Mucinex

Shock, Cardiogenic, Catarrh, Migraine + 51 more

Treatment

20 Active Studies for Mucinex

Treatment for

Shock, Cardiogenic

What is Mucinex

Phenylephrine

The Generic name of this drug

Treatment Summary

Guaifenesin is an expectorant medication used to treat coughs and chest congestion. It has been used since 1952 and is available both in prescription and over-the-counter products. It is believed to help clear mucus from the lungs, but it is not known for sure if it works reliably. In 2007, the FDA received a petition asking them to notify the public that some of the products containing guaifenesin were not safe for use in children under 6 years old. The FDA then reached an agreement with major manufacturers in 2008 to label products with guaifenesin as not suitable for use in children

Scot-Tussin Original SF Multi-Symptom

is the brand name

image of different drug pills on a surface

Mucinex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Scot-Tussin Original SF Multi-Symptom

Phenylephrine

1956

146

Effectiveness

How Mucinex Affects Patients

Guaifenesin is used to reduce dry, unproductive coughing and increase the amount of phlegm and bronchial secretions. It does this by reducing the stickiness and surface tension of the material, making it easier to cough up. Additionally, it increases the flow of gastric secretions which helps support the activity of cilia (tiny hairs that help remove secretions from the airways).

How Mucinex works in the body

Guaifenesin is thought to work as an expectorant by thinning the mucus in your airways, making it easier to cough out. It may also cause your body to produce more mucus, which helps clear out any blockages in your airways. Additionally, research suggests that guaifenesin may work as an anticonvulsant and muscle relaxant by blocking signals from a certain type of nerve receptor.

When to interrupt dosage

The proposed dosage of Mucinex is determined by the diagnosed affliction, such as Pollen Allergy, Drug Allergy and Allergic Reaction. The measure of dosage relies upon the administration strategy outlined in the table beneath.

Condition

Dosage

Administration

Sneezing

, 2.5 mg/mL, 0.5 mg/mL, 5.0 mg, 5.0 mg/mL, 2.5 mg, 1.0 mg/mL, 10.0 mg, 10.0 mg/mL, 15.0 mg, 0.000025 mg/mg, 0.0025 mg/mg, 0.001 mg/mg, 0.0065 mg/mg, 6.5 mg, 75.0 mg, 7.8 mg, 0.25 mg/mg, 6.0 mg, 4.0 mg/mL, 162.0 mg, 6.25 mg, 0.0000025 mg/mg, 3.33 mg/mL, 30.0 mg, 1.5 mg/mL, 1.75 mg/mL, 7.5 mg/mL, 25.0 mg/mL, 100.0 mg/mL, 12.5 mg/mL, 0.01 mL/mL, 25.0 mg, 0.0026 mg/mg, 1.25 mg/mL, 15.0 mg/mL, 0.00255 mg/mg, 0.0025 mg/mL, 1.25 mg, 0.08 mg/mL, 0.16 mg/mL, 0.05 mg/mL, 0.3 mg/mL, 0.04 mg/mL, 0.1 mg/mL, 2.173 mg/mL, 8.0 mg, 0.00125 mg/mL, 2.0 mg/mL, 5.0 mg/mg, 0.005 mg, 5.0 %, 0.25 %, 1.0 %, 0.12 %, 0.125 %, 0.5 %, 5.25 mg, 0.074 mg/mg, 5.77 mg, 5.5 mg, 0.625 mg/mL, 2.5 %, 10.0 %, 10.16 mg/mL, 24.8 mg/mg, 0.01425 mg/mg, 0.01 mg/mg, 0.025 mg/mg, 1.2 mg/mL, 20.0 mg, 12.0 mg, 8.5 mg, 0.8 mg/mL, 7.0 mg, 40.0 mg, 35.0 mg, 19.0 mg, 10000.0 mg, 0.005 mg/mg, 20.0 mg/mL, 15.5 mg/mL, 8.0 mg/mL, 3.5 mg/mL, 0.00024 mg, 6.0 mg/mL, 0.01 mg/mL, 0.025 mg/mL, 0.5 [arb'U]/mL, 2.0 mg, 4.975 mg/mL, 6.75 mg, 0.007 mg/mg, 0.25 mg/mL, 50.0 mg/mL, 7.5 mg, 0.333 mg/mL, 0.00025 mg/mg, 3.0 mg/mL, 1.0 mg/mg, 3.75 mg/mL, 0.2 mg/mL

