Methazolamide

Open Angle Glaucoma
Treatment
1 FDA approval
11 Active Studies for Methazolamide

What is Methazolamide

MethazolamideThe Generic name of this drug
Treatment SummaryAcetazolamide is a drug used to increase urine production to treat fluid retention and reduce eye pressure in glaucoma. It works by blocking an enzyme called carbonic anhydrase, which helps the body remove excess water.
Methazolamideis the brand name
image of different drug pills on a surface
Methazolamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Methazolamide
Methazolamide
1993
34

Approved as Treatment by the FDA

Methazolamide, also known as Methazolamide, is approved by the FDA for 1 uses which include Open Angle Glaucoma .
Open Angle Glaucoma
Helps manage Open Angle Glaucoma (OAG)

Effectiveness

How Methazolamide Affects PatientsMethazolamide is a medicine used to lower pressure in the eye for people with glaucoma or high eye pressure who don't respond well to other treatments. It is not an antibiotic and does not work as an anticonvulsant. Taking this drug will also increase the amount of urine produced, and also lead to the excretion of sodium, potassium, and chloride.
How Methazolamide works in the bodyMethazolamide works by blocking carbonic anhydrase, a molecule that helps produce bicarbonate ions. By stopping this process, it decreases the production of aqueous humor, a fluid in the eyes. This reduces sodium and fluid transport in the eye.

When to interrupt dosage

The prescribed dosage of Methazolamide depends on the specified circumstances. The amount of dosage is contingent upon the mode of administration (e.g. Oral or Tablet) as mentioned in the table beneath.
Condition
Dosage
Administration
Open Angle Glaucoma
, 50.0 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Methazolamide has nine contraindications and should not be taken in tandem with the conditions listed in the table below.Methazolamide Contraindications
Condition
Risk Level
Notes
Cirrhosis
Do Not Combine
adrenal gland failure
Do Not Combine
serum sodium depressed
Do Not Combine
Angle-Closure Glaucoma
Do Not Combine
hyperchloremic acidosis
Do Not Combine
Abnormal Renal Function
Do Not Combine
serum potassium depressed
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Dysfunction
Do Not Combine
There are 20 known major drug interactions with Methazolamide.
Common Methazolamide Drug Interactions
Drug Name
Risk Level
Description
Acetazolamide
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Acetazolamide.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Cyclopentamine.
Diclofenamide
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Diclofenamide.
Dorzolamide
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Dorzolamide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Hexamethonium.
Methazolamide Toxicity & Overdose RiskIn cases of overdose, an electrolyte imbalance, a buildup of acid in the body, and effects on the central nervous system may occur.
image of a doctor in a lab doing drug, clinical research

Methazolamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Methazolamide?

There are 12 ongoing clinical trials examining the effectiveness of Methazolamide in providing therapeutic relief for Glaucoma.
Condition
Clinical Trials
Trial Phases
Open Angle Glaucoma
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2

Methazolamide Reviews: What are patients saying about Methazolamide?

5Patient Review
9/11/2018
Methazolamide for Wide-Angle Glaucoma
One of the most frequent side effects I experienced was anorexia, which then led to unplanned weight loss.
4.3Patient Review
9/25/2014
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
This medication was my last resort for treating high eye pressure. It did help lower the pressure, but I felt really tired and had no energy to do anything. Also, it made me so sleepy that I just dozed off many times while watching TV.
4.3Patient Review
2/18/2015
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
After only one week of using this medication, my blood pressure has lowered significantly. I have noticed that I tend to feel tired after taking it and often fall asleep in front of the TV; however, this is much better than losing my vision.
4.3Patient Review
10/22/2009
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
4Patient Review
12/6/2011
Methazolamide for Closed Angle Glaucoma
I've been using this for over five years now and it's still working great without any noticeable side effects.
4Patient Review
1/22/2011
Methazolamide for Closed Angle Glaucoma
I've been on this medication for five years, taking 25mg twice a day. It's really helped with my essential tremor.
4Patient Review
4/19/2010
Methazolamide for Closed Angle Glaucoma
Helped with my glaucoma-related high eye pressure issues. The only potential downside I've noticed is some hearing loss over time, but I'm not sure if the two are connected.
4Patient Review
8/26/2012
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
I'm really pleased with this treatment because I didn't experience any negative side effects.
3.7Patient Review
3/29/2013
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
I've been taking Methazolamid for several years and I know that w/o my eye pressure would be a lot worse, like it used to be before, with only eye drops Cosopt, Alphagan, Lumingan. Unfortunately, the big side effect to this medication is that I feel very sleepy, very tired to the point that I don't have energy to do finish what I'm doing many times.
3.3Patient Review
6/27/2009
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
2Patient Review
1/15/2012
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
About two hours after taking the medication, I became very drowsy.
2Patient Review
1/2/2010
Methazolamide for Increased Eye Pressure caused by Another Disease
Though this medicine did lower my eye pressure like it was supposed to, I had to stop taking it because of breathing difficulties and spells of dizziness.
1Patient Review
5/21/2010
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
I started experiencing negative side effects pretty early on in the treatment, so I lowered my dosage. Even at a lower dose I was still having issues like headaches and stomach pain, so I stopped taking it altogether.
1Patient Review
5/17/2020
Methazolamide for High Eye Pressure or Glaucoma that May Worsen without Treatment
I was curious to read of other patients' experiences and side effects before trying this treatment, but unfortunately I had to stop taking it before seeing any real results because the symptoms were so severe.
1Patient Review
5/20/2010
Methazolamide for Increased Eye Pressure caused by Another Disease
I felt very tired and dizzy after taking this medication, and it made it hard to function.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about methazolamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why methazolamide is not used?

"Methazolamide only needs to be given twice a day because it has a half-life of 14 hours. It is not filtered by the kidneys."

Answered by AI

Does methazolamide lower blood pressure?

"However, you should follow the instructions from your doctor.

The pressure-lowering effects of methazolamide will 2-4 hours after you take your dose. You may still need to use your glaucoma eye drops, depending on what your doctor says."

Answered by AI

Does methazolamide cause weight loss?

"-Can be taken with food. -Drink lots of fluids to help prevent kidney stones. Common stomach and intestinal problems with methazolamide include feeling nauseous, vomiting, having diarrhea, not wanting to eat, and losing weight."

Answered by AI

What is methazolamide used to treat?

"Methazolamide is a medication used to treat glaucoma, which is a condition where increased pressure in the eye can lead to gradual loss of vision. Methazolamide works by decreasing the pressure in the eye."

Answered by AI

Clinical Trials for Methazolamide

Have you considered Methazolamide clinical trials? We made a collection of clinical trials featuring Methazolamide, we think they might fit your search criteria.
Have you considered Methazolamide clinical trials? We made a collection of clinical trials featuring Methazolamide, we think they might fit your search criteria.