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What is Micardis Hct
TelmisartanThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a common medication used to treat swelling and high blood pressure. It works by helping the body get rid of extra water and salt. It has been available since 1959 and is often used in combination with other medications like ACE inhibitors or angiotensin II receptor blockers. However, it is becoming less popular as other medications become available.
Micardis HCTis the brand name
Micardis Hct Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Micardis HCT
Telmisartan
2000
182
Approved as Treatment by the FDA
Telmisartan, also known as Micardis HCT, is approved by the FDA for 6 uses including no initial therapy and blood pressure inadequately controlled with monotherapy .no initial therapy
Used to treat no initial therapy in combination with Amlodipine
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Amlodipine
Cardiovascular Events
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
unable to take ACE inhibitors
prophylaxis of cardiovascular event
Effectiveness
How Micardis Hct Affects PatientsHydrochlorothiazide stops the body from reabsorbing salt and water in the kidneys, increasing the amount of water released in urine. The right dose for each individual can differ, but is usually between 25-100mg. People with kidney or liver problems should be careful when taking this drug.
How Micardis Hct works in the bodyHydrochlorothiazide works to reduce water reabsorption in the kidneys. It is transported from the bloodstream into epithelial cells of the distal convoluted tubule by special molecules called transporters. Then, it is sent to the lumen of the tubule by another molecule called MRP4. In the distal convoluted tubule, sodium is typically reabsorbed and pumped into the interstitium, creating a concentration gradient that draws water back into the cells. Hydrochlorothiazide blocks this process by inhibiting a transporter, SLC12A3, which reduces the concentration gradient and prevents the reabsorption
When to interrupt dosage
The advisable dosage of Micardis Hct depends on the identified condition, including Antepartum magnesium sulfate prophylaxis, blood pressure inadequately managed with monotherapy and antihypertensives. The dosage also fluctuates in correlation to the technique of delivery (e.g. Tablet, coated - Oral or Oral) outlined in the table below.Condition
Dosage
Administration
Cardiovascular Events
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
unable to take ACE inhibitors
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
prophylaxis of cardiovascular event
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
no initial therapy
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Congestive Heart Failure
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Diabetic Nephropathy
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Hypertensive disease
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
blood pressure inadequately controlled with monotherapy
, 40.0 mg, 80.0 mg, 20.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, multilayer, Tablet, multilayer - Oral
Warnings
Micardis Hct has two contraindications. It should not be taken concomitantly with the conditions in the table below.Micardis Hct ContraindicationsCondition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
Common Micardis Hct Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Telmisartan.
Amifostine
Major
Telmisartan may increase the hypotensive activities of Amifostine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Telmisartan.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Telmisartan.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Telmisartan.
Micardis Hct Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. Those who overdose on hydrochlorothiazide may experience low potassium, chloride, or sodium levels in the blood, which can be treated with fluids and electrolytes. If the patient is experiencing low blood pressure, they may need to be given medications to raise their blood pressure, and oxygen may be necessary if they have difficulty breathing.
Micardis Hct Novel Uses: Which Conditions Have a Clinical Trial Featuring Micardis Hct?
158 active clinical trials are underway to assess the potential of Micardis Hct in alleviating Cirrhosis, Edema, and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
Congestive Heart Failure
313 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
unable to take ACE inhibitors
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cardiovascular Events
3 Actively Recruiting
Not Applicable
no initial therapy
0 Actively Recruiting
Micardis Hct Reviews: What are patients saying about Micardis Hct?
5Patient Review
5/12/2017 I've been taking this medication for a while now and my blood pressure is great.
5Patient Review
11/9/2018 I've been on this medication for ten days now and I haven't experienced any negative side effects. This is in contrast to many other medications I've tried, which have had awful side effects that made them unusable.
4.3Patient Review
6/25/2014 I've been taking this medication for three years now and it's working great. I only need half a tablet, which is nice because it makes the supply last longer. The only side effect I experienced was some pain in my right leg, but that went away after a few days.
4Patient Review
6/14/2012 I had a chronic cough that made me very self-conscious. I was really hesitant to try this treatment, but it ended up helping me so much! Not only did it get rid of my cough, but I also lost weight!
3.7Patient Review
10/17/2012 This treatment really helped me with my erectile dysfunction. I was a bit worried at first, but it worked great!
2.7Patient Review
6/12/2012 I've been on this medication for over a year. Side effects include lower back ache, hair loss, and it makes me dizzy. It does not control BP. Just took it and it is 157/98. Currently have no health insurance and it is expensive. Been on many other medications with same results.
2.7Patient Review
1/26/2014 I started taking this drug to help control my blood pressure and heart rate. It was effective at first, but now it doesn't seem to be working as well. My doctor is considering changing the prescription or the strength of the medication.
2.7Patient Review
6/20/2016 My blood pressure is still inconsistent. Sometimes it's normal, and sometimes it's high.
2.3Patient Review
1/10/2016 I've been taking this medication for a few months and have noticed my lips peeling and feeling very dry, as well as a cotton-mouth feeling every morning. I was also dizzy for a couple weeks but that has gone away. Can anyone tell me if it's okay to just stop taking this medication or if I need to wean myself off?
2.3Patient Review
6/27/2012 The price tag on this drug is pretty high.
2Patient Review
4/7/2014 I was on this medication for over a decade before I started noticing serious side effects, like hair loss and irregular heartbeat. I even went to the ER once because of the palpitations. My doctor finally took me off the medication, but it really messed with my body in a lot of subtle ways.
2Patient Review
12/6/2012 I've only just started this treatment, so I can't speak to its long-term effectiveness yet.
2Patient Review
4/24/20121.7Patient Review
4/5/2013 I took this drug for three years, even though it regularly made me feel flu-like and gave me diarrhea. It didn't affect my blood pressure at all (which has always been 140/90). As soon as I stopped taking the medication, the symptoms disappeared. Now that I'm not taking anything, my blood pressure is still the same. The only people who are unhappy are the CEOs of the drug companies.
1Patient Review
9/17/2012 I would highly recommend against this medication after my mother had a stroke due to a ruptured vein in her brain. She's been fighting for her life in the ICU for the past two weeks and it's been incredibly difficult to watch.
1Patient Review
8/27/2012 This medication caused me a great deal of harm. I experienced thoughts of suicide, blistered hands, extreme rage, dehydration, depression, and a rash that covered my entire body. I was also unable to sleep at all while taking this drug.
1Patient Review
2/9/2022 I experienced terrible side effects while taking this drug. I was so exhausted that I could barely function after only a few hours of taking the first dose. My doctor had to take me off the drug because it was so debilitating.
Patient Q&A Section about micardis hct
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Micardis a good blood pressure medicine?
"Telmisartan is an effective blood pressure-lowering medication that can help protect your heart and kidneys."
Answered by AI
What is Micardis HCT used for?
"It works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of excess water.
This medication is used to treat high blood pressure by lowering it. This can prevent strokes, heart attacks, and kidney problems. The medication is a combination of two drugs, telmisartan and hydrochlorothiazide. Telmisartan relaxes blood vessels so blood can flow more easily and hydrochlorothiazide is a diuretic that helps remove excess water from the body."
Answered by AI
When should I take Micardis HCT?
"You will typically start by taking Micardis HCT at a dose of 80 mg/12.5 mg (telmisartan/hydrochlorothiazide) orally once per day. If you need to lower your blood pressure more, your healthcare provider can increase your dose to 160 mg/25 mg (telmisartan/hydrochlorothiazide) once per day."
Answered by AI