Oral, , Liquid - Oral, Liquid, Tablet, chewable - Oral, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution - Oral, Tablet, chewable, Solution, Syrup - Oral, Syrup, Powder, for solution - Oral, Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Nasal, Spray, Spray - Nasal, Tablet, coated - Oral, Tablet, coated, Suspension, Suspension - Oral, Tablet, film coated, Ointment - Rectal, Powder, for suspension, Powder, for suspension - Oral, Rectal, Suppository, Ointment, Tablet, film coated - Oral, Suppository - Rectal, Capsule, liquid filled, Ointment - Topical, Topical, Cream, Cream - Topical, Tablet, effervescent - Oral, Kit, Powder, Powder - Oral, Tablet, effervescent, Granule, effervescent, Granule, effervescent - Oral, Capsule, Gel, Gel - Topical, Capsule, gelatin coated - Oral, Granule, for solution, Granule, for solution - Oral, Capsule - Oral, Spray - Topical, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Capsule, gelatin coated, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Intravenous, Ointment - Rectal; Topical, Solution / drops - Oral, Rectal; Topical, Cream - Rectal; Topical, Capsule, coated - Oral, Capsule, coated, Cream - Rectal, Elixir, Elixir - Oral, Suspension / drops, Suspension / drops - Oral, Solution / drops - Nasal, Injection, solution - Intravenous, Tablet, multilayer - Oral, Tablet, multilayer, Liquid - Nasal, Solution - Ophthalmic, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Solution - Nasal, Liquid - Intramuscular; Intravenous; Subcutaneous, Solution - Intramuscular; Intravenous; Subcutaneous, Tablet, extended release, Tablet, extended release - Oral, Liquid - Ophthalmic, Strip, Strip - Oral, Solution / drops - Topical, Kit; Powder - Oral, Kit; Powder, Cloth, Cloth - Topical, Kit; Tablet, Kit; Tablet - Oral, Kit; Powder, for solution - Oral, Kit - Oral, Intraocular, Injection, solution, concentrate, Injection, solution, concentrate - Intraocular, Liquid - Topical, Solution - Intravenous, Gel - Rectal, Lotion - Ophthalmic, Capsule, extended release, Kit; Powder, for solution, Gel - Rectal; Topical, Injection, solution - Intraocular; Ophthalmic, Capsule, extended release - Oral, Lotion, Intraocular; Ophthalmic, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Respiratory (inhalation), Auricular (otic), Liquid - Auricular (otic), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Capsule, coated pellets - Oral, Capsule, coated pellets, Ophthalmic; Oral; Respiratory (inhalation); Topical, Nasal; Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Rectal; Topical, Solution, concentrate, Intraocular; Irrigation, Solution, concentrate - Intraocular; Irrigation, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Anorectal discomfort

Respiratory tract structure

Pain management

Induced Hyperthermia

Rhinorrhea

Respiratory tract structure

Low Blood Pressure

Delayed Hypersensitivity

Fistula

Pharyngitis

Conjunctivitis

Nasal Congestion

Seasonal Allergies

Sinus Congestion

Allergy to Tree Pollen

Influenza

Coughing

Nose

Headache

Warnings

Mucinex Contraindications

Condition

Risk Level

Notes

Hypertension

Do Not Combine

Pulse Frequency

Do Not Combine

Hypertensive disease

Do Not Combine

Ventricular Tachycardia

Do Not Combine

Pulse Frequency

Do Not Combine

Thyrotoxicosis

Do Not Combine

There are 20 known major drug interactions with Mucinex.

Common Mucinex Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be increased when combined with Phenylephrine.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Phenylephrine.

Anagrelide

Major

The metabolism of Anagrelide can be increased when combined with Phenylephrine.

Axitinib

Major

The metabolism of Axitinib can be increased when combined with Phenylephrine.

Bendamustine

Major

The metabolism of Bendamustine can be increased when combined with Phenylephrine.

