What is Namzaric
MemantineThe Generic name of this drug
Treatment SummaryMemantine is a medication used to treat Alzheimer's Disease. It was approved by the FDA in 2013 and works differently than other Alzheimer's medications, blocking the effects of the neurotransmitter glutamate which can lead to excessive stimulation in Alzheimer's Disease. Around 36 million people were estimated to have Alzheimer's Disease in 2010, with the number rising to 44 million in 2013. It is predicted that this number will reach 115 million by 2050. In 2013, the G8 dementia summit declared that finding a cure or disease-modifying therapy for Alzheimer's Disease should be a global priority, with the objective of achieving this by 2025.
Namendais the brand name
Namzaric Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Namenda
Memantine
2003
235
Approved as Treatment by the FDA
Memantine, commonly known as Namenda, is approved by the FDA for 2 uses like Alzheimer's Disease and Alzheimer's Disease .Alzheimer's Disease
Helps manage severe Alzheimer's Type Dementia
Alzheimer's Disease
Used to treat moderate Alzheimer's Type Dementia in combination with Donepezil
Effectiveness
How Namzaric Affects PatientsMemantine is a drug used to treat Alzheimer's dementia. It works by reducing the amount of calcium that enters cells when they are overstimulated by a chemical called glutamate. This leads to improved cognition and other positive effects on the central nervous system. At higher doses, memantine can reduce the ability of neurons to change and learn, but at lower doses it can improve memory and protect neurons from harm. Memantine has low activity with other types of receptors, and does not affect the effects of other drugs used to treat Alzheimer's.
How Namzaric works in the bodyGlutamate, a molecule found in the brain, can overactivate certain receptors and cause toxic effects. Memantine works by blocking these receptors and stopping glutamate from interacting with them. This helps to reduce the toxic effects of glutamate. However, it is not yet known if memantine can stop or slow the brain damage caused by Alzheimer's disease.
When to interrupt dosage
The proposed dosage of Namzaric is contingent upon the determined condition, for example Alzheimer's Disease, Alzheimer's Disease and Dementia, Vascular. The quantity of dosage can be found in the table below, based on the technique of delivery (e.g. Kit - Oral or Solution - Oral).Condition
Dosage
Administration
Alzheimer's Disease
10.0 mg, , 21.0 mg, 14.0 mg, 7.0 mg, 5.0 mg, 20.0 mg, 10.0 mg/mL, 15.0 mg, 2.0 mg/mL, 28.0 mg, 5.0 mg/pump actuation, 70.0 mg
Kit - Oral, Solution - Oral, , Oral, Kit, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, film coated - Oral, Solution, Liquid, Tablet - Oral, Capsule, Tablet, Tablet, coated, Capsule - Oral, Capsule, extended release; Kit, Capsule, extended release; Kit - Oral, Liquid - Oral
Dementia, Vascular
10.0 mg, , 21.0 mg, 14.0 mg, 7.0 mg, 5.0 mg, 20.0 mg, 10.0 mg/mL, 15.0 mg, 2.0 mg/mL, 28.0 mg, 5.0 mg/pump actuation, 70.0 mg
Kit - Oral, Solution - Oral, , Oral, Kit, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, film coated - Oral, Solution, Liquid, Tablet - Oral, Capsule, Tablet, Tablet, coated, Capsule - Oral, Capsule, extended release; Kit, Capsule, extended release; Kit - Oral, Liquid - Oral
Alzheimer's Disease
10.0 mg, , 21.0 mg, 14.0 mg, 7.0 mg, 5.0 mg, 20.0 mg, 10.0 mg/mL, 15.0 mg, 2.0 mg/mL, 28.0 mg, 5.0 mg/pump actuation, 70.0 mg
Kit - Oral, Solution - Oral, , Oral, Kit, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, film coated - Oral, Solution, Liquid, Tablet - Oral, Capsule, Tablet, Tablet, coated, Capsule - Oral, Capsule, extended release; Kit, Capsule, extended release; Kit - Oral, Liquid - Oral
Dementia, Vascular
10.0 mg, , 21.0 mg, 14.0 mg, 7.0 mg, 5.0 mg, 20.0 mg, 10.0 mg/mL, 15.0 mg, 2.0 mg/mL, 28.0 mg, 5.0 mg/pump actuation, 70.0 mg
Kit - Oral, Solution - Oral, , Oral, Kit, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, film coated - Oral, Solution, Liquid, Tablet - Oral, Capsule, Tablet, Tablet, coated, Capsule - Oral, Capsule, extended release; Kit, Capsule, extended release; Kit - Oral, Liquid - Oral
Alzheimer's Disease
10.0 mg, , 21.0 mg, 14.0 mg, 7.0 mg, 5.0 mg, 20.0 mg, 10.0 mg/mL, 15.0 mg, 2.0 mg/mL, 28.0 mg, 5.0 mg/pump actuation, 70.0 mg
Kit - Oral, Solution - Oral, , Oral, Kit, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, film coated - Oral, Solution, Liquid, Tablet - Oral, Capsule, Tablet, Tablet, coated, Capsule - Oral, Capsule, extended release; Kit, Capsule, extended release; Kit - Oral, Liquid - Oral
Alzheimer's Disease
10.0 mg, , 21.0 mg, 14.0 mg, 7.0 mg, 5.0 mg, 20.0 mg, 10.0 mg/mL, 15.0 mg, 2.0 mg/mL, 28.0 mg, 5.0 mg/pump actuation, 70.0 mg
Kit - Oral, Solution - Oral, , Oral, Kit, Capsule, extended release, Tablet, film coated, Capsule, extended release - Oral, Tablet, coated - Oral, Tablet, film coated - Oral, Solution, Liquid, Tablet - Oral, Capsule, Tablet, Tablet, coated, Capsule - Oral, Capsule, extended release; Kit, Capsule, extended release; Kit - Oral, Liquid - Oral
Warnings
Namzaric has one contraindication, so it should not be utilized for any of the conditions mentioned in the following table.Namzaric ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Memantine may interact with Toxoplasma Infections
Common Namzaric Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Memantine.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Memantine.
