Lidocaine for Headache
(LIGHT 2 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether injecting lidocaine, a local anesthetic, into specific brain blood vessels can relieve chronic migraines. Participants will receive either the lidocaine treatment or a placebo (a harmless saline solution) for comparison. Ideal candidates are adults referred for a specific brain imaging procedure who struggle with severe, hard-to-treat migraines. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to important advancements in migraine treatment.
Is there any evidence suggesting that lidocaine is likely to be safe for humans?
Studies have shown that lidocaine is generally well-tolerated when used in specific ways. Research indicates that lidocaine is safe, with no serious side effects reported. This suggests that lidocaine injections, like those in this trial, might also be safe. However, excessive use of lidocaine can be harmful, especially in young children, making it crucial to follow recommended doses. While lidocaine is already used in some treatments, its use in this trial is still being tested for safety and effectiveness.12345
Why do researchers think this study treatment might be promising for headaches?
Lidocaine is unique because it targets headaches through a new delivery method: intra-arterial administration. Unlike typical treatments for headaches, like oral pain relievers or triptans, lidocaine is directly administered into the bloodstream, which may lead to faster and more targeted pain relief. Researchers are excited about this approach because it could offer a rapid solution for those suffering from severe headaches, potentially reducing the time it takes to feel relief compared to standard options.
What evidence suggests that lidocaine might be an effective treatment for chronic headaches?
Research has shown that lidocaine, a common pain reliever, can help reduce migraine pain. Almost 88% of people with chronic migraines experienced less pain after receiving lidocaine through an IV. In smaller studies, injecting lidocaine directly into brain arteries relieved headaches for some individuals. This trial will compare intra-arterial lidocaine, which participants may receive, with a sham comparator using intra-arterial saline. These findings suggest that lidocaine could effectively treat chronic headaches.23678
Who Is on the Research Team?
Manisha Koneru, MD
Principal Investigator
The Cooper Health System
Are You a Good Fit for This Trial?
This trial is for individuals suffering from chronic headaches, including migraines and vestibular migraines. Specific eligibility criteria are not provided, but typically participants must meet certain health standards and may be excluded based on factors that could interfere with the study or their safety.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive intra-arterial lidocaine or saline for headache treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Lidocaine
Trial Overview
The study is testing if injecting lidocaine directly into two brain blood vessels can relieve intractable headaches. Participants will receive either lidocaine or a saline solution to compare effectiveness.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Intra-arterial lidocaine
Intra-arterial saline
Find a Clinic Near You
Who Is Running the Clinical Trial?
Daniel A Tonetti, MD
Lead Sponsor
Citations
Intranasal lidocaine for acute migraine: A meta-analysis ... - PMC
Intranasal lidocaine has been shown to be effective in treating patients with acute migraines; however, its efficacy is still controversial.
2.
medicalnewstoday.com
medicalnewstoday.com/articles/chronic-migraine-common-anesthetic-relieves-pain-in-new-studyChronic migraine: Common anesthetic could provide relief
Nearly 88% of chronic migraine patients receiving intravenous lidocaine during hospitalization showed a reduction in pain intensity at discharge ...
Middle meningeal artery lidocaine infusion for refractory ...
Two small case series (six patients in total) have reported successful headache relief with direct intra-arterial lidocaine infusions into the middle meningeal ...
Bilateral Middle Meningeal Artery Lidocaine Infusion for ...
To observe a ≥50% reduction in monthly migraine headache days in one month post intra-arterial lidocaine infusion into the bilateral middle meningeal artery.
A single infusion of intravenous lidocaine for primary ...
The main efficacy outcome was change in headache/facial pain intensity using a verbal rating scale (VRS) 0–10. Patients were considered ...
A Phase 1 Clinical Trial for Safety
The data from this phase 1 clinical trial suggest favorable safety and tolerability of the investigational intervention. No serious adverse ...
Intranasal Lidocaine for Treatment of Migraine
Intranasal lidocaine can be absorbed systemically and could be potentially toxic if the patient uses the agent excessively. The risk for toxicity due to ...
Lidocaine (injection route) - Side effects & uses
Because of this medicine's toxicity, it should be used with extreme caution in children younger than 6 months of age. Recommended doses should not be exceeded, ...
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.