Monopril

Congestive Heart Failure, Hypertensive disease
Treatment
20 Active Studies for Monopril

What is Monopril

FosinoprilThe Generic name of this drug
Treatment SummaryFosinopril is a medication that belongs to the ACE inhibitor class and helps to reduce blood pressure. It works by blocking the enzyme that helps convert angiotensin I (ATI) to angiotensin II (ATII), which plays a role in regulating blood pressure. Fosinopril is used to treat mild to moderate hypertension, congestive heart failure, and slow the progression of renal disease in people with diabetes and kidney damage.
Fosinopril Sodiumis the brand name
image of different drug pills on a surface
Monopril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fosinopril Sodium
Fosinopril
2003
126

Effectiveness

How Monopril Affects PatientsFosinopril is a drug that works by slowing down a system in the body called the Renin-Angiotensin-Aldosterone System (RAAS). This system helps to regulate blood pressure, water levels, and electrolyte balance in the body. Fosinopril works by blocking an enzyme (ACE, or kininase II) that helps to convert a hormone, angiotensin I, into a different hormone called angiotensin II. Angiotensin II helps increase blood pressure in the body by causing the release of aldosterone from the adrenal glands, stimulating the release of
How Monopril works in the bodyACE is an enzyme found in the body that comes in two forms. The somatic form helps regulate blood pressure, and the testicular form helps sperm mature. ACE inhibitors bind to both forms, but are most effective at blocking the somatic form. Fosinoprilat, the active ingredient in fosinopril, binds to ACE and stops it from breaking down another enzyme called ATI. When ATI isn’t broken down, it helps lower blood pressure by blocking other effects on the body, and can also increase the amount of renin released in the body.

When to interrupt dosage

The measure of Monopril is contingent upon the diagnosed condition. The magnitude of dosage is contingent upon the approach of administration outlined in the table underneath.
Condition
Dosage
Administration
Hypertensive disease
10.0 mg, , 20.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral
Congestive Heart Failure
10.0 mg, , 20.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Monopril has two counterindications and should not be administered when exhibiting any of the conditions outlined in the table below.Monopril Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Monopril.
Common Monopril Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Fosinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Fosinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Fosinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Fosinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Fosinopril.
Monopril Toxicity & Overdose RiskTaking too much fosinopril may lead to low blood pressure, and doses of 2600 mg/kg in rats have been found to be lethal. Other common side effects of taking too much fosinopril include dizziness, coughing, tiredness, and headaches.
image of a doctor in a lab doing drug, clinical research

Monopril Novel Uses: Which Conditions Have a Clinical Trial Featuring Monopril?

324 active studies are currently assessing the potential of Monopril to ameliorate Congestive Heart Failure.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
18 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Congestive Heart Failure
317 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4

Monopril Reviews: What are patients saying about Monopril?

5Patient Review
8/6/2011
Monopril for High Blood Pressure
I've been using Monopril for 25 years and it's been great. No complaints whatsoever.
5Patient Review
5/25/2012
Monopril for High Blood Pressure
I've been on monopril for 30 years. I started taking it during my pregnancy and it has effectively controlled my HBP with no adverse side effects.
5Patient Review
6/17/2010
Monopril for High Blood Pressure
I've been taking Fosinopril for more than three years with no issues whatsoever. Additionally, I haven't experienced any adverse side effects.
5Patient Review
8/6/2009
Monopril for High Blood Pressure
This treatment is effective.
5Patient Review
9/24/2008
Monopril for High Blood Pressure
4.3Patient Review
6/14/2009
Monopril for High Blood Pressure
Lisinopril (HCTZ) used to work for me, but then I started experiencing tingling in my arms and hands. The doctor replaced HCTZ with Monopril and that did the trick. No longer have tingling feeling and my blood pressure is down and manageable.
4.3Patient Review
10/4/2010
Monopril for High Blood Pressure
Though this treatment is effective, there are some side effects that can be a challenge to deal with. The cough persists, and I also experience constipation which makes it difficult.
4Patient Review
2/14/2009
Monopril for High Blood Pressure
I've been taking this for years with no negative consequences.
2.7Patient Review
12/23/2008
Monopril for High Blood Pressure
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Patient Q&A Section about monopril

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic for Monopril?

"This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

This medication is used to bring down high blood pressure. This in turn helps to prevent strokes, heart attacks, and kidney problems."

Answered by AI

Is Monopril the same as fosinopril?

"Monopril is a drug used to treat symptoms related to high blood pressure and congestive heart failure. It may be used alone or in conjunction with other medications and belongs to a class of drugs called ACE inhibitors."

Answered by AI

What is Monopril used to treat?

"Fosinopril is a drug used to lower blood pressure. High blood pressure can lead to strokes, heart attacks, and kidney problems, so by lowering it, fosinopril can help prevent these conditions. It is also used to treat heart failure."

Answered by AI

What are the side effects of Monopril?

"a cough that doesn't produce phlegm, pain in your muscles or joints, a headache, feeling tired, a runny or stuffed nose, nausea, vomiting, or diarrhea"

Answered by AI

Clinical Trials for Monopril

Have you considered Monopril clinical trials? We made a collection of clinical trials featuring Monopril, we think they might fit your search criteria.
Have you considered Monopril clinical trials? We made a collection of clinical trials featuring Monopril, we think they might fit your search criteria.
Have you considered Monopril clinical trials? We made a collection of clinical trials featuring Monopril, we think they might fit your search criteria.