hour, 0.6 mg/hour, 0.8 mg/hour, 0.1 mg/hour
, Patch, Transdermal, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal
Restless Legs Syndrome
, 0.2 mg/hour, 0.4 mg/hour, 0.3 mg/hour, 0.6 mg/hour, 0.8 mg/hour, 0.1 mg/hour
, Patch, Transdermal, Patch - Transdermal, Patch, extended release, Patch, extended release - Transdermal

Warnings

There are 20 known major drug interactions with Neupro.
Common Neupro Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Rotigotine.
Azelastine
Major
Rotigotine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Rotigotine.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Rotigotine.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Rotigotine.
Neupro Toxicity & Overdose RiskOverdosing on a dopamine agonist can cause symptoms such as nausea, vomiting, low blood pressure, involuntary movements, hallucinations, confusion, seizures, and other signs of too much dopamine in the body.
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Neupro Novel Uses: Which Conditions Have a Clinical Trial Featuring Neupro?

Currently, 45 active clinical trials are investigating the potential of Neupro to alleviate Restless Legs Syndrome, Restless Legs Syndrome and Parkinson's Disease.
Condition
Clinical Trials
Trial Phases
Restless Legs Syndrome
0 Actively Recruiting
Restless Legs Syndrome
0 Actively Recruiting
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1

Neupro Reviews: What are patients saying about Neupro?

5Patient Review
3/1/2016
Neupro for Parkinson's Disease
Neupro has been awesome for decreasing my tremors and stiffness. The only downside is that it's caused some insomnia; but, all things considered, the pros definitely outweigh the cons.
5Patient Review
5/28/2020
Neupro for Extreme Discomfort in Calves when Sitting or Lying Down
I've been using these patches for four years now and they've done wonders for my restless legs. The only downside is that it doesn't always stick well, depending on where I put it. Other than that, no negative side effects like weight gain or anything else.
5Patient Review
8/22/2016
Neupro for Parkinson's Disease
The patches are more difficult to apply when the backing is on a diagonal cut; I prefer when it's cut at a 90 degree angle.
5Patient Review
12/10/2020
Neupro for Parkinson's Disease
I sleep better than I ever have since taking this medication; however, it has caused constipation to be a problem for me.
5Patient Review
9/29/2015
Neupro for Parkinson's Disease
I have a lot more confidence in this treatment because it provides 24-hour relief.
4.3Patient Review
1/13/2021
Neupro for Extreme Discomfort in Calves when Sitting or Lying Down
While it has caused me some depression and fatigue, this medication is really effective for treating my restless leg syndrome.
4Patient Review
5/27/2015
Neupro for Parkinson's Disease
Neupro has been effective in controlling my PD symptoms; however, I now have difficulty sleeping through the night and often wake up with leg cramps. Are these common side effects that I should expect?
4Patient Review
2/25/2016
Neupro for Parkinson's Disease
After wearing neupro patch for some time, I developed an itchy rash under the patch.
3Patient Review
1/30/2017
Neupro for Extreme Discomfort in Calves when Sitting or Lying Down
This treatment has been helpful for my restless legs, but it's not perfect. The patch falls off pretty easily, so I have to tape it on every day. Some days are better than others, but this definitely isn't a cure-all.
3Patient Review
6/17/2022
Neupro for Extreme Discomfort in Calves when Sitting or Lying Down
The patches are sometimes difficult to keep on, which is an issue because they need to stay on for a full day. That said, when I was able to get them to stick, the treatment effectively relieved my restless leg syndrome.
2.7Patient Review
7/9/2020
Neupro for Parkinson's Disease
I didn't notice any improvements in my balance or walking after a month of using this treatment, and it's quite pricey.
2.3Patient Review
5/10/2021
Neupro for Parkinson's Disease
I found the patches to be very irritating and difficult to keep on. They also caused some skin irritation for me, so I had to stop using them. While I was using them, they did seem to help somewhat.
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Patient Q&A Section about neupro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is NEUPRO patch a narcotic?

"Neupro is a non-controlled substance containing rotigotine. It is a dopamine agonist that is approved to treat Parkinson's disease and restless legs syndrome. The classification is thought to work by stimulating dopamine receptors in the brain."

Answered by AI

What is NEUPRO used for?

"NEUPRO is a prescription medicine used for treating Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome."

Answered by AI

How does NEUPRO make you feel?

"The following are potential side effects of NEUPRO that patients should be aware of: hallucinations, confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs, and disorganized thinking. These symptoms can either start or worsen when taking NEUPRO."

Answered by AI

What drug class is NEUPRO?

"The active drug in Neupro is rotigotine, which is a dopamine agonist. These drugs work in a similar way and Neupro is applied to the skin as patches every day."

Answered by AI

Clinical Trials for Neupro

Have you considered Neupro clinical trials? We made a collection of clinical trials featuring Neupro, we think they might fit your search criteria.
Have you considered Neupro clinical trials? We made a collection of clinical trials featuring Neupro, we think they might fit your search criteria.
Have you considered Neupro clinical trials? We made a collection of clinical trials featuring Neupro, we think they might fit your search criteria.