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What is Methazolamide
MethazolamideThe Generic name of this drug
Treatment SummaryAcetazolamide is a drug used to increase urine production to treat fluid retention and reduce eye pressure in glaucoma. It works by blocking an enzyme called carbonic anhydrase, which helps the body remove excess water.
Methazolamideis the brand name
Methazolamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Methazolamide
Methazolamide
1993
34
Approved as Treatment by the FDA
Methazolamide, also known as Methazolamide, is approved by the FDA for 3 uses which include Acute angle-closure glaucoma and Open Angle Glaucoma (OAG) .Acute angle-closure glaucoma
Open Angle Glaucoma (OAG)
Helps manage Open Angle Glaucoma (OAG)
Open Angle Glaucoma
Helps manage Open Angle Glaucoma (OAG)
Effectiveness
How Methazolamide Affects PatientsMethazolamide is a medicine used to lower pressure in the eye for people with glaucoma or high eye pressure who don't respond well to other treatments. It is not an antibiotic and does not work as an anticonvulsant. Taking this drug will also increase the amount of urine produced, and also lead to the excretion of sodium, potassium, and chloride.
How Methazolamide works in the bodyMethazolamide works by blocking carbonic anhydrase, a molecule that helps produce bicarbonate ions. By stopping this process, it decreases the production of aqueous humor, a fluid in the eyes. This reduces sodium and fluid transport in the eye.
When to interrupt dosage
The prescribed dosage of Methazolamide depends on the specified circumstances. The amount of dosage is contingent upon the mode of administration (e.g. Oral or Tablet) as mentioned in the table beneath.Condition
Dosage
Administration
Open Angle Glaucoma
, 50.0 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Methazolamide has nine contraindications and should not be taken in tandem with the conditions listed in the table below.Methazolamide ContraindicationsCondition
Risk Level
Notes
Cirrhosis
Do Not Combine
Adrenal Insufficiency
Do Not Combine
Hyponatremia
Do Not Combine
Glaucoma, Angle-Closure
Do Not Combine
hyperchloremic acidosis
Do Not Combine
Abnormal Renal Function
Do Not Combine
Hypokalemia
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Dysfunction
Do Not Combine
Common Methazolamide Drug Interactions
Drug Name
Risk Level
Description
Acetazolamide
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Acetazolamide.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Cyclopentamine.
Diclofenamide
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Diclofenamide.
Dorzolamide
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Dorzolamide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Methazolamide is combined with Hexamethonium.
Methazolamide Toxicity & Overdose RiskIn cases of overdose, an electrolyte imbalance, a buildup of acid in the body, and effects on the central nervous system may occur.
Methazolamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Methazolamide?
There are 12 ongoing clinical trials examining the effectiveness of Methazolamide in providing therapeutic relief for Glaucoma.Condition
Clinical Trials
Trial Phases
Open Angle Glaucoma
12 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Methazolamide Reviews: What are patients saying about Methazolamide?
5Patient Review
9/11/2018 One of the most frequent side effects I experienced was anorexia, which then led to unplanned weight loss.
4.3Patient Review
9/25/2014 This medication was my last resort for treating high eye pressure. It did help lower the pressure, but I felt really tired and had no energy to do anything. Also, it made me so sleepy that I just dozed off many times while watching TV.
4.3Patient Review
2/18/2015 After only one week of using this medication, my blood pressure has lowered significantly. I have noticed that I tend to feel tired after taking it and often fall asleep in front of the TV; however, this is much better than losing my vision.
4.3Patient Review
10/22/20094Patient Review
12/6/2011 I've been using this for over five years now and it's still working great without any noticeable side effects.
Patient Q&A Section about methazolamide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why methazolamide is not used?
"Methazolamide only needs to be given twice a day because it has a half-life of 14 hours. It is not filtered by the kidneys."
Answered by AI
Does methazolamide lower blood pressure?
"However, you should follow the instructions from your doctor.
The pressure-lowering effects of methazolamide will 2-4 hours after you take your dose. You may still need to use your glaucoma eye drops, depending on what your doctor says."
Answered by AI
Does methazolamide cause weight loss?
"-Can be taken with food. -Drink lots of fluids to help prevent kidney stones. Common stomach and intestinal problems with methazolamide include feeling nauseous, vomiting, having diarrhea, not wanting to eat, and losing weight."
Answered by AI
What is methazolamide used to treat?
"Methazolamide is a medication used to treat glaucoma, which is a condition where increased pressure in the eye can lead to gradual loss of vision. Methazolamide works by decreasing the pressure in the eye."
Answered by AI
Clinical Trials for Methazolamide
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