Mucinex Toxicity & Overdose Risk

Overdosing on guaifenesin can lead to nausea and vomiting. Although there have not been any studies completed on pregnant women, one study found an increase in inguinal hernias in newborns whose mothers took guaifenesin during the first trimester. Guaifenesin is passed through breast milk, so it is important to consider the risks of taking the drug while breastfeeding. The lethal dose of guaifenesin in rats is 1510mg/kg.

image of a doctor in a lab doing drug, clinical research

Mucinex Novel Uses: Which Conditions Have a Clinical Trial Featuring Mucinex?

309 active clinical trials are currently being conducted to assess the potential of Mucinex to alleviate symptoms of Rash, Sore Throat and Cough.

Condition

Clinical Trials

Trial Phases

Low Blood Pressure

5 Actively Recruiting

Not Applicable, Phase 4, Phase 2

Eye

0 Actively Recruiting

Acute Bronchitis

7 Actively Recruiting

Phase 4, Not Applicable, Phase 3, Early Phase 1

Cold

0 Actively Recruiting

Rhinitis, Vasomotor

0 Actively Recruiting

Coughing

0 Actively Recruiting

Pupil

0 Actively Recruiting

Bronchitis

0 Actively Recruiting

bronchial congestion

0 Actively Recruiting

Shock, Cardiogenic

8 Actively Recruiting

Not Applicable, Phase 4, Early Phase 1, Phase 1, Phase 2

Respiratory tract structure

0 Actively Recruiting

Headache

0 Actively Recruiting

Catarrh

0 Actively Recruiting

Fever

2 Actively Recruiting

Not Applicable, Phase 4

Respiratory tract structure

0 Actively Recruiting

Fistula

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Pain

0 Actively Recruiting

Coughing

0 Actively Recruiting

Sneezing

0 Actively Recruiting

Mucinex Reviews: What are patients saying about Mucinex?

4.7

Patient Review

3/6/2019

Mucinex for Cough

All these people saying it doesn't work are smoking crack. I had a terrible dry cough and within 30 minutes of taking this I was finally coughing up phlegm which greatly relieved my chest pain. It doesn't cure your cough but for 12 hours it relieves it greatly.

3.7

Patient Review

1/19/2022

Mucinex for Cough

Liquid medicine is much more effective than pills for treating my chronic bronchitis, especially at night. Pills are a pain to take out of the safety packaging.

3.3

Patient Review

3/28/2017

Mucinex for Cold Symptoms

Mucinex was effective at treating my chest congestion, but the itching it caused me wasn't worth it.

2.3

Patient Review

10/5/2015

Mucinex for Cough

Mucinex did nothing for my congestion and made me feel terrible. I had dizziness, malaise, and a loss of taste and smell for five days after I stopped taking it. A week later and I'm still not back to normal. Never again.

2.3

Patient Review

3/20/2019

Mucinex for Cold Symptoms

After taking one Mucinex tablet, I experienced an accelerated heart rate and ringing in my ears. It also left me feeling very parched and mentally foggy. Overall, not a great experience - I won't be taking this again.

2.3

Patient Review

9/27/2015

Mucinex for Cold Symptoms

I was really disappointed with this drug. I had high hopes but it failed to deliver. Maybe it'll work better for someone else, though.

Patient Review

1/28/2016

Mucinex for Cough

I was pretty restless after taking this medication and it made my heart rate spike. It might be better to take during the daytime instead.

1.7

Patient Review

3/14/2016

Mucinex for Cold Symptoms

The side effects were really bad. I felt dizzy and nauseous. I would rather cough and not be able to breathe than take this again.

1.7

Patient Review

2/20/2015

Mucinex for Cold Symptoms

This product failed to provide relief on two separate occasions. In both instances, Dayquil proved more effective within fifteen minutes. I would not recommend this medication to anyone.

1.7

Patient Review

1/18/2015

Mucinex for Cough

Not only was this treatment ineffective, but it was also very expensive. I couldn't even use it properly because the instruction label wouldn't peel back!

1.3

Patient Review

7/23/2022

Mucinex for Cold Symptoms

Not only did this not help my cough at all, but it also made me feel nauseous and dizzy.

