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What is Namenda Xr
MemantineThe Generic name of this drug
Treatment SummaryMemantine is a medication used to treat Alzheimer’s Disease. It works differently from other Alzheimer’s medications by blocking glutamate, a chemical in the brain which can cause excessive stimulation in Alzheimer’s Disease. The drug was approved by the FDA in 2013 and the number of people living with Alzheimer’s Disease worldwide has been steadily increasing since then. In 2013, the G8 dementia summit concluded that dementia should be a priority and that a cure or a disease-modifying therapy should be developed by 2025.
Namendais the brand name
Namenda Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Namenda
Memantine
2003
235
Approved as Treatment by the FDA
Memantine, commonly known as Namenda, is approved by the FDA for 2 uses like Alzheimer's Disease and Alzheimer's Disease .Alzheimer's Disease
Used to treat moderate Alzheimer's Type Dementia in combination with Donepezil
Alzheimer's Disease
Helps manage severe Alzheimer's Type Dementia
Effectiveness
How Namenda Xr Affects PatientsMemantine helps to improve Alzheimer's dementia symptoms such as cognition. At lower doses, it can help with memory and protect neurons from damage caused by certain neurotransmitters. It does not interact with most other receptors, such as those for GABA, dopamine, or adrenaline. In lab studies, it has been shown not to interfere with medications such as donepezil, galantamine, or tacrine.
How Namenda Xr works in the bodyMemantine is used to treat Alzheimer's disease by blocking overactive N-methyl-D-aspartate (NMDA) receptors in the brain. These receptors are normally stimulated by a chemical called glutamate, but too much of it can be toxic to the brain. Memantine stops glutamate from overstimulating these receptors, thus preventing neurotoxicity. While this is not a cure for Alzheimer's, it can help slow down the neurodegeneration associated with the disease.
When to interrupt dosage
The measure of Namenda Xr is contingent upon the diagnosed sickness, including Alzheimer's Disease, Alzheimer's Disease and Dementia, Vascular. The dosage amount further varies as per the strategy of delivery (e.g. Kit - Oral or Solution - Oral) featured in the table beneath.Condition
Dosage
Administration
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Dementia, Vascular
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Dementia, Vascular
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alzheimer's Disease
, 5.0 mg, 10.0 mg, 2.0 mg/mL, 7.0 mg, 14.0 mg, 28.0 mg, 20.0 mg, 5.0 mg/pump actuation, 21.0 mg, 10.0 mg/mL, 15.0 mg, 70.0 mg
, Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, Capsule - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Namenda Xr has a single contraindication. If you are afflicted with any of the ailments given in the table below, Namenda Xr should not be utilized.Namenda Xr ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Memantine may interact with Pulse Frequency
Common Namenda Xr Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Memantine.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Memantine.
Antipyrine
Major
The metabolism of Antipyrine can be decreased when combined with Memantine.
Apomorphine
Major
The metabolism of Apomorphine can be decreased when combined with Memantine.
Artemether
Major
The metabolism of Artemether can be decreased when combined with Memantine.
Namenda Xr Toxicity & Overdose RiskThe toxic dose of memantine in mice is 437-498 mg/kg and in rats is 328-370 mg/kg. No evidence of cancer or genetic damage was found in mice and rats given the drug. There were also no effects on fertility or reproductive performance in animals given the drug. Memantine is a pregnancy category B drug, meaning that it has not been adequately studied in pregnant women and should only be used if the potential benefits outweigh the possible risks to the fetus. It is unknown if memantine is passed into breast milk, so caution should be taken when it is used by nursing mothers.
Namenda Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Namenda Xr?
41 active studies are assessing the potential of Namenda XR to provide therapeutic benefit for Alzheimer's Disease, Dementia, Vascular and Alzheimer's Disease-related conditions.Condition
Clinical Trials
Trial Phases
Dementia, Vascular
0 Actively Recruiting
Dementia, Vascular
0 Actively Recruiting
Alzheimer's Disease
2 Actively Recruiting
Phase 3, Phase 2
Alzheimer's Disease
0 Actively Recruiting
Alzheimer's Disease
0 Actively Recruiting
Alzheimer's Disease
41 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Namenda Xr Reviews: What are patients saying about Namenda Xr?
5Patient Review
1/16/2017 My husband takes the XR and Aricept together, and they work really well for him. He's able to function normally but doesn't have much energy or enthusiasm. I think he's just being lazy, but I understand that it's a side effect of his illness.
4Patient Review
3/12/2014 This treatment can cause a decrease in muscle strength.
3.7Patient Review
3/13/2014 I've been on this medication for three weeks and I've noticed that after taking it for six hours, I feel an urge to clean. Afterward, however, I become very sleepy. Additionally, I sometimes have nightmares; though they're not too bad. Overall, this drug has helped me more than it's hurt me.
3.3Patient Review
6/3/2016 It's hard to say for certain.
2.3Patient Review
8/23/2015 This medication caused my mother to regress; she stopped eating and her days and nights were reversed. She was also constantly crying, tearful, confused, and seeing things that weren't there. I had to take her off the medication immediately, but thankfully she's doing much better now.
1.3Patient Review
2/18/2014 My dad has been taking this medication and it's made him want to sleep all the time. He's much more sedentary now and isn't able to do tasks he could before. This is really tough on my mom who is his primary caregiver. I think they're going to talk to the doctor about taking him off the medication soon.
1Patient Review
7/10/2015 Since my mother started this medication, she's been having terrible nightmares and repeating herself constantly. I contacted her doctor and they said it wasn't the medicine, but I don't think that's true. This morning she thought people were in her room and when I told her she was dreaming, she didn't believe me. It's so sad to see what this has done to her.
1Patient Review
8/11/2014 I was prescribed this drug for my migraines, and it's helped lower the frequency with which I experience them.
1Patient Review
8/10/2015 My husband became very confused and disoriented after only four days on this medication. He stopped taking it immediately, and within 10 days was back to his old self. We were both very relieved. I would not recommend this drug to anyone.
Patient Q&A Section about namenda xr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Namenda XR do for you?
"Namenda XR is a prescription medication used to treat moderate to severe dementia related to Alzheimer's disease. It works by reducing the amount of a certain chemical in the brain that can contribute to dementia symptoms."
Answered by AI
Should Namenda be taken in the morning or at night?
"It doesn't matter what time of day you take memantine, as long as you are consistent with the timing. Try to take your doses at the same time every day."
Answered by AI
Is there a generic for Namenda XR?
"sees Amneal and Lupin releasing their own AB-rated generic versions of Allergan's Namenda XR. Mylan and Sun had received FDA approval for their own generic Namenda XR on September 28, 2016."
Answered by AI