Mirapex

Parkinson's Disease, Restless Legs Syndrome, Restless Legs Syndrome
Treatment
20 Active Studies for Mirapex

What is Mirapex

PramipexoleThe Generic name of this drug
Treatment SummaryPramipexole is a medication used to treat the symptoms of Parkinson's Disease. It works by increasing the amount of dopamine in the brain, allowing patients to better control their movement and reduce tremors, stiffness, and slow movements. Pramipexole is commonly prescribed to people with Parkinson's Disease, which affects over 6 million people worldwide. Additionally, pramipexole is also used to treat Restless Legs Syndrome (RLS). RLS is a disorder that causes uncomfortable feelings in the legs and an urge to keep moving them.
Mirapexis the brand name
image of different drug pills on a surface
Mirapex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mirapex
Pramipexole
2003
318

Effectiveness

How Mirapex Affects PatientsPramipexole is used to help treat the symptoms of Parkinson's Disease and Restless Legs Syndrome. It works by stimulating dopamine receptors to balance the amount of dopamine in the brain, which is an important neurotransmitter that affects motor movements. In addition, studies have shown that this drug can also protect dopamine neurons from damage caused by lack of blood flow or certain drugs.
How Mirapex works in the bodyThe exact way pramipexole works to treat Parkinson's disease is not yet known. It is believed that pramipexole helps stimulate the dopamine receptors in the brain, which are responsible for many functions. Studies in animals suggest that pramipexole helps regulate the amount of nerve activity that comes from the dopamine receptors. Pramipexole is a non-ergot drug that binds specifically to the dopamine D2 and D3 receptors. The exact importance of this binding is unknown.

When to interrupt dosage

The measure of Mirapex is reliant upon the diagnosed condition, including Restless Legs Syndrome, Parkinson's Disease and Restless Legs Syndrome. The amount of dosage is contingent upon the method of delivery detailed in the table below.
Condition
Dosage
Administration
Restless Legs Syndrome
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 1.5 mg, 0.75 mg, 0.375 mg, 3.0 mg, 4.5 mg, 2.25 mg, 3.75 mg, 0.088 mg, 0.18 mg, 1.1 mg, 0.7 mg, 0.35 mg, 0.26 mg, 0.52 mg, 1.05 mg, 2.1 mg, 3.15 mg, 1.57 mg, 2.62 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Parkinson's Disease
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 1.5 mg, 0.75 mg, 0.375 mg, 3.0 mg, 4.5 mg, 2.25 mg, 3.75 mg, 0.088 mg, 0.18 mg, 1.1 mg, 0.7 mg, 0.35 mg, 0.26 mg, 0.52 mg, 1.05 mg, 2.1 mg, 3.15 mg, 1.57 mg, 2.62 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Restless Legs Syndrome
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 1.5 mg, 0.75 mg, 0.375 mg, 3.0 mg, 4.5 mg, 2.25 mg, 3.75 mg, 0.088 mg, 0.18 mg, 1.1 mg, 0.7 mg, 0.35 mg, 0.26 mg, 0.52 mg, 1.05 mg, 2.1 mg, 3.15 mg, 1.57 mg, 2.62 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit

Warnings

Mirapex Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pramipexole may interact with Pulse Frequency
There are 20 known major drug interactions with Mirapex.
Common Mirapex Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Pramipexole may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Pramipexole is combined with Acebutolol.
Aclidinium
Minor
Pramipexole may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Pramipexole may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Pramipexole may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Mirapex Toxicity & Overdose RiskThe toxic dose of Pramipexole in rats is greater than 800mg/kg. Studies on mice and rats have not found Pramipexole to be carcinogenic, and no mutagenicity was detected. However, when given in high doses to rats, Pramipexole has been found to affect fertility and cause teratogenic effects. There are currently no studies of Pramipexole in human pregnancy, so it should only be used if the potential benefits outweigh the risks. It is unknown whether Pramipexole is excreted in breast milk, so it is important to weigh the potential risks
image of a doctor in a lab doing drug, clinical research

Mirapex Novel Uses: Which Conditions Have a Clinical Trial Featuring Mirapex?

45 active studies are currently exploring the potential of Mirapex in providing relief from Restless Legs Syndrome, Restless Legs Syndrome and Parkinson's Disease.
Condition
Clinical Trials
Trial Phases
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Restless Legs Syndrome
0 Actively Recruiting
Restless Legs Syndrome
0 Actively Recruiting

Mirapex Reviews: What are patients saying about Mirapex?

5Patient Review
10/8/2016
Mirapex for Extreme Discomfort in Calves when Sitting or Lying Down
I've been taking Mirapex for a while now to help with my RLS and it's worked great. I'm just curious if anyone else who takes this medication has experienced hair loss?
5Patient Review
4/21/2016
Mirapex for Extreme Discomfort in Calves when Sitting or Lying Down
Mirapex has been great for my RLS, usually. Recently I've been having breakthrough issues, but a half pill around lunchtime generally does the trick.
5Patient Review
5/16/2019
Mirapex for Extreme Discomfort in Calves when Sitting or Lying Down
I was absolutely devastated when I found out that the manufacturer had stopped making Mirapex. This drug has been a miracle for my restless leg syndrome, and the generic never worked as well for me. It's by far the most important prescription I take for a better quality of life.
5Patient Review
3/26/2015
Mirapex for Disorder characterized by Stiff, Tender & Painful Muscles
Mirapex was a total game changer for me when it came to my restless leg syndrome. I would wake up with sore legs and feet, but after taking this medication I found relief and slept soundly through the night.
4Patient Review
9/15/2015
Mirapex for Extreme Discomfort in Calves when Sitting or Lying Down
I find the packaging very difficult to use. I think it would be much easier if it came in a bottle.
View All Reviews
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Patient Q&A Section about mirapex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the most common side effects of pramipexole?

"If you experience any of the following, you should speak with a doctor: feeling dizzy or lightheaded, fainting, fatigue, hallucinations, muscle twitches, and body movements that are unusual."

Answered by AI

What does the drug Mirapex do?

"This medication is also used to treat restless legs syndrome (RLS).

Pramipexole is used to treat Parkinson's disease, either alone or with other medications. It improves your ability to move and decreases symptoms such as shakiness (tremor), stiffness, slowed movement, and unsteadiness. It may also decrease the number of episodes of not being able to move ("on-off syndrome").

This medication is also used to treat restless legs syndrome (RLS)."

Answered by AI

Is Mirapex a muscle relaxer?

"Mirapex is used to treat symptoms of Parkinson's disease such as stiffness, tremors, muscle spasms, and poor muscle control. It is also used to treat restless legs syndrome."

Answered by AI

How does Mirapex work for restless legs?

"Pramipexole (Mirapex) is a medication that improves movement by binding to and stimulating dopamine receptors in the brain, which raises the levels of dopamine."

Answered by AI

Clinical Trials for Mirapex

Have you considered Mirapex clinical trials? We made a collection of clinical trials featuring Mirapex, we think they might fit your search criteria.
Have you considered Mirapex clinical trials? We made a collection of clinical trials featuring Mirapex, we think they might fit your search criteria.
Have you considered Mirapex clinical trials? We made a collection of clinical trials featuring Mirapex, we think they might fit your search criteria.