1.3

Patient Review

11/4/2017

Mucinex for Cough

The print on the carton of this Mucinex is SO SMALL, especially if you're sick. I found myself guessing at the dosage, which is never a good idea.

Patient Review

1/28/2017

Mucinex for Cough

I tried this drug after a week of coughing, per my sister's suggestion. However, less than an hour after taking it I experienced such intense dizziness that I couldn't even stand up. My family thought I might be having a heart attack and was about to take me to the ER. It was honestly one of the most frightening experiences of my life.

Patient Review

7/2/2016

Mucinex for Cough

I had a really tight feeling in my chest after taking this, to the point where I wondered if I should go to the ER. It's been eight hours and I'm still wide awake. This also didn't do anything for my cough or wheezing. So right now I'm using Vicks vapor rub, which is an old remedy but at least it doesn't have any scary side effects. Hopefully I can get to sleep soon.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about mucinex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What symptoms does Mucinex help with?

"Mucinex is a drug that helps break up chest congestion so that it can be coughed out. It is used to treat congestion from the common cold, infections, or allergies."

Answered by AI

What is Mucinex used for?

"This medication is best for coughs that are caused by the common cold, bronchitis, and other breathing illnesses. If you have an ongoing cough from smoking or long-term breathing problems, this medication is not going to be very effective."

Answered by AI

Why should you not take Mucinex?

"The medication Mucinex may not be suitable for people with a long-standing cough related to asthma, bronchitis, emphysema, or smoking, or for those who are coughing up large amounts of phlegm. If you are pregnant or breastfeeding, talk to your doctor before taking Mucinex."

Answered by AI

Clinical Trials for Mucinex

Have you considered Mucinex clinical trials?

We made a collection of clinical trials featuring Mucinex, we think they might fit your search criteria.

Have you considered Mucinex clinical trials?

We made a collection of clinical trials featuring Mucinex, we think they might fit your search criteria.

Image of Vanderbilt University Medical Center in Nashville, United States.

High vs. Standard Dose Influenza Vaccines for Flu

18+

All Sexes

Nashville, TN

This will be a follow-up study to the "Comparison of High Dose vs. Standard Dose Influenza Vaccine in Lung Allograft Recipient" study (DMID Protocol Number 22-0014) at Vanderbilt University Medical Center. Lung transplantation is a life-saving therapy for patients with advanced lung disease, and is also associated with an improvement in quality of life. However, due to the need for life-long immunosuppression to prevent acute cellular rejection and chronic lung allograft dysfunction ("chronic rejection"), lung transplant recipients are at risk for developing major infections. In fact, one-year survival is 85%, with infection being the leading cause of death within the first year post-transplant. We will conduct a follow-up phase II, randomized, double-blind trial to assess the impact of subsequent administration of two doses of HD-IIV compared to two doses of SD-IIV among lung recipients during the early post-transplant period. Demonstration of improved immunogenicity from two doses of HD-IIV over consecutive influenza seasons would provide potential broad benefit in reducing influenza disease and its associated complications in lung transplant recipients. Moreover, studying vaccine immunogenicity and safety in the same participants over consecutive years can provide insight into the influence of immunosuppression levels and allograft aging on vaccine-mediated immune modulation. This proposed study design will contribute significantly to influenza vaccination guidance and policy for the highly vulnerable lung transplant population. This proposed study is designed to address several key knowledge gaps in vaccine-mediated protection of lung transplant recipients against influenza: * Is there increased immunogenicity with administration of one or two doses of HD-IIV or SD-IIV in the subsequent season compared to two doses of HD-IIV or SD-IIV in the first season? * What is the durability of the humoral and cellular immune response between influenza seasons and does two doses of HD-IIV or SD-IIV sustain higher HAI titers compared to two doses of HD-IIV or SD-IIV in the first season? * What is the impact of maintenance immunosuppression levels on influenza vaccine immunogenicity within the same participant? * Will the optimal immunogenic vaccination strategy be associated with an acceptable long-term safety profile over successive influenza seasons, including injection-site and systemic reactions, allosensitization, and organ rejection?

Phase 2

Recruiting

Has No Placebo

Vanderbilt University Medical Center

Natahsa Halasa, MD, MPH