Antipyrine
Major
The metabolism of Antipyrine can be decreased when combined with Memantine.
Apomorphine
Major
The metabolism of Apomorphine can be decreased when combined with Memantine.
Artemether
Major
The metabolism of Artemether can be decreased when combined with Memantine.
Namzaric Toxicity & Overdose RiskThe toxic dose of memantine for mice is 437-498mg/kg, and for rats is 328-370mg/kg. No evidence of cancer or genetic mutation was found in mice or rats given large doses. No adverse effects on fertility or reproductive performance were observed in rats given 18mg/kg/day, which is nine times the maximum recommended human dose. Pregnant women should only take this drug if the potential benefits outweigh the possible risks to the fetus. It is not known if memantine is passed through breast milk, so nursing mothers should be cautious when taking this drug.
Namzaric Novel Uses: Which Conditions Have a Clinical Trial Featuring Namzaric?
41 active trials are currently being conducted to investigate the potential of Namzaric in treating Alzheimer's Disease, Vascular Dementia, and other forms of Alzheimer's Disease.Condition
Clinical Trials
Trial Phases
Alzheimer's Disease
0 Actively Recruiting
Dementia, Vascular
0 Actively Recruiting
Alzheimer's Disease
0 Actively Recruiting
Dementia, Vascular
0 Actively Recruiting
Alzheimer's Disease
39 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Alzheimer's Disease
0 Actively Recruiting
Namzaric Reviews: What are patients saying about Namzaric?
5Patient Review
1/3/2019 My mother started taking this a month ago, and we've seen her skills with conversation,alertness, and cognition improve since then. It's not a cure-all by any means, but it's nice to see her happier and more engaged with the world around her. The fact that it comes in one pill is also great, because she has trouble swallowing pills otherwise.
4Patient Review
1/11/20163Patient Review
3/27/20172.3Patient Review
4/4/2017 Recently, I was diagnosed with Alzheimer's. I'm not entirely sure if this treatment slowed the progression of my symptoms or not. However, I have been having very vivid dreams every night--some of which are actually quite entertaining. Additionally, I've experienced appetite and weight loss; while this hasn't been a huge problem for me yet as I am at a normal weight, I don't want to lose any more weight. Next month, I will start a clinical trial with aducanumab to see if that adds too many side effects.
2.3Patient Review
8/17/2017 This didn't alleviate my symptoms whatsoever.
2Patient Review
4/21/2017 I'm not sure yet if this is working or not. I'll have to wait and see.
1Patient Review
5/12/2017 I was extremely disappointed with this medication. It did nothing to help me and I feel like it's just a way for the pharmaceutical companies to make money.
Patient Q&A Section about namzaric
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Namzaric used for?
"This medication is used to treat moderate to severe confusion related to Alzheimer's disease. It may improve memory, awareness, and the ability to perform daily functions, but it does not cure Alzheimer's disease."
Answered by AI
How long does it take for Namzaric to work?
"In the subset population that was studied, it was found that the combination of NAMENDA XR and donepezil HCl improved cognition by 2.7 units, which is similar to the 2.6 unit improvement observed in the overall study population."
Answered by AI
What kind of drug is Namzaric?
"Namzaric is a drug used to treat moderate to severe dementia in patients who are already taking memantine. It is a combination of an NMDA receptor antagonist and a reversible inhibitor of the enzyme acetylcholinesterase."
Answered by AI
What is the generic name for Namzaric?
"The generic name for this medication is memantine hydrochloride extended-release, and it is available in 7mg/10mg, 14mg/10mg, 21mg/10mg, and 28mg/10mg capsules."
Answered by AI